Title: Best Serviced Apartments in Defiance 2026 | Expedia.co.uk [Hotels in Defiance](https://expedia.co.uk/Defiance-Hotels.d6353634.Travel-Guide-Hotels)[Holiday Rentals in Defiance](https://expedia.co.uk/Defiance-Holiday-Rentals.d6353634.Travel-Guide-HolidayRentals)[Defiance Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Defiance.d6353634.Car-Hire-Guide)[Defiance Holidays](https://expedia.co.uk/Defiance.d6353634.Holidays-City-Breaks) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6353634&startDate=2026-02-27&endDate=2026-03-01&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6353634&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [8 May - 10 May](https://www.expedia.co.uk/Hotel-Search?regionId=6353634&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [5 Jun - 7 Jun](https://www.expedia.co.uk/Hotel-Search?regionId=6353634&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Defiance apartments ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/899f1dbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/02afa9a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/23d0244f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/100000000/99680000/99672100/99672035/ee4b16a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Duplex Hideaway in St. Charles, MO [](https://www.expedia.co.uk/St-Louis-Hotels-Duplex-Hideaway-In-St-Charles.h99672035.Hotel-Information) St. Charles Historic District 10/10 Exceptional (5 reviews) "I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen M. £168 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Duplex-Hideaway-In-St-Charles.h99672035.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/0e044ece.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/c1443a07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, travel cot](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/c76c6dba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/117000000/116660000/116658500/116658446/faf4ff3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 6th street 101 - Walk to Main St [](https://www.expedia.co.uk/St-Louis-Hotels-6th-Street-101-Walk-To-Main-St.h116658446.Hotel-Information) St. Charles Historic District 10/10 Exceptional (1 review) £198 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-6th-Street-101-Walk-To-Main-St.h116658446.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/928eaf94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/478dc170.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/bb7198fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/88000000/87360000/87354000/87353997/87475e7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Main Street Living! 2 Bedroom Unit right On Main! [](https://www.expedia.co.uk/St-Louis-Hotels-Main-Street-Living-2-Bedroom-Unit-Right-On-Main.h87353997.Hotel-Information) St. Charles Historic District 9.6/10 Exceptional (35 reviews) "Great Stay and great location! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela £258 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Main-Street-Living-2-Bedroom-Unit-Right-On-Main.h87353997.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/c37516f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/efc70ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/ae9526e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879600/95879524/308cfe0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Historic Bricks on Main [](https://www.expedia.co.uk/St-Louis-Hotels-The-Historic-Bricks-On-Main.h95879524.Hotel-Information) St. Charles Historic District 8.8/10 Excellent (15 reviews) "Host was very welcoming and helpful when we have any questions no matter what time of day. The place was very quaint and comfy. We would highly recommend. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chelsea L. £155 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-The-Historic-Bricks-On-Main.h95879524.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/3f60ffb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/36b99900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/80de4605.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66410000/66400800/66400703/87db6a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Amazing Renovated Historic Loft on Main Street [](https://www.expedia.co.uk/St-Louis-Hotels-Amazing-Renovated-Historic-Loft-On-Main-Street.h66400703.Hotel-Information) St. Charles Historic District 10/10 Exceptional (58 reviews) "Great place and location. Owners were easy to work with." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cory M. £183 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Amazing-Renovated-Historic-Loft-On-Main-Street.h66400703.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/d1074747.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/aa3bff55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/1db5a3ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/82000000/81510000/81509800/81509771/11a3d218.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxurious 2-Bedroom Abode with Elevated Comforts Near Main Street [](https://www.expedia.co.uk/St-Louis-Hotels-Luxurious-2-Bedroom-Abode-With-Elevated-Comforts-Near-Main-Street.h81509771.Hotel-Information) Saint Charles 9.0/10 Wonderful (2 reviews) "The overall vibe struck me as a college town apartment: the building was fine, but finishes were underwhelming. The unit itself was a little small, but workable. We had a scenario where the heater seemed to be acting up; the room actually got warmer after we shut the heat off. It was a pleasant enough stay, and served the purpose we had come for: visiting our adult children. It was a bit of a walk to get to the historic district." