Title: TOP Luxury Hotels in Santa Cruz, Seville for 2026 - Santa Cruz Upscale Hotels | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Seville-Santa-Cruz.dx6005056)[Holiday Rentals in Seville](https://expedia.co.uk/Seville-Holiday-Rentals.d3312.Travel-Guide-HolidayRentals)[Flights to Seville](https://expedia.co.uk/Cheap-Flights-To-Seville.d3312.Travel-Guide-Flights)[Things to do in Seville](https://expedia.co.uk/Things-To-Do-In-Seville.d3312.Travel-Guide-Activities)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6005056.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6005056.Holidays-City-Breaks) ![Santa Cruz](https://images.trvl-media.com/place/6005056/76322155-c0b9-4bf9-8b7b-37408ab9b072.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Luxury Hotels in Santa Cruz, Seville - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Luxury Hotels Tonight [1 Dec - 2 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-12-01&endDate=2025-12-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [2 Dec - 3 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-12-02&endDate=2025-12-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-12-05&endDate=2025-12-07&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-12-12&endDate=2025-12-14&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Santa Cruz Luxury Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/388658c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/4823eeb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/w4000h2663x0y0-e60df9ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Room, 2 Single Beds | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/8b392ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville Historical Center 9.4/10 Exceptional (1005) "Great Service and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando £348 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/8b75801c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/d06593f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite Views | City view](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/82daf4e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/1fb9b2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EME Catedral Mercer Hotel Historical Center 8.8/10 Excellent (1006) "A great hotel in a fabulous location. We thoroughly enjoyed our stay. Most of the staff were excellent and very helpful and friendly. A small criticism would be on the breakfast, which is quite moderate in terms of range and quality. But we would certainly stay here again. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Leo Roderick £139 includes taxes & fees 8 Dec - 9 Dec [](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/89c7c7fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/fada5620.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite (hydromassage bathtub) | 20 bedrooms, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/3e69fa4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite (hydromassage bathtub) | 20 bedrooms, down duvets, in-room safe, individually decorated](https://images.trvl-media.com/lodging/3000000/2540000/2534500/2534479/7c6c1e0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Rey Moro Hotel Boutique Historical Center 9.4/10 Exceptional (890) "Staff was so helpful!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Deanna £67 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Seville-Hotels-El-Rey-Moro-Hotel-Boutique.h2534479.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/eb8fd9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/0d0fb70b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/7f4e121a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Habitación Familiar (3 personas, planta baja) | Egyptian cotton sheets, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/5c9eeb5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Boutique Casa del Poeta Sevilla Historical Center 9.8/10 Exceptional (856) "Excellent hotel and staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark £164 includes taxes & fees 10 Dec - 11 Dec [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Casa-Del-Poeta.h7596882.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/42f0cb8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna, hot tub, steam room, Turkish bath/hammam, body treatments](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/09c2d373.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/d041f704.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/215a48d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Las Casas de la Judería, Sevilla Historic City Center Historical Center 9.2/10 Wonderful (1013) "This is an incredible place, we LOVED it." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ghislaine £94 includes taxes & fees 9 Dec - 10 Dec [](https://www.expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/d02c6946.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily buffet breakfast (EUR 22 per person)](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/86de78f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | Minibar, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/w2875h1920x5y0-7b3d73e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/58fc2738.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Fernando III Historical Center 9.6/10 Exceptional (1542) "Great location & staff were wonderful!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fawn £83 includes taxes & fees 9 Dec - 10 Dec [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/3d0ebbc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/a9445193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | Jetted bathtub](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/f088c3ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/790497b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Amadeus Sevilla Historical Center 9.6/10 Exceptional (1080) "A great spot with a wonderful staff and breakfast" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Don £114 includes taxes & fees 11 Dec - 12 Dec [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Amadeus.h3096166.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/556e55e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room | View from room](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/9de7fff0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/bb288488.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/11000000/10020000/10018000/10017901/d3dcda46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Boutique Palacio Pinello Historical Center 9.4/10 Exceptional (679) "The hotel is centric" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) javier £77 includes taxes & fees 4 Dec - 5 Dec [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Boutique-Palacio-Pinello.h10017901.Hotel-Information) ![Junior Suite | Minibar, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/927628c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | Living area | LCD TV](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/7cf02832.