Title: Hotels in Puxico, MO - Best Puxico Hotels from £45 - Fully Refundable Options - Expedia.co.uk

[Holiday Rentals in Puxico](https://expedia.co.uk/Puxico-Holiday-Rentals.d553248634983343452.Travel-Guide-HolidayRentals)[Puxico Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Puxico.d553248634983343452.Car-Hire-Guide)[Puxico Holidays](https://expedia.co.uk/Puxico.d553248634983343452.Holidays-City-Breaks)

![Great place for sunrises, Bald Eagles in the winter, and Milkyway shots. ](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Mike McClain 

![](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg)  
###  
Change your mind  
Book hotels with free cancellation
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Save instantly and earn perks with One Key  
[Learn about One Key](https://www.expedia.co.uk/welcome-one-key)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Go beyond your typical stay in Puxico

Pool

[](https://www.expedia.co.uk/Hotel-Search?destination=Puxico%2C+Missouri%2C+United+States+of+America&regionId=553248634983343452&latLong=36.949775%2C-90.158434&adults=2&startDate=2026-03-10&d1=2026-03-10&endDate=2026-03-12&d2=2026-03-12&amenities=POOL)

Pet friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Puxico%2C+Missouri%2C+United+States+of+America&regionId=553248634983343452&latLong=36.949775%2C-90.158434&adults=2&startDate=2026-03-10&d1=2026-03-10&endDate=2026-03-12&d2=2026-03-12&amenities=PETS)

Family friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Puxico%2C+Missouri%2C+United+States+of+America&regionId=553248634983343452&latLong=36.949775%2C-90.158434&adults=2&startDate=2026-03-10&d1=2026-03-10&endDate=2026-03-12&d2=2026-03-12&travelerType=family_friendly)

## Check prices for these dates

Tonight

[24 Feb - 25 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983343452&startDate=2026-02-24&endDate=2026-02-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[25 Feb - 26 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983343452&startDate=2026-02-25&endDate=2026-02-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983343452&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983343452&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Puxico hotels

![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/b0632430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![39-inch LCD TV with cable channels, TV](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/51bc20b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/bc31acbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 1 King Bed, Non Smoking, Kitchenette | Hypo-allergenic bedding, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/62b9e8ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Poplar Bluff

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(801 reviews)

"Would stay again"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David

£78

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Tub, 2 Rooms) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/7611279e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/fa51e0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Poplar Bluff

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

Poplar Bluff

9.2/10

Wonderful

(996 reviews)

"Great location and room "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Curtis

£79

includes taxes & fees

1 Mar - 2 Mar

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Coffee service](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchenette](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/8d2b66d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/412c9f32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/15d55416.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Motel 6 Poplar Bluff, MO

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

Poplar Bluff

8.0/10

Very good

(1,000 reviews)

"Very clean and staff was very friendly!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sherry

£51

includes taxes & fees

26 Feb - 27 Feb

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast ](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/8b122520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Poplar Bluff

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(874 reviews)

"Very clean and well maintained hotel. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael

£87

includes taxes & fees

20 Mar - 21 Mar

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d3cfa5fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/f47e0ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/966bc5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/665a33a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn By Hilton Dexter

[](https://www.expedia.co.uk/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information)

Dexter

10/10

Exceptional

(12 reviews)

"Great stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ashley

£88

includes taxes & fees

4 Mar - 5 Mar

[](https://www.expedia.co.uk/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/a0829ae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Double Room | Premium bedding, individually decorated, individually furnished](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/f646a9e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/ac6df1a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/145de6a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### EC Reed's Mercantile and Hotel

[](https://www.expedia.co.uk/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information)

Marble Hill

9.6/10

Exceptional

(84 reviews)

"Cute room, great food, fun soda fountain and friendly owners! Will return! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Leslie

[](https://www.expedia.co.uk/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information)

![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/8f51ba4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/0a692e3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/1e3aea9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/838b706d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Poplar Bluff by IHG

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information)

Poplar Bluff

8.8/10

Excellent

(720 reviews)

"Enjoyed the stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ranora

£66

includes taxes & fees

27 Mar - 28 Mar

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information)

