Title: TOP Business Hotels in Southwest Florida, FL for 2026 | Expedia.co.uk [Southwest Florida Travel Guide](https://expedia.co.uk/Southwest-Florida.dx6233839)[Hotels in Southwest Florida](https://expedia.co.uk/Southwest-Florida-Hotels.d6233839.Travel-Guide-Hotels)[Holiday Rentals in Southwest Florida](https://expedia.co.uk/Southwest-Florida-Holiday-Rentals.d6233839.Travel-Guide-HolidayRentals)[Flights to Southwest Florida](https://expedia.co.uk/Cheap-Flights-To-Southwest-Florida.d6233839.Travel-Guide-Flights)[Things to do in Southwest Florida](https://expedia.co.uk/Things-To-Do-In-Southwest-Florida.d6233839.Travel-Guide-Activities)[Southwest Florida Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southwest-Florida.d6233839.Car-Hire-Guide)[Southwest Florida Holidays](https://expedia.co.uk/Southwest-Florida.d6233839.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/6065875/bc23d051-1ceb-4c43-a754-b9feb3316d59.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6065875/bc23d051-1ceb-4c43-a754-b9feb3316d59.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southwest Florida Business Hotels Tonight [8 Apr - 9 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233839&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [9 Apr - 10 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233839&startDate=2026-04-09&endDate=2026-04-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233839&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [17 Apr - 19 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233839&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Southwest Florida business-friendly hotels ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/93000000/92410000/92408200/92408147/edcab928.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92410000/92408200/92408147/c49363b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/93000000/92410000/92408200/92408147/2262ed13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92410000/92408200/92408147/a528ee56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Nokomis Sarasota South by IHG [](https://www.expedia.co.uk/Nokomis-Hotels-Holiday-Inn-Express-Suites-Nokomis-Sarasota-South.h92408147.Hotel-Information) Nokomis 9.4/10 Exceptional (441 reviews) "Clean room , nice pool great breakfast and staff were amazing!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) CatherineA £95 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Nokomis-Hotels-Holiday-Inn-Express-Suites-Nokomis-Sarasota-South.h92408147.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/a702090f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking (Upgrade) | Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/3b030475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/54b129e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/f37d87d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Fort Myers East I-75 [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) Fort Myers 9.6/10 Exceptional (436 reviews) "Incredibly clean room would definitely stay again!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Christopher £78 includes taxes & fees 3 May - 4 May [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/d24f645a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/w3000h1926x0y0-e3428eed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Studio, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/855de8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/97000000/96930000/96929600/96929542/13c16d36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Stay America Premier Suites - Fort Myers - Airport [](https://www.expedia.co.uk/Fort-Myers-Hotels-Extended-Stay-America-Premier-Suites-Fort-Myers-Airport.h96929542.Hotel-Information) Daniels Corridor 8.8/10 Excellent (930 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cliff £53 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Fort-Myers-Hotels-Extended-Stay-America-Premier-Suites-Fort-Myers-Airport.h96929542.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/12000000/11960000/11952500/11952451/1cdc306b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/12000000/11960000/11952500/11952451/cafd0fd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11960000/11952500/11952451/c541385e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/12000000/11960000/11952500/11952451/a1d1a5ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Oaak Tree Hotel [](https://www.expedia.co.uk/Arcadia-Hotels-Oak-Park-Inn-By-OYO.h11952451.Hotel-Information) Arcadia Historic District 9.6/10 Exceptional (492 reviews) "For a historic hotel is was nice. The owner was very sweet. They provided breakfast and drinks. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tiffany £131 includes taxes & fees 10 Apr - 11 Apr [](https://www.expedia.co.uk/Arcadia-Hotels-Oak-Park-Inn-By-OYO.h11952451.Hotel-Information) ![On the beach, sun-loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f97bdde8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Balcony (Gulf View) | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f85ea0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, sun-loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/6b3a0fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sanibel Island Beach Resort [](https://www.expedia.co.uk/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) Mid Island 9.2/10 Wonderful (1,761 reviews) "Central location, lovely accommodation and great food " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Keren £212 includes taxes & fees 3 May - 4 May [](https://www.expedia.co.uk/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/120000/117100/117009/bbaa2af7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/120000/117100/117009/d81d6192.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/120000/117100/117009/01ed8c5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/120000/117100/117009/8db4d91b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Ambassador Suites Venice [](https://www.expedia.co.uk/Sarasota-Hotels-Best-Western-Plus-Ambassador-Suites-Venice.h117009.Hotel-Information) Venice 9.0/10 Wonderful (1,001 reviews) "Convenient location, helpful staff, nearby dining options." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ann £88 includes taxes & fees 5 May - 6 May [](https://www.expedia.co.uk/Sarasota-Hotels-Best-Western-Plus-Ambassador-Suites-Venice.h117009.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/4000000/3130000/3123200/3123180/f1744504.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/4000000/3130000/3123200/3123180/c9ca120d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3130000/3123200/3123180/6ab9e56b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 2 Double Beds | Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/4000000/3130000/3123200/3123180/fd8be385.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Venice [](https://www.expedia.co.uk/Sarasota-Hotels-Fairfield-Inn-Suites-By-Marriott-Venice.h3123180.Hotel-Information) Venice 9.2/10 Wonderful (1,000 reviews) "Very nice staff at both the check in and the breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin £93 includes taxes & fees 9 May - 10 May [](https://www.expedia.co.uk/Sarasota-Hotels-Fairfield-Inn-Suites-By-Marriott-Venice.h3123180.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009533/77975013.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009533/43c96be4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 Queen Bed, Non Smoking, Efficiency Suite | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009533/d4438b2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2010000/2009600/2009533/d3c93458.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Lehigh Acres Fort Myers [](https://www.expedia.co.uk/Fort-Myers-Hotels-Quality-Inn-Suites-Lehigh-Acres-Fort-Myers.h2009533.Hotel-Information) Lehigh Acres 8.2/10 Very good (1,354 reviews) "The service was good. The medican restaurant adjacent to the hotel was good. It is a decent place to stay in the city. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sergio £52 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Fort-Myers-Hotels-Quality-Inn-Suites-Lehigh-Acres-Fort-Myers.h2009533.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/106000000/105820000/105812900/105812826/f1d9a3ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/106000000/105820000/105812900/105812826/410e116d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/106000000/105820000/105812900/105812826/caf7fda4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/106000000/105820000/105812900/105812826/d55ab6db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Seminole Brighton Bay Hotel & Casino [](https://www.expedia.co.uk/Okeechobee-Hotels-Seminole-Brighton-Bay-Hotel-Casino.h105812826.Hotel-Information) Okeechobee 8.6/10 Excellent (46 reviews) "Overall a very positive experience. I would definitely stay there again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cheryl £121 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Okeechobee-Hotels-Seminole-Brighton-Bay-Hotel-Casino.h105812826.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/5633e2c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo | Private kitchen | Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/a04fe75c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo | 1 bedroom, premium bedding, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/71f6e520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Condo | Living area | Flat-screen TV, DVD player, pay films](https://images.trvl-media.com/lodging/1000000/10000/4900/4809/d8cab195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pointe Estero Beach Resort [](https://www.expedia.co.uk/Fort-Myers-Hotels-Pointe-Estero-Beach-Resort.h4809.Hotel-Information) South Island 9.2/10 Wonderful (1,006 reviews) "Beautiful beach view, friendly staff and lots of beach space for our family to enjoy!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel £389 includes taxes & fees 1 May - 2 May [](https://www.expedia.co.uk/Fort-Myers-Hotels-Pointe-Estero-Beach-Resort.h4809.