Title: TOP Southeast Minnesota Spa Hotels for 2026 - Spas in Southeast Minnesota, MN | Expedia.co.uk [Southeast Minnesota Travel Guide](https://expedia.co.uk/Southeast-Minnesota.dx6233996)[Hotels in Southeast Minnesota](https://expedia.co.uk/Southeast-Minnesota-Hotels.d6233996.Travel-Guide-Hotels)[Holiday Rentals in Southeast Minnesota](https://expedia.co.uk/Southeast-Minnesota-Holiday-Rentals.d6233996.Travel-Guide-HolidayRentals)[Flights to Southeast Minnesota](https://expedia.co.uk/Cheap-Flights-To-Southeast-Minnesota.d6233996.Travel-Guide-Flights)[Southeast Minnesota Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Minnesota.d6233996.Car-Hire-Guide)[Southeast Minnesota Holidays](https://expedia.co.uk/Southeast-Minnesota.d6233996.Holidays-City-Breaks) ![Lake Pepin & Mississippi River Scenic View](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Minnesota Spa Hotels Tonight [26 Feb - 27 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2026-02-26&endDate=2026-02-27&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [27 Feb - 28 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2026-02-27&endDate=2026-02-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2026-02-27&endDate=2026-03-01&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233996&startDate=2026-03-06&endDate=2026-03-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeast Minnesota hotels with a spa ![Body treatments, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/4b090314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool cabanas (surcharge), pool loungers](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/c875c14c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/d285c34e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Buffalo Tower Non-Smoking King Accessible | In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/59f5dda6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Treasure Island Resort & Casino [](https://www.expedia.co.uk/Welch-Hotels-Treasure-Island-Resort-And-Casino.h104463121.Hotel-Information) Welch 8.2/10 Very good (91 reviews) £88 includes taxes & fees 24 Mar - 25 Mar [](https://www.expedia.co.uk/Welch-Hotels-Treasure-Island-Resort-And-Casino.h104463121.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/dabc1b97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/40306b49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite Riverside | Premium bedding, in-room safe, individually decorated, desk](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/caabe547.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/9dfd099b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### St James Hotel, a Historic Hotel of America [](https://www.expedia.co.uk/Red-Wing-Hotels-St-James-Hotel.h8820.Hotel-Information) Red Wing 9.2/10 Wonderful (1,006 reviews) - Rejuvenate at this historic riverside hotel where the full-service spa offers massages and facials for ultimate relaxation. £121 includes taxes & fees 12 Mar - 13 Mar [](https://www.expedia.co.uk/Red-Wing-Hotels-St-James-Hotel.h8820.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/98f05f5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/9d21a7b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/f1422307.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/8b47f98d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grandstay Hotel and Suites [](https://www.expedia.co.uk/Owatonna-Hotels-Grandstay-Hotel-And-Suites.h15291258.Hotel-Information) Waseca 7.6/10 Good (251 reviews) - Rejuvenate at this hotel's full-service spa with an indoor pool and hot tub for a peaceful wellness retreat. £62 includes taxes & fees 23 Mar - 24 Mar [](https://www.expedia.co.uk/Owatonna-Hotels-Grandstay-Hotel-And-Suites.h15291258.Hotel-Information) ![Presidential Suite, Multiple Beds | Living area | 55-inch LCD TV with satellite channels, TV](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/c7a0b093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/b1555778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/86063f91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch LCD TV with satellite channels, TV](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/ef0f8d85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Rochester Mayo Clinic Area [](https://www.expedia.co.uk/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) Downtown Rochester 9.6/10 Exceptional (567 reviews) - Soothing spa treatments and daily wellness rituals await at this city centre Rochester retreat with an indoor pool and hot tub. £146 includes taxes & fees 13 Mar - 14 Mar [](https://www.expedia.co.uk/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) ![Serves lunch, dinner and happy hour](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Patio Room, 1 King Bed, Pet-Friendly, Non Smoking | Premium bedding, down duvets, pillow-top beds, desk](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/079e9789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/4090d22a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/96cfed25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Rochester Near Mayo Clinic [](https://www.expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) Rochester 8.2/10 Very good (1,214 reviews) - Rejuvenating spa retreats with daily treatments, hot tub relaxation, and attentive staff await at this hotel. £65 includes taxes & fees 21 Mar - 22 Mar [](https://www.expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/d54840be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/df1235ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/e1720891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/455654ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Round Barn Farm B & B Event Center [](https://www.expedia.co.uk/Red-Wing-Hotels-Round-Barn-Farm-B-B-Event-Center.h46980893.Hotel-Information) Red Wing 10/10 Exceptional (41 reviews) - Relax in a charming bed & breakfast with private hot tubs and deep-tissue massages, surrounded by a peaceful garden setting. [](https://www.expedia.co.uk/Red-Wing-Hotels-Round-Barn-Farm-B-B-Event-Center.h46980893.