TOP Business Hotels in Southeast Minnesota, MN for 2026

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Our top choices for Southeast Minnesota business-friendly hotels

A hotel reception desk with a wooden counter, a computer, and a vase with flowers.

A hotel room with a large bed, a separate bathroom with a bathtub, and a skylight ceiling.

A living room with stone walls, a fireplace, leather furniture, and a ceiling fan.

An indoor swimming pool with wooden beams and white chairs around it.

1. Baymont by Wyndham Kasson Rochester Area

Kasson

Lynnette

£51

includes taxes & fees

30 Sept - 1 Oct

A hotel room with a large bed, a desk with a chair, a window with a view of the outdoors, and two bedside lamps.

A gym with treadmills, elliptical machines, and a stationary bike.

An indoor swimming pool with a checkered tile wall, a door labeled 'Mechanical Room,' and a window with a view outside.

A conference room with round tables and chairs, white walls, and a carpeted floor.

2. Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

JOSEPH

£67

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

A modern dining area with round tables and chairs, a large painting on the wall, and a flat-screen TV mounted above a geometric-patterned wall.

A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

A modern indoor pool area with lounge chairs and a pool.

3. Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

Kathy

£102

includes taxes & fees

2 Oct - 3 Oct

A Holiday Inn Express building with a covered entrance, outdoor seating area, and a well-lit facade.

A hotel dining area with multiple tables and chairs, a coffee station, and a seating area with sofas.

A hotel room with two beds, a desk, a chair, a television, and a kitchenette.

A coffee station with two espresso machines and a variety of coffee pods and cups.

4. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Kutzky Park

Janet

£96

includes taxes & fees

2 Oct - 3 Oct

A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

A modern dining area with wooden tables and chairs, a kitchen with granite countertops, and a view of the outdoors through large windows.

A spacious living room with a stone fireplace, blue sofas, and a flat-screen TV.

A spacious lobby with a central seating area, a reception desk, and a fireplace.

5. Comfort Inn & Suites West - Medical Center

Rochester

yuan

£77

includes taxes & fees

10 Oct - 11 Oct

An outdoor dining area with wooden beams, tables, and chairs.

A hotel room with a bed, a desk, a chair, a television, and artwork on the walls.

A hotel room with a bed, a desk, a chair, a TV, and artwork on the walls.

A modern kitchen with a built-in microwave, refrigerator, and dark cabinetry.

6. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Downtown Rochester

thomas

£90

includes taxes & fees

24 Oct - 25 Oct

A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

A modern kitchen with wooden cabinets, a microwave, an oven, and a dishwasher.

An indoor swimming pool with a slide, seating area, and a large frog statue.

A bar with wooden stools and a neon sign.

7. AmericInn by Wyndham Rochester Near Mayo Clinic

Rochester

Jeanne

£70

includes taxes & fees

28 Sept - 29 Sept

A modern living room with a flat-screen TV, a fireplace, comfortable seating, and a large window with a city view.

A modern hotel lobby with a curved staircase, seating areas, and large windows.

A spacious lobby with modern furniture, a spiral staircase, and large windows offering views of the outdoors.

A modern indoor swimming pool with seating areas and a city view.

8. Hilton Rochester Mayo Clinic Area

Downtown Rochester

Raymond

£156

includes taxes & fees

17 Oct - 18 Oct

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Top Southeast Minnesota Hotel Reviews

Kahler Grand Hotel

10/10 Excellent

"Love to stay here everytime j Tj Tj"

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent

"Choose this hotel as it is close to Mayo clinic and has a shuttle. It was clean, the staff was very helpful and kind. Breakfast was excellent. Room was comfortable and very clean. The offered free shuttle ran every 10 minutes and was fast, efficient and saved time and parking fees as well as walking. Can't say enough nice things about this hotel. Would highly recommend."

Med City Inn & Suites - Mayo Clinic Area

8/10 Good

"Good price close to my visit"

Brentwood Inn & Suites

10/10 Excellent

"The most convenient and comfortable place to stay for accessing the Charlton, Gonda and Jacobsen buildings."

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent

"Nice hotel, very clean, hello staff."

Aspen Select

10/10 Excellent

"Very convenient to Saint Mary's hospital"

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent

"We enjoyed our stay. The breakfast was wonderful. We were disappointed the hot tub only ran for the first evening though and was down for maintenance after. And the exercise room was a bit grimy"

Boarders Inn & Suites by Cobblestone Hotels - Faribault

8/10 Good

"Sheets had some stains on them and dog hair was still all over the floor as it was on my socks and got all over the bed but overall a good stay"

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"Was there for a surgery at the Mayo and they were so helpful and accommodating. Very grateful for the facility and the staff"

Frequently asked questions

How much do business hotels in Southeast Minnesota cost?

Rates for business hotels in Southeast Minnesota range between £51 and £156 per night. No matter your budget, Expedia is here to help you locate the ideal space to get the work done. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

How many business hotels are there in Southeast Minnesota?

Choose from 85 business hotels in Southeast Minnesota. When you need to get down to work, Expedia can help you secure the ideal space with the amenities you need.

Why book your business hotel in Southeast Minnesota with Expedia?

With conveniences like conference rooms, room service and on-site cafés, our business-friendly accommodation come with all you'll need to get the job done — and then unwind! Enter your preferred travel dates and destination and Expedia will help you plan everything else.

How can I find cheap business hotels in Southeast Minnesota?

Select the "business friendly" filter, located just under the "traveller experience" heading, to find cheap business hotels in Southeast Minnesota. Then narrow your search by your per-night budget. Looking for properties outside the city centre can also help you save.

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Change your mind

Treat yourself

Be picky

Check availability on Southeast Minnesota Business Hotels

Our top choices for Southeast Minnesota business-friendly hotels

1. Baymont by Wyndham Kasson Rochester Area

2. Comfort Inn & Suites Rochester South Mayo Clinic

3. Hyatt House Rochester/Mayo Clinic Area

4. Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

5. Comfort Inn & Suites West - Medical Center

6. Hotel Indigo Rochester – Mayo Clinic Area by IHG