Mesopotamia Holidays from £1,057

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Your Mesopotamia Holiday

Book a holiday package to Mesopotamia and feel how exhilarating it is to travel just the way you like. If Corrientes is among your stops, you'll be amazed by its culture, nature and festivals. Your trip to Mesopotamia wouldn't be complete without experiencing some of its most well-known cities, starting with Corrientes. A couple of the most popular attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. Concordia is another favourite city with Mesopotamia travellers. Visitors to this exciting city enjoy Termas Del Ayui and Concordia Speedway. Quit dreaming and get packing, because your Mesopotamia holiday is only clicks away with Expedia.

Top Mesopotamia Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Up Congreso Hotel

Up Congreso Hotel

3 out of 5
El Centro
Price was £1,107, price is now £1,057 per person
£1,057
per person
16 May - 19 May
found 8 hours ago
Return direct flight included
Manchester (MAN) to Buenos Aires (EZE)
8.4/10 Very Good! (402 reviews)
Clean room and great breakfast!

Reviewed on 13 Jan 2026

Mérit Parque Leloir by Amérian

Mérit Parque Leloir by Amérian

3 out of 5
Price was £1,138, price is now £1,075 per person
£1,075
per person
16 May - 19 May
found 8 hours ago
Return direct flight included
Manchester (MAN) to Buenos Aires (EZE)
9.2/10 Wonderful! (25 reviews)
Excellent property and services

Reviewed on 6 Aug 2025

Apassionata Tango Hotel

Apassionata Tango Hotel

3 out of 5
Balvanera
Price was £1,134, price is now £1,071 per person
£1,071
per person
16 May - 19 May
found 8 hours ago
Return direct flight included
Manchester (MAN) to Buenos Aires (EZE)
8.2/10 Very Good! (39 reviews)
Our stay at Apassionata was amazing. Fabian is incredibly attentive and kind and made us feel very welcome. He was always unavailable for questions and concerns and was quick to resolve any problems. Initially we had some issues with the heating in our room and when it couldn't be fixed, we were quickly moved to a much better room. The small size of the hotel allowed so that we got to know the other guests that were staying there. Overall our stay at Apassionata was fabulous.

Reviewed on 26 Sept 2019

Mérit San Telmo by Amérian

Mérit San Telmo by Amérian

3 out of 5
El Centro
Price was £1,129, price is now £1,070 per person
£1,070
per person
16 May - 19 May
found 8 hours ago
Return direct flight included
Manchester (MAN) to Buenos Aires (EZE)
8.4/10 Very Good! (822 reviews)
Property needs to be remodeled. Everything inside is outdated or is falling apart

Reviewed on 29 Nov 2025

CASARICA Aparts

CASARICA Aparts

3.5 out of 5
El Centro
Price was £1,128, price is now £1,072 per person
£1,072
per person
16 May - 19 May
found 8 hours ago
Return direct flight included
Manchester (MAN) to Buenos Aires (EZE)
9.2/10 Wonderful! (25 reviews)
The property overall was fine considering the price we paid. Ammenities and location was good. There is a carrefour next door. Communication with the property was good. Dislikes were the towels. They were stained. We requested additional towels but they were not any better. Water easily splashes out of the shower, making the floor wet. The main room along floor/wall looks dirty.

Reviewed on 25 Jun 2025

Things to do in Mesopotamia

In Mesopotamia, Argentina, indulge in birdwatching and hiking amidst stunning wildlife. Explore the fascinating ancient Mesopotamian culture through specialised tours, where you can witness various rituals and partake in cultural experiences. Don't miss the vibrant festive processions that showcase the region's rich traditions, making your visit both enlightening and entertaining.

Shopping

In Mesopotamia, visit the Shopping Sur to discover a variety of local crafts and souvenirs. The nearby Alto Avellaneda Shopping offers a mix of international brands and dining options. Explore local markets for unique gifts that capture the region's culture and charm.

Recreation

Mesopotamia Wellness Retreat offers rejuvenating spa treatments in a tranquil setting, surrounded by lush landscapes. Engage in yoga sessions by the river, and indulge in organic cuisine sourced from local farms, promoting both relaxation and healthy living during your stay.

Adventure

In Mesopotamia, explore the lush landscapes of the Iberá Wetlands, where you can kayak through vibrant ecosystems teeming with wildlife. Experience thrilling boat rides on the Paraná River, and hike the captivating trails of the Quebrada de los Cóndores to witness stunning vistas and unique birdwatching opportunities.