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greg L. £205 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Luxurious-2-Bedroom-Abode-With-Elevated-Comforts-Near-Main-Street.h81509771.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/w908h683x58y0-1bba5a4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, music library, computer monitors](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/w1284h853x0y0-2c9a7301.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/eccdc192.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/68000000/67420000/67418600/67418516/c8b25c03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sunny SparkingClean King bed Apt- CreveCoeurPark [](https://www.expedia.co.uk/St-Louis-Hotels-Sunny-SparkingClean-King-Bed-Apt-CreveCoeurPark.h67418516.Hotel-Information) Maryland Heights 9.8/10 Exceptional (12 reviews) "Good Stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lanai £206 includes taxes & fees 7 Mar - 8 Mar [](https://www.expedia.co.uk/St-Louis-Hotels-Sunny-SparkingClean-King-Bed-Apt-CreveCoeurPark.h67418516.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/67000000/66460000/66454500/66454439/c8faea22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66460000/66454500/66454439/3580d825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/67000000/66460000/66454500/66454439/1d241474.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/67000000/66460000/66454500/66454439/0abbf90b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lofts of North Main Street [](https://www.expedia.co.uk/St-Louis-Hotels-The-Lofts-Of-North-Main-Street.h66454439.Hotel-Information) St. Charles Historic District 9.6/10 Exceptional (160 reviews) "Very nice place near all the action. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Weston G. £167 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-The-Lofts-Of-North-Main-Street.h66454439.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/779822a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/w1600h1064x0y68-502efe55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/2039c7b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/69000000/68770000/68768700/68768642/f288c4f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Prime Loft of Main Street [](https://www.expedia.co.uk/St-Louis-Hotels-Prime-Loft-Of-Main-Street.h68768642.Hotel-Information) St. Charles Historic District 9.8/10 Exceptional (104 reviews) "The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary ann S. £177 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Prime-Loft-Of-Main-Street.h68768642.Hotel-Information) ![Fridge, microwave, stovetop, toaster](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/c7c5c786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/7f98cd91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/6d55ea86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, toaster](https://images.trvl-media.com/lodging/100000000/99520000/99519000/99518901/2a429583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming Duplex on Main [](https://www.expedia.co.uk/St-Louis-Hotels-Charming-Duplex-On-Main.h99518901.Hotel-Information) St. Charles Historic District 10/10 Exceptional (16 reviews) "We had an AMAZING time here and you can't beat the close walking distance to main st!! Absolutely loved our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendy K. £177 includes taxes & fees 25 Feb - 26 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Charming-Duplex-On-Main.h99518901.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/88a8c36e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books, computer monitors](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/19c9294d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/45cfe29b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/103000000/102400000/102390100/102390052/f3ac6df0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Hidden Gem - 2BR Basement Apartment on 7 Acres [](https://www.expedia.co.uk/Moscow-Mills-Hotels-The-Hidden-Gem-2BR-Basement-Apartment-On-7-Acres.h102390052.Hotel-Information) Moscow Mills 10/10 Exceptional (12 reviews) "Great place, nice neighborhood. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie L. £204 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/Moscow-Mills-Hotels-The-Hidden-Gem-2BR-Basement-Apartment-On-7-Acres.h102390052.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/68484390.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/39c4586a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/85c7ab01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/58000000/57120000/57115600/57115533/806bc19d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Great for Business Travelers! Studio Suite Near Edward Jones! Shared Pool + Free Breakfast! [](https://www.expedia.co.uk/St-Louis-Hotels-Great-For-Business-Travelers-Studio-Suite-Near-Edward-Jones-Shared-Pool-Free-Breakfast.h57115533.Hotel-Information) Maryland Heights 9.6/10 Exceptional (4 reviews) "It was an easy experience renting this place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dominic M. £124 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/St-Louis-Hotels-Great-For-Business-Travelers-Studio-Suite-Near-Edward-Jones-Shared-Pool-Free-Breakfast.h57115533.