Defiance Holidays from £1,370

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Your Defiance Holiday

Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a holiday package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Centre and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance holiday is just a few clicks away with Expedia.

The Latest Defiance Holiday Deals

Price found within the past 48 hours. Click for updated prices.
Hilton St. Louis Airport

Hilton St. Louis Airport

3.5 out of 5
Woodson Terrace
per person
1 Aug - 5 Aug
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
7.6/10 Good! (1,002 reviews)
Asked for a room with 2 queen beds. Did not get

Reviewed on 15 Jun 2025

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
per person
1 Aug - 5 Aug
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
If microwave not in room for the price you pay should at least have microwave in snack area. Pricey for one meal to be warmed up

Reviewed on 19 Jun 2025

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 out of 5
Central West End
per person
1 Aug - 5 Aug
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
9/10 Wonderful! (1,010 reviews)
All my expectations for staying at the Chase were satisfied. I couldn’t get the Keurig coffeemaker in my room to work. I did not receive a timely wake-up call 2 nights in a row. The staff were very friendly and good.

Reviewed on 15 Jun 2025

The Cheshire

The Cheshire

4 out of 5
per person
1 Aug - 5 Aug
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
8.6/10 Excellent! (1,000 reviews)
Very charming hotel. We felt like we were part of the Queens circle.

Reviewed on 11 Jun 2025

DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4 out of 5
Central West End
per person
1 Aug - 5 Aug
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
8.2/10 Very Good! (1,000 reviews)
Proximity to BJ Hospital.

Reviewed on 5 Jun 2025

Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
per person
1 Aug - 5 Aug
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
9/10 Wonderful! (1,749 reviews)
The hotel is walking distance to the Metrolink Train. We hopped on and rode to the Arch, Union Station, and everywhere we wanted to go. We didn't drive our car at all for the 2 days we were there.

Reviewed on 20 Jun 2025

Defiance Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Population
160
Max Temp Winter
4ºC
Max Temp Summer
32ºC
Top Sights
Augusta Winery, Chandler Hill Vineyards and Montelle Winery

Our pick of the best Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,936 reviews)
"The property itself was great. The staff were awesome. EXPEDIA NEVER SENT MY CONFIRMATION TO THE HOTEL. SO CHECK-IN TOOK OVER A HALF HOUR."

Reviewed on 20 Jun 2025

Hollywood Casino & Hotel St. Louis
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3 out of 5
13639 Riverport Dr, Maryland Heights, MO
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the ...
7.2/10 Good! (1,005 reviews)
"Big room acess easy to use."

Reviewed on 18 Jun 2025

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,005 reviews)
"They stay was great, just as described by many of the guest ratings I read beforehand. Check in was a mess however! We drove all day and arrived at 8:00pm only to find out they only had one king bed rooms available. I told her I reserved a 2 queen bed room and told her there was no way 4 grown adults ..."

Reviewed on 21 Jun 2025

Ameristar Casino Resort and Spa
See all 816 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Holidays

All Inclusive Holidays

Beach Holidays

Beach Holidays

Family Friendly Holidays

Family Friendly Holidays

Frequently asked questions

How much does a Defiance travel package cost?
Our Defiance travel packages, which start at just £1,370, are the perfect way to save big bucks. All you have to do is choose your preferred flights, hotels and rental cars to create your ideal itinerary.
If I'm not able to travel, can I cancel my Defiance travel package?
Your situation can change suddenly, so yes. You may be able to cancel or alter your Defiance travel package at no cost if you've booked in the last 24 hours. For bookings older than that, you can still cancel and rebook, but your car rental company, airline or hotel may charge additional fees. Need more information? Visit our Customer Service Portal. We're here to help make sure your getaway goes off without a hitch.
How do I get a cheap travel package to Defiance?
Secure flights that fit your busy schedule, add a hotel to your booking and watch the savings grow with a Defiance travel package. It's that easy! From hotels and flights to rental cars and tours, Expedia makes travelling cheap and easy. And with more than 550 airlines and 1,000,000 properties around the globe to choose from, you'll never be short of choice.
Does Expedia offer Book Now, Pay Later Defiance holidays?
We do. Expedia has teamed up with online lender Klarna to help you conveniently pay for your holiday in manageable instalments. Simply choose the payment plan best suited to your needs during checkout and take away the stress of budgeting for your trip. Don't forget to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your travel buck. Check out our flexible payment options below:
  • Pay monthly holidays: Klarna offers manageable monthly payment plans that suit all types of budgets, so you can lock in that well-earned holiday sooner.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna allows you to pay for your trip over multiple transactions.
  • Low deposit holidays: Clicking the "book now" button is much easier with this plan. Just put down a small deposit on your booking and then start working on your travel plans.

Where should I stay in Defiance?
A getaway to Defiance isn't complete without seeing Sugar Creek Winery, August A. Busch Memorial Conservation Area and Chandler Hill Vineyards. Spend your nights close to these tourist attractions and make sightseeing a breeze.
What are the top hotels in Defiance?
Embassy Suites St. Louis - St. Charles and Country Inn & Suites by Radisson, St. Charles, MO are two of the most popular properties in Defiance. Why not check out the amenities and facilities at each and then make a decision?
How far in advance should I book my Defiance holiday?
It's hard to pick the perfect time for airfares, but we normally say the earlier, the better. Most international journeys on Expedia become available up to 12 months in advance. If you're booking last minute, don't despair. Cheap prices occasionally appear within a few weeks of departure dates.
What does an Expedia Defiance travel package include?
Rental cars, flights and hotels --- we have them well covered. With Expedia, you can create your Defiance package the way you want. All you have to do is figure out just what you need. Once you've made your booking, you can add on extras like activities and experiences. The more you bundle, the greater the savings!
What should I know before booking a Defiance travel package?
So many places to explore, so many things to see and do. With a package, you'll be able to tick more of them off your list. Bundle your hotels, rental cars and flights and see how much you save.
Can I choose my airline with a Defiance Expedia travel package?
Yes, you're in charge. We offer more than 550 partner airlines worldwide, so you can design your Defiance trip according to your needs and budget.

Discover the most popular places to visit in Defiance

Gateway Arch showing a city, city views and skyline

Gateway Arch

5/5(16 reviews)

Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.

Gateway Arch

Dome at America’s Center

5/5(4 reviews)

Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art galleries.

Dome at America’s Center

Six Flags St. Louis

5/5(1 review)

Bring the children to Six Flags St. Louis and have a fun-filled day at this theme park in St. Louis. While in this romantic area, you can savour the top-notch restaurants.

Six Flags St. Louis

Unmissable things to do in Defiance

St Louis: City Museum General Admission Ticket

St Louis: City Museum General Admission Ticket

£16
per adult
94% of travellers recommend
St Louis: City Museum General Admission Ticket
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis: Gateway Ghouls and Hauntings Walking Tour

£24
per adult
St. Louis: Gateway Ghouls and Hauntings Walking Tour
St Louis Self-Guided Driving and Walking Audio Tour

St Louis Self-Guided Driving and Walking Audio Tour

£11
per traveller
St Louis Self-Guided Driving and Walking Audio Tour
See all activities in Defiance

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.