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/61e51f32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/0fb5698e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/d6da8b6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/200000/199000/198946/673d14c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mystic Lake Casino Hotel [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Mystic-Lake-Casino-Hotel.h198946.Hotel-Information) Prior Lake 9.0/10 Wonderful (2,436 reviews) - Revitalise in this serene lakeside resort with 3 spa treatment rooms and a blissful steam room for wellness seekers. £96 includes taxes & fees 22 Mar - 23 Mar [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Mystic-Lake-Casino-Hotel.h198946.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/d500dbb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/90f9b86d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/b65aee43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/55000000/54180000/54172300/54172209/w4500h3279x0y2-db2e0240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Viking Lakes Hotel [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Omni-Viking-Lakes-Hotel.h54172209.Hotel-Information) Eagan 9.6/10 Exceptional (1,013 reviews) - Indulge in rejuvenating wellness treatments at this upscale hotel with seven spa rooms and an indoor pool near TCO Performance Centre. £130 includes taxes & fees 13 Mar - 14 Mar [](https://www.expedia.co.uk/Minneapolis-St-Paul-Hotels-Omni-Viking-Lakes-Hotel.h54172209.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-12&endDate=2026-03-13®ionId=6233996&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at spa hotels in Southeast Minnesota Pool Breakfast included Hot tub 4 stars 5 stars ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_6233996) ## Spa hotels with hot tubs in Southeast Minnesota ![Indoor pool, pool cabanas (surcharge), pool loungers](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/c875c14c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/21f7d30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Buffalo Tower Non-Smoking King Accessible | In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/59f5dda6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Body treatments, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/105000000/104470000/104463200/104463121/4e79af59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Treasure Island Resort & Casino [](https://www.expedia.co.uk/Welch-Hotels-Treasure-Island-Resort-And-Casino.h104463121.Hotel-Information) Welch 8.2/10 Very good (91) £88 includes taxes & fees 24 Mar - 25 Mar [](https://www.expedia.co.uk/Welch-Hotels-Treasure-Island-Resort-And-Casino.h104463121.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/98f05f5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/9d21a7b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/f1422307.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/16000000/15300000/15291300/15291258/8b47f98d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grandstay Hotel and Suites [](https://www.expedia.co.uk/Owatonna-Hotels-Grandstay-Hotel-And-Suites.h15291258.Hotel-Information) Waseca 7.6/10 Good (251) £62 includes taxes & fees 23 Mar - 24 Mar [](https://www.expedia.co.uk/Owatonna-Hotels-Grandstay-Hotel-And-Suites.h15291258.Hotel-Information) ![Serves lunch, dinner and happy hour](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Patio Room, 1 King Bed, Pet-Friendly, Non Smoking | Premium bedding, down duvets, pillow-top beds, desk](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/079e9789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/4090d22a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/96cfed25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AmericInn by Wyndham Rochester Near Mayo Clinic [](https://www.expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) Rochester 8.2/10 Very good (1214) £65 includes taxes & fees 21 Mar - 22 Mar [](https://www.expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/d54840be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/df1235ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/e1720891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/47000000/46990000/46980900/46980893/455654ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Round Barn Farm B & B Event Center [](https://www.expedia.co.uk/Red-Wing-Hotels-Round-Barn-Farm-B-B-Event-Center.h46980893.Hotel-Information) Red Wing 10/10 Exceptional (41) [](https://www.expedia.co.uk/Red-Wing-Hotels-Round-Barn-Farm-B-B-Event-Center.h46980893.Hotel-Information) ![Presidential Suite, Multiple Beds | Living area | 55-inch LCD TV with satellite channels, TV](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/c7a0b093.