Title: TOP Boutique Hotels in Southern Indiana for 2025 | Expedia.co.uk [Southern Indiana Travel Guide](https://expedia.co.uk/Southern-Indiana.dx6059635)[Hotels in Southern Indiana](https://expedia.co.uk/Southern-Indiana-Hotels.d6059635.Travel-Guide-Hotels)[Holiday Rentals in Southern Indiana](https://expedia.co.uk/Southern-Indiana-Holiday-Rentals.d6059635.Travel-Guide-HolidayRentals)[Flights to Southern Indiana](https://expedia.co.uk/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights)[Things to do in Southern Indiana](https://expedia.co.uk/Things-To-Do-In-Southern-Indiana.d6059635.Travel-Guide-Activities)[Southern Indiana Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Indiana.d6059635.Car-Hire-Guide)[Southern Indiana Holidays](https://expedia.co.uk/Southern-Indiana.d6059635.Holidays-City-Breaks) ![Jasper which includes heritage architecture and night scenes](https://images.trvl-media.com/place/6059640/16d9f2cd-d8c5-4e0c-aff0-83c634643d22.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Dubois County Visitors Center # Search Boutique Hotels in Southern Indiana - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Indiana Boutique Hotels Tonight [9 Nov - 10 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-11-09&endDate=2025-11-10&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Nov - 11 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-11-10&endDate=2025-11-11&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [14 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [21 Nov - 23 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6059635&startDate=2025-11-21&endDate=2025-11-23&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southern Indiana Boutique Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/2a2a7fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel Downtown Louisville 9.4/10 Exceptional (1106) "Wonderful hotel with lots of history; clean rooms; Nice lounge and restaurants." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim £136 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.2/10 Wonderful (1002) "Room was very clean and staff were very friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer £164 includes taxes & fees 23 Nov - 24 Nov [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/46279487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/76841ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/ce1b7eaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed, Fireplace | 3 bedrooms, premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/86d15582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Market Street Inn Jeffersonville 9.8/10 Exceptional (119) "We’ve stayed at this beautiful B&B twice. The location, charm, cleanliness, and staff make it an absolute treasure." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Austin £143 includes taxes & fees 10 Nov - 11 Nov [](https://www.expedia.co.uk/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-23&endDate=2025-11-24®ionId=6059635&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Southern Indiana Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Cottages in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Cottages.d6233674-aaCottages.Travel-Guide-Accommodation) - [Casino Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Casino-Hotel.0-0-d6233674-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Gay-Friendly-Hotel.0-0-d6233674-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Historic-Hotel.0-0-d6233674-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Hotel-With-A-Bar.0-0-d6233674-thotelwithabar.Travel-Guide-Filter-Hotels) - 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