Title: The 10 Best 5 Star Hotels in Lower Matecumbe Key - 2025 Updated Prices | Expedia.co.uk [Lower Matecumbe Key Travel Guide](https://expedia.co.uk/Lower-Matecumbe-Key.dx553248635975749077)[Hotels in Lower Matecumbe Key](https://expedia.co.uk/Lower-Matecumbe-Key-Hotels.d553248635975749077.Travel-Guide-Hotels)[Holiday Rentals in Lower Matecumbe Key](https://expedia.co.uk/Lower-Matecumbe-Key-Holiday-Rentals.d553248635975749077.Travel-Guide-HolidayRentals)[Flights to Lower Matecumbe Key](https://expedia.co.uk/Cheap-Flights-To-Lower-Matecumbe-Key.d553248635975749077.Travel-Guide-Flights)[Lower Matecumbe Key Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Lower-Matecumbe-Key.d553248635975749077.Car-Hire-Guide)[Lower Matecumbe Key Holidays](https://expedia.co.uk/Lower-Matecumbe-Key.d553248635975749077.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/497000/497078-annes-beach.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Lower Matecumbe Key, Islamorada - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Lower Matecumbe Key 5 Star Hotels Tonight [3 Nov - 4 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749077&startDate=2025-11-03&endDate=2025-11-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [4 Nov - 5 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749077&startDate=2025-11-04&endDate=2025-11-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749077&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [14 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749077&startDate=2025-11-14&endDate=2025-11-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Lower Matecumbe Key 5 Star Hotels ![Private beach, sun-loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/9b929f51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/981feca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/79d31a44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cheeca Lodge & Spa Matecumbe 9.2/10 Wonderful (1269) "This resort was amazing!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul £222 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/94000000/93070000/93061400/93061348/9b3c41b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/94000000/93070000/93061400/93061348/0917a41a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/94000000/93070000/93061400/93061348/ab76abc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/94000000/93070000/93061400/93061348/5de75c93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Condo in the Keys Tavernier 8.4/10 Very good (10) "The condo was clean, kitchen was stocked with utensils, easy to get to and easy to get around town. We enjoyed our stay and will be back. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard [](https://www.expedia.co.uk/Tavernier-Hotels-Condo-In-The-Keys.h93061348.Hotel-Information) ![Design Villa, Canal View | Balcony](https://images.trvl-media.com/lodging/110000000/109730000/109724500/109724487/5d9195bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, memory-foam beds](https://images.trvl-media.com/lodging/110000000/109730000/109724500/109724487/478c87a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/110000000/109730000/109724500/109724487/4e0d8909.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![75-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/110000000/109730000/109724500/109724487/e85faba6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Waterfront House with Boat Dock Hammer Point 6.0/10 (1) "Covered porch was nice for time outside. Inside was in need of work. Closets unfinished, no place to put any luggage, advertises a king bed and a queen bed, but only had a king and a full, no tp, or tissue products when we arrived. None of the above were deal breakers but just allot of small things that add up to frustration." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew [](https://www.expedia.co.uk/Tavernier-Hotels-Waterfront-House-With-Boat-Dock.h109724487.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Lower-Matecumbe-Key-Hotels.s50-0-d553248635975749077.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Lower-Matecumbe-Key-Hotels.s50-0-d553248635975749077.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Lower Matecumbe Key. ![Baker's Cay Resort Key Largo, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/20000/14100/14042/bbdba544_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baker's Cay Resort Key Largo, Curio Collection by Hilton 97000 Overseas Hwy, Key Largo, FL £312 1 Dec - 2 Dec includes taxes & fees 8.6/10 Excellent! (1,002 reviews) [](https://expedia.co.uk/Key-Largo-Hotels-Bakers-Cay-Resort-Key-Largo.h14042.Hotel-Information) ![Hawks Cay Resort](https://images.trvl-media.com/lodging/1000000/10000/6100/6068/b1845555_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hawks Cay Resort 61 Hawks Cay Blvd, Marathon, FL £235 17 Nov - 18 Nov includes taxes & fees 8/10 Very Good! (1,017 reviews) [](https://expedia.co.uk/Marathon-Hotels-Hawks-Cay-Resort.h6068.Hotel-Information) ![Amara Cay Resort](https://images.trvl-media.com/lodging/1000000/70000/62000/61976/84b50729_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Amara Cay Resort 80001 Overseas Hwy, Islamorada, FL £172 4 Dec - 5 Dec includes taxes & fees 8.8/10 Excellent! (1,277 reviews) [](https://expedia.co.uk/Islamorada-Hotels-Amara-Cay-Resort.h61976.Hotel-Information) Still don't see what you're looking for? [See all properties in Lower Matecumbe Key.