TOP Luxury Hotels in Southeast Minnesota, MN for 2026 - Southeast Minnesota Upscale Hotels

A mural of Red Wing with a steamship, houses, and a bridge.

Change your mind
Book hotels with free cancellation
Treat yourself
Save instantly and earn perks with One Key
Learn about One Key
Be picky
Search almost a million properties worldwide

Check availability on Southeast Minnesota Luxury Hotels

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Southeast Minnesota luxury hotels

Shared common gathering area on the main level

A modern hotel with a symmetrical facade, multiple balconies, and a central entrance.

A bedroom with a large window offering a view of a road, trees, and a body of water.

A modern kitchen with white cabinets, a stainless steel dishwasher, and a dining area with a wooden table and chairs.

1. Condo with stunning views of Lake Pepin - Attached Garage - Unit 101

Lake City

£188

includes taxes & fees

13 Oct - 14 Oct

A brick building with multiple floors, large windows, and a sign for 'Pharmacy'.

A modern living room with a leather sofa, a fireplace, and a large window.

A spacious restaurant with high ceilings, exposed brick walls, and large windows. Tables are set with white tablecloths and black chairs.

A modern hotel room with a balcony, a dining area, and a large bed with a view of the outdoors.

2. The Charmant Hotel

Historic Downtown La Crosse

Elegant riverside sophistication awaits at this historic La Crosse hotel with pillowtop beds, rainfall showers, and two bars.

£150

includes taxes & fees

25 Oct - 26 Oct

A modern living room with a fireplace, large windows, and a cozy seating area.

A modern hotel with a prominent glass facade and a sign reading "OMNI Hotel Viking Lakes."

A modern lobby with large wooden columns, comfortable seating, and a reception desk.

A modern living room with a sofa, armchairs, a coffee table, and a dining area with a bar.

3. Omni Viking Lakes Hotel

Eagan

£154

includes taxes & fees

1 Nov - 2 Nov

A modern hotel room with a wooden ceiling, a grey sofa, a round ottoman, and a bed with a beige blanket.

A bedroom with a wooden bed, a wooden headboard, a green accent wall, and framed pictures.

A blue building with the sign "The Port Hotel" and a large glass door.

A compact kitchen area with a microwave, refrigerator, and a laptop on a white countertop. There are wooden shelves above holding books and decorative items. A door is visible to the right.

4. Work & Wander | Cafés & Cozy Comforts

Prescott

£109

includes taxes & fees

2 Nov - 3 Nov

A bedroom with a bed, a dresser, a television, a dining table with chairs, and a door leading to another room.

A hotel room with a bed, a desk, and a kitchenette.

A hotel room with a large bed, a window with curtains, a bedside lamp, and a wall-mounted heater.

5. Blue Way Inn and Suites Eagan - 2 Queen Bed Non Smoking

Eagan

£77

includes taxes & fees

13 Oct - 14 Oct

View all properties

Top Southeast Minnesota Hotel Reviews

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"Good! Didn’t use the pool but it looked great, especially for families with kids! Just peeked in quick at the breakfast to get a few things and it was good!"

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Pool and hot tub under maintenance."

Brentwood Inn & Suites

8/10 Good

"I definitely recommend staying at the Brentwood if you have Mayo apts . Free parking, clean rooms, excellent staff, and of course location make this a great place. I would recommend too if your just on holiday in Rochester because of the shops and other bustling activity around."