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May 1 - May 2
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May 2 - May 3
This weekend
May 3 - May 5
Next weekend
May 10 - May 12

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Top 10 Defiance hotels and places to stay

Aerial view
TheOutPostInn Bed&Breakfast - The Blue Victorian
10.0 out of 10, Exceptional, (2)
"In downtown, quaint Marthasville MO, this old renovated home was a perfect getaway for my wife and I. The room was clean, the bed was huge and the amenities were spot on. The breakfast in the morning was a major bonus as well."
The price is £151
includes taxes & fees
2 May - 3 May
TheOutPostInn Bed&Breakfast - The Blue Victorian
Front of property
Central Hotel
3.5 star property
10.0 out of 10, Exceptional, (91)
"This hotel is quiet and quaint!!!"
The price is £135
includes taxes & fees
10 May - 11 May
Central Hotel
Exterior
Private entire lower level is included. GameRoom and living room also included.
10.0 out of 10, Exceptional, (1)
"Not much available for cooking but we made it work. Boiled crab legs n baked biscuits on the grill! Beautiful weekend with the snow storm and views"
Private entire lower level is included. GameRoom and living room also included.
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Interior
The Cyclist! Katy Trail comfort in Marthasville,MO
10.0 out of 10, Exceptional, (6)
"Wonderful place to get away to and relax!"
The price is £198
includes taxes & fees
2 May - 3 May
The Cyclist! Katy Trail comfort in Marthasville,MO
Exterior
Zia New Haven
3.0 star property
10.0 out of 10, Exceptional, (2)
"The property was nice and really clean, you can tell there was much attention put into every detail. The hosts were very communicative from the start and they were responsive to our questions. The area is really quiet, and outside from the Pinckney Bend Distillery there are not many activities you can do in the area. It does serve well as a place where you can easily go to Hermann or Washington (about 20 mins driving distance)."
Zia New Haven
Exterior
Cozy Cottage, we're told it's heavenly!
10.0 out of 10, Exceptional, (146)
"Loved this cozy little peaceful property. Tucked into the hills woods perfectly with trails nearby. Short drive to Washington MO. I'll definitely be staying here again"
Cozy Cottage, we're told it's heavenly!
Exterior
Cozy little house blocks from the Park & Fair Grounds. EV Charger equipped.
10.0 out of 10, Exceptional, (45)
"Warm and welcoming home with extremely comfortable beds. The host communicated with us in advance that the trash can foot pedal was not working, which was not a big deal, but the advance communication was greatly appreciated. Would definitely stay again if in the area."
The price is £226
includes taxes & fees
2 May - 3 May
Cozy little house blocks from the Park & Fair Grounds. EV Charger equipped.
Interior
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
10.0 out of 10, Exceptional, (8)
"Refreshing retreat for our small church. Relaxing. Everything we needed was there. Open floor plan made time together better. The fireplace and views are amazing."
The price is £843
includes taxes & fees
5 May - 6 May
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
Smart TV
Katy Haus: Hot tub, Wineries, Fenced yard, Dog-friendly
10.0 out of 10, Exceptional, (79)
"Exactly as described"
The price is £268
includes taxes & fees
8 May - 9 May
Katy Haus: Hot tub, Wineries, Fenced yard, Dog-friendly
Property grounds
Beekeeper's Cottage - Hot Tub, Heated Pool, Dog-friendly, Downtown
10.0 out of 10, Exceptional, (11)
"Beautiful home! My girls loved their rooms. It was great having our dog stay with us for our spring break too! The game room add on was totally worth it. We had a relaxing stay. Perfect outdoor space for us as well. Enjoyed a fire and s’mores and hot tub too! Only things that would have made it better- more lounge seating in the main space, nightlights for the girls rooms, and baking pans. I had to run out and buy a pan to make brownies. Our number combo wasn’t working on the door at Checkin,...
The price is £490
includes taxes & fees
2 May - 3 May
Beekeeper's Cottage - Hot Tub, Heated Pool, Dog-friendly, Downtown
Fridge, microwave, oven, stovetop
Innsbrook lakefront A-Frame, fishing, hiking, kayaking and relax.
10.0 out of 10, Exceptional, (10)
"Quiet location nestled in the timbers of Innsbrook Resort. Easy access to fingerling of lake. The chalet was very spacious and accommodating during our stay. This time of year brings a lot of fallen leaves - would have been nice if porch had leaves blown off prior to arrival or a broom on property to clear decking/approach to chalet. Would highly recommend a weekend stay with your family at this property."
The price is £383
includes taxes & fees
2 May - 3 May
Innsbrook lakefront A-Frame, fishing, hiking, kayaking and relax.
Family Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
River Sirens Hotel
2.5 star property
9.8 out of 10, Exceptional, (103)
"This was a very beautiful property! Very modern and CLEAN! They had all the extra touches! From a stocked fridge, to coffee and vouchers to a nearby coffee shop that was a must see, to top line soaps and linens…made our stay luxurious! Would highly recommend it and the story behind the River siren sprinkled throughout the hotel was a cool historical touch!"
The price is £136
includes taxes & fees
12 May - 13 May
River Sirens Hotel
Property grounds
Zia, New Haven! 1905 Doc's Office Transformed into a Quaint Vacation Apartment!
9.8 out of 10, Exceptional, (12)
"Stayed fo 2 nightts with my cousin while we attended a Bachelorette party in Herman. Everything was amazing from communicating with the owner to the unit itself. Will stay again."
Zia, New Haven! 1905 Doc's Office Transformed into a Quaint Vacation Apartment!
Property grounds
Pinckney Bend Bed & Breakfast
3.0 star property
9.6 out of 10, Exceptional, (84)
"This place was a very clean and nice place to stay! We will be back!"
The price is £128
includes taxes & fees
12 May - 13 May
Pinckney Bend Bed & Breakfast
Exterior
Authentic Log cabin with something for everyone!
9.6 out of 10, Exceptional, (312)
"Me and a couple of my besties stayed for the weekend so we could run a race, and enjoy some wineries near by. The cabin was so great! Very chill and relaxing. Lots of space, comfortable beds, and we felt very safe! We will definitely be renting again!"
Authentic Log cabin with something for everyone!
Exterior
Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel
2.5 star property
9.4 out of 10, Exceptional, (570)
"Driving cross country was nice place to stay "
The price is £144
includes taxes & fees
5 May - 6 May
Holiday Inn Express & Suites Wentzville St Louis West, an IHG Hotel
1 bedroom, free WiFi, bed sheets
TheHistorian! Daniel Boone Country-Marthasville,MO
9.4 out of 10, Exceptional, (9)
"Very clean. Nicely decorated. Very easy check in"
The price is £167
includes taxes & fees
2 May - 3 May
TheHistorian! Daniel Boone Country-Marthasville,MO
Lobby lounge
Holiday Inn Express Warrenton, an IHG Hotel
2.5 star property
9.2 out of 10, Wonderful, (436)
"Everything was great "
The price is £130
includes taxes & fees
16 May - 17 May
Holiday Inn Express Warrenton, an IHG Hotel
Balcony view
The Inn at Elijah McLeans
4.0 star property
9.2 out of 10, Wonderful, (83)
"It’s nice but they certainly need to upgrade their television package, that would keep from returning. "
The price is £131
includes taxes & fees
6 May - 7 May
The Inn at Elijah McLeans
Interior
The Wineaux! Wine Country charm in Marthasville,MO
9.2 out of 10, Wonderful, (5)
"Got in late enjoyed a good bed and shower after 2 days of pedaling."
The price is £198
includes taxes & fees
2 May - 3 May
The Wineaux! Wine Country charm in Marthasville,MO
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See all available properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More cheap stays in Defiance

