Title: TOP Luxury Hotels in Ohio River Valley for 2025 - Ohio River Valley Upscale Hotels | Expedia.co.uk [Ohio River Valley Travel Guide](https://expedia.co.uk/Ohio-River-Valley.dx6233674)[Hotels in Ohio River Valley](https://expedia.co.uk/Ohio-River-Valley-Hotels.d6233674.Travel-Guide-Hotels)[Holiday Rentals in Ohio River Valley](https://expedia.co.uk/Ohio-River-Valley-Holiday-Rentals.d6233674.Travel-Guide-HolidayRentals)[Flights to Ohio River Valley](https://expedia.co.uk/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights)[Ohio River Valley Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Ohio-River-Valley.d6233674.Car-Hire-Guide)[Ohio River Valley Holidays](https://expedia.co.uk/Ohio-River-Valley.d6233674.Holidays-City-Breaks) ![Indianapolis featuring autumn colours and a cemetery](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/25000/25344-Indianapolis.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Ohio River Valley ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Ohio River Valley Luxury Hotels Tonight [22 Sept - 23 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-09-22&endDate=2025-09-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [23 Sept - 24 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-09-23&endDate=2025-09-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-09-26&endDate=2025-09-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233674&startDate=2025-10-03&endDate=2025-10-05&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Ohio River Valley Luxury Hotels ## Our top choices for Ohio River Valley luxury hotels ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/w3822h2860x18y0-dc47fc22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/3cf8c2c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/b16740d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1290000/1287500/1287480/w2558h3836x3y4-7244cc45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Conrad Indianapolis Downtown Indianapolis 9.2/10 Wonderful (1004) "Very luxury hotel - and friendly staff Specially Justin and Jessie at front desk are the best " £177 includes taxes & fees 7 Oct - 8 Oct [](https://www.expedia.co.uk/Indianapolis-Hotels-Conrad-Indianapolis.h1287480.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/cef338e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville Downtown Louisville 9.2/10 Wonderful (1006) "Nice property. Room was comfortable, easy check in and check out. Staff were pleasant and atmosphere was cool. " £152 includes taxes & fees 2 Oct - 3 Oct [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/220feee7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/bff88489.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![15 restaurants, breakfast served](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/95e75b78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/14a6fe74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### West Baden Springs Hotel West Baden Springs 9.6/10 Exceptional (310) [](https://www.expedia.co.uk/West-Baden-Springs-Hotels-West-Baden-Springs-Hotel.h1745075.Hotel-Information) ![1 bedroom, Egyptian cotton sheets, premium bedding, in-room safe](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/e40ec4ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner and brunch served](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/17dd1cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/5b64e900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/6000000/5290000/5287100/5287002/083528eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Cincinnati Downtown Cincinnati 8.8/10 Excellent (1008) "Quick check in and gracious welcomes!" £146 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Cincinnati-Hotels-21c-Museum-Hotel-Cincinnati.h5287002.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/90dd12e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/fdaa6912.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/05efa2e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12500/12411/bf4689cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Cincinnatian Hotel Curio Collection by Hilton Downtown Cincinnati 7.6/10 Good (1008) "Great location, good staff" £135 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/Cincinnati-Hotels-The-Cincinnatian-Hotel-Curio-Collection-By-Hilton.h12411.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/4fd8456f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel Downtown Louisville 9.4/10 Exceptional (1072) "Would definitely stay here again" [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/ab0af7cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/594caae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville 9.0/10 Wonderful (3631) "Hotel was nice and had beautiful historic features and such an awesome location. " £125 includes taxes & fees 1 Oct - 2 Oct [](https://www.expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/53b2e008.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Loft, 1 King Bed, Kitchenette | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/e8eba286.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 1 King Bed, Kitchenette | 1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/c26bf422.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15110000/15108500/15108459/0d267bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Covington Cincinnati Riverfront Covington 9.6/10 Exceptional (1008) "Awesome place to stay" [](https://www.expedia.co.uk/Cincinnati-Hotels-Hotel-Covington-Cincinnati-Riverfront.h15108459.Hotel-Information) ![Dinner served](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/4e79a8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/f30004bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/c4d1fb67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Louisville Downtown Downtown Louisville 9.0/10 Wonderful (1023) "Very nice clean hotel and wonderful breakfast. I would definitely stay there again" £133 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/574acdfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, individually furnished, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/a7fe0148.