A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.

Find hotels in Puxico, MO from £41

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
28 Aug - 29 Aug
Tomorrow
29 Aug - 30 Aug
This weekend
28 Aug - 30 Aug
Next weekend
4 Sept - 6 Sept

Filter by

Star rating

Guest rating

Our top choices for Puxico hotels

1. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
Dexter
United States
Joyce
£81
includes taxes & fees
7 Sept - 8 Sept
Hampton Inn By Hilton Dexter

2. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Philip
£77
includes taxes & fees
13 Sept - 14 Sept
Hampton Inn Poplar Bluff

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
Poplar Bluff
United States
Arsenia
£84
includes taxes & fees
7 Sept - 8 Sept
Fairfield Inn & Suites by Marriott Poplar Bluff

4. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
Poplar Bluff
United States
Paige
£72
includes taxes & fees
27 Sept - 28 Sept
Holiday Inn Poplar Bluff by IHG

5. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
United States
Paul
£85
includes taxes & fees
6 Sept - 7 Sept
Drury Inn & Suites Poplar Bluff

6. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
Dexter
United States
Steven
£71
includes taxes & fees
17 Sept - 18 Sept
Travelodge by Wyndham Dexter

7. Econo Lodge Dexter

Econo Lodge Dexter
Dexter
United States
Herman
£42
includes taxes & fees
27 Sept - 28 Sept
Econo Lodge Dexter

8. Dexter Inn

Dexter Inn
Dexter
United States
Edward
£52
includes taxes & fees
30 Aug - 31 Aug
Dexter Inn

9. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
Poplar Bluff
United States
Muhammad
£67
includes taxes & fees
20 Sept - 21 Sept
Comfort Inn Poplar Bluff North

10. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
Poplar Bluff
United States
Kathleen
£65
includes taxes & fees
30 Aug - 31 Aug
Motel 6 Poplar Bluff, MO

11. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
Poplar Bluff
United States
Diana
£46
includes taxes & fees
10 Sept - 11 Sept
Super 8 by Wyndham Poplar Bluff Missouri

12. Lake Wappapello

Lake Wappapello
Williamsville
United States
Tonya
£70
includes taxes & fees
29 Aug - 30 Aug
Lake Wappapello

13. OYO Hickory House Inn

OYO Hickory House Inn
Dexter
United States
Tammy
£41
includes taxes & fees
27 Sept - 28 Sept
OYO Hickory House Inn

14. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
United States
JANEEN
£74
includes taxes & fees
30 Aug - 31 Aug
EC Reed's Mercantile and Hotel
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Puxico

Head to sights like Mark Twain National Forest and Mingo Wilderness as you discover Puxico.

See all hotels in Puxico
A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain

Top Puxico Hotel Reviews

Dexter Inn

Dexter Inn

8/10 Good
"breakfast was good, staff friendly, pool area needs work"
Edward 2-night trip
Posted 2 days ago
Dexter Inn
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

10/10 Excellent
"loved it!!!"
George 1-night trip
Posted 3 days ago
Fairfield Inn & Suites by Marriott Poplar Bluff
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

10/10 Excellent
"We travel frequently and this is a place we have enjoyed when in this area. We have stayed here several times"
Garth 1-night trip
Posted 5 days ago
Hampton Inn Poplar Bluff
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

10/10 Excellent
"Great place! Room was nice and there breakfast in the mercantile was top notch!"
Drew 1-night trip
Posted 5 days ago
EC Reed's Mercantile and Hotel
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

8/10 Good
"The room was clean but other parts like the elevator were very dirty. Staff were amazing"
Joshua 1-night trip
Posted 5 days ago
Holiday Inn Poplar Bluff by IHG
Econo Lodge Dexter

Econo Lodge Dexter

10/10 Excellent
"Staff are kind, welcoming and helpful! Property is clean and well. For the pri"
Elizabeth 1-night trip
Posted 5 days ago
Econo Lodge Dexter
Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!

10/10 Excellent
"Great property, it is a bit hard to find. So I definatly got lost along the way. Holly was super helpful, I would just really make sure to map your way and not rely solely on google maps. The internet is shotty at best making it much harder to find your way. Overall great experience."
IMm B. 1-night trip
Posted 7 days ago
Cozy hobby farm cabin under the stars!
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

10/10 Excellent
"Best Hampton Inn that I have ever stayed in. Excellent service and Wonderful staff. Extremely helpful with disabled husband."
Stephen 2-night trip
Posted 8 days ago
Hampton Inn By Hilton Dexter
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

10/10 Excellent
"It’s was clean and very well maintained"
Larry 1-night trip
Posted 11 days ago
Travelodge by Wyndham Dexter

More cheap stays in Puxico

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2831 N Westwood Blvd Poplar Bluff MO
£46
10 Sept - 11 Sept
includes taxes & fees
Super 8 by Wyndham Poplar Bluff Missouri
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO
£65
30 Aug - 31 Aug
includes taxes & fees
8/10 Very good! (1,000 reviews)
Motel 6 Poplar Bluff, MO
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2582 N Westwood Blvd Poplar Bluff MO
£67
20 Sept - 21 Sept
includes taxes & fees
7.8/10 Good! (436 reviews)
Comfort Inn Poplar Bluff North
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

1608 E Business US 60 Dexter MO
£71
17 Sept - 18 Sept
includes taxes & fees
7.6/10 Good! (420 reviews)
Travelodge by Wyndham Dexter
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO
£77
13 Sept - 14 Sept
includes taxes & fees
9.4/10 Exceptional! (921 reviews)
Hampton Inn Poplar Bluff
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2179 Gill Plaza Drive Dexter MO
£81
7 Sept - 8 Sept
includes taxes & fees
9.8/10 Exceptional! (66 reviews)
Hampton Inn By Hilton Dexter

Frequently asked questions

When is the best time to go to Puxico?
The best time to visit Puxico, Missouri, is during the spring (late April to early June) and autumn (September to October) months.These periods offer pleasant weather, with comfortable temperatures and generally less humidity, making it ideal for outdoor activities and exploring the local area. Spring brings blooming dogwoods and redbuds, while autumn showcases beautiful fall foliage, particularly in the surrounding Mingo National Wildlife Refuge.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Puxico.
How much is the nightly rate at a Puxico hotel?
Prices for hotels in Puxico often vary, but you can find a great deal from £41 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia