Title: TOP Luxury Hotels in Santa Cruz, Seville for 2026 - Santa Cruz Upscale Hotels | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Seville-Santa-Cruz.dx6005056)[Holiday Rentals in Seville](https://expedia.co.uk/Seville-Holiday-Rentals.d3312.Travel-Guide-HolidayRentals)[Flights to Seville](https://expedia.co.uk/Cheap-Flights-To-Seville.d3312.Travel-Guide-Flights)[Things to do in Seville](https://expedia.co.uk/Things-To-Do-In-Seville.d3312.Travel-Guide-Activities)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6005056.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6005056.Holidays-City-Breaks) ![Santa Cruz](https://images.trvl-media.com/place/6005056/76322155-c0b9-4bf9-8b7b-37408ab9b072.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6005056/76322155-c0b9-4bf9-8b7b-37408ab9b072.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Luxury Hotels Tonight [26 Jan - 27 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-01-26&endDate=2026-01-27&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [27 Jan - 28 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-01-27&endDate=2026-01-28&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-02-06&endDate=2026-02-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Santa Cruz luxury hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/388658c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/01fb742c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/9eff12c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/e2911775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) Historical Center 9.4/10 Exceptional (1,003 reviews) "Stunning hotel with incredible food in the heart of Sevilla! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca £344 includes taxes & fees 2 Feb - 3 Feb [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/8b75801c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/d06593f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/6b5e554b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar, al fresco dining, open daily](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/b88f4a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EME Catedral Mercer Hotel [](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) Historical Center 8.8/10 Excellent (1,001 reviews) "Great location, and thank you to all the staff for making our stay so enjoyable. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Samir £144 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/89c7c7fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/f96337a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite (hydromassage bathtub) | 20 bedrooms, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/7c6c1e0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![20 bedrooms, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/a7e83004.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Rey Moro Hotel Boutique [](https://www.expedia.co.uk/Seville-Hotels-El-Rey-Moro-Hotel-Boutique.h2534479.Hotel-Information) Historical Center 9.4/10 Exceptional (901 reviews) "Location was absolutely perfect the staff was even better. 5 star" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christine £89 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Seville-Hotels-El-Rey-Moro-Hotel-Boutique.h2534479.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/7f4e121a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Habitación Familiar (3 personas, planta baja) | Egyptian cotton sheets, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/5c9eeb5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/eb8fd9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/0d0fb70b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Boutique Casa del Poeta Sevilla [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Casa-Del-Poeta.h7596882.Hotel-Information) Historical Center 9.8/10 Exceptional (880 reviews) "Fantastic property and staff. We spent 7 night here and it was perfect. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Harold £153 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Casa-Del-Poeta.h7596882.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/6b5db424.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/c93ed0d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/215a48d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/d285787b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Las Casas de la Judería, Sevilla Historic City Center [](https://www.expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) Historical Center 9.2/10 Wonderful (1,004 reviews) "Gorgeous property. Great location. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Iris £98 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) ![Seasonal outdoor pool, open noon to 9 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/6d9fae57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | Minibar, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/667b4e5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/350bfe9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse Apartment with Terrace - Annex building | Living area | LCD TV](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/414064f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Fernando III [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) Historical Center 9.6/10 Exceptional (1,527 reviews) "Great location, breakfast & staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anup £95 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/3d0ebbc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/a9445193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/3c7d596b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/327fa087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Amadeus Sevilla [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Amadeus.h3096166.Hotel-Information) Historical Center 9.6/10 Exceptional (1,120 reviews) "Fantastic stay" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Amélie £100 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Amadeus.h3096166.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/556e55e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/4f158aad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/9dc6293b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/e750bbff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Boutique Palacio Pinello [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Boutique-Palacio-Pinello.h10017901.Hotel-Information) Historical Center 9.4/10 Exceptional (687 reviews) "The location was perfect everything was nearby. Maybe, if they were vegan options for bfast but everything else was great " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Pedro £93 includes taxes & fees 9 Feb - 10 Feb [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Boutique-Palacio-Pinello.h10017901.