Title: TOP Business Hotels in Northeast Missouri, MO for 2026 | Expedia.co.uk [Northeast Missouri Travel Guide](https://expedia.co.uk/Northeast-Missouri.dx6058818)[Hotels in Northeast Missouri](https://expedia.co.uk/Northeast-Missouri-Hotels.d6058818.Travel-Guide-Hotels)[Holiday Rentals in Northeast Missouri](https://expedia.co.uk/Northeast-Missouri-Holiday-Rentals.d6058818.Travel-Guide-HolidayRentals)[Flights to Northeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Northeast-Missouri.d6058818.Travel-Guide-Flights)[Things to do in Northeast Missouri](https://expedia.co.uk/Things-To-Do-In-Northeast-Missouri.d6058818.Travel-Guide-Activities)[Northeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Northeast-Missouri.d6058818.Car-Hire-Guide)[Northeast Missouri Holidays](https://expedia.co.uk/Northeast-Missouri.d6058818.Holidays-City-Breaks) ![Grant\'s Farm which includes heritage architecture](https://images.trvl-media.com/place/6069377/88294c82-c384-49b1-b936-14bc595df677.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6069377/88294c82-c384-49b1-b936-14bc595df677.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Northeast Missouri Business Hotels Tonight [22 Jan - 23 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-01-22&endDate=2026-01-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [23 Jan - 24 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-01-23&endDate=2026-01-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Northeast Missouri business-friendly hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/55269a5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/2edd84af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/34f8e499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillow-top beds, desk](https://images.trvl-media.com/lodging/1000000/20000/16300/16210/140ce6ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Foristell [](https://www.expedia.co.uk/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information) Foristell 8.2/10 Very good (923 reviews) "Clean rooms, pleasant staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £62 includes taxes & fees 24 Jan - 25 Jan [](https://www.expedia.co.uk/Warrenton-Hotels-Quality-Inn.h16210.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1460000/1453000/1452969/863f6b2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Non Smoking | Desk, iron/ironing board, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/2000000/1460000/1453000/1452969/75dec586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/2000000/1460000/1453000/1452969/afa867ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1460000/1453000/1452969/c4a58a29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Sullivan [](https://www.expedia.co.uk/Washington-Hotels-Comfort-Inn-Sullivan.h1452969.Hotel-Information) Sullivan 8.6/10 Excellent (824 reviews) "The gentleman that checked us in was absolutely amazing the hotel was very clean I highly recommend this hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shonda £91 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Washington-Hotels-Comfort-Inn-Sullivan.h1452969.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/4d0e3d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/1ed98bfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/68c9f9ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn St. Louis Airport [](https://www.expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) St. Ann 9.4/10 Exceptional (2,784 reviews) "Staff was great and breakfast and lobby was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheila £79 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/6c9e28fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/de075f26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/1817d317.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/44eec777.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Depot Inn and Suites [](https://www.expedia.co.uk/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information) La Plata 9.8/10 Exceptional (626 reviews) "Staff is amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maggie £63 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/d38dcff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/50b5788d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 9:00 AM to 10:00 PM, pool loungers](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/ac681623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/36000000/35850000/35848800/35848753/da587b35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Wentzville St Louis West by IHG [](https://www.expedia.co.uk/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information) Wentzville 9.4/10 Exceptional (864 reviews) "Beautiful hotel, friendly staff, good breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erika £116 includes taxes & fees 31 Jan - 1 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Holiday-Inn-Express-Suites-Wentzville-St-Louis-West.h35848753.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/0683cbec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/5c0eb04d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed | Desk, iron/ironing board, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/5a40455a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/863ee254.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Hannibal West [](https://www.expedia.co.uk/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information) Hannibal 9.6/10 Exceptional (1,003 reviews) "Clean and great location!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) janet £85 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/d203c711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking | Pillow-top beds, desk, blackout curtains, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/9c660a01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Kirksville-University Area [](https://www.expedia.co.uk/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) Kirksville 9.0/10 Wonderful (160 reviews) "Great breakfast let me check in early was very nice " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jamie £57 includes taxes & fees 26 Jan - 27 Jan [](https://www.expedia.co.uk/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/416a6a90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/w3840h2559x0y1-9ec7e104.