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/c3151f09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/1a5467b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/9f6898b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393467/e19f192f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Main Street Balcony Apartment by StayLage! [](https://www.expedia.co.uk/St-Louis-Hotels-Main-Street-Balcony-Apartment-By-StayLage.h83393467.Hotel-Information) St. Charles Historic District 9.6/10 Exceptional (36 reviews) "The unit was so nice and clean. We enjoyed being right on Main St, close to shops and dining. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura L. £313 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Main-Street-Balcony-Apartment-By-StayLage.h83393467.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/9764dd9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/656d8a9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/1024eebd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100820000/100819200/100819176/e85f6ae5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Cul-de-Sac Retreat [](https://www.expedia.co.uk/St-Louis-Hotels-The-Cul-De-Sac-Retreat.h100819176.Hotel-Information) Saint Charles 8.4/10 Very good (9 reviews) "Great house, great location - close to the St. Charles convention center" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joe H. £196 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-The-Cul-De-Sac-Retreat.h100819176.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/8ce1ade3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/f417e034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, coffee/tea maker, toaster, cookware/dishes/utensils](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/d5db9384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/82000000/81500000/81497000/81496999/w2039h1365x0y0-9d7c4c40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio on Historic Main by StayLage [](https://www.expedia.co.uk/St-Louis-Hotels-Studio-On-Historic-Main-By-StayLage.h81496999.Hotel-Information) St. Charles Historic District 9.0/10 Wonderful (33 reviews) "Nice property.. Clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Belinda J. £141 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Studio-On-Historic-Main-By-StayLage.h81496999.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/b34f5a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/749523e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/0a6eda2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/111000000/110650000/110646300/110646218/0e98ec38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AK\`s STL Pearl Grey House - Game Room [](https://www.expedia.co.uk/St-Louis-Hotels-AKs-STL-Pearl-Grey-House-Game-Room.h110646218.Hotel-Information) Maryland Heights 9.0/10 Wonderful (8 reviews) "My kids loved this house! It was very comfortable for my family of 7\. We were able to cook dinner, play games, watch TV, and were within close proximity to all things St. Louis. We would definitely stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tiffanny B. £342 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-AKs-STL-Pearl-Grey-House-Game-Room.h110646218.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/82000000/81220000/81217800/81217721/ad9c21ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/82000000/81220000/81217800/81217721/0aa12e09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/82000000/81220000/81217800/81217721/051e8903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/82000000/81220000/81217800/81217721/2a47f4f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Uncork on Historic Main! [](https://www.expedia.co.uk/St-Louis-Hotels-Uncork-On-Historic-Main.h81217721.Hotel-Information) St. Charles Historic District 9.2/10 Wonderful (14 reviews) "Was a great stay on an amazing streer" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Justin R. £275 includes taxes & fees 28 Feb - 1 Mar [](https://www.expedia.co.uk/St-Louis-Hotels-Uncork-On-Historic-Main.h81217721.Hotel-Information) ![A heated pool](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/7405cfec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/b209c6cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/f671dd2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83610000/83605400/83605308/8149b724.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Great for Business Travelers! Pool + Gym [](https://www.expedia.co.uk/St-Louis-Hotels-Great-For-Business-Travelers-Pool-Gym.h83605308.Hotel-Information) O'Fallon £118 includes taxes & fees 27 Feb - 28 Feb [](https://www.expedia.co.uk/St-Louis-Hotels-Great-For-Business-Travelers-Pool-Gym.h83605308.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/fb26db8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/f71e6fd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/446fac6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/123000000/122440000/122431300/122431219/f2b0954b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 2nd Street Loft - Riverview [](https://www.expedia.co.uk/Washington-Hotels-2nd-Street-Loft-Riverview.h122431219.Hotel-Information) Washington £116 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/Washington-Hotels-2nd-Street-Loft-Riverview.h122431219.