A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Find luxury hotels in Florida Keys

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
  • Be picky

    Search almost a million properties worldwide

Check availability on Florida Keys Luxury Hotels

Tonight
31 Aug - 1 Sept
Tomorrow
1 Sept - 2 Sept
This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

Our top choices for Florida Keys luxury hotels

1. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
£345
includes taxes & fees
1 Sept - 2 Sept
The Islands of Islamorada

2. Ocean Key Resort - A Noble House Resort

Ocean Key Resort - A Noble House Resort
Key West Historic District
£269
includes taxes & fees
27 Sept - 28 Sept
Ocean Key Resort - A Noble House Resort

3. Pier House Resort & Spa

Pier House Resort & Spa
Key West Historic District
£256
includes taxes & fees
1 Oct - 2 Oct
Pier House Resort & Spa

4. Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West
Old Town Key West
£244
includes taxes & fees
1 Sept - 2 Sept
Opal Key Resort & Marina, Key West

5. Santa Maria Suites

Santa Maria Suites
Old Town Key West
  • Lavish Key West retreat features luxury suites, designer touches, 2 pools, and vibrant bar scene.
£282
includes taxes & fees
1 Sept - 2 Sept
Santa Maria Suites

6. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
£253
includes taxes & fees
13 Sept - 14 Sept
Playa Largo Resort & Spa, Autograph Collection

7. Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa
Key West Historic District
£219
includes taxes & fees
29 Sept - 30 Sept
Hyatt Centric Key West Resort and Spa

8. Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton
Old Town Key West
  • Beachfront luxury graces historic Key West resort with private shore access and spa treatments.
£226
includes taxes & fees
14 Sept - 15 Sept
Casa Marina Key West, Curio Collection by Hilton

9. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
£212
includes taxes & fees
1 Sept - 2 Sept
Reefhouse Resort & Marina

10. The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton
Old Town Key West
£197
includes taxes & fees
8 Sept - 9 Sept
The Reach Key West, Curio Collection by Hilton
View all properties

Find out more about Florida Keys

Florida Keysand its attractions for luxury travelers

The Florida Keys offer an exquisite playground for luxury travellers seeking both relaxation and adventure. Begin your journey in Key West, where you can explore the vibrant streets lined with historical architecture and indulge in exquisite dining at renowned establishments like Latitudes, known for its stunning sunset views and fresh seafood. Next, venture to the tranquil surroundings of Little Palm Island, a private resort accessible only by boat or seaplane, where you can unwind in a thatched-roof bungalow with unparalleled ocean views and a full-service spa. For those interested in marine life, a day trip to the Dry Tortugas National Park is a must; here, you can snorkel in crystal-clear waters, discovering vibrant coral reefs and diverse wildlife. The Keys also boast some of the finest fishing opportunities, with charter services available to take you out for a day on the water, targeting species like tarpon and bonefish. Finally, enjoy the laid-back elegance of Islamorada, where luxury resorts such as Cheeca Lodge offer lavish accommodations alongside activities like paddleboarding and sunset cruises. Staying in these luxurious settings ensures that every detail of your experience is catered to, allowing you to focus on making unforgettable memories.

Top Florida Keys Hotel Reviews

Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent
"Rainbow Reef is next door. Huge patio to dry gear. Scuba divers perfect spot!"
Marcy 4-night trip
Posted less than an hour ago
Waterside Suites & Marina
Bayside Inn Key Largo

Bayside Inn Key Largo

10/10 Excellent
"Great place"
luis 3-night trip
Posted 2 hours ago
Bayside Inn Key Largo
Lime Tree Bay Resort

Lime Tree Bay Resort

10/10 Excellent
"The property was very clean and has all the things needed for the stay. Only little details might be fixed like the cover of the outside furniture. Other than that the experience was excellent. Good for people that like fishing. Amazing canal in the back of the townhouse."
Marieta 2-night trip
Posted 2 hours ago
Lime Tree Bay Resort
Islander Resort

Islander Resort

8/10 Good
"Great property with an amazing concept, especially in an area where there aren’t many high-end properties offering this style and experience. The facilities are excellent, and overall we really enjoyed our stay. My only negative feedback is that a few members of staff were constantly on their phones watching clips and videos, often with the volume turned up. We found this quite annoying, particularly when trying to relax quietly by the pool. It would be great if staff could be reminded to use headphones or keep phone use to a minimum in guest relaxation areas. Room maintaince could also be better."
Asoka 2-night trip
Posted 3 hours ago
Islander Resort
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"The staff was amazing and very, very helpful! Amazing at trouble shooting and went over the top to help us out! The breakfast was very good, better than you would expect for a hotel and we really enjoyed the waterfront area."
Rebecca 4-night trip
Posted 3 hours ago
Hampton Inn Key Largo Manatee Bay
Amara Cay Resort

Amara Cay Resort

10/10 Excellent
"Beautiful!"
Ana 2-night trip
Posted 6 hours ago
Amara Cay Resort
Chesapeake Beach Resort

Chesapeake Beach Resort

10/10 Excellent
"Lindo y acogedor lugar, cerca del sandbar con marina para poner tu bote. Nuestra eetancia fue excelente. El staff bien amable y atento. Volveremos Gracias"
Leidys 2-night trip
Posted 9 hours ago
Chesapeake Beach Resort
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

10/10 Excellent
"we loved it !!!"
Ilyan 2-night trip
Posted 15 hours ago
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Hawks Cay Resort

Hawks Cay Resort

10/10 Excellent
"Great place. Loved the area, the staff very helpful and nice. The villa could used a better cleaning but overall was a great stay, will definitely be back!!!"
Clara 3-night trip
Posted 17 hours ago
Hawks Cay Resort

Explore a world of travel with Expedia