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/046d0e63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/980000/976200/976140/f8b9cd17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Southwest St. Louis [](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-Southwest-St-Louis.h976140.Hotel-Information) Valley Park 9.6/10 Exceptional (1,005 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maureen £104 includes taxes & fees 27 Jan - 28 Jan [](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-Southwest-St-Louis.h976140.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/188fac9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/97b3b5d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/51c38da4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/ac863486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Warrenton [](https://www.expedia.co.uk/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information) Warrenton 7.4/10 Good (1,001 reviews) "Nice place and nice people " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Columbus £63 includes taxes & fees 26 Jan - 27 Jan [](https://www.expedia.co.uk/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information) ![Free daily English breakfast ](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/d4056513.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed with Sofa bed, Kitchenette | Living area | 55-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/737d5070.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/4a2e04c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite, Multiple Beds | Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/4fe3b63f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Hotel Quincy [](https://www.expedia.co.uk/Quincy-Hotels-Heritage-Hotel-Quincy.h110496029.Hotel-Information) Quincy 8.8/10 Excellent (285 reviews) "Great hotel clean and quiet " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danielle £50 includes taxes & fees 29 Jan - 30 Jan [](https://www.expedia.co.uk/Quincy-Hotels-Heritage-Hotel-Quincy.h110496029.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-05&endDate=2026-02-06®ionId=6058818&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Northeast Missouri Hotel Reviews ![The Cheshire](https://images.trvl-media.com/lodging/1000000/30000/26100/26061/b6ec06de_y.jpg) ### The Cheshire 10/10 Excellent "This was an amazing hotel. The room was charming, clean and spacious. The breakfast was delicious. The staff was friendly and professional. It was very convenient to the zoo and art museum. I definitely recommend staying here." [](https://expedia.co.uk/St-Louis-Hotels-The-Cheshire.h26061.Hotel-Information) ![Embassy Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/5000000/4540000/4531500/4531472/d41360b0_y.jpg) ### Embassy Suites by Hilton St. Louis Downtown 10/10 Excellent "We always stay at embassy wherever we go. Always worth it and always perfect! St. Louis Embassy did not disappoint!" [](https://expedia.co.uk/St-Louis-Hotels-Embassy-Suites-By-Hilton-St-Louis-Downtown.h4531472.Hotel-Information) ![River City Casino & Hotel](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/33f9207d_y.jpg) ### River City Casino & Hotel 10/10 Excellent "Excellent service. Excellent accommodations. Excellent food." [](https://expedia.co.uk/St-Louis-Hotels-River-City-Casino-Hotel.h6456459.Hotel-Information) ![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/0bb9dbf3_y.jpg) ### Pear Tree Inn St. Louis Near Union Station 10/10 Excellent "Great staff!" [](https://expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Near-Union-Station.h26572.Hotel-Information) ![Clayton Plaza Hotel & Extended Stay](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/b3c5d3cd_y.jpg) ### Clayton Plaza Hotel & Extended Stay 10/10 Excellent "The room was great and the staff professional and friendly. The breakfast is always fabulous. " [](https://expedia.co.uk/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) ![Drury Inn & Suites St. Louis Union Station](https://images.trvl-media.com/lodging/1000000/40000/37700/37651/151222b4_y.jpg) ### Drury Inn & Suites St. Louis Union Station 10/10 Excellent "The staff were very friendly. We greatly enjoyed our stayed. The location was great with local attractions in walking distance. We will definitely stay here on our next trip to St. Louis." [](https://expedia.co.uk/St-Louis-Hotels-Drury-Inn-St-Louis-At-Union-Station.h37651.Hotel-Information) ![Magnolia Hotel St. Louis, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/9000000/8140000/8132000/8131949/4b87c2a3_y.jpg) ### Magnolia Hotel St. Louis, a Tribute Portfolio Hotel 10/10 Excellent "Everything was great the customer service rep at the desk exceptional customer service. " [](https://expedia.co.uk/St-Louis-Hotels-Magnolia-Hotel-St-Louis.h8131949.Hotel-Information) ![Pear Tree Inn St. Louis Airport](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2_y.jpg) ### Pear Tree Inn St. Louis Airport 10/10 Excellent "It was very clean. The staff were all friendly and efficient! Breakfast was good and the bed was so comfortable. I would definitely recommend!" [](https://expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![Marriott St. Louis Grand](https://images.trvl-media.com/lodging/1000000/910000/904800/904712/4c313173_y.jpg) ### Marriott St. Louis Grand 10/10 Excellent "Large room, very clean, centrally located!" [](https://expedia.co.uk/St-Louis-Hotels-Marriott-St-Louis-Grand.h904712.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Northeast Missouri cost? ### How many business hotels are there in Northeast Missouri? ### Why book your business hotel in Northeast Missouri with Expedia? ### How can I find cheap business hotels in Northeast Missouri? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Gay-Friendly Hotels in Boonville ](https://www.expedia.co.uk/Boonville-Hotels-Gay-Friendly-Hotel.0-0-d6775-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Cairo Hotels ](https://www.expedia.co.uk/Cairo-Hotels.d553248634983322461.Travel-Guide-Hotels) - [Callao Hotels ](https://www.expedia.co.uk/Callao-Hotels.d3000444667.Travel-Guide-Hotels) - [Canton Hotels ](https://www.expedia.co.uk/Canton-Hotels.d7238.Travel-Guide-Hotels) - [Adults Only Resorts & in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Adults-Only-Resorts.0-0-d901-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - 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