Title: Best Resorts in Santee in 2026 | Expedia.co.uk [Hotels in Santee](https://expedia.co.uk/Santee-Hotels.d9953.Travel-Guide-Hotels)[Holiday Rentals in Santee](https://expedia.co.uk/Santee-Holiday-Rentals.d9953.Travel-Guide-HolidayRentals)[Santee Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santee.d9953.Car-Hire-Guide)[Santee Holidays](https://expedia.co.uk/Santee.d9953.Holidays-City-Breaks) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=9953&startDate=2026-02-20&endDate=2026-02-22&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=9953&startDate=2026-02-27&endDate=2026-03-01&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=9953&startDate=2026-03-13&endDate=2026-03-15&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=9953&startDate=2026-04-10&endDate=2026-04-12&adults=2&lodging=HOTEL_RESORT&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in Santee ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.co.uk/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (719 reviews) "Large, clean room, friendly staff, nice breakfast. Would stay again. Also a nice Mexican restaurant nearby for dinner. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan £87 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1c5cc7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very good (1,424 reviews) "Room were very clean and staff was very helpful. I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charolette £61 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Santee 9.8/10 Exceptional (1,007 reviews) "Our room was super clean, breakfast was good. And the hotel was nice and quiet." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) john £98 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/044c704d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/67da47be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ab86ecd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn [](https://www.expedia.co.uk/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) Santee 8.8/10 Excellent (1,002 reviews) "Nice rooms and very good breakfast items." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen £91 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Frette Italian sheets, premium bedding, pillow-top beds](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed with Sofa bed, Non Smoking (Non Smoking/Interior Hall) | Frette Italian sheets, premium bedding, pillow-top beds](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/91286f8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/0b55a618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) Santee 8.0/10 Very good (1,005 reviews) "Clean rooms, nice staff, decent breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale £82 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/278d9dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/5f0b6fe1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/6fa02d10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8:00 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/8a3aa504.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Santee by IHG [](https://www.expedia.co.uk/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) Santee 8.2/10 Very good (999 reviews) "Everything was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie £103 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/eeb5fa18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/ebe97e99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) Santee 7.0/10 Good (697 reviews) "Nice quiet room and a delicious breakfast at a reasonable rate." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph B £50 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Free breakfast ](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/d82e6496.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/fcd98400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5472b058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Santee-I-95 [](https://www.expedia.co.uk/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) Santee 9.6/10 Exceptional (1,003 reviews) "Liked the size of the room, the staff and the breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Virginia £107 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/c321e70e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel cot](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/f5487ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/431d124d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel cot](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/42ada466.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! [](https://www.expedia.co.uk/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) Santee 10/10 Exceptional (38 reviews) "Great house, very modern interior. Very clean. Close to town. We’ll definitely book the house on our fishing trip. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John H. £254 includes taxes & fees 4 Mar - 5 Mar [](https://www.expedia.co.uk/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/f4d74712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/8e450cea_edited_f3d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/0120967f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/25be5d48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tranquil Getaways W/Heated Pool and Fishing [](https://www.expedia.co.uk/Santee-Hotels-Tranquil-Studio-Cottage-With-Heated-Pool-And-Fishing-Access.h94846723.Hotel-Information) Elloree 8.4/10 Very good (6 reviews) "Great property the pool was so fun! Mostly stayed on the property and lounged around for a nice relaxing stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tori P. £149 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/Santee-Hotels-Tranquil-Studio-Cottage-With-Heated-Pool-And-Fishing-Access.h94846723.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/14910802.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/3c5e3a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/224b7c6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games, books](https://images.trvl-media.com/lodging/108000000/107480000/107471600/107471514/270fd065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing! [](https://www.expedia.co.uk/Santee-Hotels-Peaceful-Condo-On-Lake-Marion-In-Santee.h107471514.Hotel-Information) Santee 10/10 Exceptional (11 reviews) "Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greg M. £359 includes taxes & fees 17 Feb - 18 Feb [](https://www.expedia.co.uk/Santee-Hotels-Peaceful-Condo-On-Lake-Marion-In-Santee.h107471514.Hotel-Information) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/cd0ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/4c792a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/1295e8cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/50891687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Santee I-95 [](https://www.expedia.co.uk/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) Santee 6.0/10 (473 reviews) "Clean room but needs an exhaust fan in the bathroom " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leesa £48 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2262fc91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/dc3438b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/77599f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) Santee 6.8/10 (441 reviews) "The staff was very friendly and helpful. Room was clean and beds were so comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy £61 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/070e1043.