Title: TOP Southeast Minnesota Spa Hotels for 2025 - Spas in Southeast Minnesota, MN | Expedia.co.uk [Southeast Minnesota Travel Guide](https://expedia.co.uk/Southeast-Minnesota.dx6233996)[Hotels in Southeast Minnesota](https://expedia.co.uk/Southeast-Minnesota-Hotels.d6233996.Travel-Guide-Hotels)[Holiday Rentals in Southeast Minnesota](https://expedia.co.uk/Southeast-Minnesota-Holiday-Rentals.d6233996.Travel-Guide-HolidayRentals)[Flights to Southeast Minnesota](https://expedia.co.uk/Cheap-Flights-To-Southeast-Minnesota.d6233996.Travel-Guide-Flights)[Southeast Minnesota Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Minnesota.d6233996.Car-Hire-Guide)[Southeast Minnesota Holidays](https://expedia.co.uk/Southeast-Minnesota.d6233996.Holidays-City-Breaks) ![Rochester showing skyline and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63803-Rochester.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Southeast Minnesota, MN ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Minnesota Spa Hotels Tonight [11 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2025-10-11&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2025-10-12&endDate=2025-10-13&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Minnesota Spa Hotels ![Lobby](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/f590e78a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/ffa93f1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/20c6a208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/9d21a7b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grandstay Hotel and Suites Waseca 7.6/10 Good (240) "It was clean room and pleasant staff." £69 includes taxes & fees 13 Oct - 14 Oct [](https://www.expedia.co.uk/Owatonna-Hotels-Grandstay-Hotel-And-Suites.h15291258.Hotel-Information) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/a6d4835a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/8ed672f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/8e8e2669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite Riverside | 1 bedroom, premium bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/caabe547.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### St James Hotel, a Historic Hotel of America Red Wing 9.2/10 Wonderful (1007) "Love the historical hotel. Very clean and the staff was great. " £138 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/Red-Wing-Hotels-St-James-Hotel.h8820.Hotel-Information) ![Luxury Single Room | Individually decorated, individually furnished, desk, soundproofing](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/e51df0cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/455654ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/02fc8ee1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/d54840be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Round Barn Farm B & B Event Center Red Wing 10/10 Exceptional (39) "Beautiful property with great hosts! Strongly recommend!" [](https://www.expedia.co.uk/Red-Wing-Hotels-Round-Barn-Farm-B-B-Event-Center.h46980893.Hotel-Information) ![Serves lunch, dinner and happy hour](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, desk](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/8d7f7147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking | Premium bedding, down duvets, pillow-top beds, desk](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/493f76e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/3b0f1e42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Rochester Near Mayo Clinic Rochester 8.2/10 Very good (1063) "Great, inexpensive stay for mayo ..EXCELLENT STAFF!!" £63 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/b1555778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/86063f91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/f4c0d6e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/1213b471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Rochester Mayo Clinic Area Downtown Rochester 9.6/10 Exceptional (518) "Great hotel and location. Will definitely select this property again for my next stay in Rochester. " £148 includes taxes & fees 31 Oct - 1 Nov [](https://www.expedia.co.uk/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/d6da8b6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/61e51f32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/673d14c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/0fb5698e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mystic Lake Casino Hotel Prior Lake 9.0/10 Wonderful (2276) "Great hotel and restaurants. " £103 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Mystic-Lake-Casino-Hotel.h198946.Hotel-Information) ![Walk-Out, 1 Queen Bed, Non Smoking, Jetted Tub & Fireplace (1st Floor) | Terrace/patio](https://images.trvl-media.com/lodging/2000000/1480000/1479300/1479277/24fb4c02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 Queen Bed (1st Floor) | Private spa tub](https://images.trvl-media.com/lodging/2000000/1480000/1479300/1479277/b0140aff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/2000000/1480000/1479300/1479277/ccf52467.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1480000/1479300/1479277/2a74761f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Afton House Inn Afton 8.2/10 Very good (235) "Staff was incredible, very historic pace, and peaceful. " [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Afton-House-Inn.h1479277.Hotel-Information) ![Couples treatment room(s), sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/93adc461.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dinner served](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/06ffc248.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/91361409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/b65aee43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Viking Lakes Hotel Eagan 9.6/10 Exceptional (909) "Great property, clean, loads of amenities, and very friendly staff! " £126 includes taxes & fees 24 Oct - 25 Oct [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Omni-Viking-Lakes-Hotel.h54172209.