£109 Cheap Flights from San Diego (SAN) to St. Louis (STL)

View £109 flight on Wed, 3 Jun 2026Opens in a new window

Flight 1

Popular airlines from San Diego Intl. Airport (SAN) to Lambert-St. Louis International Airport (STL)

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Cheap Flights from San Diego (SAN) to St. Louis (STL)

Prices were available within the past 7 days and start at £109 for one-way flights and £501 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Mon, 4 May - Mon, 11 May
SAN
San Diego
STL
St. Louis
£501 Return, found 10 hours ago
£501
Return
found 10 hours ago
Select Alaska Airlines flight, departing Mon, 4 May from San Diego to St. Louis, returning Mon, 11 May, priced at £501 found 10 hours ago
Alaska Airlines
Mon, 4 May - Mon, 11 May
SAN
San Diego
STL
St. Louis
£531 Return, found 10 hours ago
£531
Return
found 10 hours ago
Select Alaska Airlines flight, departing Mon, 4 May from San Diego to St. Louis, returning Mon, 11 May, priced at £531 found 10 hours ago
Alaska Airlines
Mon, 4 May - Mon, 11 May
SAN
San Diego
STL
St. Louis
£560 Return, found 10 hours ago
£560
Return
found 10 hours ago
Select Alaska Airlines flight, departing Mon, 4 May from San Diego to St. Louis, returning Mon, 11 May, priced at £560 found 10 hours ago
Alaska Airlines
Mon, 4 May - Mon, 11 May
SAN
San Diego
STL
St. Louis
£560 Return, found 10 hours ago
£560
Return
found 10 hours ago
Select Alaska Airlines flight, departing Mon, 4 May from San Diego to St. Louis, returning Mon, 11 May, priced at £560 found 10 hours ago

Frequently asked questions

Which airlines fly direct from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Enter SAN to STL and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
To find a cheap flight from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The best airline to fly with from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will differ from traveller to traveller. If you like to fly early, WN offers early morning flights. If price is the most important factor, WN typically offers the lowest fares. AS offers the most daily flights from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St Louis Intl.), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
There is approximately 1 nonstop flight per day from San Diego Intl. (SAN) to Lambert-St. Louis Intl. (STL). For even more choice, look at flights that include layovers, as there are around 131 connecting flights per day. Some common connection points include Seattle - Tacoma Intl. (SEA), O'Hare Intl. (ORD), and Sky Harbor Intl. (PHX).
What is the earliest flight from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The earliest flight from San Diego Intl. (SAN) to Lambert-St. Louis Intl. (STL) typically departs at approximately 6:00 AM local time, operated by American Airlines. This is a seasonal service active in March and April. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
You'll typically find the most flights from San Diego Intl. (SAN) to Lambert-St. Louis Intl. (STL) on a Friday, with around 106 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include Southwest Airlines, Alaska Airlines, and American Airlines. Fridays offer notably more flight options compared to other days of the week, making it a good day to consider for your journey.
What are the most popular departure times for flights from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The most popular departure times for flights from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) are in the early morning, from 6am to 9am. Approximately 36% of passengers prefer this time window. Many major carriers, including American Airlines, Southwest Airlines and United Airlines, offer flights during this window. Many travellers prefer these early morning flights as they allow you to arrive at your destination with plenty of time to start your day.
How long does it take to fly from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Direct flights from SAN to STL usually take about 3 hours 30 minutes, traveling roughly 1,555 miles. If you opt for a connecting flight, expect to add around 5 hours to your journey. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Select the "Business class" and "First class" filters when looking for SAN to STL flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight with Expedia?
It's easy to earn miles on a San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for St. Louis from San Diego Intl. (SAN)?
From San Diego Intl. (SAN), you can fly directly into Lambert-St. Louis Intl. (STL) to reach St. Louis. Some flights may connect through major hubs like McCarran Intl. (LAS), Sky Harbor Intl. (PHX), Los Angeles Intl. (LAX) before reaching St. Louis. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) at the last minute?
Typically, booking a last minute flight from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package?
Securing a San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
If you booked your San Diego, CA (SAN-San Diego Intl.) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
San Diego Intl.
Destination airport
Lambert-St. Louis Intl.
Return price
£500
Distance
2487 km
Average flight time
5 hours 51 mins

Book with confidence

Compare flights from San Diego to St. Louis easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from San Diego to St. Louis. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Lambert-St. Louis Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from San Diego Intl. to Lambert-St. Louis Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from San Diego Intl. (SAN) to Lambert-St. Louis Intl. (STL)

The easiest way to view the best deals on flights from San Diego to St. Louis today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from San Diego Intl. to Lambert-St. Louis Intl. start at just £501 and range up to £560.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near San Diego and St. Louis
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your San Diego to St. Louis flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from San Diego Intl. to Lambert-St. Louis Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from San Diego to St. Louis easily and book with confidence

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*Available to Expedia members.