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/15891663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/aa973f8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Rey Alfonso X Historical Center 9.6/10 Exceptional (1115) "Thoroughly enjoyed our stay and would highly recommend. Staff were very friendly and helpful and the breakfast very tasty! " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) John £92 includes taxes & fees 9 Dec - 10 Dec [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) ![Breakfast buffet](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/a8224707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/c9b2c4a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/638adfcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room | View from room](https://images.trvl-media.com/lodging/3000000/2530000/2529600/2529596/091d3423.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### U-Sense Sevilla Centro Historical Center 9.4/10 Exceptional (411) "Nice location and very nice room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) isabella £87 includes taxes & fees 3 Dec - 4 Dec [](https://www.expedia.co.uk/Seville-Hotels-Hotel-La-Bella-Sevilla.h2529596.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-15&endDate=2025-12-16®ionId=6005056&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Santa Cruz ### Santa Cruzand its attractions for luxury travelers In the charming Santa Cruz neighbourhood of Spain, luxury travellers can indulge in a blend of culture, gastronomy, and relaxation. Begin your day with a visit to the stunning Plaza de la Catedral, where the magnificent cathedral showcases intricate architecture, perfect for a leisurely stroll or a sophisticated photo op. For art enthusiasts, the nearby Museo de Bellas Artes offers a captivating collection of Spanish masterpieces, providing an ideal backdrop for an afternoon of cultural enrichment. After soaking in the sights, unwind at the picturesque Parque García Sanabria, a lush oasis featuring exotic plants and a beautiful lake, perfect for a picnic or a quiet moment. When it comes to dining, Santa Cruz boasts high-end restaurants such as La Casa de la Pasta, where you can savour exquisite local flavours in an elegant setting. After a day of exploration, retreat to one of the luxury hotels in the area, where you can expect personalised service and lavish amenities. For instance, hotels like Iberostar Grand Mencey offer opulent spa facilities and gourmet dining options, ensuring that your stay is as relaxing as it is memorable. Experience the perfect blend of comfort and sophistication, all while being just steps away from the vibrant life of Santa Cruz. ## Top Santa Cruz Hotel Reviews ![Hotel Fernando III](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/d02c6946_y.jpg) ### Hotel Fernando III 10/10 Excellent "Hotel in a great location. Pool terrace a huge bonus. Staff very efficient." [](https://expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Las Casas de la Judería, Sevilla Historic City Center](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/42f0cb8c_y.jpg) ### Las Casas de la Judería, Sevilla Historic City Center 10/10 Excellent "Third time at this hotel. Excellent!" [](https://expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) ![Hotel Amadeus Sevilla](https://images.trvl-media.com/lodging/4000000/3100000/3096200/3096166/3d0ebbc8_y.jpg) ### Hotel Amadeus Sevilla 10/10 Excellent "Yes room on arrival was spotless,but cleaning thereafter could be improved. Staff were all courteous and helpful." [](https://expedia.co.uk/Seville-Hotels-Hotel-Amadeus.h3096166.Hotel-Information) ![Hotel Boutique Casa del Poeta Sevilla](https://images.trvl-media.com/lodging/8000000/7600000/7596900/7596882/eb8fd9af_y.jpg) ### Hotel Boutique Casa del Poeta Sevilla 10/10 Excellent "Beautiful courtyards and lovely rooms. Staff was very courteous. Location was excellent." [](https://expedia.co.uk/Seville-Hotels-Hotel-Casa-Del-Poeta.h7596882.Hotel-Information) ![Hotel Murillo](https://images.trvl-media.com/lodging/2000000/1430000/1427000/1426919/908c5e0f_y.jpg) ### Hotel Murillo 10/10 Excellent "The staff was kind and attentive. Location was walking distance from many attractions. Water pressure in the shower was so nice. Unlike many hotels in the world, the hot water was readily available. " [](https://expedia.co.uk/Seville-Hotels-Hotel-Murillo.h1426919.Hotel-Information) ![Hotel Rey Alfonso X](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/927628c0_y.jpg) ### Hotel Rey Alfonso X 10/10 Excellent "Excellent location and friendly staff." [](https://expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) ![EME Catedral Mercer Hotel](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/8b75801c_y.jpg) ### EME Catedral Mercer Hotel 10/10 Excellent "Great location, and thank you to all the staff for making our stay so enjoyable. " [](https://expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ![Hotel Alfonso XIII, a Luxury Collection Hotel, Seville](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/e6036d75_y.jpg) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville 10/10 Excellent "excellent service beautiful place " [](https://expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![Hotel Boutique Corral del Rey by ALUZ Collection](https://images.trvl-media.com/lodging/3000000/2540000/2538900/2538846/4df04252_y.jpg) ### Hotel Boutique Corral del Rey by ALUZ Collection 10/10 Excellent "Fabulous hotel, we had a deluxe double room which was very well appointed and comfortable. Breakfast was everything we needed and the staff were very helpful. We are planning another trip to Seville next year (as we managed to coincide with storm Claudia this time)and are planning to book Corral del Rey again" [](https://expedia.co.uk/Seville-Hotels-Hotel-Boutique-Corral-Del-Rey.h2538846.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury trip to Santa Cruz? > While you're visiting, you might want to think about enjoying the monuments and museums, which Santa Cruz is known for. ### What's the best luxury place to stay in Santa Cruz? > [EME Catedral Mercer Hotel](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) is a luxury hotel with 2 restaurants and a full-service spa, and it's a popular choice for Expedia travellers looking for an elegant place to stay. [Hotel Alfonso XIII, a Luxury Collection Hotel, Seville](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) and [El Rey Moro Hotel Boutique](https://www.expedia.co.uk/Seville-Hotels-El-Rey-Moro-Hotel-Boutique.h2534479.Hotel-Information) are other upscale choices for your trip. ### What's there to see and do in Santa Cruz? > Take in the sights and attractions that Santa Cruz offers with a visit to Convent of the Incarnation, Giralda Tower and General Archive of the Indies. If you have a little extra time during your trip, you might want to make a stop at Murillo Gardens and Archbishop's Palace. ### How can I get around Santa Cruz? > It's easier to get around town comfortably when you know your options. 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