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Top Holiday Rentals in Defiance

The St. Charles Guest House, lovely historic home, fun for families and groups
10.0 out of 10, Exceptional, (106)
"Had a wonderful weekend get away in St. Charlies. The house was so close to main street, but far enough away not to hear the noise. The house had everything and more! The water and snacks were a nice touch. Everything was very clean. Would stay here again."
The St. Charles Guest House, lovely historic home, fun for families and groups
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
10.0 out of 10, Exceptional, (184)
"The cottage is immaculately furnished inside, and the bed is very comfortable. Just a very short walk to Main Street. Would recommend to anyone who is visiting St. Charles."
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Cozy Cottage, we're told it's heavenly!
10.0 out of 10, Exceptional, (147)
"Loved this cozy little peaceful property. Tucked into the hills woods perfectly with trails nearby. Short drive to Washington MO. I'll definitely be staying here again"
Cozy Cottage, we're told it's heavenly!
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Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
10.0 out of 10, Exceptional, (51)
"So much outdoor lake fun. Hot tub, paddle boards, kayaks, fire pit, beach and multiple decks and seating areas. Lake life!"
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.
10.0 out of 10, Exceptional, (1)
"We enjoyed staying in this home. It had everything we needed, and was perfect for just lounging around and taking it easy. Close to everything. The host was very helpful, and responded immediately to all our inquiries. We would definitely stay here again."
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
10.0 out of 10, Exceptional, (185)
"We had a great time! The Red Barn was just what we needed for some quiet time to relax and take our time in St. Charles. The location is the perfect distance from the main street so you don't have to walk far to find something to do, but it's also not right on the "main drag" where you'd have people walking by all the time. Thanks for the hospitality!"
1790's Renovated Barn, Main Street St. Charles, Hot Tub in private backyard!
Cowboy cabin, March availability, look for discounted weekly rates!
10.0 out of 10, Exceptional, (163)
"My stay at the cabin was very peaceful and easy. I couldn't ask any more from the owners. My kid LOVED the loft space and the owners dogs that would visit from time to time"
Cowboy cabin, March availability, look for discounted weekly rates!
Escape the city to quiet and picturesque Golden Eagle, IL..
10.0 out of 10, Exceptional, (309)
"Very beautiful home in a wonderful country setting. Very clean and comfortable with many nice touches. We can’t wait to find some time to come back again."
Escape the city to quiet and picturesque Golden Eagle, IL..
The Lewis & Clark Hangout
10.0 out of 10, Exceptional, (2)
"Nice place and wonderful host"
The price is £329
includes taxes & fees
5 May - 6 May
The Lewis & Clark Hangout
Spacious, Beautiful St. Charles Home - Remodeled - Sleeps 10!
10.0 out of 10, Exceptional, (29)
"Nice property in historic district. Large rooms. good value!"
The price is £349
includes taxes & fees
7 May - 8 May
Spacious, Beautiful St. Charles Home - Remodeled - Sleeps 10!
Remodeled Kirkwood Guest house
10.0 out of 10, Exceptional, (54)
"My husband and I stayed here while visiting some friends in St. Louis. The apartment is located above the garage but do not let that deter you. Ryan was super friendly we ran into him a few times but there was NO awkwardness or inconvenience getting to or from the apartment. The apartment was super clean and comfy and larger than expected. Kirkwood is a beautiful area, safe and very close to downtown St. Louis. Would Definitely Stay here again."
Remodeled Kirkwood Guest house
Central Luxe 5br Home - Hot Tub & Views - 🥂 🍷
10.0 out of 10, Exceptional, (39)
"We loved the VRBO. A great place to unwind and relax after a long day of winery-hopping. Would definitely recommend."
The price is £502
includes taxes & fees
8 May - 9 May
Central Luxe 5br Home - Hot Tub & Views - 🥂 🍷
Historic headquarters of city founder! Gated parking!
10.0 out of 10, Exceptional, (11)
"The pictures don’t do this charming, historic property justice. Lynn was wonderful to work with and has provided every amenity to make for a comfortable stay. The gated private parking is also a huge plus. We’ll definitely book again."
Historic headquarters of city founder! Gated parking!
1st Capitol Mansion - Suite 401
10.0 out of 10, Exceptional, (3)
"Nice property and a great location to all the shops and restaurants that St. Charles has to offer. The place was clean and nicely updated. Will definitely stay here again!"
The price is £218
includes taxes & fees
6 May - 7 May
1st Capitol Mansion - Suite 401
1st Capitol Mansion Boutique Hotel ADA Suite 202
10.0 out of 10, Exceptional, (2)
"Loved everything about our stay ❤️"
The price is £183
includes taxes & fees
5 May - 6 May
1st Capitol Mansion Boutique Hotel ADA Suite 202
Katy Haus: Hot tub, Wineries, Fenced yard, Dog-friendly
10.0 out of 10, Exceptional, (79)
"Exactly as described"
The price is £267
includes taxes & fees
8 May - 9 May
Katy Haus: Hot tub, Wineries, Fenced yard, Dog-friendly
Peaceful lake chalet - WIFI, kayaks, private dock
10.0 out of 10, Exceptional, (41)
"Had a very peaceful night at the beautiful cabin with the fire going. We enjoyed the large deck and beautiful scenery ! I got to catch the biggest fish (bass) of my life and so many more🐟! Highly recommend this cabin if you a looking for a peaceful, unique/luxury cabin get away!"
Peaceful lake chalet - WIFI, kayaks, private dock
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
10.0 out of 10, Exceptional, (8)
"Refreshing retreat for our small church. Relaxing. Everything we needed was there. Open floor plan made time together better. The fireplace and views are amazing."
The price is £840
includes taxes & fees
5 May - 6 May
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
Prime Loft of Main Street
9.8 out of 10, Exceptional, (63)
"Location can’t be beat. On Main, walkable to tons of places."
The price is £195
includes taxes & fees
5 May - 6 May
Prime Loft of Main Street
Cheerful 2-Bed Townhome Near Park w Garage Parking
9.8 out of 10, Exceptional, (20)
"Location is close to the interstate making it accessible to the airport and an easy drive to downtown St. Louis. Just a short drive to the quaint downtown St. Charles which we took advantage for a quick meal at Lewis and Clark. Owners are responsive and check in/out was easy. Accommodations were clean and kitchen has updated appliances. Great fenced backyard was perfect for our pup."
Cheerful 2-Bed Townhome Near Park w Garage Parking
Don't see what you're looking for?
See all available properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Defiance Holiday Rental Travel Info