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/15891663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/5ca7832f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | Minibar, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/927628c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (EUR 22 per person)](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/a677ceeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Rey Alfonso X [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) Historical Center 9.6/10 Exceptional (1,133 reviews) "The staff and the hotel were great! The staff were very friendly and helpful. Room was very clean and spacious. Definitely will be staying there again during my next visit to Sevilla. Thank you for everything!!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ANDRES £95 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) ![Superior Double Room | View from room](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/091d3423.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast buffet](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/b6d9d789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/daf0dc58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room | Minibar, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/9d85302e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### U-Sense Sevilla Centro [](https://www.expedia.co.uk/Seville-Hotels-Hotel-La-Bella-Sevilla.h2529596.Hotel-Information) Historical Center 9.4/10 Exceptional (419 reviews) "Nice location and very nice room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) isabella £76 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/Seville-Hotels-Hotel-La-Bella-Sevilla.h2529596.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-09&endDate=2026-02-10®ionId=6005056&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santa Cruz ### Santa Cruzand its attractions for luxury travelers In the charming Santa Cruz neighbourhood of Spain, luxury travellers can indulge in a blend of culture, gastronomy, and relaxation. Begin your day with a visit to the stunning Plaza de la Catedral, where the magnificent cathedral showcases intricate architecture, perfect for a leisurely stroll or a sophisticated photo op. For art enthusiasts, the nearby Museo de Bellas Artes offers a captivating collection of Spanish masterpieces, providing an ideal backdrop for an afternoon of cultural enrichment. After soaking in the sights, unwind at the picturesque Parque García Sanabria, a lush oasis featuring exotic plants and a beautiful lake, perfect for a picnic or a quiet moment. When it comes to dining, Santa Cruz boasts high-end restaurants such as La Casa de la Pasta, where you can savour exquisite local flavours in an elegant setting. After a day of exploration, retreat to one of the luxury hotels in the area, where you can expect personalised service and lavish amenities. For instance, hotels like Iberostar Grand Mencey offer opulent spa facilities and gourmet dining options, ensuring that your stay is as relaxing as it is memorable. Experience the perfect blend of comfort and sophistication, all while being just steps away from the vibrant life of Santa Cruz. ## Top Santa Cruz Hotel Reviews ![Hotel Alfonso XIII, a Luxury Collection Hotel, Seville](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/388658c0_y.jpg) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville 10/10 Excellent "All perfect" [](https://expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![Hotel Fernando III](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/d02c6946_y.jpg) ### Hotel Fernando III 10/10 Excellent "What a great 4-day stay. From check in to check out , the service, condition of the room, and spaciousness has been great. Very central location to attractions. Will not hesitate to stay again! " [](https://expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Hotel Murillo](https://images.trvl-media.com/lodging/2000000/1430000/1427000/1426919/908c5e0f_y.jpg) ### Hotel Murillo 10/10 Excellent "The room was well put together upon arrival the staff provided excellent service, including a map with landmarks and local shops that she pointed out to me." [](https://expedia.co.uk/Seville-Hotels-Hotel-Murillo.h1426919.Hotel-Information) ![Hotel Boutique Casa del Poeta Sevilla](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/eb8fd9af_y.jpg) ### Hotel Boutique Casa del Poeta Sevilla 10/10 Excellent "A beautiful hotel in a perfect location! The service was exceptional! The check-in was better than any other hotel we've been to. They took our IDs and showed us to a nice sitting room where we enjoyed music and fresh drinks. Once we were ready, they came to us and explained everything and took us too our room. They had already moved our luggage into the room. We would highly recommend staying at this hotel in Seville!" [](https://expedia.co.uk/Seville-Hotels-Hotel-Casa-Del-Poeta.h7596882.Hotel-Information) ![Hotel Boutique Corral del Rey by ALUZ Collection](https://images.trvl-media.com/lodging/3000000/2540000/2538900/2538846/4df04252_y.jpg) ### Hotel Boutique Corral del Rey by ALUZ Collection 10/10 Excellent "Not to brag but to inspire...everything was excellent. Clean, quiet, complete, great food, and that nostalgic Spanish ambience. Must mention, the manager, Ysabel and her crew are the best! We will miss this place!" [](https://expedia.co.uk/Seville-Hotels-Hotel-Boutique-Corral-Del-Rey.h2538846.Hotel-Information) ![Hotel Amadeus Sevilla](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/3d0ebbc8_y.jpg) ### Hotel Amadeus Sevilla 10/10 Excellent "The building itself is 300+ years old, and I was in awe of the doors and windows, many of which I assume were original to the building. The entire hotel is decorated with string instruments and music-themed decor. The ladies at the front desk were very helpful and very personable. The breakfast was served at our table and the food was fresh, varied, and delicious. " [](https://expedia.co.uk/Seville-Hotels-Hotel-Amadeus.h3096166.Hotel-Information) ![Las Casas de la Judería, Sevilla Historic City Center](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/42f0cb8c_y.jpg) ### Las Casas de la Judería, Sevilla Historic City Center 10/10 Excellent "Really unique hotel with many courtyards. Nice spacious room with moderate size bathroom . Nice breakfast area and piano bar. Fantastic location . David from the Rock.🇨🇦🇨🇦🇨🇦 (Platinum Expedia )" [](https://expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) ![Hotel Doña Maria](https://images.trvl-media.com/lodging/2000000/1180000/1177700/1177678/ecf448a5_y.jpg) ### Hotel Doña Maria 10/10 Excellent "Clean room, excellent bar, great location" [](https://expedia.co.uk/Seville-Hotels-Hotel-Dona-Maria.h1177678.Hotel-Information) ![Hotel Murillo Reinoso](https://images.trvl-media.com/lodging/2000000/1430000/1427000/1426950/590f2587_y.jpg) ### Hotel Murillo Reinoso 10/10 Excellent "Location " [](https://expedia.co.uk/Seville-Hotels-Apartamentos-Murillo.h1426950.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury trip to Santa Cruz? ### What's the best luxury place to stay in Santa Cruz? ### What's there to see and do in Santa Cruz? ### How can I get around Santa Cruz? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - 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