Defiance Holidays from £1,225
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Your Defiance Holiday
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a holiday package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Centre and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance holiday is just a few clicks away with Expedia.
Top Defiance Flight + Hotel Deals
The Knight Center at Washington University
Reviewed on 14 May 2026
Defiance Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 160 |
Max Temp Winter | 4ºC |
Max Temp Summer | 32ºC |
Top Sights | Augusta Winery, Chandler Hill Vineyards and Montelle Winery |
Top hotels in Defiance
Hollywood Casino & Hotel St. Louis
Clean Rooms excellent environment
Reviewed on 14 May 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Room felt dirty, old bed bug shells, ac didn’t work
Reviewed on 15 May 2026
The Wildwood Hotel
We thoroughly enjoyed our stay! We did miss getting our room cleaned on the second day and they never came back on the third. The only thing that could have improved the stay was that. The area around was so cute and we had a safe and great vacation!
Reviewed on 16 May 2026
Popular places to visit
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Dome at America’s Center
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art galleries.
Six Flags St. Louis
Bring the children to Six Flags St. Louis and have a fun-filled day at this theme park in St. Louis. While in this romantic area, you can savour the top-notch restaurants.
What to do in Defiance
St. Louis: Museum of Illusions Entry Ticket
St. Louis Premium Small Group Tour With Arch & River Cruise
St. Louis Ghost Tour: Sinister Sins & Shadows
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
