Title: Mesopotamia Travel Guide: Best of Mesopotamia, Argentina Travel 2025 | Expedia.co.uk [Hotels in Mesopotamia](https://expedia.co.uk/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Holiday Rentals in Mesopotamia](https://expedia.co.uk/Mesopotamia-Holiday-Rentals.d6208836.Travel-Guide-HolidayRentals)[Flights to Mesopotamia](https://expedia.co.uk/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mesopotamia.d6208836.Car-Hire-Guide)[Mesopotamia Holidays](https://expedia.co.uk/Mesopotamia.d6208836.Holidays-City-Breaks) # Mesopotamia Travel Guide ## Tourist Guide ![Mesopotamia showing a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196544-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia showing forest scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196542-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/71000/71962-Iguazu.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia featuring a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196547-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Mesopotamia which includes a river or creek and a cascade](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196546-Mesopotamia.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Mesopotamia Things to do #### The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration. A heady mix of ancient history, natural beauty and flamboyant festivals features in Argentina’s hot and humid Mesopotamia region. Be inspired by thundering waterfalls, spot exotic wildlife, experience indigenous traditions and relax at sleepy riverside resorts. Mesopotamia sits sandwiched between two mighty rivers, the Río Paraná and Rió Uruguay, and is covered with subtropical rainforests and wetlands. It includes the provinces of Misiones, Corrientes and Entre Ríos. Straddling the Río Iguazú in Misiones province, and shared between Argentina and Brazil, is the UNESCO-protected Iguazú National Park. Come here to admire the 275 individual waterfalls that make up the Iguazú Falls. Follow trails to panoramic lookouts, ride on a speedboat beneath a cascade and see wildlife such as toucans and monkeys. Access the Brazilian side of the park via a short drive from the town of Puerto Iguazú. Tour the towns of Misiones to appreciate the province’s diversity. Find a gemstone mine in Wanda, flower-filled gardens in Montecarlo and colonial architecture in Oberá. Visit 17th-century Jesuit ruins at San Ignacio. Saltos del Moconá, in Parque Provincial Moconá, is another waterfall worth visiting. Discover a breezy esplanade, graceful architecture and artisan markets, which showcase Guarani culture, in Corrientes city. Spend some time at easy-going river towns, including Itati and Ituzaingó. Be amazed by the craggy, granite ravine of Barrancas del Empedrado and hike amid thick forest in Mburucuya National Park. Go in search of some 350 bird species and the rare maned wolf at Esteros del Iberá wetlands reserve. Hot springs, fishing trips, pristine reserves and boisterous carnival parties await in Entre Ríos province. Gualeguaychú explodes into colour in February with arguably Argentina’s most famous carnival. The powdery, white sand at nearby Ñandubaysal evokes images of a tropical island paradise. Fish for huge dorado in Santa Elena and enjoy the charm of riverfront Colón. Don’t miss the enormous yatay palm trees in El Palmar National Park. The southern area of Mesopotamia is just a short bus ride from Buenos Aires. You can also fly to Corrientes and Puerto Iguazú and then get around the region via public buses and organised tours. - Top hotels in Mesopotamia - Top Holiday Rentals in Mesopotamia ![Costarenas Hotel & Spa](https://images.trvl-media.com/lodging/16000000/15370000/15362200/15362145/43c3ae01_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Costarenas Hotel & Spa 12 de Abril y Quiros, Colon, Entre Rios £80 16 Sept - 17 Sept Stay at this 3.5-star spa hotel in Colon. Enjoy free breakfast, free Wi-Fi and an outdoor pool. Popular attractions Dr. Herminio J. Quiros Park and Termas De ... [](https://expedia.co.uk/Hotel-Search?startDate=16%2F09%2F2025&endDate=17%2F09%2F2025&selected=15362145&PinnedHotelID=15362145&HadPinnedHotel=true®ionId=6208836) ![Hotel