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-22&endDate=2026-04-23®ionId=6233839&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Southwest Florida Hotel Reviews ![Spark by Hilton Sarasota Siesta Key Gateway](https://images.trvl-media.com/lodging/1000000/30000/26400/26397/18d283d6_y.jpg) ### Spark by Hilton Sarasota Siesta Key Gateway 6/10 Okay "Lacking amenities, limited breakfast options. Rooms smaller than they appeared in photos." [](https://expedia.co.uk/Sarasota-Hotels-Best-Western-Plus-Siesta-Key-Gateway.h26397.Hotel-Information) ![Lani Kai Beachfront Resort](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/9bc89705_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Room was fully equipped, I had issues with Parking. In ad it said Parking on site included in price, or off-site for $20/ day. We parked vehicle on Grounds and didn't move it for 4 Days but was charged $80 anyways. Nice that Everything is Available on site, food, bars, Beach chairs, shopping, coffee. Restaurant on roof has good food and Breakfast was nice. Other Issue: Our Room was on 5th floor. Next floor up is Sky Deck/ Bar/ Restaurant/ Lounge: Kinda Loud noise coming Through the Ceiling. Band till about 1am, moving furniture etc. Great Location on Beach. Great Food within walking Distance. Would definitely stay again. " [](https://expedia.co.uk/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Compass by Margaritaville Hotel Naples](https://images.trvl-media.com/lodging/1000000/550000/543700/543614/03101902_y.jpg) ### Compass by Margaritaville Hotel Naples 10/10 Excellent "Very nice place! Fun atmosphere " [](https://expedia.co.uk/Naples-Hotels-Compass-Hotel-Naples.h543614.Hotel-Information) ![Hilton Marco Island Beach Resort and Spa](https://images.trvl-media.com/lodging/1000000/20000/17600/17575/65dd4041_y.jpg) ### Hilton Marco Island Beach Resort and Spa 8/10 Good " Overall great property for families . Had to ask housekeeping staff repeatedly to repair shower gel container . Robe never provided " [](https://expedia.co.uk/Naples-Hotels-Hilton-Marco-Island-Beach-Resort.h17575.Hotel-Information) ![Holiday Inn Express Cape Coral-Fort Myers Area by IHG](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/42ce38d8_y.jpg) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 10/10 Excellent "Everything was perfect" [](https://expedia.co.uk/Fort-Myers-Hotels-Holiday-Inn-Express-Cape-Coral-Fort-Myers-Area.h26860.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Naples Downtown](https://images.trvl-media.com/lodging/1000000/30000/24700/24612/3a0774b2_y.jpg) ### La Quinta Inn & Suites by Wyndham Naples Downtown 8/10 Good "The overall condition of the property was good. The pool area did not look well kept, needed more chlorine, and needed to be vacuumed. Staff were very friendly. Breakfasts were average. " [](https://expedia.co.uk/Naples-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Naples-Downtown.h24612.Hotel-Information) ![Golden Host Resort - Sarasota](https://images.trvl-media.com/lodging/1000000/30000/21400/21331/6dc32504_y.jpg) ### Golden Host Resort - Sarasota 6/10 Okay "A bit run down, but enjoyed the 60’s vibe. Pool area was nice. Could use a deep clean and fresh paint." [](https://expedia.co.uk/Sarasota-Hotels-Golden-Host-Resort-Sarasota.h21331.Hotel-Information) ![Naples Grande Beach Resort](https://images.trvl-media.com/lodging/1000000/20000/15900/15898/018506a5_y.jpg) ### Naples Grande Beach Resort 10/10 Excellent "Incredible stay, resort was amazing! Will stay here again" [](https://expedia.co.uk/Naples-Hotels-Naples-Grande-Beach-Resort.h15898.Hotel-Information) ![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f97bdde8_y.jpg) ### Sanibel Island Beach Resort 8/10 Good "This was mostly an amazing stay. The room was nice and same with the bathroom. I only have 2 complaints: 1) we were on the first floor and the footsteps above us were very loud and woke us many times during the night. 2) the chairs at the pool do not allow your lower back to rest on the chair unless you sit on the metal bar. They were uncomfortable! However, the chairs at the beach were an amazing bonus." [](https://expedia.co.uk/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Southwest Florida cost? ### How many business hotels are there in Southwest Florida? ### Why book your business hotel in Southwest Florida with Expedia? ### How can I find cheap business hotels in Southwest Florida? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Other - More ways to book - [Gay-Friendly Hotels in Audubon ](https://www.expedia.co.uk/Audubon-Naples-Hotels-Gay-Friendly-Hotel.0-n553248635976469139-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Bonita Springs ](https://www.expedia.co.uk/Bonita-Springs-Hotels-Adults-Only-Resorts.0-0-d6403-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Resorts & in Bonita Springs ](https://www.expedia.co.uk/Bonita-Springs-Hotels-Beach-Hotels.0-0-d6403-tBeachHotels.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Bonita Springs ](https://www.expedia.co.uk/Bonita-Springs-Hotels-Boutique-Hotel.0-0-d6403-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - 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