Beginning of main content
Nectar
Collect Nectar points

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys Luxury Hotels

See all 1,084 Hotels in Florida Keys
Little Palm Island Resort & Spa - A Noble House Resort

Little Palm Island Resort & Spa - A Noble House Resort

28500 Overseas Hwy, Little Torch Key
5.0 out of 5.0
4.9 out of 5 (44 reviews)
fabulous accommodation and staff...service is superb
  3 Jul 2017
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.5 out of 5.0
4.5 out of 5 (379 reviews)
It’s a good hotel for one time The facilities are good, quiet and calm but there is not much activities like what a resort should have. I guess the resort is suitable for elders and families but not for young couples.
  19 Feb 2018

£216

£216
The Marker Waterfront Resort Key West

The Marker Waterfront Resort Key West

200 William Street, Key West
4.5 out of 5.0
4.6 out of 5 (899 reviews)
Good and the BadBad They have 2 towels they stock the rooms with: Grand comfort collection=motel towels & T-Y Emerald Collection=hotel towels Tub is not jetted, just a regular tub Sister and brother-in-law had a bad experience at this hotel on the same trip we were on with them Fees were a bit high Given pushback ...
  18 Feb 2018

£260

£260
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.5 out of 5.0
4.4 out of 5 (1,433 reviews)
Daughter got married here on the beach at sunset. Beautiful hotel and spa facilities. Close enough to Miami in terms of travel, but you feel like you're away in the Caribbean.
  11 Sep 2017
Casa Marina, A Waldorf Astoria Resort

Casa Marina, A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.5 out of 5.0
4.2 out of 5 (2,176 reviews)
We enjoyed our stay, though the staff near the pool could have used more help. Over all I would recommend this hotel.
  20 Feb 2018

£320

£320
Kingsail Resort

Kingsail Resort

7050 Overseas Highway, Marathon
2.5 out of 5.0
3.4 out of 5 (1,567 reviews)
Nice quaint keys hotelVery clean and neat. The only thing I didn't care for was the ice machine, I had stomach problems the next day. It wasn't very clean.
  23 Aug 2017
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.5 out of 5.0
4.5 out of 5 (3,192 reviews)
Beautiful location and viewsSo convenient to all off the old town/Duval street attractions. Love the Duval loop bus. What a nice way to get back and forth if you need it. Get place
  20 Feb 2018

£255

£255
Parmer's Resort

Parmer's Resort

565 Barry Avenue, Little Torch Key
2.5 out of 5.0
4.0 out of 5 (920 reviews)
Wonderful place to stayGreat "Old Charm" look and feel. Wonderful views ~ Clean comfortable rooms ~ Nice warm pool and great cookies in the afternoons! A short ride into Key West if you like, with a few good restaurants very close. Recommended place to stay!
  11 Feb 2018

£143

£143
H2O Suites - Adults Only

H2O Suites - Adults Only

1212 Simonton Street, Key West
4.0 out of 5.0
5.0 out of 5 (96 reviews)
Beautiful place and excellent staffEverything was perfect! Would definitely stay again!! Thank you to all the staff who made our stay memorable!
  23 Jan 2018

£304

£304
Seashell Motel & Key West Hostel

Seashell Motel & Key West Hostel

718 South Street, Key West
2.0 out of 5.0
2.8 out of 5 (671 reviews)
Great location to Duvall St., the beach, and trolley.
  16 Feb 2018

£105

£105
Map

Recently booked Florida Keys hotels

Sheraton Suites Key West
4.0 out of 5.0
Last booking: 18 minutes ago
Paradise Inn Key West-Adults Only
4.0 out of 5.0
Last booking: 18 minutes ago
Lime Tree Bay Resort
4.0 out of 5.0
Last booking: 24 minutes ago
Ocean Key Resort - A Noble House Resort
4.0 out of 5.0
Last booking: 25 minutes ago
Playa Largo Resort & Spa, Autograph Collection
4.0 out of 5.0
Last booking: 32 minutes ago
Casa Marina, A Waldorf Astoria Resort
4.5 out of 5.0
Last booking: 36 minutes ago
NYAH Key West-Adults Only
3.0 out of 5.0
Last booking: 39 minutes ago
Curry House
3.0 out of 5.0
Last booking: 43 minutes ago
DoubleTree Resort by Hilton Grand Key - Key West
4.0 out of 5.0
Last booking: 49 minutes ago

Pocket Guide: Luxury Hotels Hotels in Florida Keys

Find Luxury Hotels in Florida Keys

Florida Keys is the perfect luxury hotel backdrop. Stylish accommodation and five-star service define the islands’ best hotels, while Champagne cruises, lobster dinners and private yacht charters provide the entertainment.

Luxury Activities in the Florida Keys

Stay in a luxury hotel in Key Largo, the closest island to the US mainland, and you’ll have the diverse underwater scenery of John Pennekamp Coral Reef State Park on your doorstep. The best way to see the famous park is by skipping the crowds and hiring an in-water guide for a private snorkelling tour of its spectacular coral reef.

Further down the keys are the stylish inns, boutique shops and gourmet beach cafes of Islamorada. Fishing is the number one attraction here, and you can charter a luxury air-conditioned yacht to experience the sport fishing capital of the world in style.

If you’d rather eat the seafood than catch it, there are luxury hotels close to the award-winning restaurants of Marathon. When it comes to exploring this area further, the waters and famous Seven Mile Bridge are best viewed from the sky on a private helicopter tour.

If golfing is high up your list of must-dos, the quirky island of Key West is home to an 18-hole championship golf course. Although Key West marks the end of the Overseas Highway, it’s not quite the end of the keys. They continue for a further 70 miles and the ultimate way to see them is on board a seaplane. Tours offer an aerial perspective of the last of the islands and the dolphins, sharks and shipwrecks that call them home.

Choose a Luxury Hotel in the Florida Keys

There are plenty of lavish options if you’re looking to blow the budget on a luxury hotel in the Florida Keys, but luxury doesn’t always come with a hefty price tag. You can find affordable mid-range resorts and guesthouses the length of the island with lavish extras like king-sized beds or private beaches that are worthy of the luxury tag.