y Spa Termas del Este](https://images.trvl-media.com/lodging/34000000/33350000/33347000/33346911/459986e2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel y Spa Termas del Este Presidente Raúl alfonsín 877, Federacion Stay at this 3-star spa hotel in Federacion. Enjoy free breakfast, free Wi-Fi and free parking. Popular attractions Termas Federacion Water Park and Termas de ... [Get rates](https://expedia.co.uk/Hotel-Search?startDate=29%2F09%2F2025&endDate=30%2F09%2F2025&selected=33346911&PinnedHotelID=33346911&HadPinnedHotel=true®ionId=6208836) [](https://expedia.co.uk/Hotel-Search?startDate=29%2F09%2F2025&endDate=30%2F09%2F2025&selected=33346911&PinnedHotelID=33346911&HadPinnedHotel=true®ionId=6208836) ![Hathor Concordia](https://images.trvl-media.com/lodging/5000000/4670000/4668300/4668235/cc821f0d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hathor Concordia Ruta Nacional 14-km 264.5, Concordia, Entre Rios Stay at this 3-star business-friendly hotel in Concordia. Enjoy free breakfast, free Wi-Fi and room service. Popular attractions Concordia Golf Course and Castillo ... [Get rates](https://expedia.co.uk/Hotel-Search?startDate=29%2F09%2F2025&endDate=30%2F09%2F2025&selected=4668235&PinnedHotelID=4668235&HadPinnedHotel=true®ionId=6208836) [](https://expedia.co.uk/Hotel-Search?startDate=29%2F09%2F2025&endDate=30%2F09%2F2025&selected=4668235&PinnedHotelID=4668235&HadPinnedHotel=true®ionId=6208836) [See all 494 properties in Mesopotamia](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=16%2F09%2F2025&endDate=17%2F09%2F2025®ionId=6208836) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Agustín 1 Apart](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/9cad496d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Agustín 1 Apart 130 Gral. Pedro Ferré, Parana, Entre Ríos Stay at this 4-star aparthotel in Parana. Enjoy free Wi-Fi, parking (surcharge) and on-site spa services. Popular attractions Plaza de Mayo and Museu De Sitio ... [](https://expedia.co.uk/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information) ![Donsuites Apart Hotel](https://images.trvl-media.com/lodging/5000000/4950000/4947900/4947848/fb045420_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Donsuites Apart Hotel La Rioja 442, Corrientes, Corrientes Stay at this 3-star aparthotel in Corrientes. Enjoy free breakfast, free Wi-Fi and a rooftop terrace. Popular attractions Museo de Artesanías Tradicionales Folclóricas ... [](https://expedia.co.uk/Corrientes-Hotels-Donsuites-Apart-Hotel.h4947848.Hotel-Information) ![cabañas tesouro](https://images.trvl-media.com/lodging/83000000/82760000/82759900/82759864/ed260a79_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### cabañas tesouro mariano sanchez 158, Gualeguaychú, Entre Ríos Stay at this 3-star cabin in Gualeguaychú. Enjoy free Wi-Fi, a garden and furnished balconies or patios. Popular attractions Nuestra Senora Gaucha del Mate Monument ... [](https://expedia.co.uk/Gualeguaychu-Hotels-Cabanas-Tesouro.h82759864.Hotel-Information) [See all properties in Mesopotamia](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6208836&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Mesopotamia hotel availability [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-15&endDate=2025-09-16) [Tonight](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-15&endDate=2025-09-16) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-15&endDate=2025-09-16) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-15&endDate=2025-09-16)[15 Sept - 16 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-15&endDate=2025-09-16) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-16&endDate=2025-09-17) [Tomorrow night](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-16&endDate=2025-09-17) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-16&endDate=2025-09-17) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-16&endDate=2025-09-17)[16 Sept - 17 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=2025-09-16&endDate=2025-09-17) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [This weekend](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025)[19 Sept - 21 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=19%2F09%2F2025&endDate=21%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) [Next weekend](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) [](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025)[26 Sept - 28 Sept](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6208836&startDate=26%2F09%2F2025&endDate=28%2F09%2F2025) ### Popular places to visit ![El Palmar National Park](https://mediaim.expedia.com/destination/2/04a7d2876dc5e0ece83e6d60439d3e42.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### El Palmar National Park Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay. [](https://expedia.co.uk/El-Palmar-National-Park-Ubajay.d6096826.Attraction) ![San José Palace](https://mediaim.expedia.com/destination/2/d1f7ef40d5e0538d8a5a460f8d569c5e.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San José Palace You can spend an afternoon browsing the exhibits at San José Palace during your trip to Caseros. [](https://expedia.co.uk/San-Jose-Palace-Caseros.d553248635974793605.Attraction) #### Termas de Federacion Bring the children to Termas de Federacion and enjoy this exciting theme park in Federacion. Stroll along the beaches or discover the area's waterfalls. [](https://expedia.co.uk/Termas-De-Federacion-Federacion.d553248621532463682.Attraction) #### Termas De Colón Enjoy an outing to Termas De Colón during your stay in Colon. Discover the area's theatre scene and spas. [](https://expedia.co.uk/Termas-De-Colon-Colon.d553248635939591385.Attraction) #### Termas Concepcion Entrerios Bring your family to Termas Concepcion Entrerios and enjoy the excitement of this theme park in Concepción del Uruguay. Experience the area's art scene and museums. [](https://expedia.co.uk/Termas-Concepcion-Entrerios-Concepcion-del-Uruguay.d553248621532463656.Attraction) #### Basilica Nuestra Senora De Itati Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati. [](https://expedia.co.uk/Basilica-Nuestra-Senora-De-Itati-Municipo-de-Itati.d553248621532463967.Attraction) ## Cities near Mesopotamia ![Misiones which includes views as well as a couple](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/80000/80252-Misiones-Province.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Posadas [](https://expedia.co.uk/Posadas.dx2887) ![Rosario](https://mediaim.expedia.com/destination/1/15c19af6d32f4bdb8f5f454dedd0554e.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Rosario [](https://expedia.co.uk/Rosario.dx3026) ![Photo by Staci Travels](https://mediaim.expedia.com/destination/2/a93c7abbc3040bd02450f8d8d4c93094.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Carmelo [](https://expedia.co.uk/Carmelo.dx602813) ![Photo by Alejandro Ferrari](https://mediaim.expedia.com/destination/2/11375876ba96a0f4d6b62442f228c109.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Corrientes [](https://expedia.co.uk/Corrientes.dx6054203) - Cities near Mesopotamia [Concordia](https://expedia.co.uk/Concordia.dx892)[Posadas](https://expedia.co.uk/Posadas.dx2887)[Rosario](https://expedia.co.uk/Rosario.dx3026)[Salto](https://expedia.co.uk/Salto.dx3293)[Carmelo](https://expedia.co.uk/Carmelo.dx602813)[Esquina](https://expedia.co.uk/Esquina.dx6049079)[Corrientes](https://expedia.co.uk/Corrientes.dx6054203)[Fray Bentos](https://expedia.co.uk/Fray-Bentos.dx6085046)[Colon](https://expedia.co.uk/Colon.dx6144191)[Gualeguaychú](https://expedia.co.uk/Gualeguaychu.dx6201387)[Arenitas Blancas](https://expedia.co.uk/Arenitas-Blancas.dx6287721)[Nueva Palmira](https://expedia.co.uk/Nueva-Palmira.dx6287949)[Nuevo Berlin](https://expedia.co.uk/Nuevo-Berlin.dx6287950)[Colonia Carlos Pellegrini](https://expedia.co.uk/Colonia-Carlos-Pellegrini.dx6343234)[Itaqui](https://expedia.co.uk/Itaqui.dx6352005)[São Borja](https://expedia.co.uk/Sao-Borja.dx6352007)[Monte Caseros](https://expedia.co.uk/Monte-Caseros.dx6354755)[San Lorenzo](https://expedia.co.uk/San-Lorenzo.dx6358759)[Uguay](https://expedia.co.uk/Uguay.dx3000007149) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)