Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Save up to 17% by booking Flight + Hotel.

Search 321,000 hotels and 400 airlines worldwide.


Santee

Santee is a destination in South Carolina Midlands that offers plenty of surprises!

Santee Vacation Packages

From Santee, it is roughly 50 miles northwest to Columbia and 60 miles southeast to Charleston.

The area around this destination features a number of wonderful natural areas. Two attractions nearby to Santee are Congaree National Park (30 miles away) and Colleton State Park (30 miles away).

One way to treat yourself in Santee is to open up your wallet at Santee Outlets.

Many people recommend stopping at Santee Cooper Country Club and Santee National Golf Club.

Vance and Elloree are two more places worth visiting while you're in the area. They're 5 miles and 6 miles away, respectively.

When you are ready to venture further afield, pay a visit to a regional hub. Sumter sits 30 miles away and serves up a varied list of attractions, such as Sumpter Gallery of Art, Crystal Lakes Golf Course and Dillion Park. Swan Lake Iris Gardens and Sumter Mall are also great if you're still looking for more.

There are some great calorie-burning outdoor activities in this region for when you want to get up and get active. Get your pulse up with a bit of hiking or zip-lining.

This area provides vacationers with plenty of relaxing pursuits in the great outdoors, such as cycling and picnicking.

Make your way to the water and make a splash with some swimming and rafting, a couple of the popular ways to get all wet here.

When the weather is fine, why not explore the region's gardens?

Time will seem to almost stand still when you wander through the historic mansions of South Carolina Midlands.

In order to truly appreciate the heart and soul of South Carolina Midlands, you're going to need to acquaint yourself with its particular scents and flavors.

Look around for oysters and fish, two renowned local ingredients.

Being here during the 4th of July will give you a good look at Independence Day.

When your departure time is nearing, know that Charleston International Airport is about 50 miles to the southeast.


Top Hotel Deals

See all 50 Hotels in Santee
£82
Best Western Plus Santee Inn

Best Western Plus Santee Inn

I 95 Exit 98, Santee
4.3
of 5, from 542 reviews
2.5 out of 5.0

Situated in Santee, this hotel is 0.5 mi (0.9 km) from Santee Outlets and 2.9 mi (4.6 km) from Lake Marion. Santee State Park is 3.8 mi (6.2 km) away.

£76
Hampton Inn Santee I-95

Hampton Inn Santee I-95

9060 Old Number Six Hwy, Santee
4.6
of 5, from 429 reviews
2.5 out of 5.0

Situated in Santee, this hotel is 0.6 mi (0.9 km) from Santee Outlets and within 6 miles (10 km) of Lake Marion and Santee State Park. Foxboro Golf Club and Wyboo Golf Club are also within 25 miles (40 km).

£71
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

221 Britain St, Santee
3.9
of 5, from 291 reviews
2.5 out of 5.0

Situated in a rural location, this hotel is 0.9 mi (1.5 km) from Santee Outlets and within 6 miles (10 km) of Lake Marion and Santee State Park. Foxboro Golf Club and Wyboo Golf Club are also within 25 miles (40 km).

£37
Red Roof Inn Santee

Red Roof Inn Santee

9091 Old Hwy 6, Santee
2.8
of 5, from 160 reviews
2.0 out of 5.0

Located in the heart of Santee, this motel is 0.7 mi (1.2 km) from Santee Outlets and 2.5 mi (4 km) from Lake Marion. Santee State Park is 3.4 mi (5.5 km) away.

£45
Knights Inn Santee

Knights Inn Santee

249 Britain Street, Santee
2.9
of 5, from 397 reviews
2.0 out of 5.0

Located in the heart of Santee, this hotel is 0.8 mi (1.3 km) from Santee Outlets and within 6 miles (10 km) of Lake Marion and Santee State Park. Foxboro Golf Club and Wyboo Golf Club are also within 25 miles (40 km).

£49
Quality Inn And Suites

Quality Inn And Suites

8929 Bass Dr, Santee
2.9
of 5, from 49 reviews
2.5 out of 5.0

Located in the heart of Santee, this hotel is 0.8 mi (1.3 km) from Santee Outlets and 2.4 mi (3.9 km) from Lake Marion. Santee State Park is 3.4 mi (5.4 km) away.

£41
Super 8 Santee

Super 8 Santee

9125 Old Highway 6, Santee
3.2
of 5, from 112 reviews
2.0 out of 5.0

Situated in Santee, this motel is 0.7 mi (1.2 km) from Santee Outlets and within 6 miles (10 km) of Lake Marion and Santee State Park. Foxboro Golf Club and Wyboo Golf Club are also within 25 miles (40 km).

£33
Econo Lodge

Econo Lodge

9112 Old 6 Highway, Santee
3.1
of 5, from 217 reviews
2.0 out of 5.0

Located in the heart of Santee, this hotel is 0.7 mi (1.1 km) from Santee Outlets and 3 mi (4.9 km) from Lake Marion. Santee State Park is 4 mi (6.4 km) away.

Top Deals on Flights

These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply.