Title: TOP Luxury Hotels in Santa Cruz, Seville for 2025 - Santa Cruz Upscale Hotels | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Seville-Santa-Cruz.dx6005056)[Holiday Rentals in Seville](https://expedia.co.uk/Seville-Holiday-Rentals.d3312.Travel-Guide-HolidayRentals)[Flights to Seville](https://expedia.co.uk/Cheap-Flights-To-Seville.d3312.Travel-Guide-Flights)[Things to do in Seville](https://expedia.co.uk/Things-To-Do-In-Seville.d3312.Travel-Guide-Activities)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6005056.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6005056.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/346000/346532-Cabildo-Catedral.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Santa Cruz, Seville ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Luxury Hotels Tonight [17 Oct - 18 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-17&endDate=2025-10-18&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [18 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-18&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Santa Cruz Luxury Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/e6036d75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/b5af0c33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Classic Room | Restaurant | 2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/c6240a75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/9eff12c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville Historical Center 9.4/10 Exceptional (1008) "A fabulous hotel with fabulous service in the most amazing building " £490 includes taxes & fees 17 Nov - 18 Nov [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/8b75801c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/1fb9b2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite Views | City view](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/82daf4e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/d06593f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EME Catedral Mercer Hotel Historical Center 8.8/10 Excellent (1011) "A beautiful hotel in an exceptional location. Very friendly staff, especially Emma Martin. Lovely rooftop bar, modern rooms and on the whole a lovely stay. Will be our first choice for our next trip to Seville " £153 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/89c7c7fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite (hydromassage bathtub) | 20 bedrooms, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/3e69fa4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/fada5620.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite (hydromassage bathtub) | 20 bedrooms, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/7c6c1e0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Rey Moro Hotel Boutique Historical Center 9.4/10 Exceptional (881) "Great location, clean, quite and nice restaurant " £138 includes taxes & fees 12 Nov - 13 Nov [](https://www.expedia.co.uk/Seville-Hotels-El-Rey-Moro-Hotel-Boutique.h2534479.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/eb8fd9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Habitación Familiar (3 personas, planta baja) | Egyptian cotton sheets, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/5c9eeb5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/0d0fb70b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/7f4e121a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Boutique Casa del Poeta Sevilla Historical Center 9.8/10 Exceptional (832) "Excellent hotel and staff. " £181 includes taxes & fees 17 Nov - 18 Nov [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Casa-Del-Poeta.h7596882.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/42f0cb8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/215a48d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | 1 bedroom, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/df9b16c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot tub, steam room, Turkish bath/hammam, body treatments](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/09c2d373.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Las Casas de la Judería, Sevilla Historic City Center Historical Center 9.2/10 Wonderful (1013) "Gorgeous hotel and we loved the uniqueness of the rooms. Comfy beds. Good breakfast and a great location. " £117 includes taxes & fees 17 Nov - 18 Nov [](https://www.expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/d02c6946.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | 2 bedrooms, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/w2875h1920x5y0-7b3d73e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/350bfe9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (EUR 22 per person)](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/86de78f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Fernando III Historical Center 9.6/10 Exceptional (1525) "Really enjoyed our stay here. The staff was excellent and the location was super convenient and walkable." £124 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/3d0ebbc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/968cbcbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/a9445193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | Jetted bathtub](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/f088c3ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Amadeus Sevilla Historical Center 9.6/10 Exceptional (1043) "Very nice quaint hotel " £126 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Amadeus.h3096166.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/556e55e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/d3dcda46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/bb288488.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/4f158aad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Boutique Palacio Pinello Historical Center 9.4/10 Exceptional (663) "Very nice hotel. Close to the cathedral in the center of Seville. The staff very helpful and friendly" £125 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Boutique-Palacio-Pinello.h10017901.Hotel-Information) ![Junior Suite | Minibar, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/927628c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | Living area | LCD TV](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/7cf02832.