Comfort Inn St Louis – Airport

Comfort Inn St Louis – Airport

11225 Lone Eagle Dr, Building A, Bridgeton, MO
The price is £78 per night from May 19 to May 20
£78
per night
19 May - 20 May
8.4/10 Very Good! (553 reviews)

Accommodation near Defiance attractions

Image for St. Louis Union Station

St. Louis Union Station

4.5/5(4 reviews)

You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's great live music or attend a baseball game.

See properties
St. Louis Union Station

Defiance Travel Info

Number of hotels
792
Highest price
£843
Lowest price
£78
Known attractions
Augusta Winery, Chandler Hill Vineyards and Montelle Winery

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay, based on our traveller data. Two other options for your visit to the area are La Quinta Inn & Suites by Wyndham St. Louis Westport and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.

What are some of the best holiday rentals that Defiance has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This holiday home rental outside of Defiance is located on a river, and offers a fireplace, air conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes! The majority of room reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

What are some accommodation options with pools in Defiance?

La Quinta Inn & Suites by Wyndham St. Louis Westport: Hotel, 12-minute walk from Westport Plaza. Offers continental, an outdoor pool and complimentary high-speed (wired) Internet access. The Wildwood Hotel and Sonesta ES Suites St. Louis - Chesterfield are two additional hotels with an on-site pool. View all hotels with pools in Defiance.

How is it staying in Defiance?

Visitors can enjoy all that Defiance has to offer, including the wineries and parks. A top sight in the area is Six Flags St. Louis. In Defiance, there are 12 hotels and other accommodation options to choose from. Find out more about Defiance.

What should I do while I'm visiting Defiance?

Natural beauty is on display at Missouri River, August A. Busch Memorial Conservation Area and Broemmelsiek Park. Additionally, you'll find Six Flags St. Louis in the area. Take a look at what more there is to see and do in Expedia's Defiance guide.

What's the weather like in Defiance?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for Defiance is 1228 mm.

Defiance Hotel Reviews
Expedia verified reviews

Country Inn & Suites by Radisson, St. Charles, MO

Country Inn & Suites by Radisson, St. Charles, MO

5/5 Excellent
"Best hotel visit in years! "
A verified traveller stayed at Country Inn & Suites by Radisson, St. Charles, MO
Posted 2 days ago
Country Inn & Suites by Radisson, St. Charles, MO