Title: TOP Business Hotels in Northeast Missouri, MO for 2026 | Expedia.co.uk [Northeast Missouri Travel Guide](https://expedia.co.uk/Northeast-Missouri.dx6058818)[Hotels in Northeast Missouri](https://expedia.co.uk/Northeast-Missouri-Hotels.d6058818.Travel-Guide-Hotels)[Holiday Rentals in Northeast Missouri](https://expedia.co.uk/Northeast-Missouri-Holiday-Rentals.d6058818.Travel-Guide-HolidayRentals)[Flights to Northeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Northeast-Missouri.d6058818.Travel-Guide-Flights)[Things to do in Northeast Missouri](https://expedia.co.uk/Things-To-Do-In-Northeast-Missouri.d6058818.Travel-Guide-Activities)[Northeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Northeast-Missouri.d6058818.Car-Hire-Guide)[Northeast Missouri Holidays](https://expedia.co.uk/Northeast-Missouri.d6058818.Holidays-City-Breaks) ![Grant\'s Farm which includes heritage architecture](https://images.trvl-media.com/place/6069377/88294c82-c384-49b1-b936-14bc595df677.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6069377/88294c82-c384-49b1-b936-14bc595df677.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Northeast Missouri Business Hotels Tonight [17 Mar - 18 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-03-17&endDate=2026-03-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [18 Mar - 19 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-03-18&endDate=2026-03-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [20 Mar - 22 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [27 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058818&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Northeast Missouri business-friendly hotels ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking | Pillow-top beds, desk, blackout curtains, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/9c660a01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/d203c711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Kirksville-University Area [](https://www.expedia.co.uk/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) Kirksville 9.2/10 Wonderful (176 reviews) "The hotel staff was very friendly and accommodating and even offered assistance with luggage. Check-in was fast. Staff even offered choice of rooms and provided pros and cons of each. Room was extremely clean, linens nice, and shower had great pressure. Hot breakfast of bacon, eggs, waffles along with pastries and fruit. Great stay! Very much worth the money." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda £53 includes taxes & fees 2 Apr - 3 Apr [](https://www.expedia.co.uk/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/6c9e28fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/de075f26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/1817d317.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, minibar, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/0bdc571d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Depot Inn and Suites [](https://www.expedia.co.uk/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information) La Plata 9.8/10 Exceptional (640 reviews) "Clean, comfortable rooms and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marlin £65 includes taxes & fees 22 Mar - 23 Mar [](https://www.expedia.co.uk/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information) ![Desk, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/d6669a71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/ba8e13b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/b520e740.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/16300/16249/74fd9989.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western On The River [](https://www.expedia.co.uk/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information) Hannibal 8.6/10 Excellent (1,004 reviews) "Tony did a great job at front desk answering all our questions about the room and Hannibal." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven £84 includes taxes & fees 19 Mar - 20 Mar [](https://www.expedia.co.uk/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/4e0fe2c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/7d037912.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cots/infant beds, rollaway beds](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/79af7d21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/983700/983646/12a7ffe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Hannibal West [](https://www.expedia.co.uk/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information) Hannibal 8.0/10 Very good (1,007 reviews) "Excellent hotel with great bathroom amenities and an excellent breakfast. Our traveling companion said the biscuits and gravy were the best she'd ever had. Highly recommend this hotel and the included breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendy £70 includes taxes & fees 26 Mar - 27 Mar [](https://www.expedia.co.uk/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information) ![Jetted bathtub](https://images.trvl-media.com/lodging/1000000/910000/904200/904104/7407aae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/910000/904200/904104/338e7091.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Honeymoon Suite, 1 King Bed, Non Smoking, Jetted Tub | Jetted bathtub](https://images.trvl-media.com/lodging/1000000/910000/904200/904104/763fd4e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Honeymoon Suite, 1 King Bed, Non Smoking, Jetted Tub | Living area | 32-inch TV with satellite channels](https://images.trvl-media.com/lodging/1000000/910000/904200/904104/f2923eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Oak Hill Inn & Suites [](https://www.expedia.co.uk/Canton-Hotels-Oak-Hill-Inn-Suites.h904104.Hotel-Information) Canton 9.2/10 Wonderful (914 reviews) "As always, Great Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chad £76 includes taxes & fees 1 Apr - 2 Apr [](https://www.expedia.co.uk/Canton-Hotels-Oak-Hill-Inn-Suites.h904104.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/863ee254.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed | Desk, iron/ironing board, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/5a40455a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/f63d6bd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/12000000/11310000/11309000/11308942/f01081f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Hannibal West [](https://www.expedia.co.uk/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information) Hannibal 9.6/10 Exceptional (1,001 reviews) "Would highly recommend to anyone needed an excellent hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth £95 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Hannibal-Hotels-Sleep-Inn-Suites.h11308942.Hotel-Information) ![Free daily English breakfast ](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/d4056513.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite, Multiple Beds | Premium bedding, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/4fe3b63f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 King Bed with Sofa bed, Kitchenette | Living area | 55-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/737d5070.