![Courtyard](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/10259602.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast ](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/9dd5e5a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/dc88ded9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin | Desk, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/40000000/39450000/39440300/39440279/8df6c129.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Bullwinkles Rustic Lodge

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information)

Poplar Bluff

8.4/10

Very good

(213 reviews)

"Had to "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brenda

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Bullwinkles-Rustic-Lodge.h39440279.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/1db8fd06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/1e44f2fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking | Desk, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/a754d6e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking | Desk, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/a73d6a9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn Poplar Bluff North

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information)

Poplar Bluff

7.8/10

Good

(405 reviews)

"Everything is fine "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bob

£77

includes taxes & fees

3 Mar - 4 Mar

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information)

![Breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/2812fc22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed, Accessible, Non Smoking | Desk, blackout curtains, iron/ironing board, free rollaway beds](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/d5132360.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/7385d4a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travelodge by Wyndham Dexter

[](https://www.expedia.co.uk/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information)

Dexter

7.6/10

Good

(395 reviews)

"Clean room, friendly staff and quiet stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Margo

£72

includes taxes & fees

1 Mar - 2 Mar

[](https://www.expedia.co.uk/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information)

![Breakfast area](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/f3b3697d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/1413eaea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/b7cdd094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/df5fef26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Dexter Inn

[](https://www.expedia.co.uk/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information)

Dexter

7.0/10

Good

(335 reviews)

"Nice rooms, friendly staff, "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sarah

£50

includes taxes & fees

16 Mar - 17 Mar

[](https://www.expedia.co.uk/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/a26934b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/3340c554.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/49fa46e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/2b360823.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Poplar Bluff Missouri

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information)

Poplar Bluff

6.6/10

(635 reviews)

"Very clean and staff was great"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dawn

£46

includes taxes & fees

8 Mar - 9 Mar

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/caa808f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/e5416d3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/cb936040.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/440000/437700/437691/8363a93f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Econo Lodge Dexter

[](https://www.expedia.co.uk/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information)

Dexter

6.8/10

(256 reviews)

"The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michelle

£50

includes taxes & fees

26 Mar - 27 Mar

[](https://www.expedia.co.uk/Sikeston-Hotels-Econo-Lodge-Dexter.h437691.Hotel-Information)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/1eb5943b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/415149fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/81d44800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking | Bathroom | Free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152272/e9ec5dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### OYO Hickory House Inn

[](https://www.expedia.co.uk/Sikeston-Hotels-Hickory-House-Inn.h1152272.Hotel-Information)

Dexter

5.6/10

(135 reviews)

"We enjoyed every moment of our stay. Wonderful service—everyone was friendly and helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Albert

£45

includes taxes & fees

7 Mar - 8 Mar

[](https://www.expedia.co.uk/Sikeston-Hotels-Hickory-House-Inn.h1152272.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12&regionId=553248634983343452&adults=2&sort=RECOMMENDED&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Holiday Sale

Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save.

[Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_SPRING_PROMO_553248634983343452)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels.d553248634983343452.Travel-Guide-Hotels)[

Sign up, it's free

](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPuxico-Hotels.d553248634983343452.Travel-Guide-Hotels)

## Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico. 

[See all hotels in Puxico](https://www.expedia.co.uk/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12&adults=2&regionId=553248634983343452)

![Great place for sunrises, Bald Eagles in the winter, and Milkyway shots. ](https://images.trvl-media.com/place/553248634983343452/de6c5278-53d4-4238-882c-19c2c1cec581.jpg?impolicy=fcrop&w=309&h=400&p=1&q=high)

Photo by Mike McClain 

## Top Puxico Hotel Reviews

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg)

### Motel 6 Poplar Bluff, MO

10/10 Excellent

"The room was very clean. "

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Hampton Inn Poplar Bluff](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d_y.jpg)

### Hampton Inn Poplar Bluff

10/10 Excellent

"Clean quiet all amenities in place "

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg)

### Drury Inn & Suites Poplar Bluff

10/10 Excellent

"Staff was fantastic "

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Hampton Inn By Hilton Dexter](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/w3836h2556x4y4-c3d811b2_y.jpg)

### Hampton Inn By Hilton Dexter

10/10 Excellent

"Nice clean rooms, wonderful friendly staff. Very accommodating and suited our need well."