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635975749077&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635975749077&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635975749077&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635975749077&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635975749077&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=04%2F11%2F2025&endDate=05%2F11%2F2025®ionId=553248635975749077&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Lower Matecumbe Key Venture to sights like Anne's Beach and Sunset Drive Beach as you discover Lower Matecumbe Key. [See all hotels in Lower Matecumbe Key](https://www.expedia.co.uk/Hotel-Search?startDate=2025-11-17&endDate=2025-11-18&adults=2®ionId=553248635975749077) ![D1TFGW Beautiful Anne's Beach in summer with deck in Lower Matecumbe Key, Florida Keys, USA](https://images.trvl-media.com/place/553248635975749077/bacc300b-9bce-4a51-b8cb-bc1d50c7c5e1.jpg?impolicy=fcrop&w=900&h=550&p=1&q=high) ## Top Lower Matecumbe Key Hotel Reviews ![Cheeca Lodge & Spa](//images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723_y.jpg) ### Cheeca Lodge & Spa 10/10 Excellent "Always a great stay at Cheeca. Lovely property, great restaurants, clean rooms and wonderful service by the staff. 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[Resorts in Upper Matecumbe Key](https://www.expedia.co.uk/Upper-Matecumbe-Key-Hotel-Resorts.d553248635975749648-aaHotelResorts.Travel-Guide-Accommodation) - [Beach Resorts & in Upper Matecumbe Key](https://www.expedia.co.uk/Upper-Matecumbe-Key-Hotels-Beach-Hotels.0-0-d553248635975749648-tBeachHotels.Travel-Guide-Filter-Hotels) - [Upper Matecumbe Key Hotels](https://www.expedia.co.uk/Upper-Matecumbe-Key-Hotels.d553248635975749648.Travel-Guide-Hotels) - [Windley Key Hotels](https://www.expedia.co.uk/Windley-Key-Hotels.d553248635976197663.Travel-Guide-Hotels) - [Flights to Islamorada](https://www.expedia.co.uk/Cheap-Flights-To-Islamorada.d10768.Travel-Guide-Flights) - [Flights to Upper Matecumbe Key](https://www.expedia.co.uk/Cheap-Flights-To-Upper-Matecumbe-Key.d553248635975749648.Travel-Guide-Flights) - [Flights to Windley Key](https://www.expedia.co.uk/Cheap-Flights-To-Windley-Key.d553248635976197663.Travel-Guide-Flights) - [Flights from Islamorada](https://www.expedia.co.uk/lp/flights/10768/flights-from-islamorada) - [Florida Keys Brewing Co.](https://www.expedia.co.uk/Florida-Keys-Brewing-Co-Matecumbe.d553248635997958830.Attraction) - [Islamorada Holidays](https://www.expedia.co.uk/Islamorada.d10768.Holidays-City-Breaks) - [Visit Islamorada](https://www.expedia.co.uk/Islamorada.dx10768) - [Visit Layton](https://www.expedia.co.uk/Layton.dx6177793) - [Visit Lignumvitae Key Botanical State Park](https://www.expedia.co.uk/Lignumvitae-Key-Botanical-State-Park.dx553248621532652349) - [Visit Long Key](https://www.expedia.co.uk/Long-Key.dx177527) - [Visit Upper Matecumbe Key](https://www.expedia.co.uk/Upper-Matecumbe-Key.dx553248635975749648) - [All inclusive Holiday Packages Lignumvitae Key Botanical State Park](https://www.expedia.co.uk/lp/theme-holidays/all-inclusive-holidays/553248621532652349/Lignumvitae-Key-Botanical-State-Park) - [Budget Rental Cars in Lower Arsnicker Keys](https://www.expedia.co.uk/Budget-Car-Rentals-In-Lower-Arsnicker-Keys.d553248635975748872-c39.Car-Rental-Guide-Suppliers) - [Car hire Islamorada](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Islamorada.d10768.Car-Hire-Guide) - [Car hire Layton](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Layton.d6177793.Car-Hire-Guide) - [Drive-A-Matic Rental Cars in Windley Key](https://www.expedia.co.uk/Drive-A-Matic-Car-Rentals-In-Windley-Key.d553248635976197663-c1082.Car-Rental-Guide-Suppliers) - [Easirent Rental Cars in Lower Arsnicker Keys](https://www.expedia.co.uk/Easirent-Car-Rentals-In-Lower-Arsnicker-Keys.d553248635975748872-c1039.Car-Rental-Guide-Suppliers) - [Goldcar Key’n Go Rental Cars in Windley Key](https://www.expedia.co.uk/Goldcar-Keyn-Go-Car-Rentals-In-Windley-Key.d553248635976197663-c1044.Car-Rental-Guide-Suppliers) - [Localiza Argentina Rental Cars in Windley Key](https://www.expedia.co.uk/Localiza-Argentina-Car-Rentals-In-Windley-Key.d553248635976197663-c1097.Car-Rental-Guide-Suppliers) - [Midway Car Rental Rental Cars in Lower Arsnicker Keys](https://www.expedia.co.uk/Midway-Car-Rental-Car-Rentals-In-Lower-Arsnicker-Keys.d553248635975748872-c27.Car-Rental-Guide-Suppliers) - [Islamorada Holiday Rentals](https://www.expedia.co.uk/Islamorada-Holiday-Rentals.d10768.Travel-Guide-HolidayRentals) - [Things to do in Islamorada](https://www.expedia.co.uk/Things-To-Do-In-Islamorada.d10768.Travel-Guide-Activities) - [Things to do in Windley Key](https://www.expedia.co.uk/Things-To-Do-In-Windley-Key.d553248635976197663.Travel-Guide-Activities) - [Book 5 Star Hotels in Lower Matecumbe Key on Expedia.com](https://www.expedia.com/5Star-Lower-Matecumbe-Key-Hotels.s50-0-d553248635975749077.Travel-Guide-Filter-Hotels)