Nightlife

In Mesopotamia, Argentina, experience vibrant nightlife at lively bars and clubs in Posadas. Visit hotspots like La Ronda and La Vida, where you can enjoy live music, regional cocktails, and dance until dawn. The atmosphere is warm, welcoming, and filled with the rhythm of Latin beats.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Mesopotamia

Mesopotamia, Argentina, offers a wealth of adventure and scenic beauty, particularly through its national parks. Visitors can immerse themselves in the rich history of the ancient Mesopotamians, exploring their numerous gods and the vibrant festivals that once celebrated their culture. Whether you seek outdoor experiences or a glimpse into the past, Mesopotamia promises an enriching getaway for all types of travellers.

  • Portal Carambola: A stunning national park 22.5km from Mesopotamia, offering breathtaking scenery, outdoor adventures, and a chance to immerse yourself in nature's beauty.

Best time to go to Mesopotamia

The best time to visit Mesopotamia depends on your weather preferences. The hottest average temperature around Mesopotamia is in January and February. February is mostly sunny. The coolest average temperature around Mesopotamia is in May and July. July is mostly sunny.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January80.1°F (26.700000000000003°C)Light RainSunnyModerately HighAverage
February77.7°F (25.4°C)Light RainMostly Sunny
March72.9°F (22.700000000000003°C)Light RainMostly SunnyModerately HighAverage
April66.7°F (19.3°C)Light RainMostly SunnyAverageAverage
May59.5°F (15.3°C)Light RainMostly Sunny
June60.1°F (15.6°C)Light RainMostly Sunny
July53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly High
August63.7°F (17.6°C)Light RainMostly SunnyAverageSlightly High
September60.6°F (15.9°C)Light RainMostly SunnyAverageAverage
October65.8°F (18.8°C)Light RainMostly SunnyAverageAverage
November72.3°F (22.4°C)Light RainSunnyModerately HighAverage
December77.0°F (25.0°C)Light RainSunnyAverageSlightly High

Tips to save on your trip to Mesopotamia

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling to Mesopotamia during the low season () for more affordable options.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Mesopotamia Holiday Packages

Encounter a range of tropical vegetation and animals in the lush terrain of this area where you will find one of the world’s largest waterfalls.

Mesopotamia is a vast green and tropical expanse that has some of Argentina’s most idyllic landmarks. It contains the world-famous Iguazú FallsOpens in a new window, which is among the widest and tallest waterfalls in the world. Travel around this lush area for its exotic animals and vegetation and small towns with thriving culture.

The highlight of the region is the Iguazú National Park, which consists of tropical forests and the roaring waterfall that can be seen from the Brazilian and Argentine sides of the park. Wander through the forests to spot exotic creatures, such as tapirs, anteaters and ocelots.

The town of Puerto Iguazú outside the park has many steak restaurants and the Three Borders Mark, which has a fountain and a view of the Brazilian and Paraguayan flanks of the river. Bring the kids to the Hummingbird Garden (Jardin de los Picaflores).

Travel south for a few hours by bus to reach the Ibera Wetlands, which contains extraordinary flooded forests. It is a maze of water networks stretching across an area of 3.2 million acres (1.3 million hectares) with fascinating animals roaming its wet fields. Nearby is Posadas, where you will find the San Roque González de Santa Cruz Bridge linking Argentina and Paraguay.

At the southern end of the area is Gualeguaychú, which hosts a thriving carnival around the Gualeguaychú Plaza San Martín at the beginning of Lent. Listen to the Chamamé folk music of the area that blends Spanish guitar and accordion.

Located in the northeastern region of Argentina, Mesopotamia lies on the borders with Paraguay and Brazil. It incorporates the provinces of Entre RíosOpens in a new window, CorrientesOpens in a new window and MisionesOpens in a new window. Fly to Cataratas del Iguazú International Airport and stay in the town of Puerto Iguazú during your trip to the falls. Get around the vast region by bus. Expect scorching summers with heavy rainfall and warm winters. Try the Argentine traditional hot beverage of mate, a herbal tea made from leaves from the yerba plant, which is mostly grown in this area.

Mesopotamia is made up of fertile land with gushing cascades, exotic flora and fauna and intriguing towns.

