Title: Cheap Car Hire in Defiance, USA - Expedia.co.uk [Defiance Travel Guide](https://expedia.co.uk/Defiance.dx6353634)[Hotels in Defiance](https://expedia.co.uk/Defiance-Hotels.d6353634.Travel-Guide-Hotels)[Flights to Defiance](https://expedia.co.uk/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Defiance Holidays](https://expedia.co.uk/Defiance.d6353634.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Defiance, USA ## Search and Compare from Car Companies in Defiance ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Defiance \* Price found within the past 6 days. Click for updated prices. Sun, 15 Feb - Mon, 16 Feb ### Compact Kia Soul or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 13009 Manchester Rd, Saint Louis, Missouri 63131-1807, USA 17.29 mi from Defiance city centre ![Kia Soul](//mediaim.expedia.com/cars/41/e7c1fd21-3564-4890-a4ed-2f7ca59d757f.jpg) #### £45 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.603120&olon=-90.460170&date1=15/02/2026&date2=16/02/2026&pprfrr=null&tprfrr=45.4&cvrfrr=ZI&ctrfrr=CC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22compact%22]) Sun, 15 Feb - Mon, 16 Feb ### Standard Volkswagen Jetta or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 13009 Manchester Rd, Saint Louis, Missouri 63131-1807, USA 17.29 mi from Defiance city centre ![Volkswagen Jetta](//mediaim.expedia.com/cars/41/518390a3-aa30-4ee4-9bb5-1243de3d0866.jpg) #### £46 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.603120&olon=-90.460170&date1=15/02/2026&date2=16/02/2026&pprfrr=null&tprfrr=46.0&cvrfrr=ZI&ctrfrr=SC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22standard%22]) Sun, 15 Feb - Mon, 16 Feb ### Full Size Toyota Camry or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 13009 Manchester Rd, Saint Louis, Missouri 63131-1807, USA 17.29 mi from Defiance city centre ![Toyota Camry](//mediaim.expedia.com/cars/41/f8359e2f-1f3f-4c65-ac4c-bc85e53c01f5.jpg) #### £46 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.603120&olon=-90.460170&date1=15/02/2026&date2=16/02/2026&pprfrr=null&tprfrr=46.0&cvrfrr=ZI&ctrfrr=FC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22fullsize%22]) Sun, 15 Feb - Mon, 16 Feb ### Midsize Toyota Corolla or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 13009 Manchester Rd, Saint Louis, Missouri 63131-1807, USA 17.29 mi from Defiance city centre ![Toyota Corolla](//mediaim.expedia.com/cars/41/724f6f6b-c451-44b5-b34e-8d67280e16eb.jpg) #### £46 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.603120&olon=-90.460170&date1=15/02/2026&date2=16/02/2026&pprfrr=null&tprfrr=45.8&cvrfrr=ZI&ctrfrr=IC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22midsize%22]) Sun, 15 Feb - Mon, 16 Feb ### Economy Hyundai Venue or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 13009 Manchester Rd, Saint Louis, Missouri 63131-1807, USA 17.29 mi from Defiance city centre ![Hyundai Venue](//mediaim.expedia.com/cars/41/8790b76e-3028-4f1e-b3ff-9c11cf788d03.jpg) #### £52 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.603120&olon=-90.460170&date1=15/02/2026&date2=16/02/2026&pprfrr=null&tprfrr=52.2&cvrfrr=ZI&ctrfrr=EC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22economy%22]) Thu, 12 Feb - Fri, 13 Feb ### Standard Elite SUV Ford Explorer or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) #### Pick-up location 2721 State Hwy K, O'Fallon, Missouri 63366, USA 10.26 mi from Defiance city centre ![Ford Explorer](//mediaim.expedia.com/cars/39/0117d125-955b-455f-87f1-0c60b7d7c1bc.jpg) #### £61 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.768056&olon=-90.700278&date1=12/02/2026&date2=13/02/2026&pprfrr=null&tprfrr=60.83&cvrfrr=ZD&ctrfrr=RF&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22suv%22]) Thu, 12 Feb - Fri, 13 Feb ### Mini Van Chrysler Pacifica or similar - 5 people - Unlimited mileage ![Budget](//mediaim.expedia.com/cars/logos/ZD.png) #### Pick-up location 2721 State Hwy K, O'Fallon, Missouri 63366, USA 10.26 mi from Defiance city centre ![Chrysler Pacifica](//mediaim.expedia.com/cars/39/e7400a6a-2473-474b-9d79-35076bd3a23f.jpg) #### £81 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.768056&olon=-90.700278&date1=12/02/2026&date2=13/02/2026&pprfrr=null&tprfrr=80.6&cvrfrr=ZD&ctrfrr=MV&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22minivan%22]) Sun, 15 Feb - Mon, 16 Feb ### Premium Toyota Crown or similar - 5 people - Unlimited mileage ![Avis](//mediaim.expedia.com/cars/logos/ZI.png) #### Pick-up location 13009 Manchester Rd, Saint Louis, Missouri 63131-1807, USA 17.29 mi from Defiance city centre ![Toyota Crown](//mediaim.expedia.com/cars/41/edb2e73f-8e89-438f-8867-f09c3dac1153.jpg) #### £88 total found 1 day ago [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&olat=38.603120&olon=-90.460170&date1=15/02/2026&date2=16/02/2026&pprfrr=null&tprfrr=88.2&cvrfrr=ZI&ctrfrr=PC&crfrr=pricefeedResponseFlex&SearchType=Place&selCC=[%22premium%22]) ### Don't see what you're looking for? See all car hire in Defiance [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Defiance,%20Missouri,%20United%20States%20of%20America&dpln=6353634&date1=17/02/2026&date2=19/02/2026&crfrr=defaultFlex&SearchType=Place) ## Frequently asked questions ### How much is a rental car per day in Defiance? ### Can I hire a car from Lambert-St. Louis Intl. Airport (STL)? ### What happens if I need to cancel my Defiance car reservation? ### What types of cars can I rent in Defiance? ### Where can I go on a road trip from Defiance? > - Around 85 miles from Defiance, Columbia is a must-do for many road-trippers. With sights such as University of Missouri, you'll have no shortage of things to keep you busy here. > - Around 100 miles away, Springfield is another destination worth sticking on your itinerary. Don't miss Illinois State Fairgrounds while you're in town. > - No trip is complete without exploring Starved Rock State Park. This well-known nature spot is approximately 210 miles from Defiance. Get out into the fresh air and relax! ### How do I find the best car hire deals in Defiance with Expedia? ### How old do you have to be to hire a car in Defiance? ### What do you need to hire a car in Defiance? ### What is the cheapest car hire in Defiance? ### Can I hire a car for a month or longer in Defiance? ### Where can I find a Defiance hire car if I am younger than 25? ### Can I drive in Defiance with my current driver's license? > - Age restrictions: You'll need to be 25 in most states to be able to hire a car, although in some areas allow drivers as young as 21\. We recommend checking local rules and regulations, as well as the car hire website before you travel to understand all the terms and conditions. > - Driving limitations: Be sure to read the fine print before you leave the lot to avoid unnecessary fees. When hiring a car in the United States, you typically can't cross country borders into Canada or Mexico, drive onto ferries or go off-roading with your hire vehicle. Please read the regulations before booking! ### Why should I rent a Defiance car with Expedia? ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | £45 | | Our second best deal of the day: | £46 | | Our third best deal of the day: | £52 | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app