£279 Cheap Flights from Detroit (DTW) to St. Louis (STL)

View £279 flight on Wed, 20 May 2026Opens in a new window

Flight 1

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to Lambert-St. Louis International Airport (STL)

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Cheap Flights from Detroit (DTW) to St. Louis (STL)

Prices were available within the past 7 days and start at £279 for one-way flights and £605 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Wed, 20 May - Wed, 27 May
DTW
Detroit
STL
St. Louis
£605 Return, found 6 days ago
£605
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from Detroit to St. Louis, returning Wed, 27 May, priced at £605 found 6 days ago
Alaska Airlines
Sun, 17 May - Sun, 24 May
DTW
Detroit
STL
St. Louis
£661 Return, found 6 days ago
£661
Return
found 6 days ago
Select Alaska Airlines flight, departing Sun, 17 May from Detroit to St. Louis, returning Sun, 24 May, priced at £661 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
DTW
Detroit
STL
St. Louis
£672 Return, found 6 days ago
£672
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from Detroit to St. Louis, returning Wed, 27 May, priced at £672 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
DTW
Detroit
STL
St. Louis
£679 Return, found 6 days ago
£679
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from Detroit to St. Louis, returning Wed, 27 May, priced at £679 found 6 days ago
Alaska Airlines
Tue, 9 Jun - Tue, 16 Jun
DTW
Detroit
STL
St. Louis
£682 Return, found 1 day ago
£682
Return
found 1 day ago
Select Alaska Airlines flight, departing Tue, 9 Jun from Detroit to St. Louis, returning Tue, 16 Jun, priced at £682 found 1 day ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
DTW
Detroit
STL
St. Louis
£687 Return, found 6 days ago
£687
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from Detroit to St. Louis, returning Wed, 27 May, priced at £687 found 6 days ago
Alaska Airlines
Wed, 20 May - Wed, 27 May
DTW
Detroit
STL
St. Louis
£702 Return, found 6 days ago
£702
Return
found 6 days ago
Select Alaska Airlines flight, departing Wed, 20 May from Detroit to St. Louis, returning Wed, 27 May, priced at £702 found 6 days ago
Alaska Airlines
Sun, 17 May - Sun, 24 May
DTW
Detroit
STL
St. Louis
£705 Return, found 6 days ago
£705
Return
found 6 days ago
Select Alaska Airlines flight, departing Sun, 17 May from Detroit to St. Louis, returning Sun, 24 May, priced at £705 found 6 days ago
Alaska Airlines
Mon, 1 Jun - Sun, 7 Jun
DTW
Detroit
STL
St. Louis
£720 Return, found 1 day ago
£720
Return
found 1 day ago
Select Alaska Airlines flight, departing Mon, 1 Jun from Detroit to St. Louis, returning Sun, 7 Jun, priced at £720 found 1 day ago
Alaska Airlines
Sun, 17 May - Sun, 24 May
DTW
Detroit
STL
St. Louis
£735 Return, found 6 days ago
£735
Return
found 6 days ago
Select Alaska Airlines flight, departing Sun, 17 May from Detroit to St. Louis, returning Sun, 24 May, priced at £735 found 6 days ago

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city centre is 20 minutes. Flights from £846
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city centre20 min
Flights from £846

Frequently asked questions

What is the cheapest month to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
August is typically the cheapest month to fly from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL), with average return fares of approximately £159. This is about 31% lower than the average price throughout the year. August often sees lower prices as it's outside the peak summer travel season for many destinations, leading to reduced demand. Other cheap months to fly from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL) include July and September.
Which airlines fly direct from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Enter DTW to STL and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
To find a cheap flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The best airline to fly with from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will differ from traveller to traveller. If you like to fly early, WN offers early morning flights. If price is the most important factor, WN typically offers the lowest fares. WN offers the most daily flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The best time to fly from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL) for the best value is typically in July or August. Based on booking data from the past year, you can expect to find return flights for around £159 during these months. This is a great time to travel if you're looking to save on airfare.
How many flights per day from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
There are approximately 6 nonstop flights per day from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL). For even more choice, look at flights that include layovers, as there are around 70 connecting flights per day. Some common connection points include O'Hare Intl. (ORD), Nashville Intl. (BNA), and Midway Intl. (MDW).
What is the earliest flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The earliest flight from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL) typically departs at approximately 5:00 AM local time. This service is operated by AA and 9X. This is a seasonal service active in July and August. An early departure like this can help maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
You'll typically find the most flights from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL) on a Friday, with around 47 flights available. This gives you a good selection for your travel plans. Major airlines on this route include American Airlines, United Airlines, and Southwest Airlines. Friday offers notably more flight options compared to other days of the week.
What are the most popular departure times for flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
The most popular departure times for flights from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL) are in the early morning, from 6am to 9am. About 29% of passengers prefer this time window. Many major carriers, including American Airlines, Southwest Airlines and United Airlines, offer flights during this window. This timing works well because it allows you to get an early start on your day in St. Louis.
How long does it take to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Flying nonstop from DTW to STL takes around 1 hour 50 minutes, with the route covering approximately 440 miles. Flights with a layover typically take 4 hours 40 minutes longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
Select the "Business class" and "First class" filters when looking for DTW to STL flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight with Expedia?
It's easy to earn miles on a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for St. Louis from Detroit Metropolitan Wayne County (DTW)?
From Detroit Metropolitan Wayne County (DTW), you can fly directly into Lambert-St. Louis Intl. (STL) to reach St. Louis. Some flights may connect through major hubs like Nashville Intl. (BNA), Baltimore Washington Intl. Thurgood Marshall (BWI), O'Hare Intl. (ORD) before reaching St. Louis. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) at the last minute?
Typically, booking a last minute flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package?
Securing a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.)?
If you booked your Detroit, MI (DTW-Detroit Metropolitan Wayne County) to St. Louis, MO (STL-Lambert-St. Louis Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

0
Origin airport
Detroit Metropolitan Wayne County
Destination airport
Lambert-St. Louis Intl.
Airlines serving
Alaska Airlines
Return price
£605
Distance
703 km

Book with confidence

Compare flights from Detroit to St. Louis easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Detroit to St. Louis. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Lambert-St. Louis Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Detroit Metropolitan Wayne County (DTW) to Lambert-St. Louis Intl. (STL)

The easiest way to view the best deals on flights from Detroit to St. Louis today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl. start at just £605 and range up to £735.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Detroit and St. Louis
  • booking your flight during May, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Detroit to St. Louis flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Detroit to St. Louis easily and book with confidence

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