Mesopotamia Essential Information

Language
Spanish
Currency
Argentine pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Ministro Pistarini Intl. Airport (EZE)

Top hotels in Mesopotamia

O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
The price is £34 per night from 17 Mar to 18 Mar
£34
17 Mar - 18 Mar
7.8/10 Good! (78 reviews)
Si un huesped pregunta si se olvida algo en la habitacion tener la deliquicadesa de contestar por eso la calificaccion no me volveria a quedar

Reviewed on 23 Dec 2025

O2 Hotel Gualeguaychú
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5 Concordia Entre Rios
Fully refundableReserve now, pay when you stay
The price is £50 per night from 15 Apr to 16 Apr
£50
15 Apr - 16 Apr
8.6/10 Excellent! (370 reviews)
AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road.

Reviewed on 22 Dec 2025

Hathor Concordia
Turismo Hotel Casino

Turismo Hotel Casino

2.5 out of 5
650 Entre Ríos Corrientes Corrientes
Fully refundableReserve now, pay when you stay
The price is £84 per night from 17 Mar to 18 Mar
£84
17 Mar - 18 Mar
8/10 Very Good! (4 reviews)
Boa infraestrutura, e localização!

Reviewed on 4 Feb 2026

Turismo Hotel Casino
See all 513 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Can I cancel my flight booking to Mesopotamia due to COVID-19?
If you haven't booked yet, glance over the terms and conditions of the airline you're considering. If you've already reserved your flight to Mesopotamia, make use of our Customer Service Portal. It will help determine which COVID-19 policies apply to your booking and provide advice on the next steps.
What's the best way to find cheap flights to Mesopotamia that have flexible change policies?
Search for your bargain flights to Mesopotamia, then tick the "No change fee" box directly underneath the "Flexible change policies" heading. It's that easy. We know that plans change and flexibility is essential, so you can book with confidence with Expedia.
What are some of the general tips for travellers to Mesopotamia during the COVID-19 outbreak?
If it's your first time travelling during the COVID-19 pandemic, you'll notice a range of new rules and restrictions in place. Take note of these tips and make your escape to Mesopotamia a smooth one:
  • Research if any travel restrictions apply to your destination and origin before booking. Also check if there are any requirements you'll have to follow on arrival, such as health testing.
  • Keep your face mask on even during airport screening. A TSA employee will require you to lower your mask temporarily to verify your identity.
  • Instead of handing a TSA employee your boarding pass, position it directly on the scanner yourself. When that's done, hold it up for inspection.
  • You're permitted to take one container of hand sanitizer up to 12 oz (350 ml) in your hand luggage. This will need to be taken out for screening.
  • Place any personal items (phone, wallet and keys for example) in your carry-on rather than a bin to minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA employee to handle and inspect your belongings.

Which airlines fly to Mesopotamia?
Book your ticket with LATAM Airlines and then start putting together your Mesopotamia travel itinerary. This top airline provides 143 flights each month to Ministro Pistarini Intl. Airport (EZE), a major gateway.
How can I find cheap tickets to Mesopotamia?
One of the easiest ways to snare cheap tickets to Mesopotamia is to be flexible with your dates. Search for your flights, then click "flexible dates" above the results. It will bring up the cheapest prices for nearby days. The lowest price for a flight to Mesopotamia in the last seven days was . Booking ahead will generally help you get an even better deal.
How much is a flight to Mesopotamia?
You could have scored a return ticket to Mesopotamia from anywhere between and in the last seven days. For one-way trips leaving from (), the lowest amount paid during this period was just .
What are the most popular airports to fly into in Mesopotamia?
Book your flight to Ministro Pistarini Intl. Airport (EZE) and sample all that Mesopotamia has to offer. As the region's main entry point, around 850 flights land here each month.
When is the cheapest time to fly to Mesopotamia?
Leave for Mesopotamia early on in the week and you'll usually be rewarded more economical fares. Tuesday is typically the cheapest day to get on a plane, followed closely by Monday. If you'd like to avoid the most expensive flights, keep clear of Saturdays.
How much is a plane ticket to Mesopotamia?
Seats to Mesopotamia ranged from to in the last seven days. Normally, the earlier you make a reservation, the better the deal.
Which airlines with flights to Mesopotamia employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have adopted new precautionary measures to help their passengers and crew get back in the air. Here are some good examples:
  • Aerolineas Argentinas - this airline is known for conducting passenger temperature checks and cleaning with disinfectant.
  • LATAM Airlines - this airline is known for providing passenger masks and capped capacity flights.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.