Title: The Best Hotels Closest to Santo Spirito Hospital in Rome - 2026 Updated Prices | Expedia.co.uk

[Rome City Centre Travel Guide](https://expedia.co.uk/Rome-Rome-City-Centre.dx553248633938945217)[Santo Spirito Hospital Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santo-Spirito-Hospital.d6227560.Car-Hire-Guide)[Santo Spirito Hospital Holidays](https://expedia.co.uk/Santo-Spirito-Hospital-Rome-City-Centre.d6227560.Attraction)

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## Check prices for these dates

Tonight

[14 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6227560&startDate=2026-02-14&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[15 Feb - 16 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6227560&startDate=2026-02-15&endDate=2026-02-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6227560&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6227560&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Property class

## Our top choices for Santo Spirito Hospital hotels

![Exterior](https://images.trvl-media.com/lodging/100000000/99820000/99813800/99813784/7fbc1659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/100000000/99820000/99813800/99813784/26771930.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/100000000/99820000/99813800/99813784/cdcf5165.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Studio Suite, Terrace | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/100000000/99820000/99813800/99813784/76a4e14c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Passpartout Boutique Palace

[](https://www.expedia.co.uk/Rome-Hotels-Passpartout-Boutique-Palace.h99813784.Hotel-Information)

0.3 mi from Santo Spirito Hospital

9.8/10

Exceptional

(252 reviews)

"Wonderful hotel that we really enjoyed! Staff was excellent to work with and location was perfect being so close to the Vatican. Restaurant below us was a great choice as well!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew

£119

includes taxes & fees

24 Feb - 25 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Passpartout-Boutique-Palace.h99813784.Hotel-Information)

![Property entrance](https://images.trvl-media.com/lodging/104000000/103430000/103422400/103422372/b6c9dfaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Triple Room | Desk, laptop workspace, soundproofing, free WiFi](https://images.trvl-media.com/lodging/104000000/103430000/103422400/103422372/3affd7a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hiking](https://images.trvl-media.com/lodging/104000000/103430000/103422400/103422372/6b339196.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Building design](https://images.trvl-media.com/lodging/104000000/103430000/103422400/103422372/926021b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Porta Castello Suites

[](https://www.expedia.co.uk/Rome-Hotels-Porta-Castello-Suites.h103422372.Hotel-Information)

0.3 mi from Santo Spirito Hospital

9.6/10

Exceptional

(189 reviews)

"Second time staying here. Wonderful staff and beautiful room. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Diana

£92

includes taxes & fees

18 Feb - 19 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Porta-Castello-Suites.h103422372.Hotel-Information)

![View from room](https://images.trvl-media.com/lodging/22000000/21630000/21625200/21625159/67d7aa8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/22000000/21630000/21625200/21625159/488d6f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/22000000/21630000/21625200/21625159/e7eeecac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/22000000/21630000/21625200/21625159/22da7511.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charme 308

[](https://www.expedia.co.uk/Rome-Hotels-Charme-308.h21625159.Hotel-Information)

Ponte, 0.2 mi from Santo Spirito Hospital

9.6/10

Exceptional

(95 reviews)

"Great location! The room was spotless. We loved everything about this place."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Heather

£129

includes taxes & fees

24 Feb - 25 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Charme-308.h21625159.Hotel-Information)

![Free daily continental breakfast ](https://images.trvl-media.com/lodging/21000000/20230000/20220700/20220696/5a43eae5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20230000/20220700/20220696/5d310436.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Double or Twin Room | Premium bedding, in-room safe, desk, soundproofing](https://images.trvl-media.com/lodging/21000000/20230000/20220700/20220696/ed8ab6fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/21000000/20230000/20220700/20220696/a19f3364.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### B&B Roma Borgo 91

[](https://www.expedia.co.uk/Rome-Hotels-BB-Roma-Borgo-91.h20220696.Hotel-Information)

0.3 mi from Santo Spirito Hospital

9.8/10

Exceptional

(63 reviews)

"Everything was fantastic. Best hosts ever"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Malcolm

