Title: TOP Safari Hotels in Santa Cruz Island for 2026 | Expedia.co.uk [Santa Cruz Island Travel Guide](https://expedia.co.uk/Santa-Cruz-Island.dx6053670)[Hotels in Santa Cruz Island](https://expedia.co.uk/Santa-Cruz-Island-Hotels.d6053670.Travel-Guide-Hotels)[Holiday Rentals in Santa Cruz Island](https://expedia.co.uk/Santa-Cruz-Island-Holiday-Rentals.d6053670.Travel-Guide-HolidayRentals)[Flights to Santa Cruz Island](https://expedia.co.uk/Cheap-Flights-To-Santa-Cruz-Island.d6053670.Travel-Guide-Flights)[Things to do in Santa Cruz Island](https://expedia.co.uk/Things-To-Do-In-Santa-Cruz-Island.d6053670.Travel-Guide-Activities)[Santa Cruz Island Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz-Island.d6053670.Car-Hire-Guide)[Santa Cruz Island Holidays](https://expedia.co.uk/Santa-Cruz-Island.d6053670.Holidays-City-Breaks) ![Galapagos Marine Iguana walking and swimming on Tortuga bay. Marine iguanas on beach on Santa Cruz Island, Galapagos Islands. Animals, wildlife and amazing nature in Ecuador, South America](https://images.trvl-media.com/place/6053670/54bcca80-11e8-424a-9353-2c1a8014c5d5.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Safari Hotels in Santa Cruz Island - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz Island Safari Hotels Tonight [16 Dec - 17 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-12-16&endDate=2025-12-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [17 Dec - 18 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6053670&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz Island hotels with on-site safari ![Water view](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/e0f99a26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/9f35d995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Regional cuisine ](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/d668ff9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/15000000/14850000/14842500/14842408/bb82add7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Twin Hotel Galapagos [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Twin-Hotel-Galapagos-By-Rotamundos.h14842408.Hotel-Information) Bella Vista 8.4/10 Very good (44) "This hotle is fantastic lovely people that work here Very helpful with booking tours ect . To rooms are so fantastic, comfortable bed can’t get any better and good breakfast." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Chelsea £85 21 Dec - 22 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Twin-Hotel-Galapagos-By-Rotamundos.h14842408.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/970defe5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/a4d476dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/88fb6834.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Habitación estándar, 1 cama King size, vista a la piscina | Premium bedding, pillow-top beds, individually furnished, desk](https://images.trvl-media.com/lodging/14000000/13110000/13104300/13104250/a013d8ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palo Santo Galapagos Hotel [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Palo-Santo-Galapagos-Hotel.h13104250.Hotel-Information) Puerto Ayora 8.6/10 Excellent (17) "This is a really nice property, but for me a pool is very important when I stay at a resort. The pool water was cloudy and not very appealing/inviting. The area around the pool itself was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wesley £178 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Palo-Santo-Galapagos-Hotel.h13104250.Hotel-Information) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/0d93ae7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/4548d4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/0f077b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/23000000/22870000/22869400/22869358/896e6132.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### This two-bedroom is a perfect island getaway. [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-This-Two-Bedroom-Is-A-Perfect-Island-Getaway.h22869358.Hotel-Information) Puerto Ayora, Santa Cruz Island 8.8/10 Excellent (5) "Donna communicated with us before our trip to provide information about arrival and to offer transportation assistance from the airport. Once we were there she offered to arrange tours, suggest dining places and made reservations for us. She did everything she could to make our stay easy and enjoyable. On one of the tours she was our guide. That was so helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia H. £152 17 Dec - 18 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-This-Two-Bedroom-Is-A-Perfect-Island-Getaway.h22869358.Hotel-Information) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/42a7dffa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/4113332d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/1707fdb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711108/cd828067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ocean view Penthouse [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Penthouse.h121711108.Hotel-Information) Puerto Ayora, Santa Cruz Island 10/10 Exceptional (1) "We enjoyed our stay. The air conditioning was a welcome retreat after a day spent exploring. The views are amazing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greta S. £155 19 Dec - 20 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Penthouse.h121711108.Hotel-Information) ![TV, books](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/df21dec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/493b5535.