[](https://expedia.co.uk/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information)

![Travelodge by Wyndham Dexter](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86_y.jpg)

### Travelodge by Wyndham Dexter

10/10 Excellent

"Clean and quiet "

[](https://expedia.co.uk/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information)

![Dexter Inn](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/4768517d_y.jpg)

### Dexter Inn

10/10 Excellent

"Nice rooms, friendly staff, "

[](https://expedia.co.uk/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information)

![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg)

### Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent

"Very clean . Every staff member was genuinely friendly and cared about your needs. Very fast check in/out. Breakfast was better than most. Great coffee. "

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

![Super 8 by Wyndham Poplar Bluff Missouri](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/29f9134c_y.jpg)

### Super 8 by Wyndham Poplar Bluff Missouri

10/10 Excellent

"Will be staying again. Thank you "

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information)

![Shop House located 8 miles from Otter Slough Conservation Area](https://images.trvl-media.com/lodging/101000000/100180000/100176800/100176703/eb6bb38f_y.jpg)

### Shop House located 8 miles from Otter Slough Conservation Area

10/10 Excellent

"Close to town, clean, friendly owner."

[](https://expedia.co.uk/Dexter-Hotels-Shop-House-Located-8-Miles-From-Otter-Slough-Conservation-Area.h100176703.Hotel-Information)

## More cheap stays in Puxico

![Super 8 by Wyndham Poplar Bluff Missouri](https://images.trvl-media.com/lodging/1000000/860000/855400/855304/29f9134c_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO

£46

8 Mar - 9 Mar

includes taxes & fees

6.6/10 (635 reviews)

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Super-8-By-Wyndham-Poplar-Bluff-Missouri.h855304.Hotel-Information)

![Dexter Inn](https://images.trvl-media.com/lodging/1000000/860000/856200/856148/4768517d_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Dexter Inn

1807 W Business US Highway 60 Dexter MO

£50

16 Mar - 17 Mar

includes taxes & fees

7/10 Good! (335 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Dexter-Inn.h856148.Hotel-Information)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

£51

26 Feb - 27 Feb

includes taxes & fees

8/10 Very Good! (1,000 reviews)

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Travelodge by Wyndham Dexter](https://images.trvl-media.com/lodging/1000000/90000/84800/84779/8be70c86_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Travelodge by Wyndham Dexter

1608 E Business US 60 Dexter MO

£72

1 Mar - 2 Mar

includes taxes & fees

7.6/10 Good! (395 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Travelodge-By-Wyndham-Dexter.h84779.Hotel-Information)

![Hampton Inn Poplar Bluff](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

£78

8 Mar - 9 Mar

includes taxes & fees

9.4/10 Exceptional! (801 reviews)

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Fairfield Inn & Suites by Marriott Poplar Bluff

3109 Oak Grove Poplar Bluff MO

£87

20 Mar - 21 Mar

includes taxes & fees

9.4/10 Exceptional! (874 reviews)

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

## Frequently asked questions

### When is the best time to go to Puxico?

> These periods offer pleasant weather, with comfortable temperatures and generally less humidity, making it ideal for outdoor activities and exploring the local area. Spring brings blooming dogwoods and redbuds, while autumn showcases beautiful fall foliage, particularly in the surrounding Mingo National Wildlife Refuge.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Puxico hotel booking with Expedia?