£190

includes taxes & fees

21 Feb - 22 Feb

[](https://www.expedia.co.uk/Rome-Hotels-BB-Roma-Borgo-91.h20220696.Hotel-Information)

![Building design](https://images.trvl-media.com/lodging/19000000/18080000/18077800/18077759/w3000h2046x0y0-ff654102.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/19000000/18080000/18077800/18077759/0a97b61f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, minibar, in-room safe, individually decorated](https://images.trvl-media.com/lodging/19000000/18080000/18077800/18077759/c74d88e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/19000000/18080000/18077800/18077759/cee86342.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel De' Ricci - Small Luxury Hotels of The World

[](https://www.expedia.co.uk/Rome-Hotels-Hotel-De-Ricci-Small-Luxury-Hotels-Of-The-World.h18077759.Hotel-Information)

Regola, 0.4 mi from Santo Spirito Hospital

10/10

Exceptional

(115 reviews)

"Amazing hotel, well located. "

![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg)

Sabine

£327

includes taxes & fees

18 Feb - 19 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Hotel-De-Ricci-Small-Luxury-Hotels-Of-The-World.h18077759.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/10000000/9860000/9852900/9852866/3c8e3cd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/10000000/9860000/9852900/9852866/10b8593e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Quadruple Room | Hypo-allergenic bedding, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/10000000/9860000/9852900/9852866/bfc54359.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden](https://images.trvl-media.com/lodging/10000000/9860000/9852900/9852866/e1640eaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Sant' Anna

[](https://www.expedia.co.uk/Rome-Hotels-Hotel-Sant-Anna.h9852866.Hotel-Information)

0.3 mi from Santo Spirito Hospital

9.6/10

Exceptional

(326 reviews)

"Rooms were immaculate, staff were courteous, breakfast was wonderful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

[](https://www.expedia.co.uk/Rome-Hotels-Hotel-Sant-Anna.h9852866.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/3000000/2550000/2540800/2540709/b2b2de31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/3000000/2550000/2540800/2540709/e36ad021.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Triple Room | Select Comfort beds, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/3000000/2550000/2540800/2540709/9e76c3c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Triple Room | Select Comfort beds, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/3000000/2550000/2540800/2540709/333c2030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### B&B At Your Place

[](https://www.expedia.co.uk/Rome-Hotels-BB-At-Your-Place.h2540709.Hotel-Information)

0.3 mi from Santo Spirito Hospital

9.4/10

Exceptional

(423 reviews)

"The location was superb. It was very near the Vatican and other tourist places. Luca arranged for our pick up and drop off at the airport. We had fresh towels everyday and croissants, coffee and tea was available everyday."

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Kristina

[](https://www.expedia.co.uk/Rome-Hotels-BB-At-Your-Place.h2540709.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/26000000/25060000/25058600/25058580/8a3529ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Prestige with Private Garden - Vertical Garden Area | Living area | 42-inch Smart TV with satellite channels, TV](https://images.trvl-media.com/lodging/26000000/25060000/25058600/25058580/16a1b5e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/26000000/25060000/25058600/25058580/400ee406.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Prestige with Private Garden - Vertical Garden Area | Deep-soaking bathtub](https://images.trvl-media.com/lodging/26000000/25060000/25058600/25058580/bf3bc0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Horti 14 Borgo Trastevere Hotel

[](https://www.expedia.co.uk/Rome-Hotels-Horti-14-Borgo-Trastevere.h25058580.Hotel-Information)

0.4 mi from Santo Spirito Hospital

9.6/10

Exceptional

(336 reviews)

"Excellent staff. Very friendly, responsive, and knowledgeable. Fantastic area with many lical dining options. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David

£156

includes taxes & fees

25 Feb - 26 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Horti-14-Borgo-Trastevere.h25058580.Hotel-Information)

![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/5000000/4470000/4464300/4464282/522f2437.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Suite (Spa Access) | Egyptian cotton sheets, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/5000000/4470000/4464300/4464282/beba5662.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Suite (Spa Access) | View from room](https://images.trvl-media.com/lodging/5000000/4470000/4464300/4464282/fc32d11f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/5000000/4470000/4464300/4464282/8d857537.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villa Agrippina Gran Meliá - The Leading Hotels of the World