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/111000000/110500000/110496100/110496029/4a2e04c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Hotel Quincy [](https://www.expedia.co.uk/Quincy-Hotels-Heritage-Hotel-Quincy.h110496029.Hotel-Information) Quincy 8.8/10 Excellent (316 reviews) "Clean room great service and staff is very helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Miguel £60 includes taxes & fees 18 Mar - 19 Mar [](https://www.expedia.co.uk/Quincy-Hotels-Heritage-Hotel-Quincy.h110496029.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/aadfb5be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/70cee110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/c9087452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham [](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) Fenton 8.0/10 Very good (1,137 reviews) "We stayed for a concert. Room was clean and staff were friendly. We would stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Faith £77 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/c19d4fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Refrigerator & Microwave | Hypo-allergenic bedding, down duvets, in-room safe, desk](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/de278a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/0d60e323.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Kirksville [](https://www.expedia.co.uk/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) Kirksville 9.2/10 Wonderful (602 reviews) "Very clean room, very friendly and helpful staff. Great place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colten £107 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/188fac9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/97b3b5d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/052a5869.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/130000/124500/124484/ac863486.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Warrenton [](https://www.expedia.co.uk/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information) Warrenton 7.4/10 Good (1,000 reviews) "The front desk stuff were nice and welcoming. The room was clean and the breakfast was great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dan £69 includes taxes & fees 25 Mar - 26 Mar [](https://www.expedia.co.uk/Warrenton-Hotels-Baymont-By-Wyndham-Warrenton.h124484.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-31&endDate=2026-04-01®ionId=6058818&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Northeast Missouri Hotel Reviews ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg) ### The Wildwood Hotel 10/10 Excellent "First time in the St. louis area & staying at this hotel. The property was in a great little location that wasn’t overly far from St. louis. The staff were lovely and very kind. Our room actually go upgraded for free as well as a free beverage due to my expedia status (i’ve done lots of traveling but have never had this before). The breakfast was decent, there was lots of options for everyone. We didn’t have the opportunity to use the pool or hot tub but there was always people in the area and looked very clean. Overall very impressed and would come back!" [](https://expedia.co.uk/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/3056142b_y.jpg) ### Pear Tree Inn St. Louis Near Union Station 8/10 Good "Beds were stiff" [](https://expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Near-Union-Station.h26572.Hotel-Information) ![ The Royal Sonesta Chase Park Plaza St. Louis](https://images.trvl-media.com/lodging/1000000/470000/465800/465749/9bee4fd7_y.jpg) ### The Royal Sonesta Chase Park Plaza St. Louis 10/10 Excellent "The property was well maintained, and everybody was very helpful polite the day was phenomenal. We couldn’t ask for anything else. It was great." [](https://expedia.co.uk/St-Louis-Hotels-The-Chase-Park-Plaza-Royal-Sonesta-St-Louis.h465749.Hotel-Information) ![Clayton Plaza Hotel & Extended Stay](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/5c61cbf8_y.jpg) ### Clayton Plaza Hotel & Extended Stay 6/10 Okay "Friendly staff at breakfast. The hotel rooms are ok, the bathrooms are nice and updated, but the floors in the rooms need to mopped properly as they feel quite sticky and dirty. Good that it has a gym, but there’s a mismatch of single weights of varying size. The use of plastic wrapped plastic cutlery at breakfast is not great, would be great if that was changed into something more environmentally friendly." [](https://expedia.co.uk/St-Louis-Hotels-Clayton-Plaza-Hotel-Extended-Stay.h18144.Hotel-Information) ![Renaissance St. Louis Airport Hotel](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/a81cbeae_y.jpg) ### Renaissance St. Louis Airport Hotel 10/10 Excellent "Clean room " [](https://expedia.co.uk/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) ![Hilton St. Louis Airport](https://images.trvl-media.com/lodging/1000000/10000/7800/7743/c57dfbd2_y.jpg) ### Hilton St. Louis Airport 10/10 Excellent "The room was amazing an I enjoyed the quite. " [](https://expedia.co.uk/St-Louis-Hotels-Hilton-St-Louis-Airport.h7743.Hotel-Information) ![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/b53f4594_y.jpg) ### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham 2/10 Terrible "Rooms were filthy, trash behind headboards, dirty sheets on pull out sofa bed, shower was dirty, no toliet paper in bathroom, dirty diaper and popcorn spilled all in elevators. Room smelled terrible of Marijuana when we entered. When we arrived our door to our room was open and unlocked. The trash had not even been taken out. Went to swim and the hot tub had so much chlorine in it that it caused my daughter to receive chemical burns all over her body. The smell of chlorine was so bad we had to open the doors to the indoor pool to let the smell out. The heated pool was freezing cold. " [](https://expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information) ![Pear Tree Inn St. Louis Airport](https://images.trvl-media.com/lodging/2000000/1100000/1096600/1096579/fc156cf2_y.jpg) ### Pear Tree Inn St. Louis Airport 10/10 Excellent "I only spent one night, but the hotel is clean, has a good breakfast, friendly staff, and a great airport shuttle. Good place to stay." [](https://expedia.co.uk/St-Louis-Hotels-Pear-Tree-Inn-St-Louis-Airport.h1096579.Hotel-Information) ![Drury Inn & Suites St. Louis Union Station](https://images.trvl-media.com/lodging/1000000/40000/37700/37651/151222b4_y.jpg) ### Drury Inn & Suites St. Louis Union Station 10/10 Excellent "Good experience. " [](https://expedia.co.uk/St-Louis-Hotels-Drury-Inn-St-Louis-At-Union-Station.h37651.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Northeast Missouri cost? ### How many business hotels are there in Northeast Missouri? ### Why book your business hotel in Northeast Missouri with Expedia? ### How can I find cheap business hotels in Northeast Missouri? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Gay-Friendly Hotels in Boonville ](https://www.expedia.co.uk/Boonville-Hotels-Gay-Friendly-Hotel.0-0-d6775-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Cairo Hotels ](https://www.expedia.co.uk/Cairo-Hotels.d553248634983322461.Travel-Guide-Hotels) - [Callao Hotels ](https://www.expedia.co.uk/Callao-Hotels.d3000444667.Travel-Guide-Hotels) - [Canton Hotels ](https://www.expedia.co.uk/Canton-Hotels.d7238.Travel-Guide-Hotels) - [Adults Only Resorts & in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Adults-Only-Resorts.0-0-d901-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - 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