### How much is the nightly rate at a Puxico hotel?

## Explore a world of travel with Expedia

- Accommodation
- Flights
- Packages
- Cars
- Other
- More ways to book

- [Allenville Hotels ](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels)
- [Annapolis Hotels ](https://www.expedia.co.uk/Annapolis-Hotels.d6282465.Travel-Guide-Hotels)
- [Benton Hotels ](https://www.expedia.co.uk/Benton-Hotels.d553248634983369680.Travel-Guide-Hotels)
- [Bernie Hotels ](https://www.expedia.co.uk/Bernie-Hotels.d3000349284.Travel-Guide-Hotels)
- [Bertrand Hotels ](https://www.expedia.co.uk/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels)
- [Blodgett Hotels ](https://www.expedia.co.uk/Blodgett-Hotels.d3000349291.Travel-Guide-Hotels)
- [Bloomfield Hotels ](https://www.expedia.co.uk/Bloomfield-Hotels.d6351829.Travel-Guide-Hotels)
- [Campbell Hotels ](https://www.expedia.co.uk/Campbell-Hotels.d3000444671.Travel-Guide-Hotels)
- [Canalou Hotels ](https://www.expedia.co.uk/Canalou-Hotels.d3000349311.Travel-Guide-Hotels)
- [Adults Only Resorts & in Cape Girardeau ](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Adults-Only-Resorts.0-0-d820-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
- [Historic Hotels in Cape Girardeau ](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Historic-Hotel.0-0-d820-tHistoricHotel.Travel-Guide-Filter-Hotels)
- [Catron Hotels ](https://www.expedia.co.uk/Catron-Hotels.d3000349317.Travel-Guide-Hotels)
- [Dexter Hotels ](https://www.expedia.co.uk/Dexter-Hotels.d55097.Travel-Guide-Hotels)
- [Fisk Hotels ](https://www.expedia.co.uk/Fisk-Hotels.d553248634983120615.Travel-Guide-Hotels)
- [Gideon Hotels ](https://www.expedia.co.uk/Gideon-Hotels.d3000349377.Travel-Guide-Hotels)
- [Glen Allen Hotels ](https://www.expedia.co.uk/Glen-Allen-Hotels.d553248634983455025.Travel-Guide-Hotels)
- [Holcomb Hotels ](https://www.expedia.co.uk/Holcomb-Hotels.d553248634983299452.Travel-Guide-Hotels)
- [Jackson Hotels ](https://www.expedia.co.uk/Jackson-Hotels.d55765.Travel-Guide-Hotels)
- [Malden Hotels ](https://www.expedia.co.uk/Malden-Hotels.d8702.Travel-Guide-Hotels)
- [Marble Hill Hotels ](https://www.expedia.co.uk/Marble-Hill-Hotels.d3000445212.Travel-Guide-Hotels)
- [Marquand Hotels ](https://www.expedia.co.uk/Marquand-Hotels.d553248634983260789.Travel-Guide-Hotels)
- [Hotels with Restaurant in Marston ](https://www.expedia.co.uk/Marston-Hotels-Hotel-With-Restaurant.0-0-d55824-thotelwithrestaurant.Travel-Guide-Filter-Hotels)
- [Miner Hotels ](https://www.expedia.co.uk/Miner-Hotels.d553248634983441802.Travel-Guide-Hotels)
- [Morehouse Hotels ](https://www.expedia.co.uk/Morehouse-Hotels.d553248634983462037.Travel-Guide-Hotels)
- [Oran Hotels ](https://www.expedia.co.uk/Oran-Hotels.d3000445386.Travel-Guide-Hotels)
- [Piedmont Hotels ](https://www.expedia.co.uk/Piedmont-Hotels.d3000445413.Travel-Guide-Hotels)
- [Gay-Friendly Hotels in Poplar Bluff ](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Gay-Friendly-Hotel.0-0-d9449-tGayFriendlyHotel.Travel-Guide-Filter-Hotels)
- [Poplar Bluff Hotels ](https://www.expedia.co.uk/Poplar-Bluff-Hotels.d9449.Travel-Guide-Hotels)
- [Qulin Hotels ](https://www.expedia.co.uk/Qulin-Hotels.d3000349508.Travel-Guide-Hotels)
- [Sedgewickville Hotels ](https://www.expedia.co.uk/Sedgewickville-Hotels.d3000349537.Travel-Guide-Hotels)
- [Gay-Friendly Hotels in Sikeston ](https://www.expedia.co.uk/Sikeston-Hotels-Gay-Friendly-Hotel.0-0-d6058766-tGayFriendlyHotel.Travel-Guide-Filter-Hotels)
- [Hotels with Indoor Pools in Sikeston ](https://www.expedia.co.uk/Sikeston-Hotels-Hotels-With-Indoor-Pools.0-0-d6058766-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels)
- [Sikeston Hotels ](https://www.expedia.co.uk/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)
- [Resorts in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotel-Resorts.d6058763-aaHotelResorts.Travel-Guide-Accommodation)
- [Golf Hotels in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-Golf-Hotels.0-0-d6058763-tGolfHotels.Travel-Guide-Filter-Hotels)
- [Hotels with Connecting Rooms in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-Hotel-With-Connecting-Rooms.0-0-d6058763-thotelwithconnectingrooms.Travel-Guide-Filter-Hotels)
- [Hotels with smoking rooms in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-Hotels-With-Smoking-Rooms.0-0-d6058763-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)
- [La Quinta Inn & Suites Hotels in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-La-Quinta-Inn-Suites.0-0-d6058763--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-Luxury-Hotel.0-0-d6058763-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-Pet-Friendly-Hotel.0-0-d6058763-tPetFriendlyHotel.Travel-Guide-Filter-Hotels)
- [Romantic Hotels in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-Romantic-Hotel.0-0-d6058763-tRomanticHotel.Travel-Guide-Filter-Hotels)
- [Spa Hotels in Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri-Hotels-Spa-Hotels.0-0-d6058763-tSpaHotels.Travel-Guide-Filter-Hotels)
- [Southeast Missouri Hotels ](https://www.expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)
- [Wappapello Hotels ](https://www.expedia.co.uk/Wappapello-Hotels.d183505.Travel-Guide-Hotels)
- [Williamsville Hotels ](https://www.expedia.co.uk/Williamsville-Hotels.d553248634983506457.Travel-Guide-Hotels)