[](https://www.expedia.co.uk/Rome-Hotels-Villa-Agrippina-Gran-Melia-The-Leading-Hotels-Of-The-World.h4464282.Hotel-Information)

Trastevere, 0.1 mi from Santo Spirito Hospital

9.2/10

Wonderful

(943 reviews)

"Excellent services"

![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg)

Jane

£377

includes taxes & fees

28 Feb - 1 Mar

[](https://www.expedia.co.uk/Rome-Hotels-Villa-Agrippina-Gran-Melia-The-Leading-Hotels-Of-The-World.h4464282.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/88000000/87480000/87474300/87474265/fef040a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite | In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/88000000/87480000/87474300/87474265/563f5326.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exclusive Condo | Living area](https://images.trvl-media.com/lodging/88000000/87480000/87474300/87474265/16e3b99a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exclusive Condo | Private kitchen | Electric kettle](https://images.trvl-media.com/lodging/88000000/87480000/87474300/87474265/55d77758.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Passepartout

[](https://www.expedia.co.uk/Rome-Hotels-Passepartout.h87474265.Hotel-Information)

Parione, 0.4 mi from Santo Spirito Hospital

9.6/10

Exceptional

(304 reviews)

"Rooms are stylish and clean. Staff are very welcoming and knowledgeable about the area. The location is super convenient for tourists as it is walking distance to all the key destinations."

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Danielle

£97

includes taxes & fees

25 Feb - 26 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Passepartout.h87474265.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/106000000/105450000/105440500/105440467/4d8154b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/106000000/105450000/105440500/105440467/568b5682.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/106000000/105450000/105440500/105440467/1b45ebd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![LCD TV](https://images.trvl-media.com/lodging/106000000/105450000/105440500/105440467/c5ca4824.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Boutique Hotel Piedra Rome City Centre

[](https://www.expedia.co.uk/Rome-Hotels-Boutique-Hotel-Piedra-Rome-City-Centre.h105440467.Hotel-Information)

Prati, 0.3 mi from Santo Spirito Hospital

9.6/10

Exceptional

(50 reviews)

"Beautiful accommodations and great location. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Diana

£124

includes taxes & fees

15 Feb - 16 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Boutique-Hotel-Piedra-Rome-City-Centre.h105440467.Hotel-Information)

![Property entrance](https://images.trvl-media.com/lodging/3000000/2700000/2691500/2691433/1683d571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/3000000/2700000/2691500/2691433/10b64029.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/3000000/2700000/2691500/2691433/17e2b9ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Triple Room | Frette Italian sheets, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/3000000/2700000/2691500/2691433/acdd145a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Maison dell'Orologio

[](https://www.expedia.co.uk/Rome-Hotels-La-Maison-DellOrologio.h2691433.Hotel-Information)

Ponte, 0.3 mi from Santo Spirito Hospital

9.4/10

Exceptional

(257 reviews)

"Beautiful hotel so convenient to walk to the town .. staff was wonderful and the food amazing "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luz

[](https://www.expedia.co.uk/Rome-Hotels-La-Maison-DellOrologio.h2691433.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/32000000/31360000/31351000/31350986/d18944b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room | Bathroom | Shower, eco-friendly toiletries, hair dryer, bidet](https://images.trvl-media.com/lodging/32000000/31360000/31351000/31350986/155cdcf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Room | 1 bedroom, premium bedding, memory-foam beds, minibar](https://images.trvl-media.com/lodging/32000000/31360000/31351000/31350986/e0c02e56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/32000000/31360000/31351000/31350986/e3593231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Velantia Vaticano - Guesthouse

[](https://www.expedia.co.uk/Rome-Hotels-St-Peter-Suites.h31350986.Hotel-Information)

Prati, 0.4 mi from Santo Spirito Hospital

9.6/10

Exceptional

(8 reviews)

"Great place to stay for a few days in Rome. Good location, great restaurant next door. Bed was super complicated. Would recommend for a couple or single person. "

![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg)