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/b1555778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/86063f91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch LCD TV with satellite channels, TV](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/ef0f8d85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Rochester Mayo Clinic Area [](https://www.expedia.co.uk/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) Downtown Rochester 9.6/10 Exceptional (567) £146 includes taxes & fees 13 Mar - 14 Mar [](https://www.expedia.co.uk/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-12&endDate=2026-03-13®ionId=6233996&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&amenities=HOT_TUB&openPlayBack=true) ## Find out more about Southeast Minnesota ### Top Southeast Minnesota attractions for a relaxing vacation Southeast Minnesota is a hidden gem for travellers seeking rejuvenation and relaxation, particularly those inclined to indulge in hotels with spas. Begin your journey in Rochester, renowned for the prestigious Mayo Clinic, where you can enjoy a luxurious spa experience followed by a stroll through the serene landscapes of Quarry Hill Nature Center, featuring picturesque trails and native wildlife. Just a short drive away, the charming town of Lanesboro offers a unique blend of art and nature; consider renting a bike to explore the scenic Root River State Trail, or unwind at a local spa that incorporates natural elements into its treatments. The historic district of Winona showcases beautiful architecture and an array of boutique shops, perfect for a leisurely afternoon, and the nearby Garvin Heights Vineyards provides wine tasting with breathtaking views of the Mississippi River. For an ideal stay, consider hotels in the heart of Rochester, where you’ll find top spas and attentive service, allowing you to unwind in style after a day of exploration. With its welcoming atmosphere and array of wellness activities, Southeast Minnesota promises a refreshing escape that caters to your every need. ## Top Southeast Minnesota Hotel Reviews ![St James Hotel, a Historic Hotel of America](https://images.trvl-media.com/lodging/1000000/10000/8900/8820/c90b9231_y.jpg) ### St James Hotel, a Historic Hotel of America 10/10 Excellent "The room was lovely and very comfortable. We had a too notch stay at a not too notch price. We enjoyed the town and the restaurant at the hotel. We felt welcomed. Other patrons were happy and friendly." [](https://expedia.co.uk/Red-Wing-Hotels-St-James-Hotel.h8820.Hotel-Information) ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Our stays with the Kahler Grand were tied to medical procedures at the Mayo Clinic. The staff understands Mayo is the reason the majority of guests are in Rochester. Everyone is kind, warm, and respectful. My husband and I want to acknowledge Salma who helped us extend our stay after our flight was cancelled last minute. She was both empathetic and professional. The hotel is above an easily accessed underground tunnel system of shops, restaurants, and connections to Mayo and other hospital building shuttle stops." [](https://expedia.co.uk/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Spark by Hilton Rochester South](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg) ### Spark by Hilton Rochester South 10/10 Excellent "Staff were very friendly, entire space was exceptionally clean, and the pool and the hot tub were some of the best maintained that I have seen. 10-10 experience. " [](https://expedia.co.uk/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Hotel Indigo Rochester – Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/48e45010_y.jpg) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG 10/10 Excellent "The room was very nice-bed and pillows were comfortable. Really loved the access to the Skywalk, this was a large feature for us and one that will influence our decision to stay there again in the future! " [](https://expedia.co.uk/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "Nice clean rooms. We had a couple requests and they were very accommodating for us. Definitely will stay there again. " [](https://expedia.co.uk/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/39da8a7c_y.jpg) ### SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys 10/10 Excellent "Was not the original place I thought we were staying at but were pleasantly surprized. Nice, clean, great staff. Close to the hospital. Would definitely recommend and stay there again. " [](https://expedia.co.uk/Rochester-Hotels-SpringHill-Suites-By-Marriott-Rochester-Mayo-ClinicSt-Marys.h101902.Hotel-Information) ![Aspen Suites](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/6c7e0658_y.jpg) ### Aspen Suites 10/10 Excellent "The staff were very kind and caring. " [](https://expedia.co.uk/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information) ![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "From the friendly manager to the easy check in to the nice, clean, quiet room to the pleasant included breakfast it was a great stay. And bonus is free soup in the evening and free shuttle leaving & returning regularly to & from Mayo's." [](https://expedia.co.uk/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Kahler Inn and Suites - Mayo Clinic Area](https://images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Everything was as it was described! 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