Find luxury hotels in Southern Indiana

    price find illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Top Southern Indiana Luxury Hotels

21c Museum Hotel Louisville
Front of property

21c Museum Hotel Louisville

4.5 star property
9.2 out of 10, Wonderful, (1008)
"We had a great stay and very much enjoyed the art and the atmosphere. "
The price is £152
includes taxes & fees
2 Sept - 3 Sept
21c Museum Hotel Louisville
West Baden Springs Hotel
Exterior

West Baden Springs Hotel

4.5 star property
9.6 out of 10, Exceptional, (310)
West Baden Springs Hotel
The Brown Hotel
Lobby

The Brown Hotel

4.5 star property
9.4 out of 10, Exceptional, (1053)
"Beautiful hotel, great location, helpful staff. Will definitely stay here again"
The price is £125
includes taxes & fees
28 Aug - 29 Aug
The Brown Hotel
Galt House Hotel Trademark Collection by Wyndham
4 restaurants, breakfast, lunch, dinner served; American cuisine

Galt House Hotel Trademark Collection by Wyndham

4.0 star property
8.8 out of 10, Excellent, (3552)
"Wonderful and fun place to stay "
The price is £106
includes taxes & fees
2 Sept - 3 Sept
Galt House Hotel Trademark Collection by Wyndham
Embassy Suites Louisville Downtown
Dinner served

Embassy Suites Louisville Downtown

4.0 star property
9.0 out of 10, Wonderful, (1007)
"Very nice clean hotel and wonderful breakfast. I would definitely stay there again"
The price is £118
includes taxes & fees
4 Sept - 5 Sept
Embassy Suites Louisville Downtown
Econo Lodge Downtown Louisville
Standard Room, 2 Double Beds, Non Smoking | Desk, blackout curtains, soundproofing, iron/ironing board

Econo Lodge Downtown Louisville

2.0 star property
7.2 out of 10, Good, (1007)
"Close to the airport and there's a large bar district within easy walking distance. "
The price is £56
includes taxes & fees
24 Sept - 25 Sept
Econo Lodge Downtown Louisville
Seelbach Hilton Louisville Downtown
Lobby

Seelbach Hilton Louisville Downtown

4.0 star property
8.6 out of 10, Excellent, (1001)
"nice ambiance"
The price is £119
includes taxes & fees
31 Aug - 1 Sept
Seelbach Hilton Louisville Downtown
Baymont by Wyndham Corydon
Property amenity

Baymont by Wyndham Corydon

2.5 star property
7.6 out of 10, Good, (1001)
"Decent place to stay for the price. "
The price is £53
includes taxes & fees
7 Sept - 8 Sept
Baymont by Wyndham Corydon
Courtyard by Marriott Evansville East
Property amenity

Courtyard by Marriott Evansville East

3.0 star property
8.8 out of 10, Excellent, (1002)
"I loved the room, the area, and the staff is so so amazing that the person who’s job I am taking over for practically DEMANDED I stay there and it was everything she raved about and then some!"
The price is £135
includes taxes & fees
31 Aug - 1 Sept
Courtyard by Marriott Evansville East
Travelodge by Wyndham Sellersburg / Louisville North
Individually furnished, blackout curtains, iron/ironing board

Travelodge by Wyndham Sellersburg / Louisville North

2.0 star property
6.6 out of 10, (664)
"Stayed over night while traveling through on trip, wonderful clean room and king bed was comfortable. Great hotel for pricing!! "
The price is £56
includes taxes & fees
15 Sept - 16 Sept
Travelodge by Wyndham Sellersburg / Louisville North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Luxury 4* hotels in Southern Indiana

Hotel Genevieve part of JdV by Hyatt
3 bars/lounges, cocktail bar, rooftop bar

Hotel Genevieve part of JdV by Hyatt

4.0 star property
9.2 out of 10, Wonderful, (939)
The price is £118
includes taxes & fees
31 Aug - 1 Sept
Hotel Genevieve part of JdV by Hyatt
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southern Indiana

Find out more about Southern Indiana

Popular luxurious hotels

Most upscale stays in Southern Indiana in 2025

Luxury hotels in Southern Indiana
5-Star hotels
5-Star hotels
4-Star hotels
4-Star hotels

Top Southern Indiana Hotel Reviews

Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

10/10 Excellent
"Hotel was nice although older tge rooms had been refreshed. It was clean..breakfast was very good and plentiful.."
Tammy 2-night trip
Posted 4 days ago
Hampton Inn New Albany Louisville West

Explore a world of travel with Expedia

Explore a world of travel with Expedia