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/2b30ef66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/690000/687800/687701/1802b8f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Olentangy Motor Inn Grandview Heights 9.0/10 Wonderful (1195) "This updated, adorable motor inn is an excellent option when looking for a reasonably priced stay at a well maintained property." £118 includes taxes & fees 18 Oct - 19 Oct [](https://www.expedia.co.uk/Columbus-Hotels-Olentangy-Motor-Inn.h687701.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-06&endDate=2025-10-07®ionId=6233674&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Luxury 4-star hotels in Ohio River Valley ![5 restaurants, breakfast, dinner served; American cuisine ](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/3a4b6792.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/e3f97fe5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, dinner served; American cuisine ](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/31f323b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, in-room safe, desk](https://images.trvl-media.com/lodging/102000000/101750000/101749800/101749750/f4871865.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Terre Haute Casino Resort Terre Haute 9.4/10 Exceptional (557) £114 includes taxes & fees 23 Sept - 24 Sept [](https://www.expedia.co.uk/Terre-Haute-Hotels-Terre-Haute-Casino-Resort.h101749750.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1900000/1897400/1897350/b24d7833.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1900000/1897400/1897350/bb3a13f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bicycling](https://images.trvl-media.com/lodging/2000000/1900000/1897400/1897350/6427324b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1900000/1897400/1897350/8c700465.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### I Hotel And Illinois Conference Center Champaign 9.8/10 Exceptional (1815) [](https://www.expedia.co.uk/Champaign-Hotels-I-Hotel-And-Conference-Center.h1897350.Hotel-Information) ![Staircase](https://images.trvl-media.com/lodging/20000000/19300000/19294100/19294032/02753ebe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Traditional Room, 1 King Bed | 1 bedroom, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/20000000/19300000/19294100/19294032/4c50f064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/20000000/19300000/19294100/19294032/b2bf656e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/20000000/19300000/19294100/19294032/1ac23e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ironworks Hotel Indy Indianapolis 9.8/10 Exceptional (1623) £149 includes taxes & fees 20 Oct - 21 Oct [](https://www.expedia.co.uk/Indianapolis-Hotels-Ironworks-Hotel-Indy.h19294032.Hotel-Information) ![1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/94000000/93190000/93187900/93187879/ee0d92e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/94000000/93190000/93187900/93187879/48c89e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/94000000/93190000/93187900/93187879/w2880h1508x0y5-a3c9852c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/94000000/93190000/93187900/93187879/fb60fb85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Derby City Gaming & Hotel - A Churchill Downs Property Louisville 9.4/10 Exceptional (1445) [](https://www.expedia.co.uk/Louisville-Hotels-Derby-City-Gaming-Hotel.h93187879.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/96000000/95220000/95210600/95210585/be8d1ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/96000000/95220000/95210600/95210585/w3837h2625x3y3-94679c25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/96000000/95220000/95210600/95210585/w3837h2594x3y3-f80be80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/96000000/95220000/95210600/95210585/w3840h2602x0y3-bb731fb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Royer Urbana Champaign, Tapestry Collection by Hilton Urbana 9.0/10 Wonderful (69) £88 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/Urbana-Hotels-Hotel-Royer-Urbana.h95210585.Hotel-Information) ![Interior detail](https://images.trvl-media.com/lodging/58000000/57260000/57258100/57258038/78e86d9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/58000000/57260000/57258100/57258038/7b9c1c27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/58000000/57260000/57258100/57258038/2e775e98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/58000000/57260000/57258100/57258038/91231645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bottleworks Hotel Downtown Indianapolis 9.8/10 Exceptional (1574) £156 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Boston-Hotels-Bottleworks-Hotel.h57258038.Hotel-Information) ![Deluxe Single Room, 1 King Bed, River View | View from room](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f322db40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/15339a2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine ](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/765b8556.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f5558cfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Grady Downtown Louisville 9.4/10 Exceptional (1008) £219 includes taxes & fees 9 Oct - 10 Oct [](https://www.expedia.co.uk/Louisville-Hotels-The-Grady.h61215907.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/21000000/20650000/20645300/20645297/0ef7db2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20650000/20645300/20645297/b9849b5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/21000000/20650000/20645300/20645297/89e21b4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/21000000/20650000/20645300/20645297/f50ab8a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hancock Hotel Findlay 9.6/10 Exceptional (1008) [](https://www.expedia.co.uk/Findlay-Hotels-Hancock-Hotel.h20645297.Hotel-Information) ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/2abf4070.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/e30e3380.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/c9ab692a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/68000000/67640000/67630700/67630659/37096296.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bradley Hotel Downtown 9.4/10 Exceptional (850) £123 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/Fort-Wayne-Hotels-The-Bradley.h67630659.Hotel-Information) ![Deluxe Room, 1 King Bed (Culbertson Suite) | Balcony](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/298a5147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Ballroom](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/15562c87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/033ac7bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/17000000/16890000/16881700/16881647/8a916a96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Pepin Mansion Historic B&B New Albany 9.8/10 Exceptional (621) £70 includes taxes & fees 25 Sept - 26 Sept [](https://www.expedia.co.uk/Louisville-Hotels-The-Pepin-Mansion-Historic-BB.h16881647.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-06&endDate=2025-10-07®ionId=6233674&adults=2&star=50&sort=RECOMMENDED&star=40&openPlayBack=true) ## Find out more about Ohio River Valley ### Ohio River Valleyand its attractions for luxury travelers The Ohio River Valley offers a range of luxurious experiences for discerning travellers. Begin your journey in Cincinnati, where the historic Over-the-Rhine district is home to stunningly restored 19th-century buildings that house upscale boutiques and Michelin-starred restaurants, perfect for indulging in gourmet cuisine. Just a short drive away, the serene beauty of the Riverbend Music Center provides a picturesque setting for outdoor concerts, where you can enjoy world-class performances in a breathtaking natural backdrop. For a touch of elegance, the charming town of Marietta boasts the historic Lafayette Hotel, offering luxurious accommodations alongside a rich maritime history. Nature enthusiasts will relish a visit to the stunning Red River Gorge, where private guided hikes can lead you through dramatic cliffs and lush forests, all while enjoying the comforts of a high-end lodge. Finally, don’t miss the opportunity to explore the iconic Bourbon Trail; several distilleries in the region offer exclusive tastings and tours, allowing you to savour the finest spirits. With a stay at one of the opulent hotels in the area, you can unwind in style after a day of exploring, enjoying personalised service and lavish amenities that elevate your experience. ## Top Ohio River Valley Hotel Reviews ![Holiday Inn Express & Suites Cincinnati Riverfront by IHG](//images.trvl-media.com/lodging/1000000/50000/42500/42480/a153a670_y.jpg) ### Holiday Inn Express & Suites Cincinnati Riverfront by IHG 10/10 Excellent "Staff was wonderful! Other properties around you looked a little sketchy. " [](https://expedia.co.uk/Cincinnati-Hotels-Holiday-Inn-Express-Suites-Cincinnati-Riverfront.h42480.Hotel-Information) ![Galt House Hotel Trademark Collection by Wyndham](//images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Fastest and easiest check in! Very clean, quiet, and beautiful!" [](https://expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![I Hotel And Illinois Conference Center](//images.trvl-media.com/lodging/2000000/1900000/1897400/1897350/b24d7833_y.jpg) ### I Hotel And Illinois Conference Center 10/10 Excellent "This was a quick stop for us. Very clean, looks new and a great staff. Good breakfast and a great deal for the price we paid. If in the area, we will be back!" [](https://expedia.co.uk/Champaign-Hotels-I-Hotel-And-Conference-Center.h1897350.Hotel-Information) ![Sheraton Indianapolis Hotel at Keystone Crossing](//images.trvl-media.com/lodging/1000000/20000/14900/14838/e72753e3_y.jpg) ### Sheraton Indianapolis Hotel at Keystone Crossing 10/10 Excellent "will always stay here! second time!" [](https://expedia.co.uk/Indianapolis-Hotels-Sheraton-Indianapolis-Hotel-At-Keystone-Crossing.h14838.Hotel-Information) ![Radisson Hotel Cincinnati Riverfront](//images.trvl-media.com/lodging/1000000/10000/2800/2755/68cff2fd_y.jpg) ### Radisson Hotel Cincinnati Riverfront 10/10 Excellent "Comfy bed, amazing view. Overall great stay" [](https://expedia.co.uk/Cincinnati-Hotels-Radisson-Hotel-Cincinnati-Riverfront.h2755.Hotel-Information) ![Hyatt Regency Cincinnati](//images.trvl-media.com/lodging/1000000/20000/18700/18646/1ec5d305_y.jpg) ### Hyatt Regency Cincinnati 10/10 Excellent "Great location and hotel was in good condition." [](https://expedia.co.uk/Cincinnati-Hotels-Hyatt-Regency-Cincinnati.h18646.Hotel-Information) ![Hilton Columbus Downtown](//images.trvl-media.com/lodging/6000000/5280000/5270400/5270320/6a2e3c37_y.jpg) ### Hilton Columbus Downtown 10/10 Excellent "Nice hotel, convenient location " [](https://expedia.co.uk/Columbus-Hotels-Hilton-Columbus-Downtown.h5270320.Hotel-Information) ![Hilton Cincinnati Netherland Plaza](//images.trvl-media.com/lodging/1000000/10000/5900/5818/3a03c8ac_y.jpg) ### Hilton Cincinnati Netherland Plaza 10/10 Excellent "Absolutely love this hotel. Bar is great. Location is great. Staff is great " [](https://expedia.co.uk/Cincinnati-Hotels-Hilton-Cincinnati-Netherland-Plaza.h5818.Hotel-Information) ![Omni Severin Hotel](//images.trvl-media.com/lodging/1000000/20000/17700/17640/3e6b70fc_y.jpg) ### Omni Severin Hotel 10/10 Excellent "Great location. Nice, clean rooms. Friendly staff! 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