Title: Defiance Travel Guide: Best of Defiance, St. Louis Travel 2026 | Expedia.co.uk [Hotels in Defiance](https://expedia.co.uk/Defiance-Hotels.d6353634.Travel-Guide-Hotels)[Holiday Rentals in Defiance](https://expedia.co.uk/Defiance-Holiday-Rentals.d6353634.Travel-Guide-HolidayRentals)[Defiance Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Defiance.d6353634.Car-Hire-Guide)[Defiance Holidays](https://expedia.co.uk/Defiance.d6353634.Holidays-City-Breaks) # Defiance Travel Guide ## Tourist Guide ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Defiance](https://images.trvl-media.com/place/6353634/60cf9eba-ccb0-4aca-9293-e0a7a277f81d.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Defiance](https://images.trvl-media.com/place/6353634/6f5fc4b3-f0c6-464a-a072-974d5bce8000.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Defiance](https://images.trvl-media.com/place/553248621532648567/f82f9409-75a2-47f3-a8fc-2d7c278cc07c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Defiance Things to do - Top hotels in Defiance - Top Holiday Rentals in Defiance ![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/76ca3207_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hollywood Casino & Hotel St. Louis 777 Casino Center Drive Maryland Heights MO £108 6 Apr - 7 Apr includes taxes & fees Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ... 8.4/10 Very Good! (2,192 reviews) room very clean pretty plain for a suite very spacious and comfortable Reviewed on 1 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=06%2F04%2F2026&endDate=07%2F04%2F2026&selected=82568&PinnedHotelID=82568&HadPinnedHotel=true®ionId=6353634) ![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham 1088 South Highway Drive Fenton MO £78 5 Apr - 6 Apr includes taxes & fees Stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ... 8/10 Very Good! (1,175 reviews) Nice hotel, good breakfast happy they had a hot tub and a pool. The hours for the hot tub are kind of crappy. We wished it opened sooner. But other than that, it was a nice hotel. Reviewed on 2 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=05%2F04%2F2026&endDate=06%2F04%2F2026&selected=42122&PinnedHotelID=42122&HadPinnedHotel=true®ionId=6353634) ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Wildwood Hotel 2801 Fountain Pl Wildwood MO £78 6 Apr - 7 Apr includes taxes & fees Stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the convenient parking ... 9.2/10 Wonderful! (1,632 reviews) Breakfast was great. Parking was close to entrance and extremely safe Reviewed on 3 Apr 2026 [](https://expedia.co.uk/Hotel-Search?startDate=06%2F04%2F2026&endDate=07%2F04%2F2026&selected=1768149&PinnedHotelID=1768149&HadPinnedHotel=true®ionId=6353634) [See all 876 properties in Defiance](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=05%2F04%2F2026&endDate=06%2F04%2F2026®ionId=6353634) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Authentic Log cabin with something for everyone!](https://images.trvl-media.com/lodging/19000000/18980000/18973600/18973501/ba1361ba_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Authentic Log cabin with something for everyone! Marthasville MO Stay at this golf cabin in Marthasville. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Garbs House and Boone Monument Village are located ... 9.6/10 Exceptional! (394 reviews) The cabin was clean and delightful. We enjoyed the peace and quiet of the lake. No time to take advantage of kayak because of wedding. Enjoyed feeding the fish and sitting on the deck drinking coffee in the morning. Tami was great at answering questions promptly. Reviewed on 30 Mar 2026 [](https://expedia.co.uk/Washington-Hotels-Authentic-Log-Cabin-With-Something-For-Everyone.h18973501.Hotel-Information) ![St. Charles 1860's Gem - Sleeps 6!](https://images.trvl-media.com/lodging/35000000/34490000/34480500/34480442/8ece9774_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### St. Charles 1860's Gem - Sleeps 6! St Charles MO Stay at this family-friendly holiday home in St. Charles. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Ameristar Casino St. Charles ... 9.8/10 Exceptional! (148 reviews) Very nice historical place Reviewed on 22 Mar 2026 [](https://expedia.co.uk/St-Louis-Hotels-St-Charles-1860s-Gem-Sleeps-8.h34480442.Hotel-Information) ![1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!](https://images.trvl-media.com/lodging/35000000/34090000/34086400/34086396/63ec81c8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets! St. Charles MO Stay at this cottage in St. Charles. Enjoy free Wi-Fi, a water park and patios. Popular attractions Ameristar Casino St. Charles and Hollywood Casino Amphitheatre ... [](https://expedia.co.uk/St-Louis-Hotels-1830s-Luxury-Brick-Cottage.h34086396.Hotel-Information) [See all properties in Defiance](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6353634&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Defiance hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6353634&startDate=2026-04-04&endDate=2026-04-05)[4 Apr - 5 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6353634&startDate=2026-04-04&endDate=2026-04-05) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6353634&startDate=2026-04-05&endDate=2026-04-06)[5 Apr - 6 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6353634&startDate=2026-04-05&endDate=2026-04-06) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6353634&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026)[10 Apr - 12 Apr](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6353634&startDate=10%2F04%2F2026&endDate=12%2F04%2F2026) ### Popular places to visit ![Union Station, St. Louis, MO](https://images.trvl-media.com/place/502868/8704491b-9324-4c56-89ed-94a638702313.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### St. Louis Union Station You can learn more about the history of St. Louis during your trip to a well-known site such as St. Louis Union Station. Experience the area's great live music or attend a baseball game. [](https://expedia.co.uk/St-Louis-Union-Station-St-Louis.d502868.Attraction) ![Busch Stadium](https://images.trvl-media.com/place/3284/67189e41-0060-455b-85a9-ab65c9125a63.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Busch Stadium Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theatre scene or attend a baseball game. [](https://expedia.co.uk/Busch-Stadium-St-Louis.d502872.Attraction) ![Gateway Arch](https://images.trvl-media.com/place/502855/34e3411a-eeba-4fa1-95fe-3ad9b54938f4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Gateway Arch Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark. [](https://expedia.co.uk/Gateway-Arch-Downtown-St-Louis.d502855.Attraction) ![St. Louis Zoo](https://images.trvl-media.com/place/502878/51adfd0a-5175-4aa9-aa40-2221835ea3ae.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### St. Louis Zoo In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world. [](https://expedia.co.uk/St-Louis-Zoo-St-Louis.d502878.Attraction) ![Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.](https://images.trvl-media.com/place/502873/da730472-6151-40a1-b074-013a6c50d0f4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Enterprise Center Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's great live music or attend a baseball game. [](https://expedia.co.uk/Enterprise-Center-St-Louis.d502873.Attraction) ![Forest Park](https://images.trvl-media.com/place/553248635823456129/8a0353b6-e0c6-4e86-b04a-b6ff6d82d7ea.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Forest Park Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit. [](https://expedia.co.uk/Forest-Park-St-Louis.d6005687.Attraction) ### Things to do ![St. Louis: Gateway Ghouls and Hauntings Walking Tour](https://mediaim.expedia.com/localexpert/47668485/dd78fc5b-2837-423e-80a2-c4dfd8151a08.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### St. Louis Ghost Tour: Sinister Sins & Shadows £18 per adult [](https://expedia.co.uk/things-to-do/st-louis-ghost-tour-sinister-sins-shadows.a47668485.activity-details) ![Lemp Haunted Neighborhood Walking Tour](https://mediaim.expedia.com/localexpert/1357747/5cac0135-b8b0-4916-b5c1-48e8a0a93aab.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Lemp Haunted Neighborhood Walking Tour £22 per adult **84%** of travellers recommend [](https://expedia.co.uk/things-to-do/lemp-haunted-neighborhood-walking-tour.a1357747.activity-details) ![Downtown St. Louis Smartphone Guided Audio Walking Tour App](https://mediaim.expedia.com/localexpert/49595158/04b4ccdd-3590-44c6-ae14-398df578c2e0.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Downtown St. Louis Smartphone Guided Audio Walking Tour App £6 per adult **100%** of travellers recommend [](https://expedia.co.uk/things-to-do/downtown-st-louis-smartphone-guided-audio-walking-tour-app.a49595158.activity-details) [See all activities in Defiance](https://expedia.co.uk/Things-To-Do-In-Defiance.d6353634.Travel-Guide-Activities) ## Cities near Defiance ![St. Louis](https://images.trvl-media.com/place/502855/5f501368-a6cd-4154-9de4-4f7a5e79516f.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### St. Louis ![The Arch in St. Louis](https://images.trvl-media.com/place/183477/afc6fa4e-344e-48ef-a2d0-a1cdfadea28d.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Lake St Louis - Cities near Defiance - Places of interest [St. Louis](https://expedia.co.uk/St-Louis.dx178309)[Lake St Louis](https://expedia.co.uk/Lake-St-Louis.dx183477) - [Six Flags St. Louis ](https://expedia.co.uk/Six-Flags-St-Louis-St-Louis.d6147083.Attraction) - [St Charles Convention Center ](https://expedia.co.uk/St-Charles-Convention-Center-St-Louis.d6265791.Attraction) - [Magic House - St. Louis Children's Museum ](https://expedia.co.uk/Magic-House-St-Louis-Childrens-Museum-St-Louis.d6191631.Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app