Title: Holiday Rentals Charleston from £78: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Hotels in Charleston](https://expedia.co.uk/Charleston-Hotels.d7182.Travel-Guide-Hotels)[Charleston Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Charleston.d7182.Car-Hire-Guide)[Charleston Holidays](https://expedia.co.uk/Charleston.d7182.Holidays-City-Breaks) ![Bridge over Mississippi River, New Orleans in background](https://images.trvl-media.com/place/6209928/57ec11c5-0aa9-4b04-9ae1-c121ec0bef56.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Holiday Rentals in Charleston - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=7182&startDate=2025-12-26&endDate=2025-12-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=7182&startDate=2026-02-06&endDate=2026-02-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=7182&startDate=2026-03-06&endDate=2026-03-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=7182&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Charleston holiday rentals ![Interior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/e90509fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/9000af4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/379d384a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/44505503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information) 9.4/10 Exceptional (45) "This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jordan S. £106 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/1e923d10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/b93a717d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/b002a425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/dbe95a1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Remodeled-1920s-Dutch-Colonial-Revival-In-Downtown-Cape-Girardeau.h76544096.Hotel-Information) 10/10 Exceptional (28) "Great property and a super host! He was super helpful and always willing to help with any questions we had. Would definitely rent here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark M. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Remodeled-1920s-Dutch-Colonial-Revival-In-Downtown-Cape-Girardeau.h76544096.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/85f62077.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/23c71fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/3bc4c831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Olive Branch [](https://www.expedia.co.uk/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) 9.8/10 Exceptional (35) "Beautiful place, host was kind and and quick to respond to messages " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa W. £108 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) 8.6/10 Excellent (48) "I would definitely stay here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bonita £78 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/1be40475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/6f998875.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, bed sheets](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d4f180ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d47379a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Miller City [](https://www.expedia.co.uk/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) 9.8/10 Exceptional (20) "cute A frame in a secluded spot. Couldn’t ask for a more relaxing situation. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason M. [](https://www.expedia.co.uk/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/fa9f5d7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/da9b2a8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/93cee70f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/8f1fe4ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-3-Bedroom-3-Full-Bath-In-Beautiful-Historic-District-Downtown-Cape-Girardeau.h120661701.Hotel-Information) 10/10 Exceptional (3) "Cute place, clean and spacious. Convenient location. Very nice stay! Would stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca E. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-3-Bedroom-3-Full-Bath-In-Beautiful-Historic-District-Downtown-Cape-Girardeau.h120661701.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/211494f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/d33a9d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/6a739ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information) 8.6/10 Excellent (36) "Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Emily D. £163 includes taxes & fees 16 Dec - 17 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/95000000/95000000/94995100/94995011/33116e16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/95000000/95000000/94995100/94995011/eaa0c055.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/95000000/95000000/94995100/94995011/4e4ad4b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/95000000/95000000/94995100/94995011/317bffa1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Historic-Victorian-Walkable-To-Downtown-Cape-Girardeau-King-Bed-Fast-Wifi.h94995011.Hotel-Information) 10/10 Exceptional (10) "A large and comfortable house with cool historical details and just about everything you need to have a great, easy, smooth-running vacation. Great location for downtown exploring." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Virginia C. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Historic-Victorian-Walkable-To-Downtown-Cape-Girardeau-King-Bed-Fast-Wifi.h94995011.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/d70c82b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/73a1d2fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/1959f5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/29d5afe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Olive Branch [](https://www.expedia.co.uk/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information) 9.2/10 Wonderful (25) "This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mike b. £108 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/54000000/53860000/53856300/53856204/90-fd293c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/54000000/53860000/53856300/53856204/285ec107.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/54000000/53860000/53856300/53856204/b5b744c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/54000000/53860000/53856300/53856204/90-eeb9e84e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Kevil [](https://www.expedia.co.uk/Quiet-Home-On-Horse-Farm.h53856204.Hotel-Information) 10/10 Exceptional (185) "Very clean and comfortable stay in the country" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joe S. [](https://www.expedia.co.uk/Quiet-Home-On-Horse-Farm.h53856204.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/102000000/101991800/101991724/93d8caae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/102000000/102000000/101991800/101991724/08219975.