Title: TOP Safari Hotels in Santa Cruz Island for 2025 | Expedia.co.uk [Santa Cruz Island Travel Guide](https://expedia.co.uk/Santa-Cruz-Island.dx6053670)[Hotels in Santa Cruz Island](https://expedia.co.uk/Santa-Cruz-Island-Hotels.d6053670.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz Island](https://expedia.co.uk/Santa-Cruz-Island-Holiday-Rentals.d6053670.Travel-Guide-HolidayRentals)[Flights to Santa Cruz Island](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz-Island.d6053670.Travel-Guide-Flights)[Things to do in Santa Cruz Island](https://expedia.co.uk/Things-To-Do-In-Santa-Cruz-Island.d6053670.Travel-Guide-Activities)[Santa Cruz Island Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz-Island.d6053670.Car-Hire-Guide)[Santa Cruz Island Holidays](https://expedia.co.uk/Santa-Cruz-Island.d6053670.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/1/04d5e478ee175ffd174b1e23d51916f4.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Safari Hotels in Santa Cruz Island ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Island Safari Hotels Tonight [27 Oct - 28 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-10-27&endDate=2025-10-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [28 Oct - 29 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-10-28&endDate=2025-10-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [31 Oct - 2 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz Island Safari Hotels ![Water view](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/e0f99a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/476a30cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Regional cuisine ](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/d668ff9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/9f35d995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Twin Hotel Galapagos Bella Vista 8.4/10 Very good (43) "This hotle is fantastic lovely people that work here Very helpful with booking tours ect . To rooms are so fantastic, comfortable bed can’t get any better and good breakfast." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Chelsea £63 1 Nov - 2 Nov [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Twin-Hotel-Galapagos-By-Rotamundos.h14842408.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/970defe5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/88fb6834.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Studio Suite, Pool View | Premium bedding, pillow-top beds, individually furnished, desk](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/dadbf046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Habitación estándar, 1 cama King size, vista a la piscina | Premium bedding, pillow-top beds, individually furnished, desk](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/a013d8ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palo Santo Galapagos Hotel Puerto Ayora 8.6/10 Excellent (17) "This is a really nice property, but for me a pool is very important when I stay at a resort. The pool water was cloudy and not very appealing/inviting. The area around the pool itself was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wesley £179 1 Nov - 2 Nov [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Palo-Santo-Galapagos-Hotel.h13104250.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/863e8c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/47d8324c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, cookware/dishes/utensils, spices, dining tables](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/592985cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/7b3c7f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dominga Terrace Unknown £83 30 Oct - 31 Oct [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h116005423.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/85e6a887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/e8b73278.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, in-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/e4e37840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/b38bc4cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfortable Galarous Island Suite Puerto Ayora £132 2 Nov - 3 Nov [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-GalaRous-Serve-You-With-Quality-And-Warmth-In-Your-Home.h60598658.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/6e3cf51a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/f20e4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/84bd8893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, books](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/9f903199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Island Life Two-Bedroom Galapagos Casita Puerto Ayora 10/10 Exceptional (3) "We had a great time and are grateful to John and Donna for hosting us. The casita was very comfortable and quiet. Great wifi and air conditioning for when we needed to relax. Thank you again!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Victoria K. £154 28 Oct - 29 Oct [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Island-Life-Two-Bedroom-Galapagos-Casita.h37756447.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/74000000/73130000/73126000/73125965/d658dc68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 bedrooms, in-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/74000000/73130000/73126000/73125965/0d6e2e71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast ](https://images.trvl-media.com/lodging/74000000/73130000/73126000/73125965/0ebbe17e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/74000000/73130000/73126000/73125965/71cd0696.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### King Studio with Sofa Bed Puerto Ayora £858 28 Oct - 29 Oct [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Hotel.h73125965.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-10&endDate=2025-11-11®ionId=6053670&adults=2&recreation_group_explore=safari_on_site&sort=RECOMMENDED&openPlayBack=true) ## Top Santa Cruz Island Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [1 Star Hotels in Santa Fe Island](https://www.expedia.co.uk/1Star-Santa-Fe-Island-Hotels.s10-0-d6336630.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Santa Fe Island](https://www.expedia.co.uk/2Star-Santa-Fe-Island-Hotels.s20-0-d6336630.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Santa Fe Island](https://www.expedia.co.uk/3Star-Santa-Fe-Island-Hotels.s30-0-d6336630.Travel-Guide-Filter-Hotels) - [4 Star Hotels in North Seymour Island](https://www.expedia.co.uk/4Star-North-Seymour-Island-Hotels.s40-0-d6336659.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Santa Fe Island](https://www.expedia.co.uk/4Star-Santa-Fe-Island-Hotels.s40-0-d6336630.Travel-Guide-Filter-Hotels) - 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