A historic fountain with water jets, surrounded by lush greenery and a white church with a bell tower in the background.
Photo by Tahino2000
Open Photo by Tahino2000

Santa Fe de Antioquia Holidays from £1,105

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Top Santa Fe de Antioquia flight + hotel deals

Price found within the past 48 hours. Click for updated prices.
  • 4 Sept - 8 Sept

    Leviu by Bernalo Hotels + Flight

    El Poblado
    4 nights
    2.5 star property
    8.6/10 - Excellent (140 reviews)
    Return London (LON) - Medellín (MDE)
    LGW - MDE1 stop MDE - LGW1 stop
    £1,286
    £1,105
    per traveller
    found 9 hours agoAdditional charges may apply
    Leviu by Bernalo Hotels
  • 4 Sept - 8 Sept

    Apartaestudio Luxury + Flight

    Sabaneta
    4 nights
    3.0 star property
    Return London (LON) - Medellín (MDE)
    LGW - MDE1 stop MDE - LGW1 stop
    £305,213
    £241,064
    per traveller
    found 9 hours agoAdditional charges may apply
    Apartaestudio Luxury
  • 4 Sept - 8 Sept

    La Doble Ele Boutique + Flight

    El Poblado
    4 nights
    4.5 star property
    9.6/10 - Exceptional (4 reviews)
    "The staff were all fantastic. Friendly and great communication. Clean and comfortable room…excellent decor. There was a service fee of $88 for any guest. This amount seems excessive and honestly…just unnecessary. Other than that, fantastic stay."
    Reviewed June 29, 2026
    Return London (LON) - Medellín (MDE)
    LGW - MDE1 stop MDE - LGW1 stop
    £1,405
    £1,215
    per traveller
    found 6 hours agoAdditional charges may apply
    La Doble Ele Boutique
  • 4 Sept - 8 Sept

    Cavalta by Bernalo Hotels + Flight

    Laureles
    4 nights
    3.5 star property
    8.6/10 - Excellent (257 reviews)
    "Mi estadía fue muy buena. Me encantó la ubicación del hotel, la limpieza de las habitaciones y en general el ambiente. Lo único que quisiera mencionar es que en el área del restaurante el servicio de los alimentos puede mejorar. Cuando los huéspedes llegan, no siempre se atiende en el orden de llegada, incluso cuando se notifica. El personal hizo el ajuste cuando lo comenté, pero considero que sería ideal contar con más personal para que el servicio sea más organizado. Gracias."
    Reviewed July 28, 2026
    Return London (LON) - Medellín (MDE)
    LGW - MDE1 stop MDE - LGW1 stop
    £1,405
    £1,221
    per traveller
    found 9 hours agoAdditional charges may apply
    Cavalta by Bernalo Hotels
  • 4 Sept - 8 Sept

    Hotel Poblado Plaza + Flight

    El Poblado
    4 nights
    3.5 star property
    9.2/10 - Wonderful (823 reviews)
    "Good"
    Reviewed July 27, 2026
    Return London (LON) - Medellín (MDE)
    LGW - MDE1 stop MDE - LGW1 stop
    £1,294
    £1,154
    per traveller
    found 9 hours agoAdditional charges may apply
    Hotel Poblado Plaza

Where to stay in Santa Fe de Antioquia

Find the best Santa Fe de Antioquia areas for the activities you enjoy most.

Zona Colonial

While visiting Zona Colonial, you might make a stop by sights like Cathedral of Santa Fe de Antioquia and Bolivar Square.

Discover the most popular places to visit in Santa Fe de Antioquia

What to do in Santa Fe de Antioquia

Santa Fe de Antioquia Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

Why should I book my Santa Fe de Antioquia holiday with Expedia?

Choose Expedia to plan your next escape simply and all in the same place. Our insider tip for getting a great deal on a Santa Fe de Antioquia retreat? Bundle your flights, accommodation and/or hire car into a package holiday. Then add a few awesome tours and activities. Most bookings also include flexible cancellation policies, so there's no need to worry if you have to switch up your travel plans. Round-the-clock assistance with making changes to your trip is on-hand via our Customer Service Portal link.