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/102000000/102000000/101991800/101991724/714d009a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/102000000/102000000/101991800/101991724/13648c57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Rivers-Dawn-Modernized-Historic-Home-River-Views-King-Bed-Fast-Wifi.h101991724.Hotel-Information) 10/10 Exceptional (4) "The home was beautiful inside and very clean. The bed was comfortable, and the area was quiet. My father and I really enjoyed our stay. I would stay there again over anywhere else I have stayed in cape. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shawn [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Rivers-Dawn-Modernized-Historic-Home-River-Views-King-Bed-Fast-Wifi.h101991724.Hotel-Information) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/74000000/73250000/73241700/73241636/2aaac254.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/74000000/73250000/73241700/73241636/w1787h960x0y0-328ad9de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/74000000/73250000/73241700/73241636/a7f86deb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/74000000/73250000/73241700/73241636/5ea71602.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Quaint.h73241636.Hotel-Information) 9.8/10 Exceptional (43) "Location was perfect. The house was clean and met all our needs. Would definitely stay here again in the future." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beau L. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Quaint.h73241636.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/110000000/109110000/109109100/109109006/bd476bf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Games room](https://images.trvl-media.com/lodging/110000000/109110000/109109100/109109006/f5e1cb3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, desk, bed sheets, wheelchair access](https://images.trvl-media.com/lodging/110000000/109110000/109109100/109109006/83d01cc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/110000000/109110000/109109100/109109006/25fbc7e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Tamms [](https://www.expedia.co.uk/Tamms-Hotels-Attention-Hunters-Deer-Camp.h109109006.Hotel-Information) 10/10 Exceptional (23) "Great place to stay, nice people" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack W. [](https://www.expedia.co.uk/Tamms-Hotels-Attention-Hunters-Deer-Camp.h109109006.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/564d6e43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) 10/10 Exceptional (148) "Such a great place and location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy H. £187 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, table football](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/a7fa16a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/d2b33581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Games room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/f1c736a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) 9.6/10 Exceptional (7) "Nice place, great times" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jace W. £335 includes taxes & fees 15 Dec - 16 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19220000/19211900/19211821/adc03455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/20000000/19220000/19211900/19211821/1461710a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/20000000/19220000/19211900/19211821/56d7f7ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/20000000/19220000/19211900/19211821/122eda61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Historical-Kage-House-Short-Term-Rental-Located-In-Old-Town-Cape.h19211821.Hotel-Information) 10/10 Exceptional (223) "Property location was perfect.Deck view was great.Very clean and comfortable place." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert M. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Historical-Kage-House-Short-Term-Rental-Located-In-Old-Town-Cape.h19211821.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/110000000/109930000/109929600/109929505/23d7d447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/110000000/109930000/109929600/109929505/cf643107.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, music library, stereo](https://images.trvl-media.com/lodging/110000000/109930000/109929600/109929505/9a37fcb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/110000000/109930000/109929600/109929505/ebfa2413.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Urban-2-Bedroom-Escape-In-Downtown-Cape-Girardeau.h109929505.Hotel-Information) 10/10 Exceptional (9) "Great house in a great location. Well-stocked kitchen with some thoughtful extras. You can tell that the owner cares which means a lot to someone originally from Cape. 10/10 would stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth C. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Urban-2-Bedroom-Escape-In-Downtown-Cape-Girardeau.h109929505.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/101000000/100610000/100608400/100608350/64a218d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/101000000/100610000/100608400/100608350/aa158a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100610000/100608400/100608350/a33b3870.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, travel cot, free WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100610000/100608400/100608350/cb5fc4a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Downtown-4BR-With-2-King-Beds-Walking-Distance-To-SEMO-And-The-River-Front.h100608350.Hotel-Information) 9.0/10 Wonderful (22) "Enjoyed by all! Relaxing and plenty to do. Very clean and comfortable!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terresa V. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Downtown-4BR-With-2-King-Beds-Walking-Distance-To-SEMO-And-The-River-Front.h100608350.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/108000000/107910000/107909400/107909366/b1eb2df2_edited_275e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/108000000/107910000/107909400/107909366/4e5085d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/108000000/107910000/107909400/107909366/e6834e40_edited_d3e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/108000000/107910000/107909400/107909366/33244d4d_edited_0159.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Charming-3-Bedroom-House-Near-Downtown.h107909366.Hotel-Information) 10/10 Exceptional (2) "My husband and I along with one other couple stayed here while in Cape for a wedding. The location was nice and was a short distance for driving or Ubering around town. The price was great!! Highly recommend." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danielle U. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Charming-3-Bedroom-House-Near-Downtown.h107909366.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/114000000/113830000/113827700/113827646/da5e3977.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113830000/113827700/113827646/65004720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113830000/113827700/113827646/dcdd13f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/114000000/113830000/113827700/113827646/1a78d262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Downtown-Cape-2-Bdrm2-Bath-Apt.h113827646.Hotel-Information) 9.0/10 Wonderful (2) "Great location and the one issue was resolved quickly and no fault of the property owner. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin S. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Downtown-Cape-2-Bdrm2-Bath-Apt.h113827646.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27®ionId=7182&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find holiday rentals that suit your style Apartments [](https://www.expedia.co.uk/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America®ionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-03-12&d1=2026-03-12&endDate=2026-03-15&d2=2026-03-15&lodging=APARTMENT) Private holiday homes [](https://www.expedia.co.uk/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America®ionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-03-12&d1=2026-03-12&endDate=2026-03-15&d2=2026-03-15&lodging=VACATION_HOME) Cabins [](https://www.expedia.co.uk/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America®ionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-03-12&d1=2026-03-12&endDate=2026-03-15&d2=2026-03-15&lodging=CABIN) Cottages [](https://www.expedia.co.uk/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America®ionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-03-12&d1=2026-03-12&endDate=2026-03-15&d2=2026-03-15&lodging=COTTAGE) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCharleston-Holiday-Rentals.d7182.Travel-Guide-HolidayRentals)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCharleston-Holiday-Rentals.d7182.Travel-Guide-HolidayRentals) ## Top Charleston Hotel Reviews ![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg) ### Candlewood Suites Cape Girardeau by IHG 10/10 Excellent "Very nice, spacious, loved the kitchen, the pool and the location." [](https://expedia.co.uk/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Clean room and spacious " [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife. " [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "Very nice room, staff was nice. The tv room and bathroom were cold. No heat in those rooms." [](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Everyone was great" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Easy parking , quiet and comfortable bed , we’ll stop again on our way back " [](https://expedia.co.uk/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Exactly what I’ve come to expect from a Hampton." [](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Staff are very pleasant. Room is clean and well-maintained. Good value for the money. Appreciate they are pet-friendly. I stay there monthly. Don't consider other options." [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Pear Tree Inn Cape Girardeau Near the Medical Center](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg) ### Pear Tree Inn Cape Girardeau Near the Medical Center 10/10 Excellent "Very nice staff and very clean" [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ## Find out more about Charleston **Everything you need to know about** **Charleston** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Charleston holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Charleston holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Charleston holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Charleston. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in . Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Charleston holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in. The selection of Charleston holiday rentals we have selected for you start as low as £78 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Charleston rentals** At Expedia, we put the best Charleston holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Charleston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Charleston holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Charleston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.co.uk ### Trending destinations on Expedia.co.uk - [Holiday Rentals in the Cotswold ](https://www.expedia.co.uk/lp/b/vr/cotswold) - [Holiday Rentals in Lake District ](https://www.expedia.co.uk/lp/b/vr/lake-district) - [Devon Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Devon.d6046196.Holiday-Rental-Destinations) - [Norfolk Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Norfolk.d6046223.Holiday-Rental-Destinations) - [Bedfordshire Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Bedfordshire.d6046189.Holiday-Rental-Destinations) - [Dorset Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Dorset.d6046198.Holiday-Rental-Destinations) - [Northumberland Holiday Rentals ](https://www.expedia.com/Destinations-In-Northumberland.d6046225.Vacation-Rental-Destinations) - [Herefordshire Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Herefordshire.d6046203.Holiday-Rental-Destinations) - [Essex Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Essex.d6046201.Holiday-Rental-Destinations) - [Cumbria Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Cumbria.d6046194.Holiday-Rental-Destinations) - [Yorkshire Holiday Rentals ](https://www.expedia.co.uk/Yorkshire-Holiday-Rentals.d6342462.Travel-Guide-HolidayRentals) - [South Wales Holiday Rentals ](https://www.expedia.co.uk/South-Wales-Holiday-Rentals.d6054274.Travel-Guide-HolidayRentals) - [North Wales Holiday Rentals ](https://www.expedia.co.uk/North-Wales-Holiday-Rentals.d6054276.Travel-Guide-HolidayRentals) - [London Holiday Rentals ](https://www.expedia.co.uk/London-Holiday-Rentals.d178279.Travel-Guide-HolidayRentals) - [York Holiday Rentals ](https://www.expedia.co.uk/York-Holiday-Rentals.d5489.Travel-Guide-HolidayRentals) - [Blackpool Holiday Rentals ](https://www.expedia.co.uk/Blackpool-Holiday-Rentals.d619.Travel-Guide-HolidayRentals) - [Isle of Wight Holiday Rentals ](https://www.expedia.com/Destinations-In-Isle-Of-Wight.d6046218.Vacation-Rental-Destinations) - [Scarborough Holiday Rentals ](https://www.expedia.co.uk/Scarborough-Holiday-Rentals.d5680.Travel-Guide-HolidayRentals) - [Edinburgh Holiday Rentals ](https://www.expedia.co.uk/Edinburgh-Holiday-Rentals.d6069845.Travel-Guide-HolidayRentals) - [Bath Holiday Rentals ](https://www.expedia.co.uk/Bath-Holiday-Rentals.d6084496.Travel-Guide-HolidayRentals) - [Bournemouth Holiday Rentals ](https://www.expedia.co.uk/Bournemouth-Holiday-Rentals.d654.Travel-Guide-HolidayRentals) - [England Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-England.d11218.Holiday-Rental-Destinations) - [Scotland Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Scotland.d11219.Holiday-Rental-Destinations) - [Cornwall Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Cornwall.d6046193.Holiday-Rental-Destinations) - [Wales Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Wales.d11220.Holiday-Rental-Destinations) - [Northern Ireland Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Northern-Ireland.d11221.Holiday-Rental-Destinations) ## Frequently asked questions ### Can I find a holiday rental in Charleston? ### What are some of the best holiday rentals that Charleston has to offer? ### What can I see and do in Charleston? ### What are holiday rentals like in Charleston? ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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