Claudette

[](https://www.expedia.co.uk/Rome-Hotels-St-Peter-Suites.h31350986.Hotel-Information)

![Staircase](https://images.trvl-media.com/lodging/4000000/3090000/3089300/3089240/42b73d55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![22-inch TV with digital channels, printers](https://images.trvl-media.com/lodging/4000000/3090000/3089300/3089240/75eb4d72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Staircase](https://images.trvl-media.com/lodging/4000000/3090000/3089300/3089240/dcf4a6d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Double Room | Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/4000000/3090000/3089300/3089240/d9d51011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### All’Orologio

[](https://www.expedia.co.uk/Rome-Hotels-BB-AllOrologio.h3089240.Hotel-Information)

Ponte, 0.3 mi from Santo Spirito Hospital

9.4/10

Exceptional

(169 reviews)

"Very happy with my choice… staff were excellent communicators before and during my stay, loved the location. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Andrew

[](https://www.expedia.co.uk/Rome-Hotels-BB-AllOrologio.h3089240.Hotel-Information)

![Deluxe Quadruple Room, 1 Bedroom, Refrigerator | 1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/3000000/2540000/2534900/2534870/dc728777.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/3000000/2540000/2534900/2534870/cf27fc46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/3000000/2540000/2534900/2534870/ff60d7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/3000000/2540000/2534900/2534870/c829cff2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Capricci Romani

[](https://www.expedia.co.uk/Rome-Hotels-Capricci-Romani.h2534870.Hotel-Information)

0.3 mi from Santo Spirito Hospital

9.4/10

Exceptional

(363 reviews)

"Really enjoyed the location and staff. Breakfast was amazing. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Raquel

[](https://www.expedia.co.uk/Rome-Hotels-Capricci-Romani.h2534870.Hotel-Information)

![View from room](https://images.trvl-media.com/lodging/37000000/36520000/36516200/36516132/e5004a32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Double or Twin Room | Room amenity](https://images.trvl-media.com/lodging/37000000/36520000/36516200/36516132/4ba11c77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/37000000/36520000/36516200/36516132/3b3ab533.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/37000000/36520000/36516200/36516132/494b84de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Maison Ottavia

[](https://www.expedia.co.uk/Rome-Hotels-Maison-Ottavia.h36516132.Hotel-Information)

Ponte, 0.2 mi from Santo Spirito Hospital

9.4/10

Exceptional

(23 reviews)

"Great location, clean and all we need during our trip."

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Mauricio

[](https://www.expedia.co.uk/Rome-Hotels-Maison-Ottavia.h36516132.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/24000000/23110000/23101400/23101397/8f4ac4c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/24000000/23110000/23101400/23101397/cf1697b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/24000000/23110000/23101400/23101397/68f9020c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/24000000/23110000/23101400/23101397/3392d055.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Eccelso Hotel

[](https://www.expedia.co.uk/Rome-Hotels-Eccelso-Hotel.h23101397.Hotel-Information)

Prati, 0.5 mi from Santo Spirito Hospital

9.6/10

Exceptional

(208 reviews)

"Great place, great service, great location! highly recommended"

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Jensen

£101

includes taxes & fees

24 Feb - 25 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Eccelso-Hotel.h23101397.Hotel-Information)

![Suite | Premium bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/11000000/10980000/10974100/10974039/8eee2597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/11000000/10980000/10974100/10974039/dba22195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/11000000/10980000/10974100/10974039/9bbb84f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/11000000/10980000/10974100/10974039/b6186dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Pope's Window

[](https://www.expedia.co.uk/Rome-Hotels-The-Popes-Window.h10974039.Hotel-Information)

0.4 mi from Santo Spirito Hospital

9.4/10

Exceptional

(413 reviews)

"Clean room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ethel May

£97

includes taxes & fees

16 Feb - 17 Feb

[](https://www.expedia.co.uk/Rome-Hotels-The-Popes-Window.h10974039.Hotel-Information)

![Premium bedding, memory-foam beds, minibar, in-room safe](https://images.trvl-media.com/lodging/16000000/15270000/15265100/15265012/cb1845b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily full breakfast (EUR 13 per person)](https://images.trvl-media.com/lodging/16000000/15270000/15265100/15265012/f81b186b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/16000000/15270000/15265100/15265012/a0f6af62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite | Premium bedding, memory-foam beds, minibar, in-room safe](https://images.trvl-media.com/lodging/16000000/15270000/15265100/15265012/563c08b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vatican Style

[](https://www.expedia.co.uk/Rome-Hotels-Vatican-Style.h15265012.Hotel-Information)

0.3 mi from Santo Spirito Hospital

9.2/10

Wonderful

(893 reviews)

"Room was just as described we had a wonderful welcoming stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andrew

£96

includes taxes & fees

17 Feb - 18 Feb

[](https://www.expedia.co.uk/Rome-Hotels-Vatican-Style.h15265012.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/8000000/7770000/7762200/7762131/6d307011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/8000000/7770000/7762200/7762131/722bf9e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Double Room, Annex Building | Minibar, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/8000000/7770000/7762200/7762131/7cfe9a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/8000000/7770000/7762200/7762131/6442b60a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### St. Peter' Six Rooms & Suites

[](https://www.expedia.co.uk/Rome-Hotels-St-Peter-Six-Rooms-Suites.h7762131.Hotel-Information)

0.1 mi from Santo Spirito Hospital

9.0/10

Wonderful

(393 reviews)

"Very close to St. Peter square. Staff super nice the only issue was the shower had a lot of mold and the whole room had a very bad smell. We told the staff and they moved us to a different and more clean room. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Liza

£136

includes taxes & fees

23 Feb - 24 Feb

[](https://www.expedia.co.uk/Rome-Hotels-St-Peter-Six-Rooms-Suites.h7762131.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-28&endDate=2026-03-01&regionId=6227560&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Top Santo Spirito Hospital Hotel Reviews

![Trastevere Roma | UNA Esperienze](https://images.trvl-media.com/lodging/75000000/74060000/74055900/74055827/0d267171_y.jpg)

### Trastevere Roma | UNA Esperienze

10/10 Excellent

"It was an overall 5 star experience. Staff is great, rooms are comfortable, breakfast buffet is delicious, upstairs restaurant is amazing and the location is perfect. Close to everything but yet distant enough from the noise. Fully recommend and I will be staying here again on my next visit. "

[](https://expedia.co.uk/Rome-Hotels-UNAHOTELS-Trastevere-Roma.h74055827.Hotel-Information)

![Excellence Suite](https://images.trvl-media.com/lodging/15000000/14620000/14617000/14616938/5c2b5d7f_y.jpg)

### Excellence Suite

10/10 Excellent

"Funky room very clean and very spacious sauna room which looked amazing shame we had no time to try it "

[](https://expedia.co.uk/Rome-Hotels-Excellence-Suite.h14616938.Hotel-Information)

![Vatican Style](https://images.trvl-media.com/lodging/16000000/15270000/15265100/15265012/398b5057_y.jpg)

### Vatican Style

10/10 Excellent

"Thank you, 2nd visit and will return "

[](https://expedia.co.uk/Rome-Hotels-Vatican-Style.h15265012.Hotel-Information)

![Hotel Abruzzi](https://images.trvl-media.com/lodging/3000000/2530000/2529100/2529050/d92b3f8d_y.jpg)

### Hotel Abruzzi

10/10 Excellent

"The room was spotless and cleaned each day. All staff we met were friendly and helpful. The hotel is an ideal spot for visiting all attractions easily and there are numerous excellent places to eat nearby."

[](https://expedia.co.uk/Rome-Hotels-Hotel-Abruzzi.h2529050.Hotel-Information)

![Argentina Residenza Style Hotel](https://images.trvl-media.com/lodging/9000000/8330000/8328900/8328803/f30530e6_y.jpg)

### Argentina Residenza Style Hotel

10/10 Excellent

"Outstanding hotel in Rome Central, close to most of the major attractions. Very friendly helpful staff, clean spacious rooms and a good value for money breakfast."

[](https://expedia.co.uk/Rome-Hotels-Argentina-Residenza-Style-Hotel.h8328803.Hotel-Information)

![Hotel Quirinale](https://images.trvl-media.com/lodging/1000000/10000/1100/1058/df3b5a06_y.jpg)

### Hotel Quirinale

10/10 Excellent

"The hotel was great ! Spotlessly clean , lovely large room and bathroom . The breakfast was plentiful with a large selection of choice both hot and cold. We loved the location - just a stroll to the sights of the Coliseum and Trevi Fountain. A lovely stay in Rome! "

[](https://expedia.co.uk/Rome-Hotels-Hotel-Quirinale.h1058.Hotel-Information)

![Grand Hotel Olympic](https://images.trvl-media.com/lodging/1000000/80000/72900/72827/a302c22a_y.jpg)

### Grand Hotel Olympic

10/10 Excellent

"All of the above"

[](https://expedia.co.uk/Rome-Hotels-Grand-Hotel-Olympic.h72827.Hotel-Information)

![Hotel Scalinata di Spagna](https://images.trvl-media.com/lodging/3000000/2530000/2528600/2528540/1562c230_y.jpg)

### Hotel Scalinata di Spagna

10/10 Excellent

"Customer service was excellent as well as the room and the location. The breakfast was excellent as well. I will be staying here again when I come back next year. "

[](https://expedia.co.uk/Rome-Hotels-Hotel-Scalinata-Di-Spagna.h2528540.Hotel-Information)

![Hotel Dei Mellini](https://images.trvl-media.com/lodging/1000000/70000/63400/63399/db6d1bc9_y.jpg)

### Hotel Dei Mellini

10/10 Excellent

"Great time at a beautifully decorated and maintained hotel. "

[](https://expedia.co.uk/Rome-Hotels-Hotel-Dei-Mellini.h63399.Hotel-Information)

## Hotels near other Santo Spirito Hospital attractions

### Vittorio Emanuele II Bridge

Spectacular works of art adorn the balustrades and columns of this iconic bridge, which lies beside the ruins of its predecessor.

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248631901838794)

### Accademia di Storia dell‘Arte Sanitaria

You can study the exhibits at Accademia di Storia dell‘Arte Sanitaria, a museum with a story of its own, during your trip to Rome. Amble around this vibrant area's riverfront or experience its acclaimed art galleries. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532956071)

### Complesso Monumentale Santo Spirito in Saxia

Learn about the local history of Rome when you take a trip to Complesso Monumentale Santo Spirito in Saxia. Experience the acclaimed art galleries and fascinating museums in this vibrant area. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532956072)

### Chiesa di San Giovanni Battista dei Fiorentini

Chiesa di San Giovanni Battista dei Fiorentini is just one of the places to see in Rome, so why not enjoy the other things to explore during your travels? Amble around this vibrant area's riverfront or experience its acclaimed art galleries. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532501068)

### Villa Barberini al Gianicolo

You can learn about the history of Rome with a trip to Villa Barberini al Gianicolo. Amble around this vibrant area's riverfront or experience its acclaimed art galleries. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532501066)

### Palazzo Serristori

Learn about the local history of Rome when you take a trip to Palazzo Serristori. Stroll along the riverfront or experience the acclaimed theatre scene in this vibrant area. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532500467)

### Auditorio Pio

Get tickets for a show at Auditorio Pio, a theatre with a story to tell in Rome. Experience the acclaimed theatre scene and fascinating museums in this vibrant area. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532500470)

### Auditorium Conciliazione

Enjoy a performance at Auditorium Conciliazione, a theatre with a story to tell in Rome. Stroll along the riverfront or visit the churches in this vibrant area. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6146731)

## Frequently asked questions

### What's the area like around Santo Spirito Hospital?

### What's the best hotel to stay close to Santo Spirito Hospital?

### How many hotels can I expect to find close to Santo Spirito Hospital?

### If I need to cancel the hotel reservation for my stay near Santo Spirito Hospital, will I receive a refund?

### What can I see and do near Santo Spirito Hospital?

### How can I get to Santo Spirito Hospital?