Number of holiday rentals
3
Popular accommodation
Defiance cabins
Known landmarks
Augusta Winery, Chandler Hill Vineyards and Montelle Winery
International airport
St. Louis, MO (STL-Lambert-St. Louis Intl.)

Other types of properties in Defiance you may be interested in

Sonesta ES Suites St. Louis - Chesterfield
3.0 star property
8.4 out of 10, Very good, (1004)
"the price beyond expected. will consider it again when come back to st louis."
The price is £93
includes taxes & fees
19 May - 20 May
Sonesta ES Suites St. Louis - Chesterfield
Hollywood Casino & Hotel St. Louis
3.5 star property
8.2 out of 10, Very good, (1178)
"Only weird thing was the bathroom doors were barn doors that don’t lock. "
The price is £110
includes taxes & fees
30 May - 31 May
Hollywood Casino & Hotel St. Louis
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 star property
7.6 out of 10, Good, (1003)
"We have stayed there several times and like its location and the economy. The staff is very friendly. The rooms are clean but the hallways can be somewhat dirty. Sometimes there are family reunions (or similar type gatherings) at the hotel and if your room is close the party goer's rooms, then you will not sleep well! Even with that, we like the hotel."
The price is £82
includes taxes & fees
5 May - 6 May
La Quinta Inn & Suites by Wyndham St. Louis Westport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Everything you need to know about Defiance holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Defiance holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, apart-hotels, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Defiance holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Defiance holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Defiance. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Defiance holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Defiance holiday rentals we have selected for you start as low as £183 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Defiance rentals

At Expedia, we put the best Defiance holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Defiance rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Defiance holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Defiance. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find holiday rentals in Defiance?

Yes, we have holiday rentals where you'll be just 9.8 mi (15.8 km) from Six Flags St. Louis, giving you a more secluded option if you want peace and quiet. Defiance is known for its wineries and parks.

What are some of the best holiday rentals that Defiance has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This holiday home rental outside of Defiance is located on a river, and offers a fireplace, air conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family.

What’s there to see and do in Defiance?

Missouri River and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a holiday rental in Defiance like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Defiance. Holiday rentals feature amenities such as hot tubs, fire pits and patios so you'll have everything you want. If you're concerned about a sanitised environment, holiday rentals can offer a sense of security away from shared hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a traditional hotel, which makes a holiday rental an attractive option for families.

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