Title: TOP Boutique Hotels in Southeastern Indiana for 2026 | Expedia.co.uk [Southeastern Indiana Travel Guide](https://expedia.co.uk/Southeastern-Indiana.dx6233889)[Hotels in Southeastern Indiana](https://expedia.co.uk/Southeastern-Indiana-Hotels.d6233889.Travel-Guide-Hotels)[Holiday Rentals in Southeastern Indiana](https://expedia.co.uk/Southeastern-Indiana-Holiday-Rentals.d6233889.Travel-Guide-HolidayRentals)[Flights to Southeastern Indiana](https://expedia.co.uk/Cheap-Flights-To-Southeastern-Indiana.d6233889.Travel-Guide-Flights)[Southeastern Indiana Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeastern-Indiana.d6233889.Car-Hire-Guide)[Southeastern Indiana Holidays](https://expedia.co.uk/Southeastern-Indiana.d6233889.Holidays-City-Breaks) ![Bathe in the forest...find this on the roof of the outdoor shower house down the hill from the guest house.](https://images.trvl-media.com/place/553248635989202622/88a60920-d501-4b4d-b386-caf78a7f4191.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Serendipity Trip ![](https://images.trvl-media.com/place/553248635989202622/88a60920-d501-4b4d-b386-caf78a7f4191.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeastern Indiana Boutique Hotels Tonight [13 Jan - 14 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-01-13&endDate=2026-01-14&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [14 Jan - 15 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-01-14&endDate=2026-01-15&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-01-16&endDate=2026-01-18&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6233889&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeastern Indiana boutique hotels ![Front of property](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone) | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/aaadeb96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Downtown Louisville 9.2/10 Wonderful (1,000 reviews) "Excellent place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anatole £120 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/4fd8456f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/f0221042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/3c2671ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Brown Hotel [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,174 reviews) "Fantastic place to stay in Louisville." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nathaniel [](https://www.expedia.co.uk/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/a276c9db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/46279487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/d64d36b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/10000000/9680000/9678400/9678336/9d6b5686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Market Street Inn [](https://www.expedia.co.uk/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) Jeffersonville 9.8/10 Exceptional (120 reviews) "The owner, Carol, and her husband have done an amazing job restoring the building. The woodwork alone is art! Breakfast offered lots of options, was prepared to order, and was the best scrambled eggs I’ve ever had. Our server, Lisa, was friendly, personable, and efficient. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcia £155 includes taxes & fees 14 Jan - 15 Jan [](https://www.expedia.co.uk/Louisville-Hotels-Market-Street-Inn.h9678336.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-27&endDate=2026-01-28®ionId=6233889&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Southeastern Indiana Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Cottages in Ohio River Valley ](https://www.expedia.co.uk/Ohio-River-Valley-Cottages.d6233674-aaCottages.Travel-Guide-Accommodation) - [Casino Hotels in Ohio River Valley ](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Casino-Hotel.0-0-d6233674-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Ohio River Valley ](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Gay-Friendly-Hotel.0-0-d6233674-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Ohio River Valley ](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Hotel-With-A-Bar.0-0-d6233674-thotelwithabar.Travel-Guide-Filter-Hotels) - 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