Mesopotamia Holidays

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Mesopotamia Holiday

Book a holiday package to Mesopotamia and feel how exhilarating it is to travel just the way you like. If Corrientes is among your stops, you'll be amazed by its culture, nature and festivals. Your trip to Mesopotamia wouldn't be complete without experiencing some of its most well-known cities, starting with Corrientes. A couple of the most popular attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. Concordia is another favourite city with Mesopotamia travellers. Visitors to this exciting city enjoy Termas Del Ayui and Concordia Speedway. Quit dreaming and get packing, because your Mesopotamia holiday is only clicks away with Expedia.

Things to do in Mesopotamia

In Mesopotamia, Argentina, indulge in birdwatching and hiking amidst stunning wildlife. Explore the fascinating ancient Mesopotamian culture through specialised tours, where you can witness various rituals and partake in cultural experiences. Don't miss the vibrant festive processions that showcase the region's rich traditions, making your visit both enlightening and entertaining.

Shopping

In Mesopotamia, visit the Shopping Sur to discover a variety of local crafts and souvenirs. The nearby Alto Avellaneda Shopping offers a mix of international brands and dining options. Explore local markets for unique gifts that capture the region's culture and charm.

Recreation

Mesopotamia Wellness Retreat offers rejuvenating spa treatments in a tranquil setting, surrounded by lush landscapes. Engage in yoga sessions by the river, and indulge in organic cuisine sourced from local farms, promoting both relaxation and healthy living during your stay.

Adventure

In Mesopotamia, explore the lush landscapes of the Iberá Wetlands, where you can kayak through vibrant ecosystems teeming with wildlife. Experience thrilling boat rides on the Paraná River, and hike the captivating trails of the Quebrada de los Cóndores to witness stunning vistas and unique birdwatching opportunities.

Nightlife

In Mesopotamia, Argentina, experience vibrant nightlife at lively bars and clubs in Posadas. Visit hotspots like La Ronda and La Vida, where you can enjoy live music, regional cocktails, and dance until dawn. The atmosphere is warm, welcoming, and filled with the rhythm of Latin beats.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mesopotamia

Mesopotamia, Argentina, offers a wealth of adventure and scenic beauty, particularly through its national parks. Visitors can immerse themselves in the rich history of the ancient Mesopotamians, exploring their numerous gods and the vibrant festivals that once celebrated their culture. Whether you seek outdoor experiences or a glimpse into the past, Mesopotamia promises an enriching getaway for all types of travellers.

  • Portal Carambola: A stunning national park 22.5km from Mesopotamia, offering breathtaking scenery, outdoor adventures, and a chance to immerse yourself in nature's beauty.

Best time to go to Mesopotamia

The best time to visit Mesopotamia depends on your weather preferences. The hottest average temperature around Mesopotamia is in January and February. February is mostly sunny. The coolest average temperature around Mesopotamia is in May and July. July is mostly sunny.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January80.1°F (26.700000000000003°C)Light RainSunnyModerately HighAverage
February77.7°F (25.4°C)Light RainMostly Sunny
March72.9°F (22.700000000000003°C)Light RainMostly SunnyModerately HighAverage
April66.7°F (19.3°C)Light RainMostly SunnyAverageAverage
May59.5°F (15.3°C)Light RainMostly Sunny
June60.1°F (15.6°C)Light RainMostly Sunny
July53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly High
August63.7°F (17.6°C)Light RainMostly SunnyAverageSlightly High
September60.6°F (15.9°C)Light RainMostly SunnyAverageAverage
October65.8°F (18.8°C)Light RainMostly SunnyAverageAverage
November72.3°F (22.4°C)Light RainSunnyModerately HighAverage
December77.0°F (25.0°C)Light RainSunnyAverageSlightly High

Tips to save on your trip to Mesopotamia

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling to Mesopotamia during the low season () for more affordable options.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Mesopotamia Holiday Packages

Encounter a range of tropical vegetation and animals in the lush terrain of this area where you will find one of the world’s largest waterfalls.