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/1d083e2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/63644275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/fdd1c3df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/84000000/84000000/83992700/83992642/b240a86b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Back Door Guest Suite, Zia My Retreat [](https://www.expedia.co.uk/New-Haven-Hotels-Back-Door-Guest-Suit.h83992642.Hotel-Information) New Haven 10/10 Exceptional (6 reviews) "Very comfortable, spacious, great location for canoe trip. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carolyn B. £169 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/New-Haven-Hotels-Back-Door-Guest-Suit.h83992642.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-24&endDate=2026-02-25®ionId=6353634&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find holiday rentals that suit your style Private holiday homes [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=VACATION_HOME) Aparthotels [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=APART_HOTEL) Apartments [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=APARTMENT) Cabins [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=CABIN) Cottages [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=COTTAGE) Condos [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=CONDO) Villas [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=VILLA) Chalets [](https://www.expedia.co.uk/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America®ionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-05-11&d1=2026-05-11&endDate=2026-05-14&d2=2026-05-14&lodging=CHALET) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Apartments.d6353634-aaApartments.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDefiance-Apartments.d6353634-aaApartments.Travel-Guide-Accommodation) ## Top Defiance Hotel Reviews ![Courtyard by Marriott St Louis Creve Coeur](https://images.trvl-media.com/lodging/1000000/20000/11100/11052/96f17f89_y.jpg) ### Courtyard by Marriott St Louis Creve Coeur 10/10 Excellent "Yes everyone was great" [](https://expedia.co.uk/St-Louis-Hotels-Courtyard-By-Marriott-St-Louis-Creve-Coeur.h11052.Hotel-Information) ![Hollywood Casino & Hotel St. Louis](https://images.trvl-media.com/lodging/1000000/90000/82600/82568/7188325f_y.jpg) ### Hollywood Casino & Hotel St. Louis 10/10 Excellent "Everything was very, very nice. The casino smoke was unfortunate, but was not noticable in the room, of course." [](https://expedia.co.uk/St-Louis-Hotels-Hollywood-Casino-Hotel-St-Louis.h82568.Hotel-Information) ![Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/ad47a940_y.jpg) ### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West 10/10 Excellent "Comfortable room " [](https://expedia.co.uk/St-Louis-Hotels-Homewood-Suites-By-Hilton-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information) ![Crowne Plaza St. Louis Airport by IHG](https://images.trvl-media.com/lodging/1000000/10000/3100/3010/45ba14e8_y.jpg) ### Crowne Plaza St. Louis Airport by IHG 10/10 Excellent "Great place to stay " [](https://expedia.co.uk/St-Louis-Hotels-Crowne-Plaza-St-Louis-Airport.h3010.Hotel-Information) ![Drury Plaza Hotel St. Louis Creve Coeur](https://images.trvl-media.com/lodging/1000000/80000/74700/74657/3c4503ce_y.jpg) ### Drury Plaza Hotel St. Louis Creve Coeur 10/10 Excellent "Everything was very good. The staff, the cleanliness of the room, and the food prepared for the guests. Thank you" [](https://expedia.co.uk/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Creve-Coeur.h74657.Hotel-Information) ![Drury Plaza Hotel St. Louis St. Charles](https://images.trvl-media.com/lodging/19000000/18760000/18754300/18754262/7efb516b_y.jpg) ### Drury Plaza Hotel St. Louis St. Charles 10/10 Excellent "Location " [](https://expedia.co.uk/St-Louis-Hotels-Drury-Plaza-Hotel-St-Louis-St-Charles.h18754262.Hotel-Information) ![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg) ### Country Inn & Suites by Radisson, St. Charles Historic District 10/10 Excellent "From check in my time at Country Inn was wonderful! The people are so very kind and helpful, the building is spotless, location is perfect and I had everything I needed. I recommend the Country Inn & Suites!" [](https://expedia.co.uk/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information) ![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe_y.jpg) ### Ameristar Casino Resort and Spa 10/10 Excellent "The room was great. I enjoyed my stay. " [](https://expedia.co.uk/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg) ### The Wildwood Hotel 10/10 Excellent "Clean room and easy parking. " [](https://expedia.co.uk/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information) ## Find out more about Defiance ## Defiance Apartments information | Number of reviews | 502 | | ----------------- | -------------- | | Accommodation | 103 Apartments | | Lowest Price | £116 | | Highest Price | £342 | ## Frequently asked questions ### What's it like to stay at an apartment in Defiance? ### Why would you choose apartments instead of traditional hotels? ### What's the top apartment I should consider for a stay in Defiance? ### How many apartments will I find in Defiance? ### What can I expect from the weather in Defiance? ### What are the must-see places to visit in Defiance? ### What's the best way to get to and around Defiance? ## Explore a world of travel with Expedia - More ways to book - [Book Apartments in Defiance on Expedia.com ](https://www.expedia.com/Defiance-Apartments.d6353634-aaApartments.Travel-Guide-Accommodation)