Title: TOP Luxury Hotels in Southeastern Indiana for 2026 - Southeastern Indiana Upscale Hotels | Expedia.co.uk [Southeastern Indiana Travel Guide](https://expedia.co.uk/Southeastern-Indiana.dx6233889)[Hotels in Southeastern Indiana](https://expedia.co.uk/Southeastern-Indiana-Hotels.d6233889.Travel-Guide-Hotels)[Holiday Rentals in Southeastern Indiana](https://expedia.co.uk/Southeastern-Indiana-Holiday-Rentals.d6233889.Travel-Guide-HolidayRentals)[Flights to Southeastern Indiana](https://expedia.co.uk/Cheap-Flights-To-Southeastern-Indiana.d6233889.Travel-Guide-Flights)[Southeastern Indiana Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeastern-Indiana.d6233889.Car-Hire-Guide)[Southeastern Indiana Holidays](https://expedia.co.uk/Southeastern-Indiana.d6233889.Holidays-City-Breaks) ![Belle of Louisville featuring a ferry and a bay or harbour as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeastern Indiana Luxury Hotels Tonight [9 Mar - 10 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-03-09&endDate=2026-03-10&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [10 Mar - 11 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-03-10&endDate=2026-03-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-03-13&endDate=2026-03-15&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [20 Mar - 22 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-03-20&endDate=2026-03-22&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Southeastern Indiana luxury hotels ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/78105fdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/e2fb9d56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/547de83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/9798709f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel [](https://www.expedia.co.uk/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) Downtown Louisville 9.2/10 Wonderful (1,790 reviews) "Amazing stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erin £161 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/aaadeb96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/22b7d23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/06213b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,008 reviews) "Great room, super kind staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel £161 includes taxes & fees 19 Mar - 20 Mar [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/764d3439.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/4fd8456f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/2a2a7fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,188 reviews) "Fantastic place to stay in Louisville." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nathaniel [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/ac66f01b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/cf849375.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/16484a66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch flat-screen TV with satellite channels, TV](https://images.trvl-media.com/lodging/38000000/37770000/37765700/37765616/939655b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Distil, Autograph Collection [](https://www.expedia.co.uk/Louisville-Hotels-Hotel-Distil.h37765616.Hotel-Information) Downtown Louisville 9.6/10 Exceptional (455 reviews) "Great hotel & location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ana £154 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Louisville-Hotels-Hotel-Distil.h37765616.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/e116c623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine ](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/765b8556.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/f5558cfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/62000000/61220000/61216000/61215907/e68de90e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Grady [](https://www.expedia.co.uk/Louisville-Hotels-The-Grady.h61215907.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,005 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joe £124 includes taxes & fees 1 Apr - 2 Apr [](https://www.expedia.co.uk/Louisville-Hotels-The-Grady.h61215907.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/c5a6934a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 Bedroom | Living area | 55-inch flat-screen TV with digital channels, Smart TV, pay films](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/14a187ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 Bedroom | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/1c073add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6f6867fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Louisville Marriott Downtown [](https://www.expedia.co.uk/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) Downtown Louisville 9.0/10 Wonderful (1,007 reviews) "Very nice hotel. Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brad £147 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Louisville-Hotels-Louisville-Marriott-Downtown.h1111358.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/d22f4bf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/12e6fe89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hilton, Deluxe Suite, 1 Queen Bed, Non Smoking | Living area | 55-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/83bc3758.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily full breakfast for a fee](https://images.trvl-media.com/lodging/1000000/30000/26000/25958/52012810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Seelbach Hilton Louisville Downtown [](https://www.expedia.co.uk/Louisville-Hotels-The-Seelbach-Hilton-Louisville.h25958.Hotel-Information) Downtown Louisville 8.6/10 Excellent (1,006 reviews) "The area was congested but the motel was good. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Byrd £128 includes taxes & fees 3 Apr - 4 Apr [](https://www.expedia.co.uk/Louisville-Hotels-The-Seelbach-Hilton-Louisville.h25958.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/aa5bcd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9d86b349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/0261f02d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham [](https://www.expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) Downtown Louisville 9.0/10 Wonderful (4,101 reviews) "Rooms were clean and staff were friendly! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy £111 includes taxes & fees 22 Mar - 23 Mar [](https://www.expedia.co.uk/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/5c616865.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, American cuisine](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/12fca7c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/f1158083.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/108000000/107080000/107072800/107072728/cb95631e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Bourré Bonne Louisville, Curio Collection by Hilton [](https://www.expedia.co.uk/Louisville-Hotels-Canopy-By-Hilton-Louisville-Downtown.h107072728.Hotel-Information) Downtown Louisville 9.2/10 Wonderful (80 reviews) "i love this place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) THANH £126 includes taxes & fees 3 Apr - 4 Apr [](https://www.expedia.co.uk/Louisville-Hotels-Canopy-By-Hilton-Louisville-Downtown.h107072728.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/1b9613a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/w3836h2558x4y3-11fbb096.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/9764f52b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/91000000/90950000/90942200/90942141/w2691h3837x0y3-df7daefb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Genevieve part of JdV by Hyatt [](https://www.expedia.co.uk/Louisville-Hotels-Hotel-Genevieve.h90942141.Hotel-Information) Downtown Louisville 9.2/10 Wonderful (1,052 reviews) "Spotless room and courteous staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary £118 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Louisville-Hotels-Hotel-Genevieve.h90942141.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-23&endDate=2026-03-24®ionId=6233889&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_6233889) ## Top Southeastern Indiana Hotel Reviews ![Sheraton Louisville Riverside by Marriott](https://images.trvl-media.com/lodging/1000000/20000/17900/17862/aa9c9fd5_y.jpg) ### Sheraton Louisville Riverside by Marriott 10/10 Excellent "Hotel staff was great, in my opinion, the hotel is a little dated, given the condition of the bathroom, but the rooms were clean. I would stay again!" [](https://expedia.co.uk/Louisville-Hotels-Sheraton-Louisville-Riverside-Hotel.h17862.Hotel-Information) ![Hampton Inn New Albany Louisville West](https://images.trvl-media.com/lodging/1000000/30000/25400/25301/75b1f99e_y.jpg) ### Hampton Inn New Albany Louisville West 10/10 Excellent "Everything was great " [](https://expedia.co.uk/Louisville-Hotels-Hampton-Inn-New-Albany-Louisville-West.h25301.Hotel-Information) ![Travelodge by Wyndham Sellersburg / Louisville North](https://images.trvl-media.com/lodging/1000000/30000/21200/21199/b9a48afc_y.jpg) ### Travelodge by Wyndham Sellersburg / Louisville North 8/10 Good "The bedding was nice…included all amenities and a clean bathroom at a good price…some for this price don’t provide coffee or hairdryer or decent soap shampoo…will check out again next road trip…" [](https://expedia.co.uk/Sellersburg-Hotels-Travelodge-By-Wyndham-Sellersburg-Louisville-North.h21199.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - 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