Title: The Best Hotels Closest to Edisto Island Serpentarium in Edisto Island - 2026 Updated Prices | Expedia.co.uk [Edisto Island Travel Guide](https://expedia.co.uk/Edisto-Island.dx183937)[Edisto Island Serpentarium Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Edisto-Island-Serpentarium.d6335582.Car-Hire-Guide)[Edisto Island Serpentarium Holidays](https://expedia.co.uk/Edisto-Island-Serpentarium-Edisto-Island.d6335582.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [27 Mar - 28 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-03-27&endDate=2026-03-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [28 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-03-28&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [27 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Edisto Island Serpentarium hotels ![Rooftop terrace](https://images.trvl-media.com/lodging/7000000/6480000/6471600/6471565/fd13802f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/7000000/6480000/6471600/6471565/84b64925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, free pool cabanas, pool umbrellas](https://images.trvl-media.com/lodging/7000000/6480000/6471600/6471565/7737c481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/7000000/6480000/6471600/6471565/78f783c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charleston Kiawah Island/Andell Inn [](https://www.expedia.co.uk/Charleston-Hotels-Charleston-Kiawah-IslandAndell-Inn.h6471565.Hotel-Information) 8.3 mi from Edisto Island Serpentarium 9.6/10 Exceptional (528 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wesley £348 includes taxes & fees 31 Mar - 1 Apr [](https://www.expedia.co.uk/Charleston-Hotels-Charleston-Kiawah-IslandAndell-Inn.h6471565.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-10&endDate=2026-04-11®ionId=6335582&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Edisto Island Serpentarium Hotel Reviews ![The Gulls Nest Beach House](https://images.trvl-media.com/lodging/33000000/32710000/32703700/32703604/a02edf6a_y.jpg) ### The Gulls Nest Beach House 10/10 Excellent "This is my third or fourth time at this house. I love the older charm. The knotty pine walls and the size is perfect. The kitchen is great. The front screened in porch and deck have ocean view and it's so relaxing." [](https://expedia.co.uk/Edisto-Island-Hotels-The-Gulls-Nest-Beach-House.h32703604.Hotel-Information) ![Discover 5 Acres of Secluded Luxury on the Marsh and Close to the Beach: Edisto](https://images.trvl-media.com/lodging/103000000/102560000/102554800/102554763/287a39c6_y.jpg) ### Discover 5 Acres of Secluded Luxury on the Marsh and Close to the Beach: Edisto 10/10 Excellent "This place is amazing. Such a beautiful spot. The host was super nice and helpful. I would definitely come here again" [](https://expedia.co.uk/Edisto-Island-Hotels-Newly-Renovated-3BR-Edisto-Retreat-5-Acres.h102554763.Hotel-Information) ![Just Renovated! Welcome to I-Land Style 4BR, 2BTH OCEANFRONT on Edisto Beach](https://images.trvl-media.com/lodging/63000000/62610000/62603800/62603781/b6e2e956_y.jpg) ### Just Renovated! Welcome to I-Land Style 4BR, 2BTH OCEANFRONT on Edisto Beach 10/10 Excellent "I booked this little beach house last summer to surprise my girlfriend on her birthday this March. We had stayed in a time share condo but I wanted a true beachfront experience for her. This beautiful home did not dissapoint! The remodel has been done beautifully. Although we only used one bedroom, the house felt remarkably cozy for its size. If you're looking to take a small family there's room to spare. I love cooking in the kitchen! Copious amounts of counter space, 2 refrigerators, pull out drawer microwave and an electric range that looks barely used at all. Plenty of pots and pans and even some decent knives to round it out. We had reservations in Charleston for a couple of very nice restaurants, but after seeing how amazing the house was, we cancelled them and camped out in the house the entire time. My only regret is that we didn't book it for longer! It was very difficult to leave..." [](https://expedia.co.uk/Edisto-Island-Hotels-Just-Renovated-Welcome-To-I-Land-Style-4BR.h62603781.Hotel-Information) ![The Marshpad, surrounded by nature, mins to beach in gated community ](https://images.trvl-media.com/lodging/100000000/99270000/99269600/99269583/aa3c81de_y.jpg) ### The Marshpad, surrounded by nature, mins to beach in gated community 10/10 Excellent "This beautiful home is lovely and comfortable. My parents were with us and they are 82 years old. The stairwell to enter the house was easy for them to navigate and once inside, everything they needed was on the main level. Our bedrooms upstairs were spacious with comfortable beds. We were in town for a relative's wedding, but look forward to future visits to enjoy the many amenities this home offers, like the fire pit and kayaks." [](https://expedia.co.uk/Edisto-Island-Hotels-The-Marshpad.h99269583.Hotel-Information) ![Gorgeous Secluded Island W/Creek & Ocean View w/DOCK & swim! Pet-friendly/Wi-Fi](https://images.trvl-media.com/lodging/34000000/33510000/33502600/33502550/cda265b2_y.jpg) ### Gorgeous Secluded Island W/Creek & Ocean View w/DOCK & swim! Pet-friendly/Wi-Fi 10/10 Excellent "A beautiful and unique place to stay. Very dog friendly. We hope to return.Rated all categories 5 stars but the last star disappeared on the last catagory. " [](https://expedia.co.uk/Edisto-Island-Hotels-Gorgeous-Secluded-Island-Wcreeks-Ocean-Views-Wdock-Pet-Friendlyfree-Wi-Fi.h33502550.Hotel-Information) ![The Sandy Pineapple! Direct Edisto Beach oceanfront with 4 bedrooms and 2 baths](https://images.trvl-media.com/lodging/72000000/71590000/71589000/71588947/81c06a28_y.jpg) ### The Sandy Pineapple! Direct Edisto Beach oceanfront with 4 bedrooms and 2 baths 10/10 Excellent "Exactly as described. Beautiful house right on the beach. Close to restaurants, grocery store, ice cream, gift shops and coffee shop!" [](https://expedia.co.uk/Edisto-Island-Hotels-The-Sandy-Pineapple-Direct-Edisto-Beach-Oceanfront-With-4-Bedrooms-And-2-Baths.h71588947.Hotel-Information) ![4 Bedroom 2 Bath Ocean Front Vacation Rental on Edisto Beach](https://images.trvl-media.com/lodging/71000000/70870000/70868400/70868367/ce416880_y.jpg) ### 4 Bedroom 2 Bath Ocean Front Vacation Rental on Edisto Beach 10/10 Excellent "We had an amazing family weekend. The house was in great condition and in a great location. We couldn’t have asked for anything better!" [](https://expedia.co.uk/Edisto-Island-Hotels-4-Bedroom-2-Bath-Ocean-Front-Vacation-Rental-On-Edisto-Beach.h70868367.Hotel-Information) ![Gorgeous Oceanfront 6 bdrm, 6 ba. home, heated swim spa, elevator, private!](https://images.trvl-media.com/lodging/51000000/50630000/50625900/50625814/adb9c198_y.jpg) ### Gorgeous Oceanfront 6 bdrm, 6 ba. home, heated swim spa, elevator, private! 10/10 Excellent "House was very roomy, location was ideal. There were a few inconveniences but management group was very responsive. Everyone had a wonderful time. " [](https://expedia.co.uk/Edisto-Island-Hotels-Gorgeous-Oceanfront-6-Bdrm.h50625814.Hotel-Information) ![Beautiful Oceanfront 5 bedroom 5 1/2 bath home in Private Community.](https://images.trvl-media.com/lodging/108000000/107050000/107045500/107045499/a08a4600_y.jpg) ### Beautiful Oceanfront 5 bedroom 5 1/2 bath home in Private Community. 10/10 Excellent "Other than several small needed fixes like the top oven and a few sink stoppers and low battery garage door opener…things were really comfortable and we were super happy.It would have been nice for there to have been a full fuel tank for the fire pit and a safety gate on the deck so mamas didn’t need to worry about their little ones escaping but these annoyances haven’t kept us all from wanting to come again next year!" [](https://expedia.co.uk/Edisto-Island-Hotels-Beautiful-Oceanfront-Just-Built-5-Bedroom-5-12-Bath-Home-In-Private-Community.h107045499.Hotel-Information) ## Hotels near other Edisto Island Serpentarium attractions ### Botany Bay Plantation 4.3/5 (13 reviews) Explore the great outdoors at Botany Bay Plantation, a lovely green space in Edisto Island. Stroll along the beaches in this relaxing area or seek out the fishing spots. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335632) ### With These Hands Gallery You can spend time studying the exhibits at With These Hands Gallery during your travels in Edisto Island. Stroll along the beautiful beaches in this relaxing area or seek out the cycling trails. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532654849) ### Botany Bay Plantation Heritage Preserve and Wildlife Management Area 4.0/5 (5 reviews) Explore the lovely green spaces of Botany Bay Plantation Heritage Preserve and Wildlife Management Area and enjoy the cycling trails in Edisto Island. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532654847) ### Edisto Island Museum You can spend time studying the exhibits at Edisto Island Museum during your trip to Edisto Island. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335580) ### Edisto Beach State Park 4.4/5 (47 reviews) You can take time to visit Edisto Beach State Park during your travels to Edisto Island. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335576) ### Plantation Course at Edisto 3.7/5 (3 reviews) Enjoy a round of golf in Edisto Island at Plantation Course at Edisto. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335585) ### Deep Water Vineyard You can enjoy a tasting or tour at Deep Water Vineyard during your travels to Wadmalaw Island. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911209364631932928) ### Irvin House Vineyards You can enjoy a tasting or tour at Irvin House Vineyards during your travels to Wadmalaw Island. Stroll along the beautiful beaches in this relaxing area or seek out the cycling trails. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532654852) ## Frequently asked questions ### What's the area like around Edisto Island Serpentarium? ### How many hotels are there near Edisto Island Serpentarium? ### If I need to cancel the hotel reservation for my stay near Edisto Island Serpentarium, will I receive a refund? ### What can I see and do near Edisto Island Serpentarium?