Title: The Best Hotels Closest to Edisto Island Serpentarium in Edisto Island - 2026 Updated Prices | Expedia.co.uk [Edisto Island Travel Guide](https://expedia.co.uk/Edisto-Island.dx183937)[Edisto Island Serpentarium Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Edisto-Island-Serpentarium.d6335582.Car-Hire-Guide)[Edisto Island Serpentarium Holidays](https://expedia.co.uk/Edisto-Island-Serpentarium-Edisto-Island.d6335582.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [19 Jan - 20 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-01-19&endDate=2026-01-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [20 Jan - 21 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-01-20&endDate=2026-01-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6335582&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Edisto Island Serpentarium hotels ![Exterior](https://images.trvl-media.com/lodging/102000000/101970000/101969600/101969520/58127a6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/102000000/101970000/101969600/101969520/2f92e996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/102000000/101970000/101969600/101969520/6d458082.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/102000000/101970000/101969600/101969520/c6f7997e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Dunlin, Auberge Collection [](https://www.expedia.co.uk/Johns-Island-Hotels-The-Dunlin-Auberge-Collection.h101969520.Hotel-Information) 10.2 mi from Edisto Island Serpentarium 9.8/10 Exceptional (33 reviews) "Beautiful hotel, had a perfect stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Madison £505 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Johns-Island-Hotels-The-Dunlin-Auberge-Collection.h101969520.Hotel-Information) ![On the beach, sun-loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/1000000/990000/984100/984061/d99a0438.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/990000/984100/984061/da680369.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Ocean View | Premium bedding, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/990000/984100/984061/7e76e878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, 2 outdoor pools, pool cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/990000/984100/984061/caf2f608.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Sanctuary at Kiawah Island Golf Resort [](https://www.expedia.co.uk/Charleston-Hotels-The-Sanctuary-At-Kiawah-Island-Golf-Resort.h984061.Hotel-Information) 11.3 mi from Edisto Island Serpentarium 9.6/10 Exceptional (232 reviews) "Everything was fantastic " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Will £245 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Charleston-Hotels-The-Sanctuary-At-Kiawah-Island-Golf-Resort.h984061.Hotel-Information) ![House | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102063/11d2500a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102063/9c0c1848.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102063/3b91b2d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 3 bedrooms, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102063/4c68acea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Breeze in Seabrook Island [](https://www.expedia.co.uk/Seabrook-Island-Hotels-The-Breeze-In-Seabrook-Island.h120102063.Hotel-Information) 6.2 mi from Edisto Island Serpentarium £332 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Seabrook-Island-Hotels-The-Breeze-In-Seabrook-Island.h120102063.Hotel-Information) ![House | 1 bedroom, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102071/10306972.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 1 bedroom, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102071/cf5c26db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 1 bedroom, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102071/8922e509.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 1 bedroom, Internet](https://images.trvl-media.com/lodging/121000000/120110000/120102100/120102071/d03881f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hideout at Shipwatch - On The Beach [](https://www.expedia.co.uk/Kiawah-Island-Hotels-Hideout-At-Shipwatch-On-The-Beach.h120102071.Hotel-Information) 9.5 mi from Edisto Island Serpentarium £293 includes taxes & fees 28 Jan - 29 Jan [](https://www.expedia.co.uk/Kiawah-Island-Hotels-Hideout-At-Shipwatch-On-The-Beach.h120102071.