TOP Luxury Hotels in Santa Cruz, Seville for 2026 - Santa Cruz Upscale Hotels

Change your mind
Book hotels with free cancellation
Treat yourself
Save instantly and earn perks with One Key
Learn about One Key
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Santa Cruz luxury hotels

A large, ornate building with multiple balconies and a central dome, surrounded by palm trees.

1. Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Historical Center

Timeless elegance flourishes in a historic Seville hotel steps from the Royal Alcázar.

includes taxes & fees

10 Dec - 11 Dec

An arched corridor with a tiled floor, leading to a seating area with chairs and tables, and a tree in the center.

2. EME Catedral Mercer Hotel

Historical Center

Lavish retreat steps from Seville Cathedral featuring full-service spa treatments, poolside bar, and rooftop terrace with panoramic views.

includes taxes & fees

14 Dec - 15 Dec

A multi-level atrium with wooden beams, potted plants, and seating areas.

3. El Rey Moro Hotel Boutique

Historical Center

Indulge in historic luxury steps from Royal Alcázar with deep soaking tubs, rooftop terrace views, and thoughtful boutique comforts.

includes taxes & fees

3 Dec - 4 Dec

A spacious living area with a sofa, coffee table, and chairs. There is a television, a lamp, and a dining table with chairs. The room has a tiled floor and arches on the ceiling.

4. Genteel Home Casa Pimienta

Historical Center

includes taxes & fees

20 Nov - 21 Nov

A rooftop pool area with lounge chairs and a seating area, overlooking a historic building with ornate architecture.

5. Serras Sevilla

Historical Center

includes taxes & fees

9 Dec - 10 Dec

A spacious lobby with a central reception desk, multiple seating areas, and a high ceiling with skylights.

6. Hotel Mercer Sevilla 5 GL

Historical Center

Discover luxurious elegance in historic Seville where attentive staff, poolside relaxation, and boutique charm create an intimate escape.

includes taxes & fees

30 Nov - 1 Dec

A spacious courtyard with multiple seating areas, a central fountain, and decorative plants.

7. Hotel Casa Palacio Don Ramón 5* GL by Kaizen Hoteles

Historical Center

Discover colonial luxury in Seville's historic centre with facials, seasonal pool, and rooftop terrace just steps from iconic landmarks.

includes taxes & fees

9 Dec - 10 Dec

A modern interior with a central seating area, a glass partition, and a view of the outside.

8. Thompson Seville, by Hyatt

Historical Center

includes taxes & fees

3 Dec - 4 Dec

A courtyard with outdoor seating, potted plants, and a building with multiple windows and balconies.

9. CoolRooms Palacio Villapanés 5 GL

Historical Center

Palatial luxury awaits at this 5-star boutique hotel featuring a full-service spa, seasonal outdoor pool, and rooftop terrace in Seville.

includes taxes & fees

2 Dec - 3 Dec

A bar area with a glass enclosure, a chandelier, and a seating arrangement.

10. Hotel Colón Gran Meliá

Historical Center

Five-star serenity awaits at this luxury Seville hotel, where rooftop pool relaxation meets spa indulgence just steps from the cathedral.

includes taxes & fees

14 Dec - 15 Dec

View all properties

Compare popular hotels in Santa Cruz

Property	Property class	Guest rating
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville	5.0 star property	9.4 Exceptional 1,000 reviews	View
Hotel Boutique Casa del Poeta Sevilla	4.0 star property	9.8 Exceptional 996 reviews	View
EME Catedral Mercer Hotel	5.0 star property	8.8 Excellent 1,000 reviews	View
Los Seises Sevilla, a Tribute Portfolio Hotel	4.0 star property	8.4 Very good 542 reviews	View
Legado Alcázar Hotel	4.0 star property	9.8 Exceptional 1,000 reviews	View

Top Santa Cruz Hotel Reviews

Thompson Seville, by Hyatt

Historical Center

10/10 Excellent

Shalina

EME Catedral Mercer Hotel

Historical Center

10/10 Excellent

mandy

CoolRooms Palacio Villapanés 5 GL

Historical Center

10/10 Excellent

Smack bang in the middle of the old town it is in a perfect location. The staff were amazing and kind and I could not recommend them more highly. A beautiful building which has remained charming in its conversion to a hotel and whats more a lovely garden area to the rear where you can enjoy a glass or two of wine at the end of the day. Customer care is key and often the person serving was accompanied by someone in training ensuring the high level of service is passed on from one member...

Chris

A room with a bathtub, a vanity with a mirror, a bed, and a leather armchair.

Hotel Lobby Sevilla - Adults recommended

Historical Center

10/10 Excellent

What a hotel ... excellent location for exoring the historical centre, stylish, comfortable, the best breakfast experience we've ever had (thank you Jorge), amazing rooftop bar with buzzing vibe and incredible views and a warm and welcoming team. They had an annivesary treat waiting in our room which was a lovely surprise and were unobtrusive yet always ready to offer assistance or jave a quick chat. The over 18s only policy really helped deliver the kind of get away we were looking for. Our...

Lisa

A circular bar with a central island, bookshelves, and a variety of bottles and glasses.

Radisson Collection Hotel, Magdalena Plaza Sevilla

Historical Center

10/10 Excellent

Angela

Hotel Casa Palacio Don Ramón 5* GL by Kaizen Hoteles

Historical Center

10/10 Excellent

Rebecca

A hotel entrance with a tiled facade, a blue sign with an 'H' indicating the hotel, and two potted plants at the entrance.

Cavalta Boutique Hotel – Small Luxury Hotel

Triana

10/10 Excellent

Donna

A spacious balcony with a curved glass wall, furnished with white wicker chairs and a sofa, overlooking a sunset over a river.

Eurostars Torre Sevilla

Triana

10/10 Excellent

Anonymous traveller

A rooftop bar with outdoor seating, a pool, and a bar area with a view of the city skyline.

Barceló Sevilla Renacimiento

Triana

10/10 Excellent

Lovey hotel. Great for families. Nice swimming pool with indoor and outdoor sections and great morning breakfast. Very spacious hotel. It is massive and you won’t feel crowded at all. The hotel is a distance away from the tourist areas of the Cathedral, Santa Cruz and Alcázar so you have to take a taxi. We used Uber a lot and it was very cheap. A one way trip for family of 4 to the centre no more than 7 euros so we used it a lot. Would stay again.

M

Find out more about Santa Cruz

Santa Cruz and its attractions for luxury travelers

Santa Cruz offers a delightful blend of luxury and adventure, perfect for discerning travellers seeking unique experiences. Begin your day with a visit to the iconic coastal cliffs, where breathtaking views of the Pacific Ocean can be enjoyed while walking along scenic paths. For those who appreciate art, the vibrant local galleries showcase works from both established and emerging artists, making it an inspiring stop. The area is also renowned for its exquisite dining scene, featuring farm-to-table restaurants that emphasize fresh, locally sourced ingredients, providing an unforgettable culinary journey. Thrill-seekers can explore the nearby redwood forests, offering serene trails perfect for leisurely strolls or more adventurous hikes beneath the towering trees. After a day of exploration, unwind at one of the luxury accommodations that prioritize comfort and exceptional service, ensuring that every guest feels pampered and well taken care of. With attentive staff ready to cater to your every need, your stay in Santa Cruz promises to be both memorable and luxurious.

Frequently Asked Questions

Are you searching for a great accommodation for your luxury trip to Santa Cruz?

While you're visiting, you might want to think about enjoying the monuments and museums, which Santa Cruz is known for.

What's the best luxury place to stay in Santa Cruz?

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville is a luxury hotel with 2 restaurants and valet parking, and it's a popular choice for Expedia travellers looking for an elegant place to stay. EME Catedral Mercer Hotel and El Rey Moro Hotel Boutique are other upscale choices for your trip.

What's there to see and do in Santa Cruz?

Take in the sights and attractions that Santa Cruz offers with a visit to Giralda Tower, Convent of the Incarnation and Triunfo Plaza. If you have a little extra time during your trip, you might want to make a stop at Puerta del Príncipe and General Archive of the Indies.

How can I get around Santa Cruz?

It's easier to get around town comfortably when you know your options. Head to Puerta Jerez Tram Stop for metro travel.

Explore a world of travel with Expedia

Things to do in Seville
Standard Link for Things to do in Seville

Find Luxury Hotels in Santa Cruz, Seville

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Santa Cruz luxury hotels

1. Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

2. EME Catedral Mercer Hotel

3. El Rey Moro Hotel Boutique

4. Genteel Home Casa Pimienta

5. Serras Sevilla

6. Hotel Mercer Sevilla 5 GL

7. Hotel Casa Palacio Don Ramón 5* GL by Kaizen Hoteles

8. Thompson Seville, by Hyatt

9. CoolRooms Palacio Villapanés 5 GL

10. Hotel Colón Gran Meliá

Compare popular hotels in Santa Cruz

Top Santa Cruz Hotel Reviews

Thompson Seville, by Hyatt

10/10 Excellent

Find out more about Santa Cruz

Santa Cruz and its attractions for luxury travelers

Frequently Asked Questions

Are you searching for a great accommodation for your luxury trip to Santa Cruz?

What's the best luxury place to stay in Santa Cruz?

What's there to see and do in Santa Cruz?

How can I get around Santa Cruz?

Explore a world of travel with Expedia