Title: The 10 Best 5 Star Hotels in Lower Arsnicker Keys - 2025 Updated Prices | Expedia.co.uk [Lower Arsnicker Keys Travel Guide](https://expedia.co.uk/Lower-Arsnicker-Keys.dx553248635975748872)[Hotels in Lower Arsnicker Keys](https://expedia.co.uk/Lower-Arsnicker-Keys-Hotels.d553248635975748872.Travel-Guide-Hotels)[Holiday Rentals in Lower Arsnicker Keys](https://expedia.co.uk/Lower-Arsnicker-Keys-Holiday-Rentals.d553248635975748872.Travel-Guide-HolidayRentals)[Flights to Lower Arsnicker Keys](https://expedia.co.uk/Cheap-Flights-To-Lower-Arsnicker-Keys.d553248635975748872.Travel-Guide-Flights)[Lower Arsnicker Keys Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Lower-Arsnicker-Keys.d553248635975748872.Car-Hire-Guide)[Lower Arsnicker Keys Holidays](https://expedia.co.uk/Lower-Arsnicker-Keys.d553248635975748872.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Lower Arsnicker Keys, Florida ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Lower Arsnicker Keys 5 Star Hotels Tonight [19 Sept - 20 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748872&startDate=2025-09-19&endDate=2025-09-20&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [20 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748872&startDate=2025-09-20&endDate=2025-09-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748872&startDate=2025-09-19&endDate=2025-09-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748872&startDate=2025-09-26&endDate=2025-09-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Lower Arsnicker Keys 5 Star Hotels ## Our top choices for Lower Arsnicker Keys 5-star hotels ![Private beach, sun-loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/e32d7e53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/79d31a44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/981feca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cheeca Lodge & Spa Matecumbe 9.2/10 Wonderful (1205) "Great place to stay and the staff was great. " £123 includes taxes & fees 1 Oct - 2 Oct [](https://www.expedia.co.uk/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Lower-Arsnicker-Keys-Hotels.s50-0-d553248635975748872.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Lower-Arsnicker-Keys-Hotels.s50-0-d553248635975748872.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Lower Arsnicker Keys. ![Hawks Cay Resort](https://images.trvl-media.com/lodging/1000000/10000/6100/6068/b1845555_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hawks Cay Resort 61 Hawks Cay Blvd, Marathon, FL £263 28 Sept - 29 Sept includes taxes & fees 8/10 Very Good! (1,004 reviews) [](https://expedia.co.uk/Marathon-Hotels-Hawks-Cay-Resort.h6068.Hotel-Information) ![Amara Cay Resort](https://images.trvl-media.com/lodging/1000000/70000/62000/61976/84b50729_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Amara Cay Resort 80001 Overseas Hwy, Islamorada, FL £182 22 Sept - 23 Sept includes taxes & fees 8.8/10 Excellent! (1,247 reviews) [](https://expedia.co.uk/Islamorada-Hotels-Amara-Cay-Resort.h61976.Hotel-Information) ![Islander Resort](https://images.trvl-media.com/lodging/1000000/480000/475500/475438/5adae4af_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Islander Resort 82100 Overseas Highway, Islamorada, FL £186 25 Sept - 26 Sept includes taxes & fees 9/10 Wonderful! (1,002 reviews) [](https://expedia.co.uk/Islamorada-Hotels-Islander-Resort.h475438.Hotel-Information) Still don't see what you're looking for? [See all properties in Lower Arsnicker Keys.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F09%2F2025&endDate=21%2F09%2F2025®ionId=553248635975748872&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F09%2F2025&endDate=21%2F09%2F2025®ionId=553248635975748872&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F09%2F2025&endDate=21%2F09%2F2025®ionId=553248635975748872&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F09%2F2025&endDate=21%2F09%2F2025®ionId=553248635975748872&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F09%2F2025&endDate=21%2F09%2F2025®ionId=553248635975748872&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=20%2F09%2F2025&endDate=21%2F09%2F2025®ionId=553248635975748872&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Lower Arsnicker Keys Hotel Reviews ![Cheeca Lodge & Spa](//images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723_y.jpg) ### Cheeca Lodge & Spa 10/10 Excellent "Exceptional customer service, a plethora of activities and in a central location with many desirable businesses within a close reach." 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