South Main Travel Guide
Houston
Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the entertainment choices and acclaimed art galleries in this vibrant area.
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
MD Anderson Cancer Center
If MD Anderson Cancer Center is what brings you to town, hopefully you'll have a chance to explore more of Houston.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art galleries and great live music in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art galleries and lively festivals in this vibrant area.
Things to do
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Houston: Houston Botanic Garden Entry Ticket
Houston Museum of Natural Science: Butterfly Center Ticket
The Museum of Fine Arts, Houston Entry Ticket
Houston: Museum of Natural Science General Admission Ticket
Top hotels in South Main
Wyndham Houston near NRG Park/Medical Center
Terrible experience
Reviewed on 10 Apr 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Great place
Reviewed on 11 Apr 2026
Hotel Zaza Houston Museum District
I recently stayed at Hotel ZaZa Houston Museum District and had an absolutely wonderful experience from start to finish. The hotel perfectly blends luxury with a unique, artistic vibe that immediately sets it apart from more traditional stays. The atmosphere is truly one-of-a-kind—stylish, eclectic, ...
Reviewed on 10 Apr 2026
The Royal Sonesta Houston Galleria
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Reviewed on 10 Apr 2026
Blossom Hotel Houston, Curio Collection by Hilton
Conveniently
Reviewed on 10 Apr 2026
Heritage Place Houston Brookhollow
Always a great stay, clean room and great staff
Reviewed on 10 Apr 2026
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Astrodome, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travellers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
