TOP Southeastern Indiana Spa Hotels for 2026 - Spas in Southeastern Indiana

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Our top choices for Southeastern Indiana hotels with a spa

3 bars/lounges, cocktail bar, lobby lounge

Outdoor pool, open 6:00 AM to 10:00 PM, pool cabanas (surcharge)

1. Omni Louisville Hotel

Downtown Louisville

Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.

£245

includes taxes & fees

2 Oct - 3 Oct

3 restaurants; breakfast, lunch and dinner served

2. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Elizabeth

Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.

£65

includes taxes & fees

21 Oct - 22 Oct

4 restaurants; breakfast, lunch and dinner served

In-room safe, desk, laptop workspace, iron/ironing board

3. Galt House Hotel Trademark Collection by Wyndham

Downtown Louisville

Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.

£143

includes taxes & fees

5 Oct - 6 Oct

Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe

Room, Balcony | Bathroom | Designer toiletries, hair dryer, bathrobes, towels

4. 21c Museum Hotel Louisville

Downtown Louisville

Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness centre in city centre Louisville.

£179

includes taxes & fees

4 Oct - 5 Oct

5. Quality Inn Seymour I-65

Seymour

Revitalise your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness centre.

£71

includes taxes & fees

21 Oct - 22 Oct

Body treatments, hot stone massages, deep-tissue massages

Seasonal outdoor pool, open 9:00 AM to 9:00 PM, pool cabanas (surcharge)

6. Belterra Casino Resort

Florence

Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.

£65

includes taxes & fees

29 Sept - 30 Sept

Signature Apartment, 1 King Bed with Sofa bed, Pets allowed, Garden View | Bathroom | Designer toiletries, hair dryer, bathrobes, towels

Signature Apartment, 1 King Bed with Sofa bed, Pets allowed, Garden View | Terrace/patio

7. Pillow and Paddock B&B

La Grange

Relax in a cosy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.

£244

includes taxes & fees

19 Oct - 20 Oct

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Choose what matters most at spa hotels in Southeastern Indiana

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top Southeastern Indiana Hotel Reviews

Hampton Inn New Albany Louisville West

10/10 Excellent

"Just in a great location easy access to the highway"

Hyatt Select Louisville North

8/10 Good

"Breakfast is not a real buffet more like a continental, which is fine for me I just need coffee in the morning. The room was nice and clean. I was on the first floor by the elevator so it was a lot of opening of doors and noise other then that I would have given it a 5/5"