Mesopotamia is a vast green and tropical expanse that has some of Argentina’s most idyllic landmarks. It contains the world-famous Iguazú FallsOpens in a new window, which is among the widest and tallest waterfalls in the world. Travel around this lush area for its exotic animals and vegetation and small towns with thriving culture.

The highlight of the region is the Iguazú National Park, which consists of tropical forests and the roaring waterfall that can be seen from the Brazilian and Argentine sides of the park. Wander through the forests to spot exotic creatures, such as tapirs, anteaters and ocelots.

The town of Puerto Iguazú outside the park has many steak restaurants and the Three Borders Mark, which has a fountain and a view of the Brazilian and Paraguayan flanks of the river. Bring the kids to the Hummingbird Garden (Jardin de los Picaflores).

Travel south for a few hours by bus to reach the Ibera Wetlands, which contains extraordinary flooded forests. It is a maze of water networks stretching across an area of 3.2 million acres (1.3 million hectares) with fascinating animals roaming its wet fields. Nearby is Posadas, where you will find the San Roque González de Santa Cruz Bridge linking Argentina and Paraguay.

At the southern end of the area is Gualeguaychú, which hosts a thriving carnival around the Gualeguaychú Plaza San Martín at the beginning of Lent. Listen to the Chamamé folk music of the area that blends Spanish guitar and accordion.

Located in the northeastern region of Argentina, Mesopotamia lies on the borders with Paraguay and Brazil. It incorporates the provinces of Entre RíosOpens in a new window, CorrientesOpens in a new window and MisionesOpens in a new window. Fly to Cataratas del Iguazú International Airport and stay in the town of Puerto Iguazú during your trip to the falls. Get around the vast region by bus. Expect scorching summers with heavy rainfall and warm winters. Try the Argentine traditional hot beverage of mate, a herbal tea made from leaves from the yerba plant, which is mostly grown in this area.

Mesopotamia is made up of fertile land with gushing cascades, exotic flora and fauna and intriguing towns.

Mesopotamia Essential Information

Language
Spanish
Currency
Argentine pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Ministro Pistarini Intl. Airport (EZE)

Top hotels in Mesopotamia

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
The price is £108 per night from 5 Aug to 6 Aug
£108
5 Aug - 6 Aug
9.8/10 Exceptional! (39 reviews)
"Me da mucho gusto que Corrientes tenga un hotel de esta categoría. El personal es excelente, desde el front desk hasta las personas de mantenimiento. Cuando supieron que íbamos a casarnos nos enviaron una bandeja de refreshments con una hermosa tarjeta de felicitación. La presión y temperatura de ..."

Reviewed on 6 Jun 2026

Marriott Corrientes Hotel
Costarenas Hotel & Spa

Costarenas Hotel & Spa

3.5 out of 5
12 de Abril y Quiros Colon Entre Rios
Fully refundableReserve now, pay when you stay
The price is £91 per night from 1 Aug to 2 Aug
£91
1 Aug - 2 Aug
8.8/10 Excellent! (64 reviews)
"Estaba todo muy lindo"

Reviewed on 8 Jun 2026

Costarenas Hotel & Spa
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
The price is £28 per night from 6 Aug to 7 Aug
£28
6 Aug - 7 Aug
O2 Hotel Gualeguaychú
See all 529 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Stay near popular Mesopotamia attractions

A large church with a prominent dome and two bell towers.

Basilica Nuestra Senora De Itati

Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.
See properties

Frequently asked questions

Why should I book my Mesopotamia holiday with Expedia?
With excellent-value airfares, accommodation and car hire choices all in the same place, Expedia makes planning your Mesopotamia holiday a piece of cake. What's more, we can help you bundle your bookings into a package holiday so you can get even more savings. Choose from fabulous properties, add your flights and/or a hire car (and maybe also some exciting activities!) and score incredible prices. Need to cancel? Expedia offers a flexible cancellation policy for many reservations. To find out more, head over to our Customer Service Portal link.
When is the best time of year to holiday in Mesopotamia?
Mesopotamia is very popular in March, April and November. If you don't like big crowds and prefer a quieter pace, lock in your trip for June, July and August. With daytime average temperatures of 12ºC, July is the coolest period in Mesopotamia. The warmest time of year is January, when you can expect averages of 26ºC during the day. Whatever the temperature, you'll find loads to keep you entertained here.
What are the top hotels for my holiday in Mesopotamia?
Hotel Plaza and 11 Peyret Rent Aparts know how to make their guests feel welcome in Colon. If you also plan to stay in Parana, look up Hathor Concordia and Beautiful Brand New 2 Bedroom House with Garage. Both are top picks with travellers.
How do I get a cheap holiday to Mesopotamia?
Our Mesopotamia holidays mean plenty of savings for the savvy traveller. For the best deal, simply bundle your hotel, flights and activities. But bargain prices are only the start of your next epic adventure. Book with Expedia and and you'll have over 400 airlines and 321,000 hotel options worldwide to pick from. No matter your budget or style, there's a holiday here that's perfect for you. Learn more about how you can save money on your next holiday when you bundle your flight and hotel bookings with Expedia.
What should I do on my Mesopotamia holiday?
There are plenty of things to put on your travel agenda during your holiday in Mesopotamia. Termas de Federacion, Termas De Colón, Termas Del Ayui and Basilica Nuestra Senora De Itati are among the major attractions.
Do I need a visa for my Mesopotamia holiday?
Official government websites will have all the information you need on visa requirements, application procedures and necessary documentation. Your nationality and the purpose of your visit, whether it be for work or pleasure, will determine if you need a visa for Mesopotamia. Also be sure that your passport is up to date and has at least six months validity remaining beyond your return date. Finalise all your travel planning well in advance to avoid any last-minute surprises.
What should I wear on my Mesopotamia holiday?
Do some research into the types of things people in Mesopotamia wear, and maybe even look up style blogs for some fashion tips. Aim to create a versatile wardrobe full of pieces that suit your destination and show off your unique sense of style. The weather will dictate your choice of clothing, so check the forecast for the places you want to visit. Mesopotamia is at its warmest in January, with average daily temperatures of 26ºC. July is the coolest time of year here with the mercury hovering around 12ºC in the daytime.
What does an Expedia Mesopotamia holiday include?
Flights, car hires and hotels, or any combination of the three — it's your choice. Whether you're visiting Mesopotamia with the family or travelling with your friends, there's a package to match every budget and style. Once you've made your booking, why not add on some tours as well? Expedia has a wide range of properties in Mesopotamia, providing you with the freedom and flexibility to personalise your escape. Hotels and apartments are two of the most sought-after stays for visitors here.
Does Expedia offer Book Now, Pay Later Mesopotamia holidays?
Your bank balance shouldn't prevent you from going on holiday, so Expedia has devised a solution to help. Now that we've teamed up with online lender Klarna, it's easier than ever to book a dream getaway without eating away at your savings. Klarna offers flexible payment options during the checkout process that take the worry out of budgeting for your break. Consider one of these flexible payment options:

  • Pay monthly holidays: Klarna offers convenient monthly payment plans that work for all budget sizes, so you can jet away on that well-deserved holiday now.
  • No-deposit holidays: If no upfront fee for your getaway makes pressing that "book now" button more stress-free, consider a no-deposit holiday plan with Klarna so you can Book Now, Pay Later!

Can I choose my airline with a Mesopotamia Expedia holiday?
Yes — and it's simple too. Expedia has access to more than 400 partner airlines globally. Our holiday packages give you the freedom to take your pick of available flights, hotels and activities that suit you.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.