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/9e846421.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) Santee 6.6/10 (643 reviews) "A good option if traveling with pets. The hotel is clean and well maintained but dated. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £53 includes taxes & fees 17 Feb - 18 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/13247169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/2def81ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/daa776a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Santee I-95 [](https://www.expedia.co.uk/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) Santee 6.4/10 (549 reviews) "The grounds and property were clean and you could tell they take pride in what they're offering." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric £64 includes taxes & fees 17 Feb - 18 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/6c8567ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/1f93ecf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/7dca4a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/910000/905400/905358/0af71c77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) Santee 6.4/10 (310 reviews) "Last minute arrangements stay was quiet and peaceful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Iasia £52 includes taxes & fees 24 Feb - 25 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Econo-Lodge.h905358.Hotel-Information) ![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/47b4af62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/cef510a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds | Private kitchenette | Fridge, microwave](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/60d574cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/126000000/125190000/125185400/125185326/5bdd7f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Southern Lodge 601 [](https://www.expedia.co.uk/Orangeburg-Hotels-Southern-Lodge-601.h125185326.Hotel-Information) Orangeburg £54 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Southern-Lodge-601.h125185326.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/ae964a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/71b46ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/a9d1fec4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/570000/564000/563976/a0deabe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn by Marriott Orangeburg [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) Orangeburg 8.4/10 Very good (722 reviews) "Overall a great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Troy £68 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-By-Marriott-Orangeburg.h563976.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) Orangeburg 9.2/10 Wonderful (1,004 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas £92 includes taxes & fees 24 Feb - 25 Feb [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/27faffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/9246a04a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/0ca73b4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e4316a7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Manning [](https://www.expedia.co.uk/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information) Manning 8.6/10 Excellent (1,006 reviews) "The room was very clean, the staff were very nice and the breakfast was ok. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha £72 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Sumter-Hotels-SureStay-Hotel-By-Best-Western-Manning.h569301.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-24&endDate=2026-02-25®ionId=9953&adults=2&lodging=HOTEL_RESORT&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotel-Resorts.d9953-aaHotelResorts.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantee-Hotel-Resorts.d9953-aaHotelResorts.Travel-Guide-Accommodation) ## Top Santee Hotel Reviews ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/5c693db6_y.jpg) ### Tru By Hilton Santee 10/10 Excellent "Exelent service. Friendly staff " [](https://expedia.co.uk/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Comfort Inn & Suites Santee](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Place was nice and will stay there again." [](https://expedia.co.uk/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Fairfield Inn & Suites by Marriott Santee](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb_y.jpg) ### Fairfield Inn & Suites by Marriott Santee 10/10 Excellent "The room was fine, the breakfast fair, the staff great." [](https://expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg) ### Baymont by Wyndham Santee 10/10 Excellent "Friendly, knowledgeable receptionist; clean, comfortable, quiet room. I love this place." [](https://expedia.co.uk/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Holiday Inn Santee by IHG](https://images.trvl-media.com/lodging/2000000/1220000/1220000/1219924/c82722a1_y.jpg) ### Holiday Inn Santee by IHG 10/10 Excellent "Bed was so comfy….clean. Great staff." [](https://expedia.co.uk/Orangeburg-Hotels-Holiday-Inn-Santee.h1219924.Hotel-Information) ![Tru by Hilton Orangeburg](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/1bbd70f5_y.jpg) ### Tru by Hilton Orangeburg 10/10 Excellent "Very friendly staff" [](https://expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Hampton Inn Santee-I-95](https://images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "Everything was great " [](https://expedia.co.uk/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Travelodge by Wyndham Santee](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd_y.jpg) ### Travelodge by Wyndham Santee 10/10 Excellent "Clean and friendly " [](https://expedia.co.uk/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Quality Inn & Suites](https://images.trvl-media.com/lodging/92000000/91280000/91274500/91274426/3861a053_y.jpg) ### Quality Inn & Suites 10/10 Excellent "Clean room but needs an exhaust fan in the bathroom " [](https://expedia.co.uk/Santee-Hotels-Royal-Inn.h91274426.Hotel-Information) ## Find out more about Santee ## Santee Resorts information | Number of reviews | 13,039 | | ----------------- | --------- | | Accommodation | 5 Resorts | | Lowest Price | £48 | | Highest Price | £359 | ## Frequently asked questions ### What can I expect from a resort holiday in Santee? ### What's a favourite resort for my stay in Santee? ### How many resorts are there in Santee? ### What can I do in Santee? ### What's the weather like in Santee? ### What's the best way to get to and around Santee? ## Explore a world of travel with Expedia - More ways to book - [Book Resorts in Santee on Expedia.com ](https://www.expedia.com/Santee-Resorts.d9953-aaResorts.Travel-Guide-Accommodation)