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/0c451736.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/33000000/32600000/32591900/32591880/70b97955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Oceanview two-bedroom with balcony [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Balcony-Two-Bedroom-Suite.h32591880.Hotel-Information) Puerto Ayora, Santa Cruz Island 10/10 Exceptional (24) "Excellent place to stay. Walking distance to everything. A small panderia (bakery) a block away has the best croissants for breakfast. Donna and team are phenomenal." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard L. £188 19 Dec - 20 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Ocean-View-Balcony-Two-Bedroom-Suite.h32591880.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/90000000/89740000/89734500/89734424/2134b1cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/90000000/89740000/89734500/89734424/dd7442aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/90000000/89740000/89734500/89734424/a5a40f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/90000000/89740000/89734500/89734424/01c7f35d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard Studio perfect for an active Galapagos adventure [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Courtyard-Studio-Perfect-For-An-Active-Galapagos-Adventure.h89734424.Hotel-Information) Puerto Ayora £125 17 Dec - 18 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Courtyard-Studio-Perfect-For-An-Active-Galapagos-Adventure.h89734424.Hotel-Information) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711111/a25a59b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711111/c1bfd89b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711111/c03a52e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, books](https://images.trvl-media.com/lodging/122000000/121720000/121711200/121711111/80015650.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### One Bedroom with private balcony [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-One-Bedroom-With-Private-Balcony.h121711111.Hotel-Information) Puerto Ayora, Santa Cruz Island £125 17 Dec - 18 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-One-Bedroom-With-Private-Balcony.h121711111.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/863e8c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/7b3c7f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/3ca1da7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, cookware/dishes/utensils, spices, dining tables](https://images.trvl-media.com/lodging/117000000/116010000/116005500/116005423/592985cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dominga Terrace [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h116005423.Hotel-Information) Unknown £82 17 Dec - 18 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Vrbo-Property.h116005423.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/6e3cf51a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/84bd8893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, books](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/9f903199.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/38000000/37760000/37756500/37756447/247eabf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Island Life Two-Bedroom Galapagos Casita [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Island-Life-Two-Bedroom-Galapagos-Casita.h37756447.Hotel-Information) Puerto Ayora 10/10 Exceptional (3) "We had a great time and are grateful to John and Donna for hosting us. The casita was very comfortable and quiet. Great wifi and air conditioning for when we needed to relax. Thank you again!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Victoria K. £151 12 Jan - 13 Jan 2026 [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-Island-Life-Two-Bedroom-Galapagos-Casita.h37756447.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/85e6a887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/e8b73278.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/d3eb5a37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/61000000/60600000/60598700/60598658/b38bc4cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfortable Galarous Island Suite [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-GalaRous-Serve-You-With-Quality-And-Warmth-In-Your-Home.h60598658.Hotel-Information) Puerto Ayora £144 17 Dec - 18 Dec [](https://www.expedia.co.uk/Puerto-Ayora-Hotels-GalaRous-Serve-You-With-Quality-And-Warmth-In-Your-Home.h60598658.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-30&endDate=2025-12-31®ionId=6053670&adults=2&recreation_group_explore=safari_on_site&sort=RECOMMENDED&openPlayBack=true) ## Top Santa Cruz Island Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [1 Star Hotels in Santa Fe Island ](https://www.expedia.co.uk/1Star-Santa-Fe-Island-Hotels.s10-0-d6336630.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Santa Fe Island ](https://www.expedia.co.uk/2Star-Santa-Fe-Island-Hotels.s20-0-d6336630.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Santa Fe Island ](https://www.expedia.co.uk/3Star-Santa-Fe-Island-Hotels.s30-0-d6336630.Travel-Guide-Filter-Hotels) - [4 Star Hotels in North Seymour Island ](https://www.expedia.co.uk/4Star-North-Seymour-Island-Hotels.s40-0-d6336659.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Santa Fe Island ](https://www.expedia.co.uk/4Star-Santa-Fe-Island-Hotels.s40-0-d6336630.Travel-Guide-Filter-Hotels) - 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