Compare and book 5 Star hotels in Key Largo, Florida

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo 5 Star Hotels

Tonight
8 Apr - 9 Apr
Tomorrow
9 Apr - 10 Apr
This weekend
10 Apr - 12 Apr
Next weekend
17 Apr - 19 Apr

Our top choices for Key Largo 5-star hotels

Terrace/patio

Waterfront House with Boat Dock

Waterfront House with Boat Dock
5.0 star property
Hammer Point
6.0 out of 10, (3 reviews)
"Everything was fine except half way through the stay the water department came and shut off the water at the street. It came back on a few hours later, so it all worked out. The house was fine"
United States
Philip J
Waterfront House with Boat Dock
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Key Largo.
Reefhouse Resort & Marina

Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL
The price is £282 per night from 19 Apr to 20 Apr
£282
19 Apr - 20 Apr
includes taxes & fees
9.4/10 Exceptional! (1,405 reviews)
Still don't see what you're looking for?
See all properties in Key Largo.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Key Largo

The underwater paradise of John Pennekamp Coral Reef State Park offers the best snorkelling visibility before noon. Dive among colourful fish at America's first undersea park, then feast on fresh-caught grouper at waterfront restaurants where locals gather.

See all hotels in Key Largo

Top Key Largo Hotel Reviews

Find out more about Key Largo

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Key Largo?
The amount you pay for a 5-star hotel in Key Largo depends on things like when you plan to go and the length of your stay. An insider tip for scoring an awesome deal? Use our pricing filters to compare all of the available hotels for your chosen dates.

  • Search for the lowest price per night from £282

What makes a hotel 5 stars in Key Largo?
From gourmet restaurants and fitness centres to swimming pools and deluxe bedding, the 5-star experience in Key Largo is all about relaxation and luxury. But it takes more than just upscale amenities to receive a 5-star rating. Stays must also offer remarkable guest services like beauty treatments, laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Key Largo?
Our filter tool is the best way to search for exactly what you want. Select "5-star" and "All inclusive" to see the most luxurious resorts in Key Largo where your meals, accommodation, entertainment and activities are included in the price. At these getaways, your trip is pure leisure from the moment you step foot in the lobby.

Explore a world of travel with Expedia