- [Flights to Cape Girardeau ](https://www.expedia.co.uk/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)
- [Flights to Dexter ](https://www.expedia.co.uk/Cheap-Flights-To-Dexter.d55097.Travel-Guide-Flights)
- [Flights to Wappapello ](https://www.expedia.co.uk/Cheap-Flights-To-Wappapello.d183505.Travel-Guide-Flights)
- [Flights from Cape Girardeau Municipal ](https://www.expedia.co.uk/lp/airports/cgi/flights-from-cape-girardeau-municipal-airport)
- [Flights from Sikeston Memorial Municipal ](https://www.expedia.co.uk/lp/airports/sik/flights-from-sikeston-memorial-municipal-airport)
- [Flights from Bernie ](https://www.expedia.co.uk/lp/flights/3000349284/flights-from-bernie)
- [Flights from Bertrand ](https://www.expedia.co.uk/lp/flights/3000349285/flights-from-bertrand)
- [Flights from Gideon ](https://www.expedia.co.uk/lp/flights/3000349377/flights-from-gideon)
- [Flights from Qulin ](https://www.expedia.co.uk/lp/flights/3000349508/flights-from-qulin)
- [Flights from Risco ](https://www.expedia.co.uk/lp/flights/3000349516/flights-from-risco)
- [Flights from Dexter ](https://www.expedia.co.uk/lp/flights/55097/flights-from-dexter)
- [Flights from Fredericktown ](https://www.expedia.co.uk/lp/flights/55114/flights-from-fredericktown)
- [Flights from Marquand ](https://www.expedia.co.uk/lp/flights/553248634983260789/flights-from-marquand)
- [Flights from Zalma ](https://www.expedia.co.uk/lp/flights/553248634983373716/flights-from-zalma)
- [Flights from Ellsinore ](https://www.expedia.co.uk/lp/flights/553248634983439149/flights-from-ellsinore)
- [Flights from Scott City ](https://www.expedia.co.uk/lp/flights/553248634983544376/flights-from-scott-city)
- [Flights from Jackson ](https://www.expedia.co.uk/lp/flights/55765/flights-from-jackson)
- [Flights from Marston ](https://www.expedia.co.uk/lp/flights/55824/flights-from-marston)
- [Flights from Sikeston ](https://www.expedia.co.uk/lp/flights/6058766/flights-from-sikeston)
- [Flights from Annapolis ](https://www.expedia.co.uk/lp/flights/6282465/flights-from-annapolis)
- [Flights from Cape Girardeau ](https://www.expedia.co.uk/lp/flights/820/flights-from-cape-girardeau)
- [Flights from Poplar Bluff ](https://www.expedia.co.uk/lp/flights/9449/flights-from-poplar-bluff)
- [Flights from Atlanta (ATL) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/atl/cgi/atlanta-to-cape-girardeau)
- [Flights from Birmingham (BHM) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/bhm/cgi/birmingham-to-cape-girardeau)
- [Flights from Mumbai (BOM) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/bom/cgi/mumbai-to-cape-girardeau)
- [Flights from Sedalia (DMO) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/dmo/cgi/sedalia-to-cape-girardeau)
- [Flights from Dublin (DUB) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/dub/cgi/dublin-to-cape-girardeau)
- [Flights from New York (JFK) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/jfk/cgi/new-york-to-cape-girardeau)
- [Flights from Los Angeles (LAX) to Poplar Bluff (POF) ](https://www.expedia.co.uk/lp/flights/lax/pof/los-angeles-to-poplar-bluff)
- [Flights from London (LHR) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/lhr/cgi/london-to-cape-girardeau)
- [Flights from Lewiston (LWS) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/lws/cgi/lewiston-to-cape-girardeau)
- [Flights from Carbondale (MDH) to Poplar Bluff (POF) ](https://www.expedia.co.uk/lp/flights/mdh/pof/carbondale-to-poplar-bluff)
- [Flights from Chicago (MDW) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/mdw/cgi/chicago-to-cape-girardeau)
- [Flights from Stow (MMN) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/mmn/cgi/stow-to-cape-girardeau)
- [Flights from Pittsburgh (PIT) to Poplar Bluff (POF) ](https://www.expedia.co.uk/lp/flights/pit/pof/pittsburgh-to-poplar-bluff)
- [Flights from Pasco (PSC) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/psc/cgi/pasco-to-cape-girardeau)
- [Flights from San Antonio (SAT) to Poplar Bluff (POF) ](https://www.expedia.co.uk/lp/flights/sat/pof/san-antonio-to-poplar-bluff)
- [Flights from St. Louis (STL) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/stl/cgi/st-louis-to-cape-girardeau)
- [Flights from Tijuana (TIJ) to Cape Girardeau (CGI) ](https://www.expedia.co.uk/lp/flights/tij/cgi/tijuana-to-cape-girardeau)

