A beach with a wooden pavilion, clear blue sky, and dense green foliage.

Compare and book 5 Star hotels in Lower Matecumbe Key, Islamorada

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
  • Be picky

    Search almost a million properties worldwide

Check availability on Lower Matecumbe Key 5 Star Hotels

Tonight
5 Oct - 6 Oct
Tomorrow
6 Oct - 7 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Lower Matecumbe Key 5-star hotels

1. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
United States
RAIBEL
£195
includes taxes & fees
13 Oct - 14 Oct
Cheeca Lodge & Spa

2. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
United States
Christian
£430
includes taxes & fees
22 Oct - 23 Oct
The Islands of Islamorada

3. Sea Glass Cove

Sea Glass Cove
Marathon
Sea Glass Cove
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Lower Matecumbe Key.
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

97000 Overseas Hwy Key Largo FL
£278
18 Oct - 19 Oct
includes taxes & fees
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd Marathon FL
£229
13 Oct - 14 Oct
includes taxes & fees
Hawks Cay Resort
Amara Cay Resort

Amara Cay Resort

80001 Overseas Hwy Islamorada FL
£179
18 Oct - 19 Oct
includes taxes & fees
8.8/10 Excellent! (1,323 reviews)
Amara Cay Resort
Still don't see what you're looking for?
See all properties in Lower Matecumbe Key.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Lower Matecumbe Key

Venture to sights like Robbie’s of Islamorada and Anne's Beach as you discover Lower Matecumbe Key.

See all hotels in Lower Matecumbe Key
A beach with a wooden pavilion, clear blue sky, and dense green foliage.

Top Lower Matecumbe Key Hotel Reviews

Cheeca Lodge & Spa

Cheeca Lodge & Spa

10/10 Excellent
"Really a nice place. Overall the Keys are an older area with many hotels/resorts showing signs of deferred maintenance. This place was a true 5 Star. Staff is/are unbelievable. 100% recommend."
Scott 1-night trip
Posted 5 hours ago
Cheeca Lodge & Spa

Find out more about Lower Matecumbe Key

Explore a world of travel with Expedia