A narrow cobblestone street lined with colorful buildings, shops, and a prominent white archway in the distance.

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Our top choices for Santa Cruz luxury hotels

1. Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
5.0 star property
Historical Center
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Timeless elegance flourishes in a historic Seville hotel steps from the Royal Alcázar.
The price is £510
includes taxes & fees
24 Nov - 25 Nov
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

2. EME Catedral Mercer Hotel

EME Catedral Mercer Hotel
5.0 star property
Historical Center
8.8 out of 10, Excellent, (1,002 reviews)
  • cleanliness
    Lavish retreat steps from Seville Cathedral featuring full-service spa treatments, poolside bar, and rooftop terrace with panoramic views.
The price is £188
includes taxes & fees
15 Nov - 16 Nov
EME Catedral Mercer Hotel

3. El Rey Moro Hotel Boutique

El Rey Moro Hotel Boutique
4.0 star property
Historical Center
9.4 out of 10, Exceptional, (977 reviews)
  • cleanliness
    Indulge in historic luxury steps from Royal Alcázar with deep soaking tubs, rooftop terrace views, and thoughtful boutique comforts.
The price is £136
includes taxes & fees
4 Nov - 5 Nov
El Rey Moro Hotel Boutique

4. Genteel Home Mateos Gago III

Genteel Home Mateos Gago III
4.5 star property
Historical Center
10.0 out of 10, Exceptional, (1 review)
The price is £276
includes taxes & fees
30 Oct - 31 Oct
Genteel Home Mateos Gago III

5. Hotel Mercer Sevilla 5 GL

Hotel Mercer Sevilla 5 GL
5.0 star property
Historical Center
9.8 out of 10, Exceptional, (183 reviews)
  • cleanliness
    Discover luxurious elegance in historic Seville where attentive staff, poolside relaxation, and boutique charm create an intimate escape.
The price is £377
includes taxes & fees
2 Nov - 3 Nov
Hotel Mercer Sevilla 5 GL

6. Serras Sevilla

Serras Sevilla
5.0 star property
Historical Center
9.4 out of 10, Exceptional, (10 reviews)
The price is £280
includes taxes & fees
22 Nov - 23 Nov
Serras Sevilla

7. CoolRooms Palacio Villapanés 5 GL

CoolRooms Palacio Villapanés 5 GL
5.0 star property
Historical Center
9.6 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Palatial luxury awaits at this 5-star boutique hotel featuring a full-service spa, seasonal outdoor pool, and rooftop terrace in Seville.
The price is £309
includes taxes & fees
15 Nov - 16 Nov
CoolRooms Palacio Villapanés 5 GL

8. Hotel Casa Palacio Don Ramón 5* GL by Kaizen Hoteles

Hotel Casa Palacio Don Ramón 5* GL by Kaizen Hoteles
5.0 star property
Historical Center
9.8 out of 10, Exceptional, (246 reviews)
  • cleanliness
    Discover colonial luxury in Seville's historic centre with facials, seasonal pool, and rooftop terrace just steps from iconic landmarks.
The price is £317
includes taxes & fees
11 Nov - 12 Nov
Hotel Casa Palacio Don Ramón 5* GL by Kaizen Hoteles

9. Hotel Colón Gran Meliá

Hotel Colón Gran Meliá
5.0 star property
Historical Center
9.6 out of 10, Exceptional, (1,003 reviews)
  • cleanliness
    Five-star serenity awaits at this luxury Seville hotel, where rooftop pool relaxation meets spa indulgence just steps from the cathedral.
The price is £263
includes taxes & fees
24 Nov - 25 Nov
Hotel Colón Gran Meliá

10. Hotel Lobby

Hotel Lobby
5.0 star property
Historical Center
9.6 out of 10, Exceptional, (637 reviews)
  • cleanliness
    Immerse in elegant comfort near Seville Cathedral, where luxurious rooms with deep soaking tubs meet refreshing poolside cocktails.
The price is £234
includes taxes & fees
12 Nov - 13 Nov
Hotel Lobby
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Santa Cruz

Santa Cruz and its attractions for luxury travelers

Santa Cruz offers a delightful blend of luxury and adventure, perfect for discerning travellers seeking unique experiences. Begin your day with a visit to the iconic coastal cliffs, where breathtaking views of the Pacific Ocean can be enjoyed while walking along scenic paths. For those who appreciate art, the vibrant local galleries showcase works from both established and emerging artists, making it an inspiring stop. The area is also renowned for its exquisite dining scene, featuring farm-to-table restaurants that emphasize fresh, locally sourced ingredients, providing an unforgettable culinary journey. Thrill-seekers can explore the nearby redwood forests, offering serene trails perfect for leisurely strolls or more adventurous hikes beneath the towering trees. After a day of exploration, unwind at one of the luxury accommodations that prioritize comfort and exceptional service, ensuring that every guest feels pampered and well taken care of. With attentive staff ready to cater to your every need, your stay in Santa Cruz promises to be both memorable and luxurious.

Top Santa Cruz Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Santa Cruz?
While you're visiting, you might want to think about enjoying the monuments and museums, which Santa Cruz is known for.
What's the best luxury place to stay in Santa Cruz?
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville is a luxury hotel with 2 restaurants and valet parking, and it's a popular choice for Expedia travellers looking for an elegant place to stay. EME Catedral Mercer Hotel and El Rey Moro Hotel Boutique are other upscale choices for your trip.
What's there to see and do in Santa Cruz?
Take in the sights and attractions that Santa Cruz offers with a visit to Giralda Tower, Convent of the Incarnation and Triunfo Plaza. If you have a little extra time during your trip, you might want to make a stop at Puerta del Príncipe and General Archive of the Indies.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. Head to Puerta Jerez Tram Stop for metro travel.

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