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Top Holiday Rentals in Defiance

Our top choices for Defiance holiday rentals

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (44)
"Lovely stay, very sweet house in a cute neighborhood. Great for traveling with kids! Thank you!"
The price is £222
includes taxes & fees
25 Aug - 26 Aug
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (73)
"The house is beautiful, in a great location, and has all the amenities of home. Definitely glad we stayed here instead of a nearby hotel."
The price is £282
includes taxes & fees
4 Sept - 5 Sept
Stunning 1890's Home - Sleeps 8!

Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

10.0 out of 10, Exceptional, (63)
"Cute little house. Beautiful deck surrounded by woods and a gorgeous view of the lake. Cozy weekend get-a-way! All that we wanted. "
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (119)
"Everything was great!"
The price is £165
includes taxes & fees
24 Aug - 25 Aug
St. Charles 1860's Gem - Sleeps 6!

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (132)
"We loved staying here in this adorable clean house that was only 1 block off of downtown Main Street shopping. "
The St. Charles Guest House, lovely historic home, fun for families and groups

Madison House 1 -Walk to Main St

9.0 out of 10, Wonderful, (11)
"Comfy fun stay!"
The price is £178
includes taxes & fees
25 Aug - 26 Aug
Madison House 1 -Walk to Main St

Overlook Main St. in this 2 Bedroom Owners Suite!

4.0 star property
9.4 out of 10, Exceptional, (32)
"Perfect place for a visit to St Charles! Hope to return and stay here again!"
Overlook Main St. in this 2 Bedroom Owners Suite!

Peaceful chalet - *new* private beach, WIFI, kayaks

10.0 out of 10, Exceptional, (69)
"Great place. Very clean and relaxing. "
Peaceful chalet - *new* private beach, WIFI, kayaks

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

10.0 out of 10, Exceptional, (204)
"Beautiful cottage in the perfect location. "
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

Escape the city to quiet and picturesque Golden Eagle, IL..

10.0 out of 10, Exceptional, (355)
"The property is wonderful. Very clean and exceptionally cozy. Fun experience to take the ferry. Would stay again!"
Escape the city to quiet and picturesque Golden Eagle, IL..

Adorable Augusta Cabin

9.6 out of 10, Exceptional, (5)
"Absolutely beautiful area. Cabin is so cozy"
The price is £152
includes taxes & fees
24 Aug - 25 Aug
Adorable Augusta Cabin

Honky Tonk Hideaway

9.2 out of 10, Wonderful, (5)
"Great place to stay"
Honky Tonk Hideaway

Beautiful Villa Close to All St. Louis Attractions!

9.0 out of 10, Wonderful, (55)
"Warm and cozy setting."
The price is £225
includes taxes & fees
24 Aug - 25 Aug
Beautiful Villa Close to All St. Louis Attractions!

The Lofts of North Main Street

9.6 out of 10, Exceptional, (144)
"Perfect location!"
The price is £189
includes taxes & fees
25 Aug - 26 Aug
The Lofts of North Main Street

The Otter Suite at Divine Otter

8.0 out of 10, Very good, (1)
"We absolutely loved this place! I would recommend this place. We had one issue but it was resolved. If you have children, I would probably stay somewhere else. There are bars all around and gets loud at night but it does get really quiet after 1:30 a.m. The property manager was absolutely amazing and is very quick to respond to your needs. "
The Otter Suite at Divine Otter

Residence on the Roundabout

9.6 out of 10, Exceptional, (134)
"We loved it. Had everything we needed and more. Very clean and comfortable "
Residence on the Roundabout

The Lewis & Clark Hangout

9.0 out of 10, Wonderful, (17)
"Enjoyed are stay"
The price is £354
includes taxes & fees
1 Sept - 2 Sept
The Lewis & Clark Hangout

Cowboy Cabin, come sit under the trees

10.0 out of 10, Exceptional, (200)
"The cabin offered amazing porch/deck time with lots of privacy in the trees. Great for a relaxing weekend!"
Cowboy Cabin, come sit under the trees

3BR Historic St. Charles, MO-Walking distance to Main Street

9.8 out of 10, Exceptional, (6)
"Beautiful property that seems as if it was very recently completed. Would definitely stay again. Every host provides different "nice to have" items; my only comment would be that a few items such as shampoo, dish cloths, basic spices such as salt & pepper would have been great. Overall great place."
The price is £423
includes taxes & fees
21 Sept - 22 Sept
3BR Historic St. Charles, MO-Walking distance to Main Street

Sycamore Retreat - Family Friendly, Waterfront Chalet

10.0 out of 10, Exceptional, (42)
"Thanks for a relaxing stay at the Sycamore Retreat house. We loved the dock, lake, fishing area, kayaks, deck and fire pit! The beds were amazing and the living room felt like being perched in a tree house."
Sycamore Retreat - Family Friendly, Waterfront Chalet
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Frequently asked questions

Can I find holiday rentals in Defiance?

Yes, there are holiday rentals close to the most popular sights in Defiance, or you can select a more secluded option if you're looking for a relaxing stay. Defiance is known for its wineries and parks.

What are some of the best holiday rentals that Defiance has to offer?

St. Charles 1860's Gem - Sleeps 6!: This holiday home rental outside of Defiance is located on a river, and has a garden, a selection of books and air conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge and a stovetop.

How many holiday rentals will I find in Defiance?

With 4 Expedia holiday rentals, you're guaranteed to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a holiday rental in Defiance like?

Holiday rentals are private properties where you can stay for a few weeks, or just a few days, in Defiance. Holiday rentals feature amenities such as hot tubs, fire pits and patios so you'll have everything you want. If you're concerned about a sanitised environment, holiday rentals can offer a sense of security away from shared hotel lifts and lobbies bustling with people while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a traditional hotel, which makes a holiday rental an attractive option for families.