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=6233996&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Southeast Minnesota ### Top Southeast Minnesota attractions for a relaxing vacation Southeast Minnesota is a hidden gem for travellers seeking rejuvenation and relaxation, particularly those inclined to indulge in hotels with spas. Begin your journey in Rochester, renowned for the prestigious Mayo Clinic, where you can enjoy a luxurious spa experience followed by a stroll through the serene landscapes of Quarry Hill Nature Center, featuring picturesque trails and native wildlife. Just a short drive away, the charming town of Lanesboro offers a unique blend of art and nature; consider renting a bike to explore the scenic Root River State Trail, or unwind at a local spa that incorporates natural elements into its treatments. The historic district of Winona showcases beautiful architecture and an array of boutique shops, perfect for a leisurely afternoon, and the nearby Garvin Heights Vineyards provides wine tasting with breathtaking views of the Mississippi River. For an ideal stay, consider hotels in the heart of Rochester, where you’ll find top spas and attentive service, allowing you to unwind in style after a day of exploration. With its welcoming atmosphere and array of wellness activities, Southeast Minnesota promises a refreshing escape that caters to your every need. ## Top Southeast Minnesota Hotel Reviews ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](//images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "Thank you for a quick check in, beautiful and clean rooms. " [](https://expedia.co.uk/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](//images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "Great, inexpensive stay for mayo ..EXCELLENT STAFF!!" [](https://expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Spark by Hilton Rochester South](//images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg) ### Spark by Hilton Rochester South 10/10 Excellent "Brand new everything was clean and working!" [](https://expedia.co.uk/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Nice hotel convenient for medical appointments ~ nice breakfast " [](https://expedia.co.uk/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![Express Suites Riverport Inn & Suites](//images.trvl-media.com/lodging/1000000/20000/11700/11603/dccd832e_y.jpg) ### Express Suites Riverport Inn & Suites 10/10 Excellent "Very friendly staff. Parking is a little tight, but manageable. We had one of the specialty rooms with the car and a hot tub. It was a really fun experience!" [](https://expedia.co.uk/Winona-Hotels-Express-Suites-Riverport-Inn-Suites.h11603.Hotel-Information) ![St James Hotel, a Historic Hotel of America](//images.trvl-media.com/lodging/1000000/10000/8900/8820/c90b9231_y.jpg) ### St James Hotel, a Historic Hotel of America 10/10 Excellent "The best of everything!!" [](https://expedia.co.uk/Red-Wing-Hotels-St-James-Hotel.h8820.Hotel-Information) ![Best Western Rochester Hotel Mayo Clinic Area/St. Mary's](//images.trvl-media.com/lodging/1000000/10000/3700/3682/w3836h2559x4y0-f5ee734c_y.jpg) ### Best Western Rochester Hotel Mayo Clinic Area/St. Mary's 10/10 Excellent "Very relaxing " [](https://expedia.co.uk/Rochester-Hotels-Best-Western-Rochester-Hotel-Mayo-Clinic-AreaSt-Marys.h3682.Hotel-Information) ![Hotel Indigo Rochester – Mayo Clinic Area by IHG](//images.trvl-media.com/lodging/1000000/10000/5400/5327/48e45010_y.jpg) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG 10/10 Excellent "Property was very accommodating for our needs. Staff was very friendly and helpful. Rooms were great! Lovely decor and roomy. Would highly recommend this establishment." [](https://expedia.co.uk/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information) ![Country Inn & Suites Rochester South Mayo Clinic](//images.trvl-media.com/lodging/1000000/460000/455600/455558/c3584a83_y.jpg) ### Country Inn & Suites Rochester South Mayo Clinic 10/10 Excellent "Very easy to obtain a room and ease of checking in" [](https://expedia.co.uk/Rochester-Hotels-Country-Inn-Suites-By-Radisson.h455558.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [5 Star Hotels in Rochester](https://www.expedia.co.uk/5Star-Rochester-Hotels.s50-0-d3041.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Austin](https://www.expedia.co.uk/Austin-Hotels-Gay-Friendly-Hotel.0-0-d6182-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Austin](https://www.expedia.co.uk/Austin-Hotels-Hotels-With-Hot-Tubs.0-0-d6182-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotels with Indoor Pools in Bloomington](https://www.expedia.co.uk/Bloomington-Hotels-Hotels-With-Indoor-Pools.0-0-d6287-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels) - 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[Flights from London (LHR) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/lhr/rst/london-to-rochester) - [Flights from Liverpool (LPL) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/lpl/rst/liverpool-to-rochester) - [Flights from Manchester (MAN) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/man/rst/manchester-to-rochester) - [Flights from Manitowoc (MTW) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/mtw/rst/manitowoc-to-rochester) - [Flights from Newcastle (NCL) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/ncl/rst/newcastle-to-rochester) - [Flights from Chicago (ORD) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/ord/rst/chicago-to-rochester) - [Flights from Oslo (OSL) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/osl/rst/oslo-to-rochester) - [Flights from Rockford (RFD) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/rfd/rst/rockford-to-rochester) - [Flights from Seattle (SEA) to Rochester (RST)](https://www.expedia.co.uk/lp/flights/sea/rst/seattle-to-rochester) - 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[Wanamingo Holiday Rentals](https://www.expedia.co.uk/Wanamingo-Holiday-Rentals.d3000349019.Travel-Guide-HolidayRentals) - [Book Spa Hotels in Southeast Minnesota on Expedia.com](https://www.expedia.com/Southeast-Minnesota-Hotels-Spa-Hotel.0-0-d6233996-tSpaHotel.Travel-Guide-Filter-Hotels)