What is Isle of Palms South like?

Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.

How many hotels can I expect to find in Isle of Palms South?

With 10 Expedia hotels and other accommodation options in Isle of Palms South to choose from, this is a good starting point for exploring the greater Jacksonville Beach area.

If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?

Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.

What are the top things to see and do in Isle of Palms South?

Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.

The Best Hotels in Isle of Palms South, Jacksonville - 2026 Updated Prices

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Our top choices for Isle of Palms South hotels

Home2 Suites By Hilton Jacksonville Downtown

15.1 mi from Isle of Palms South

donna

includes taxes & fees

13 Jun - 14 Jun

Hyatt Studios Jacksonville/St Johns Town Center

5.4 mi from Isle of Palms South

Yoel

includes taxes & fees

26 May - 27 May

Premium bedding, desk, blackout curtains, iron/ironing board

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

13.1 mi from Isle of Palms South

Cameron

includes taxes & fees

25 May - 26 May

Holiday Inn Express Jacksonville - Blount Island by IHG

12.6 mi from Isle of Palms South

Amber

includes taxes & fees

26 May - 27 May

Hilton Jacksonville At Mayo Clinic

1.2 mi from Isle of Palms South

Tammy

includes taxes & fees

6 Jun - 7 Jun

Seahorse Oceanfront Inn

4.2 mi from Isle of Palms South

Margot

includes taxes & fees

16 Jun - 17 Jun

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

2.4 mi from Isle of Palms South

Jeffrey

includes taxes & fees

14 Jun - 15 Jun

AC Hotel Jacksonville St Johns Town Center

5.6 mi from Isle of Palms South

Doreen

includes taxes & fees

29 May - 30 May

Margaritaville Jacksonville Beach

Oceanfront, 3 mi from Isle of Palms South

Danielle

includes taxes & fees

26 May - 27 May

Wingate by Wyndham Jacksonville FL

9.4 mi from Isle of Palms South

Steven

includes taxes & fees

24 May - 25 May

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Isle of Palms, 1.2 mi from Isle of Palms South

Chad

includes taxes & fees

6 Jun - 7 Jun

Room, 2 Queen Beds, Balcony, Oceanfront (Balcony) | Premium bedding, in-room safe, desk, laptop workspace

Courtyard by Marriott Jacksonville Beach Oceanfront

Oceanfront, 3.2 mi from Isle of Palms South

Melissa

includes taxes & fees

26 May - 27 May

Best Western Oceanfront

Oceanfront, 2.9 mi from Isle of Palms South

LaTevia

includes taxes & fees

25 May - 26 May

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.3 mi from Isle of Palms South

Patsy

includes taxes & fees

31 May - 1 Jun

TownePlace Suites by Marriott® Jacksonville Mayport

6.1 mi from Isle of Palms South

Toni

includes taxes & fees

7 Jun - 8 Jun

Hyatt Regency Jacksonville

13.8 mi from Isle of Palms South

orienta

includes taxes & fees

25 May - 26 May

Studio, One King Bed, Non-Smoking | Hypo-allergenic bedding, in-room safe, desk, laptop workspace

Hampton Inn Jacksonville-I-295 East/Baymeadows

6.2 mi from Isle of Palms South

Mageshkumar

includes taxes & fees

27 May - 28 May

Tru by Hilton Jacksonville South Mandarin

13.3 mi from Isle of Palms South

michelle

includes taxes & fees

7 Jun - 8 Jun

Courtyard by Marriott Jacksonville I-295/East Beltway

8.2 mi from Isle of Palms South

Ana Maria Román

includes taxes & fees

8 Jun - 9 Jun

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

5.5 mi from Isle of Palms South

Kristin

includes taxes & fees

19 Jun - 20 Jun

View all properties

Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.

Fernandina Beach, Florida, USA Historic Downtown 1959

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

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Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

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Sawgrass

Beaches and riverfront are just a few things travellers like about Sawgrass. A stop by Mickler Beach is also recommended if you've got time to explore the area.

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Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

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American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

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Top Isle of Palms South Hotel Reviews

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

10/10 Excellent

"The hotel was so nice and clean and the staff went above and beyond to make our stay wonderful. We stopped there “impromptu”because we were heading home from Disney and the children were tired so we planned to stay one night before heading home but we were so impressed with the staff and the area we decided to make a weekend of it before traveling the rest of way home!"

Weekly Inn

2/10 Terrible

"I will never stay here again first off I was not aware there was an $100 deposit to stay here and the staff just looked at me like they didn’t care, the microwave in the room was not in English so it was difficult to use and I called the front desk three times with no answer so I had to walk up there to get help,and there were no spots to put my clothes at all!! The best part was it was quiet!!"

Southbank Hotel by Marriott Jacksonville Riverwalk

6/10 Okay

"I chose this hotel because I had been on the road for quite a few hours and I wanted to sit at a bar and have a drink. The very first photo of their hotel is their bar and that’s why I chose it. Nothing on Expedia said anything about the hotel being under construction and unfortunately, there was no bar to sit at. I didn’t mind the dust so much but again it wasn’t listed that it was under construction. I believe it’s gonna be a beautiful hotel once its all done though."

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

10/10 Excellent

"Very clean, and attention to detail. I loved walking into towel animals; it reminded me of the time I was on a cruise ship and immediately cheered me up. Breakfast was great too, and shuttles to Mayo are amazing. Although I didn't use it, knowing it was an option was nice to know."

Search Hotels in Isle of Palms South, Jacksonville

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Our top choices for Isle of Palms South hotels

Home2 Suites By Hilton Jacksonville Downtown

Hyatt Studios Jacksonville/St Johns Town Center

La Quinta Inn & Suites by Wyndham Jacksonville Mandarin

Holiday Inn Express Jacksonville - Blount Island by IHG

Hilton Jacksonville At Mayo Clinic

Seahorse Oceanfront Inn

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

AC Hotel Jacksonville St Johns Town Center

Margaritaville Jacksonville Beach

Wingate by Wyndham Jacksonville FL

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Courtyard by Marriott Jacksonville Beach Oceanfront

Best Western Oceanfront

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

TownePlace Suites by Marriott® Jacksonville Mayport

Hyatt Regency Jacksonville

Hampton Inn Jacksonville-I-295 East/Baymeadows

Tru by Hilton Jacksonville South Mandarin

Courtyard by Marriott Jacksonville I-295/East Beltway

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Where to stay in Isle of Palms South

Amelia City

Downtown Jacksonville

Sawgrass

Southside

American Beach

Top Isle of Palms South Hotel Reviews

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

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