Title: TOP Business Hotels in South Carolina Lowcountry, SC for 2025 | Expedia.co.uk [South Carolina Lowcountry Travel Guide](https://expedia.co.uk/South-Carolina-Lowcountry.dx553248635975748945)[Hotels in South Carolina Lowcountry](https://expedia.co.uk/South-Carolina-Lowcountry-Hotels.d553248635975748945.Travel-Guide-Hotels)[Holiday Rentals in South Carolina Lowcountry](https://expedia.co.uk/South-Carolina-Lowcountry-Holiday-Rentals.d553248635975748945.Travel-Guide-HolidayRentals)[Flights to South Carolina Lowcountry](https://expedia.co.uk/Cheap-Flights-To-South-Carolina-Lowcountry.d553248635975748945.Travel-Guide-Flights)[Things to do in South Carolina Lowcountry](https://expedia.co.uk/Things-To-Do-In-South-Carolina-Lowcountry.d553248635975748945.Travel-Guide-Activities)[South Carolina Lowcountry Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-Carolina-Lowcountry.d553248635975748945.Car-Hire-Guide)[South Carolina Lowcountry Holidays](https://expedia.co.uk/South-Carolina-Lowcountry.d553248635975748945.Holidays-City-Breaks) ![Hilton Head featuring heritage architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/33000/33731-Hilton-Head.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Business Hotels in South Carolina Lowcountry ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Lowcountry Business Hotels Tonight [26 Sept - 27 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748945&startDate=2025-09-26&endDate=2025-09-27&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [27 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748945&startDate=2025-09-27&endDate=2025-09-28&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748945&startDate=2025-09-26&endDate=2025-09-28&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748945&startDate=2025-10-03&endDate=2025-10-05&adults=2&travelerType=BUSINESS&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Carolina Lowcountry Business Hotels ## Top South Carolina Lowcountry Hotel Reviews ![Red Roof Inn Hardeeville](//images.trvl-media.com/lodging/2000000/1260000/1256400/1256324/cb6dafc3_y.jpg) ### Red Roof Inn Hardeeville 10/10 Excellent "Appreciate the quick pull off from interstate and the helpful clerk at a late night checkin!! " [](https://expedia.co.uk/Hilton-Head-Hotels-Red-Roof-Inn-Hardeeville.h1256324.Hotel-Information) ![Hilton Garden Inn Hilton Head](//images.trvl-media.com/lodging/1000000/700000/694500/694478/8f2d341c_y.jpg) ### Hilton Garden Inn Hilton Head 10/10 Excellent "Our stay at the Hilton Garden Inn Hilton Head was phenomenal! My wife, our 3-month-old, and I felt completely taken care of from start to finish. The staff went out of their way to be kind and accommodating, which made traveling with a baby so much easier and stress-free. The room was spotless, comfortable, and perfectly set up for us to settle in and relax. The property itself was beautifully maintained, quiet, and welcoming. About 8 years ago I stayed here on a business trip, and I couldn’t wait to come back to experience their hospitality again. I’m so glad I did—this visit exceeded my already high expectations. We left with such a positive impression and will absolutely be returning on our next trip to Hilton Head. Highly recommend this hotel to anyone looking for comfort, cleanliness, and top-notch service. " [](https://expedia.co.uk/Hilton-Head-Hotels-Hilton-Garden-Inn-Hilton-Head.h694478.Hotel-Information) ![Hilton Beachfront Resort & Spa Hilton Head Island](//images.trvl-media.com/lodging/1000000/590000/583400/583363/484680bc_y.jpg) ### Hilton Beachfront Resort & Spa Hilton Head Island 10/10 Excellent "Awesome " [](https://expedia.co.uk/Hilton-Head-Hotels-Marriott-Hilton-Head-Resort-Spa.h583363.Hotel-Information) ![Holiday Inn Express Hilton Head Island by IHG](//images.trvl-media.com/lodging/1000000/10000/1400/1341/e21613a3_y.jpg) ### Holiday Inn Express Hilton Head Island by IHG 10/10 Excellent "Quiet inconvenient" [](https://expedia.co.uk/Hilton-Head-Hotels-Holiday-Inn-Express-Hilton-Head-Island.h1341.Hotel-Information) ![Palmera Inn and Suites](//images.trvl-media.com/lodging/1000000/570000/564600/564590/28eae64d_y.jpg) ### Palmera Inn and Suites 10/10 Excellent "Our room was spacious! Great amenities & breakfast. Staff could be a little more accommodating. One downside is, they do not have daily housekeeping. Overall we had a great stay. Beautiful property. " [](https://expedia.co.uk/Hilton-Head-Hotels-Palmera-Inn-And-Suites.h564590.Hotel-Information) ![Sonesta Resort Hilton Head Island](//images.trvl-media.com/lodging/1000000/10000/2700/2618/d4363757_y.jpg) ### Sonesta Resort Hilton Head Island 10/10 Excellent "well maintained property with easy access to the beach. surrounding plantation area is very pretty." [](https://expedia.co.uk/Hilton-Head-Hotels-Sonesta-Resort-Hilton-Head-Island.h2618.Hotel-Information) ![Coral Sands Resorts by Palmera](//images.trvl-media.com/lodging/6000000/5970000/5963300/5963275/2f729558_y.jpg) ### Coral Sands Resorts by Palmera 10/10 Excellent "Great" [](https://expedia.co.uk/Hilton-Head-Hotels-Coral-Sands-Resorts-By-Palmera.h5963275.Hotel-Information) ![Beach House Resort Hilton Head](//images.trvl-media.com/lodging/1000000/30000/20700/20657/b454fbd2_y.jpg) ### Beach House Resort Hilton Head 10/10 Excellent "The Tiki Bar and the Ocean " [](https://expedia.co.uk/Hilton-Head-Island-Hotels-Beach-House-Hilton-Head.h20657.Hotel-Information) ![The Westin Hilton Head Island Resort & Spa](//images.trvl-media.com/lodging/1000000/30000/22200/22170/2c505874_y.jpg) ### The Westin Hilton Head Island Resort & Spa 10/10 Excellent "The staff was extremely friendly. Did not like the charge for late discharge. Terrible. " [](https://expedia.co.uk/Hilton-Head-Hotels-The-Westin-Hilton-Head-Island-Resort-Spa.h22170.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [1 Star Hotels in Walterboro - St. George](https://www.expedia.co.uk/1Star-Walterboro-St-George-Hotels.s10-0-d6057970.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Ladys Island](https://www.expedia.co.uk/2Star-Ladys-Island-Hotels.s20-0-d6301860.Travel-Guide-Filter-Hotels) - [Adults Only Resorts & in Beaufort](https://www.expedia.co.uk/Beaufort-Hotels-Adults-Only-Resorts.0-0-d6057941-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Resorts & in Beaufort](https://www.expedia.co.uk/Beaufort-Hotels-Beach-Hotels.0-0-d6057941-tBeachHotels.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Beaufort](https://www.expedia.co.uk/Beaufort-Hotels-Boutique-Hotel.0-0-d6057941-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Beaufort](https://www.expedia.co.uk/Beaufort-Hotels-Budget-Hotels.0-0-d6057941-tBudgetHotels.Travel-Guide-Filter-Hotels) - 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