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-02&endDate=2026-02-03®ionId=6335582&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Edisto Island Serpentarium Hotel Reviews ![Seaclusion by AvantStay | Walk to the Beach](https://images.trvl-media.com/lodging/110000000/109960000/109958800/109958745/0ff13f64_y.jpg) ### Seaclusion by AvantStay | Walk to the Beach 10/10 Excellent "Amenities were great, customer service was excellent" [](https://expedia.co.uk/Edisto-Island-Hotels-Seaclusion-By-AvantStay-Walk-To-The-Beach.h109958745.Hotel-Information) ![The Gulls Nest Beach House](https://images.trvl-media.com/lodging/33000000/32710000/32703700/32703604/d01c53f8_y.jpg) ### The Gulls Nest Beach House 10/10 Excellent "Exactly what we were looking for in a classic beach house - comfortable, clean, and laid back. Everything we needed was provided for which contributed to a wonderful visit. The front porch with the ocean view was my favorite part of the house. Will definitely rent again!" [](https://expedia.co.uk/Edisto-Island-Hotels-The-Gulls-Nest-Beach-House.h32703604.Hotel-Information) ![Moon Tide|Oceanfront Showplace|Dog Friendly|Elevator|Rooftop Deck|Family-Friendly Amenities](https://images.trvl-media.com/lodging/121000000/120260000/120253300/120253232/227deaeb_y.jpg) ### Moon Tide|Oceanfront Showplace|Dog Friendly|Elevator|Rooftop Deck|Family-Friendly Amenities 10/10 Excellent "What a place! My family and i were totally shocked impressed by all the details you used throughout the entire house. I was especially pleased with the ceiling in the family room that we klo" [](https://expedia.co.uk/Edisto-Island-Hotels-Moon-TideOceanfront-ShowplaceDog-FriendlyElevatorRooftop-DeckFamily-Friendly-Amenities.h120253232.Hotel-Information) ![Discover 5 Acres of Secluded Luxury on the Marsh and Close to the Beach: Edisto](https://images.trvl-media.com/lodging/103000000/102560000/102554800/102554763/433ba5a9_y.jpg) ### Discover 5 Acres of Secluded Luxury on the Marsh and Close to the Beach: Edisto 10/10 Excellent "This is a great location exactly as described- we will definitely come back!" [](https://expedia.co.uk/Edisto-Island-Hotels-Newly-Renovated-3BR-Edisto-Retreat-5-Acres.h102554763.Hotel-Information) ![Paradise Found- Stunning Ocean views + Unique Home](https://images.trvl-media.com/lodging/115000000/114280000/114273900/114273865/af8e8a8c_y.jpg) ### Paradise Found- Stunning Ocean views + Unique Home 10/10 Excellent "This property had everything. From the views to the seating outside so you could see the ocean or the marsh and the sunrise and sunset. It just really felt like you were at home. Would recommend and hopefully it is available every year we want to come back! The host was nice and responded in a timely manner. Wish we could have stayed longer!! " [](https://expedia.co.uk/Edisto-Island-Hotels-Paradise-Found-Stunning-Ocean-Views-Unique-Home.h114273865.Hotel-Information) ## Hotels near other Edisto Island Serpentarium attractions ### Botany Bay Plantation 4.3/5 (13 reviews) Explore the great outdoors at Botany Bay Plantation, a lovely green space in Edisto Island. Stroll along the beaches in this relaxing area or seek out the fishing spots. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335632) ### With These Hands Gallery You can spend time studying the exhibits at With These Hands Gallery during your travels in Edisto Island. Stroll along the beautiful beaches in this relaxing area or seek out the cycling trails. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532654849) ### Botany Bay Plantation Heritage Preserve and Wildlife Management Area 4.0/5 (5 reviews) Explore the lovely green spaces of Botany Bay Plantation Heritage Preserve and Wildlife Management Area and enjoy the cycling trails in Edisto Island. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532654847) ### Edisto Island Museum You can spend time studying the exhibits at Edisto Island Museum during your trip to Edisto Island. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335580) ### Edisto Beach State Park 4.4/5 (47 reviews) You can take time to visit Edisto Beach State Park during your travels to Edisto Island. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335576) ### Plantation Course at Edisto 3.7/5 (3 reviews) Enjoy a round of golf in Edisto Island at Plantation Course at Edisto. Wander the beautiful beaches in this relaxing area. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6335585) ### Deep Water Vineyard You can enjoy a tasting or tour at Deep Water Vineyard during your travels to Wadmalaw Island. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=911209364631932928) ### Irvin House Vineyards You can enjoy a tasting or tour at Irvin House Vineyards during your travels to Wadmalaw Island. Stroll along the beautiful beaches in this relaxing area or seek out the cycling trails. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532654852) ## Frequently asked questions ### What's the area like around Edisto Island Serpentarium? ### How many hotels are there near Edisto Island Serpentarium? ### If I need to cancel the hotel reservation for my stay near Edisto Island Serpentarium, will I receive a refund? ### What can I see and do near Edisto Island Serpentarium?