TOP Family-Friendly Hotels in Northeast Missouri, MO for 2026 - Northeast Missouri Family Welcoming Hotels

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Our top choices for Northeast Missouri family-friendly hotels

A playground with a slide, swings, and a climbing structure.

1. Depot Inn and Suites

La Plata

Let the kids loose at this La Plata hotel with indoor pools, playground, and game room for endless family fun.

includes taxes & fees

6 Dec - 7 Dec

A modern kitchen with a dining area, featuring a kitchen island with appliances and a coffee station.

2. Super 8 by Wyndham Kirksville-University Area

Kirksville

includes taxes & fees

22 Nov - 23 Nov

A buffet with various food items, including omelets and other dishes, arranged in metal serving trays.

3. Holiday Inn Express & Suites Kirksville - University Area by IHG

Kirksville

Family-friendly fun begins with an indoor pool adventure just a short drive from Thousand Hills State Park for outdoor exploration.

includes taxes & fees

29 Nov - 30 Nov

A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.

4. Travelier Motel

Macon

includes taxes & fees

11 Nov - 12 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

5. Best Western On The River

Hannibal

Family-friendly riverside hotel offers kids' paradise with indoor and outdoor pools, hot tub, and nearby fun park adventures.

includes taxes & fees

10 Nov - 11 Nov

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

6. Oak Hill Inn & Suites

Canton

includes taxes & fees

10 Dec - 11 Dec

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

7. Quality Inn & Suites Hannibal West

Hannibal

Family escape with an indoor pool and spacious rooms where kids splash while parents relax at the poolside bar and sun loungers.

includes taxes & fees

6 Dec - 7 Dec

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

8. Sleep Inn & Suites Hannibal West

Hannibal

Splash into a family holiday haven at this Sleep Inn & Suites with indoor pool, fitness centre, and kid-friendly amenities.

includes taxes & fees

6 Dec - 7 Dec

A hotel with a swimming pool, outdoor seating, and a sign for 'Pinemark Inn Suites & Events'.

9. Pinemark Inn & Suites

St. Clair

Family-friendly destination with seasonal pool and firepits makes for perfect relaxation in St. Clair.

includes taxes & fees

10 Nov - 11 Nov

A hotel lobby with a seating area, a dining table, a kitchen, and an exit sign.

10. Super 8 by Wyndham Washington

Washington

Family-friendly haven with spacious rooms, complimentary breakfast, and thoughtful amenities for children makes holidaying simple and fun.

includes taxes & fees

22 Nov - 23 Nov

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Choose what matters most at family-friendly hotels in Northeast Missouri

Breakfast included

Pool

Top Northeast Missouri Hotel Reviews

Depot Inn and Suites

La Plata

10/10 Excellent

David

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

Hyatt Place St. Louis/Chesterfield

Chesterfield

10/10 Excellent

Karen

A spacious lobby with a central round table, two sofas, and a chandelier.

Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

10/10 Excellent

I like the cleanest of the hotel and my rooms was fresh and clean. The Happy hour was on point the drinks was awesome and the food. Breakfast was amazing with lots of options. I was use to getting popcorn around the clock but it was not available and that was a little disappointing for me because I love my popcorn 😍The staff was a little unfriendly but overall I ❤️ my stay and this will always be my stay away from home because they really do take care of you while your staying there.

Patricia