A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Compare and book 5 Star hotels in Key Largo, Florida

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo 5 Star Hotels

Tonight
22 Aug - 23 Aug
Tomorrow
23 Aug - 24 Aug
Next weekend
28 Aug - 30 Aug
In two weeks
4 Sept - 6 Sept

Our top choices for Key Largo 5-star hotels

Terrace/patio
Exterior
Egyptian cotton sheets, premium bedding, memory-foam beds, desk
Staircase

1. Waterfront House with Boat Dock

Waterfront House with Boat Dock
Hammer Point
United States
Philip J
Waterfront House with Boat Dock
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Key Largo.
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

97000 Overseas Hwy Key Largo FL
£249
21 Sept - 22 Sept
includes taxes & fees
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Reefhouse Resort & Marina

Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL
£210
23 Aug - 24 Aug
includes taxes & fees
Reefhouse Resort & Marina
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

97450 Overseas Highway Key Largo FL
£244
21 Sept - 22 Sept
includes taxes & fees
9/10 Wonderful! (1,015 reviews)
Playa Largo Resort & Spa, Autograph Collection
Still don't see what you're looking for?
See all properties in Key Largo.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Key Largo

The underwater paradise of John Pennekamp Coral Reef State Park offers the best snorkelling visibility before noon. Dive among colourful fish at America's first undersea park, then feast on fresh-caught grouper at waterfront restaurants where locals gather.

See all hotels in Key Largo
A beach with palm trees, lounge chairs, a hammock, and a pool.

Top Key Largo Hotel Reviews

Find out more about Key Largo

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Key Largo?
The amount you pay for a 5-star hotel in Key Largo depends on things like when you plan to go and the length of your stay. An insider tip for scoring an awesome deal? Use our pricing filters to compare all of the available hotels for your chosen dates.
  • Search for the lowest price per night from £210
What makes a hotel 5 stars in Key Largo?
From gourmet restaurants and fitness centres to swimming pools and deluxe bedding, the 5-star experience in Key Largo is all about relaxation and luxury. But it takes more than just upscale amenities to receive a 5-star rating. Stays must also offer remarkable guest services like beauty treatments, laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Key Largo?
Our filter tool is the best way to search for exactly what you want. Select "5-star" and "All inclusive" to see the most luxurious resorts in Key Largo where your meals, accommodation, entertainment and activities are included in the price. At these getaways, your trip is pure leisure from the moment you step foot in the lobby.

Explore a world of travel with Expedia