- [Bernie Holidays ](https://www.expedia.co.uk/Bernie.d3000349284.Holidays-City-Breaks)
- [Dexter Holidays ](https://www.expedia.co.uk/Dexter.d55097.Holidays-City-Breaks)
- [Visit Fredericktown ](https://www.expedia.co.uk/Fredericktown.dx55114)
- [Marston Holidays ](https://www.expedia.co.uk/Marston.d55824.Holidays-City-Breaks)
- [Visit Poplar Bluff ](https://www.expedia.co.uk/Poplar-Bluff.dx9449)
- [Visit Qulin ](https://www.expedia.co.uk/Qulin.dx3000349508)
- [Sikeston Holidays ](https://www.expedia.co.uk/Sikeston.d6058766.Holidays-City-Breaks)
- [Visit Sikeston ](https://www.expedia.co.uk/Sikeston.dx6058766)
- [Visit Southeast Missouri ](https://www.expedia.co.uk/Southeast-Missouri.dx6058763)
- [Ski Holiday Packages Southeast Missouri ](https://www.expedia.co.uk/lp/theme-holidays/ski-holidays/6058763/Southeast-Missouri)

- [Rental cars Cape Girardeau Municipal airport ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Cape-Girardeau-Municipal.d6026978.Car-Hire-Guide)
- [Car hire Cape Girardeau ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Cape-Girardeau.d820.Car-Hire-Guide)
- [Island Car Rentals Rental Cars in Cobalt ](https://www.expedia.co.uk/Island-Car-Rentals-Car-Rentals-In-Cobalt.d553248634983153223-c1132.Car-Rental-Guide-Suppliers)
- [Redspot Rental Cars in Oran ](https://www.expedia.co.uk/Redspot-Car-Rentals-In-Oran.d3000445386-c1078.Car-Rental-Guide-Suppliers)
- [United Rental Cars in Southeast Missouri ](https://www.expedia.co.uk/United-Car-Rentals-In-Southeast-Missouri.d6058763-c1088.Car-Rental-Guide-Suppliers)

- [Things to do in Southeast Missouri ](https://www.expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)

- [Book Hotels in Puxico on Expedia.com ](https://www.expedia.com/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app