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/15891663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/aa973f8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Rey Alfonso X Historical Center 9.6/10 Exceptional (1068) "Yes all great location staff bar clean etc " £146 includes taxes & fees 3 Nov - 4 Nov [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) ![Breakfast buffet](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/a8224707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | View from room](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/091d3423.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/daf0dc58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/c9b2c4a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### U-Sense Sevilla Centro Historical Center 9.4/10 Exceptional (406) "It was a very great location.. Close to all my activities. I enjoyed it and the staff were very nice ❤️" [](https://www.expedia.co.uk/Seville-Hotels-Hotel-La-Bella-Sevilla.h2529596.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-31&endDate=2025-11-01®ionId=6005056&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santa Cruz ### Santa Cruzand its attractions for luxury travelers In the charming Santa Cruz neighbourhood of Spain, luxury travellers can indulge in a blend of culture, gastronomy, and relaxation. Begin your day with a visit to the stunning Plaza de la Catedral, where the magnificent cathedral showcases intricate architecture, perfect for a leisurely stroll or a sophisticated photo op. For art enthusiasts, the nearby Museo de Bellas Artes offers a captivating collection of Spanish masterpieces, providing an ideal backdrop for an afternoon of cultural enrichment. After soaking in the sights, unwind at the picturesque Parque García Sanabria, a lush oasis featuring exotic plants and a beautiful lake, perfect for a picnic or a quiet moment. When it comes to dining, Santa Cruz boasts high-end restaurants such as La Casa de la Pasta, where you can savour exquisite local flavours in an elegant setting. After a day of exploration, retreat to one of the luxury hotels in the area, where you can expect personalised service and lavish amenities. For instance, hotels like Iberostar Grand Mencey offer opulent spa facilities and gourmet dining options, ensuring that your stay is as relaxing as it is memorable. Experience the perfect blend of comfort and sophistication, all while being just steps away from the vibrant life of Santa Cruz. ## Top Santa Cruz Hotel Reviews ![Hotel Boutique Casa del Poeta Sevilla](//images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/eb8fd9af_y.jpg) ### Hotel Boutique Casa del Poeta Sevilla 10/10 Excellent "Very quiet hotel" [](https://expedia.co.uk/Seville-Hotels-Hotel-Casa-Del-Poeta.h7596882.Hotel-Information) ![Las Casas de la Juderia](//images.trvl-media.com/lodging/1000000/10000/9900/9805/42f0cb8c_y.jpg) ### Las Casas de la Juderia 10/10 Excellent "Gorgeous hotel and we loved the uniqueness of the rooms. Comfy beds. Good breakfast and a great location. " [](https://expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) ![Hotel Amadeus Sevilla](//images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/3d0ebbc8_y.jpg) ### Hotel Amadeus Sevilla 10/10 Excellent "Wonderful quiet hotel, close to the Cathedral and Alcazar. We were celebrating my wife’s birthday and the hotel did not disappoint. They were very helpful providing flowers and a chilled bottle if Cava upon our arrival." [](https://expedia.co.uk/Seville-Hotels-Hotel-Amadeus.h3096166.Hotel-Information) ![Hotel Fernando III](//images.trvl-media.com/lodging/1000000/80000/75300/75297/d02c6946_y.jpg) ### Hotel Fernando III 10/10 Excellent "Really enjoyed our stay here. The staff was excellent and the location was super convenient and walkable." [](https://expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Hotel Doña Maria](//images.trvl-media.com/lodging/2000000/1180000/1177700/1177678/ecf448a5_y.jpg) ### Hotel Doña Maria 10/10 Excellent "Comfortable and clean room" [](https://expedia.co.uk/Seville-Hotels-Hotel-Dona-Maria.h1177678.Hotel-Information) ![Hotel Rey Alfonso X](//images.trvl-media.com/lodging/1000000/920000/917100/917067/927628c0_y.jpg) ### Hotel Rey Alfonso X 10/10 Excellent "Yes all great location staff bar clean etc " [](https://expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) ![Hotel Alcántara](//images.trvl-media.com/lodging/3000000/2690000/2687200/2687132/49078a5d_y.jpg) ### Hotel Alcántara 10/10 Excellent "Lovely simple breakfast away from the hustle of the old town" [](https://expedia.co.uk/Seville-Hotels-Hotel-Alcantara.h2687132.Hotel-Information) ![Hotel Murillo](//images.trvl-media.com/lodging/2000000/1430000/1427000/1426919/908c5e0f_y.jpg) ### Hotel Murillo 10/10 Excellent "We had a very nice room with a little balcony. It is in the center of town and you can walk to most, if not all attractions. Raquel was very helpful and pleasant. Cleanliness was top notch! Would stay again when we return to Seville" [](https://expedia.co.uk/Seville-Hotels-Hotel-Murillo.h1426919.Hotel-Information) ![Hotel Alfonso XIII, a Luxury Collection Hotel, Seville](//images.trvl-media.com/lodging/1000000/10000/5700/5692/e6036d75_y.jpg) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville 10/10 Excellent "A fabulous hotel with fabulous service in the most amazing building " [](https://expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury trip to Santa Cruz? > While you're visiting, you might want to think about enjoying the monuments and museums, which Santa Cruz is known for. ### What's the best luxury place to stay in Santa Cruz? > [EME Catedral Mercer Hotel](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) is a luxury hotel with 2 restaurants and a full-service spa, and it's a popular choice for Expedia travellers looking for an elegant place to stay. [El Rey Moro Hotel Boutique](https://www.expedia.co.uk/Seville-Hotels-El-Rey-Moro-Hotel-Boutique.h2534479.Hotel-Information) and [Hotel Alfonso XIII, a Luxury Collection Hotel, Seville](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) are other upscale choices for your trip. ### What's there to see and do in Santa Cruz? > Take in the sights and attractions that Santa Cruz offers with a visit to Convent of the Incarnation, Giralda Tower and General Archive of the Indies. If you have a little extra time during your trip, you might want to make a stop at Juderia de Sevilla Interpretation Center and Triunfo Plaza. ### How can I get around Santa Cruz? > It's easier to get around town comfortably when you know your options. 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[Book Hotels in Santa Cruz on Expedia.es](https://www.expedia.es/Santa-Cruz-Sevilla-Hoteles-Hotel-De-Lujo.0-n6005056-0-tHoteldelujo.Guia-Viajes-Filter-Hoteles)