Compare and book 5 Star hotels in St. Louis, Missouri
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on St. Louis 5 Star Hotels
Our top choices for St. Louis 5-star hotels
9.4 out of 10, Exceptional, (1,003 reviews)
"It was ok"
Sasha- Kay
The price is £326
includes taxes & fees
22 Jul - 23 Jul
9.2 out of 10, Wonderful, (575 reviews)
"Friendly staff and very clean room."
Karen
The price is £433
includes taxes & fees
26 Jul - 27 Jul
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in St. Louis.
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
The price is £134 per night from 3 Aug to 4 Aug
£134
3 Aug - 4 Aug
includes taxes & fees
Still don't see what you're looking for?
See all properties in St. Louis.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
St. Louis and related destinations
The Gateway Arch towers 630 feet above the Mississippi, with a tram that takes you to spectacular views at the top. Explore Forest Park's free museums, catch a Cardinals game at Busch Stadium, and don't miss Ted Drewes' frozen custard that locals swear by.
Top St. Louis Hotel Reviews
Find out more about St. Louis
Frequently asked questions
Explore a world of travel with Expedia
- 5 Star Hotels in Chesterfield
- Hotels near Barnes Jewish Hospital
- Red Lion Hotels in Brentwood
- Hotels near Busch Stadium
- Central West End Hotels
- Hotels near Dome at America’s Center
- Hotels near Enterprise Center
- Hotels near Gateway Arch
- Marriott Hotels & Resorts in Green Park
- Mehlville Hotels
- Hotels near Old Chain of Rocks Bridge
- Hotels near River City Casino
- Best Western St. Louis
- Boyd Gaming Hotels in St. Louis
- Cheap Hotels in St. Louis
- Hotels with Waterslides in St. Louis
- St. Louis Hotels
- Hotels near St. Louis Union Station
- University City Hotels
- Flights to Kirkwood
- Flights to Lambert-St. Louis Intl.
- Flights to St. Louis
- Flights from Lambert-St. Louis Intl.
- British Airways London (LHR) to St. Louis (STL) flights
- British Airways Manchester (MAN) to St. Louis (STL) flights
- Delta Minneapolis (MSP) to St. Louis (STL) flights
- Jetblue Airways New York (JFK) to St. Louis (STL) flights
- Jetblue Airways Boston (BOS) to St. Louis (STL) flights
- Flights from St. Louis
- Flights from Aberdeen (ABZ) to St. Louis (STL)
- Flights from Amsterdam (AMS) to St. Louis (STL)
- Flights from Atlanta (ATL) to St. Louis (STL)
- Flights from Austin (AUS) to St. Louis (STL)
- Flights from Belfast (BFS) to St. Louis (STL)
- Flights from Birmingham (BHM) to St. Louis (STL)
- Flights from Birmingham (BHX) to St. Louis (STL)
- Flights from Nashville (BNA) to St. Louis (STL)
- Flights from Boston (BOS) to St. Louis (STL)
- Flights from Bristol (BRS) to St. Louis (STL)
- Flights from Baltimore (BWI) to St. Louis (STL)
- Flights from Columbia (CAE) to St. Louis (STL)
- Flights from Paris (CDG) to St. Louis (STL)
- Flights from Columbus (CMH) to St. Louis (STL)
- Flights from Cincinnati (CVG) to St. Louis (STL)
- Flights from Washington (DCA) to St. Louis (STL)
- Flights from Dallas (DFW) to St. Louis (STL)
- Flights from Detroit (DTW) to St. Louis (STL)
- Flights from Dublin (DUB) to St. Louis (STL)
- Flights from Entebbe (EBB) to St. Louis (STL)
- Flights from Edinburgh (EDI) to St. Louis (STL)
- Flights from East Midlands (EMA) to St. Louis (STL)
- Flights from Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
- Flights from Frankfurt (FRA) to St. Louis (STL)
- Flights from Glasgow (GLA) to St. Louis (STL)
- Flights from Houston (IAH) to St. Louis (STL)
- Flights from New York (JFK) to St. Louis (STL)
- Flights from Las Vegas (LAS) to St. Louis (STL)
- Flights from Los Angeles (LAX) to St. Louis (STL)
- Flights from London (LCY) to St. Louis (STL)
- Flights from New York (LGA) to St. Louis (STL)
- Flights from London (LGW) to St. Louis (STL)
- Flights from London (LHR) to St. Louis (STL)
- Flights from London (LON) to St. Louis (STL)
- Flights from Liverpool (LPL) to St. Louis (STL)
- Flights from Manchester (MAN) to St. Louis (STL)
- Flights from Kansas City (MCI) to St. Louis (STL)
- Flights from Orlando (MCO) to St. Louis (STL)
- Flights from Memphis (MEM) to St. Louis (STL)
- Flights from Mexico City (MEX) to St. Louis (STL)
- Flights from Miami (MIA) to St. Louis (STL)
- Flights from Durham (MME) to St. Louis (STL)
- Flights from Newcastle (NCL) to St. Louis (STL)
- Flights from New York (NYC) to St. Louis (STL)
- Flights from Chicago (ORD) to St. Louis (STL)
- Flights from Norfolk (ORF) to St. Louis (STL)
- Flights from Philadelphia (PHL) to St. Louis (STL)
- Flights from Pittsburgh (PIT) to St. Louis (STL)
- Flights from Richmond (RIC) to St. Louis (STL)
- Flights from San Diego (SAN) to St. Louis (STL)
- Flights from Seattle (SEA) to St. Louis (STL)
- Flights from San Francisco (SFO) to St. Louis (STL)
- Flights from Southampton (SOU) to St. Louis (STL)
- Flights from Montreal (YUL) to St. Louis (STL)
- Flights from Toronto (YYZ) to St. Louis (STL)