When is the best time of year to holiday in Santa Fe de Antioquia?

Santa Fe de Antioquia is at its busiest in January, August and November. If you're hoping for a more relaxed getaway, visit in June, July and October. To get an idea of what type of weather you can experience, the average temperature during the day in January, the coolest month in Santa Fe de Antioquia, is 17ºC. The warmest month here is July, when temperatures are around 19ºC.

What are the top hotels for my holiday in Santa Fe de Antioquia?

Many people opt to stay at Pura Vida Eco Hotel in Zona Colonial. If it's your first time in Santa Fe de Antioquia, you're guaranteed a warm welcome here.

How do I get a cheap holiday to Santa Fe de Antioquia?

Combine your hotel and flight bookings, throw in extras such as activities, and save with a Santa Fe de Antioquia holiday. You won't just score awesome discounts on your escape — you'll have a world of choice too. When you book through Expedia, you can select from more than 400 partner airlines and 321,000 hotels around the globe. Your next affordable holiday begins right here, right now! Learn more about how you can save money on your holiday when you combine your hotel and flight bookings with Expedia.

What should I do on my Santa Fe de Antioquia holiday?

Ensure your holiday in Santa Fe de Antioquia is an unforgettable one by taking in its leading attractions. Bridge of the West, Cathedral of Santa Fe de Antioquia, Iglesia de Santa Bárbara and Church of Our Lady of Chinquinquira are a few of the things you should see while you're in this city.

What is the best area to stay in when on holiday in Santa Fe de Antioquia?

There's loads to do in Santa Fe de Antioquia, so stay near its best attractions and maximise your time sightseeing. Bridge of the West is one place to put on your itinerary.

Do I need a visa for my Santa Fe de Antioquia holiday?

Visa requirements for Santa Fe de Antioquia vary depending on your nationality and reason for your visit. Make sure you check official government websites to determine if you need a visa for your trip. They'll give you the most up-to-date information, including details about application procedures or supporting documentation you might need. Research your visa requirements well ahead of time to ensure a smooth travel experience. Finally, check to see that your passport has at least six months validity from your planned date of return.

What should I wear on my Santa Fe de Antioquia holiday?

Although everyone's fashion style differs, it can be helpful to have some guidelines for what to bring during your holiday in Santa Fe de Antioquia. Think about looking up style blogs before leaving for inspiration on local dress codes or fashion trends. Pack your bags with confidence by checking the weather forecast in Santa Fe de Antioquia. July brings the warmest temperatures, with daytime averages of 19ºC, while January days average 17ºC, making it the coolest month.

What does an Expedia Santa Fe de Antioquia holiday include?

Flights, hotels and a reliable car for all your road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you've made your booking, add on some sightseeing tours and watch your savings stack up. When it comes to planning your Santa Fe de Antioquia holiday, you're in charge! Discover an excellent range of property types and pick one that matches your group size. The most in-demand rentals here are hotels and villas. With Expedia, you can easily tailor your Santa Fe de Antioquia escape just the way you like.

Does Expedia offer Book Now, Pay Later Santa Fe de Antioquia holidays?

We do. Expedia has teamed up with online lender Klarna to help you easily pay for your holiday in manageable instalments. Simply click on the payment plan best suited to your needs during checkout and take the stress out of budgeting for your next trip. Remember to bundle your flights, car hire and hotel with Expedia to get the biggest bang for your travel buck. Take a look at our flexible payment options below:

  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna's easy monthly instalment plans. If paying in multiple instalments sounds right for you, choose this option at checkout.
  • No-deposit holidays: When you want to grab an unbeatable deal but your budget doesn't quite cover it yet, Klarna's no-deposit holiday plan will allow you to Book Now, Pay Later to get what you want.

Can I choose my airline with a Santa Fe de Antioquia Expedia holiday?

Yes — and it's easy too. Expedia has access to more than 400 partner airlines all over the world. Our packages give you the freedom to take your pick of available flights, hotels and activities that fit your needs.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.