Title: The 10 Best 5 Star Hotels in Key West - 2025 Updated Prices | Expedia.co.uk [Key West Travel Guide](https://expedia.co.uk/Key-West.dx1187)[Hotels in Key West](https://expedia.co.uk/Key-West-Hotels.d1187.Travel-Guide-Hotels)[Holiday Rentals in Key West](https://expedia.co.uk/Key-West-Holiday-Rentals.d1187.Travel-Guide-HolidayRentals)[Flights to Key West](https://expedia.co.uk/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)[Things to do in Key West](https://expedia.co.uk/Things-To-Do-In-Key-West.d1187.Travel-Guide-Activities)[Key West Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Key-West.d1187.Car-Hire-Guide)[Key West Holidays](https://expedia.co.uk/Key-West.d1187.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/497000/497918-south-beach-fm.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Key West, Florida ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Key West 5 Star Hotels Tonight [26 Sept - 27 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2025-09-26&endDate=2025-09-27&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [27 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2025-09-27&endDate=2025-09-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2025-09-26&endDate=2025-09-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Key West 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Key-West-Hotels.s50-0-d1187.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Key-West-Hotels.s50-0-d1187.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Key West. ![Hyatt Centric Key West Resort and Spa](https://images.trvl-media.com/lodging/1000000/10000/1000/901/0b72a249_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Centric Key West Resort and Spa 601 Front St, Key West, FL £216 28 Sept - 29 Sept includes taxes & fees 8.8/10 Excellent! (1,019 reviews) [](https://expedia.co.uk/Key-West-Hotels-Hyatt-Centric-Key-West-Resort-And-Spa.h901.Hotel-Information) ![Oceans Edge Key West Resort, Hotel & Marina](https://images.trvl-media.com/lodging/17000000/16210000/16203000/16202992/3a4457a0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Oceans Edge Key West Resort, Hotel & Marina 5950 Peninsular Avenue, Key West, FL £172 28 Oct - 29 Oct includes taxes & fees 8.8/10 Excellent! (1,731 reviews) [](https://expedia.co.uk/Key-West-Hotels-Oceans-Edge-Key-West-Resort.h16202992.Hotel-Information) ![Southernmost Beach Resort and Guesthouses](https://images.trvl-media.com/lodging/1000000/870000/863400/863329/026f10af_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Southernmost Beach Resort and Guesthouses 1319 Duval Street, Key West, FL £199 15 Oct - 16 Oct includes taxes & fees 8.6/10 Excellent! (2,777 reviews) [](https://expedia.co.uk/Key-West-Hotels-Southernmost-Beach-Resort.h863329.Hotel-Information) Still don't see what you're looking for? [See all properties in Key West.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F09%2F2025&endDate=29%2F09%2F2025®ionId=1187&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F09%2F2025&endDate=29%2F09%2F2025®ionId=1187&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F09%2F2025&endDate=29%2F09%2F2025®ionId=1187&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F09%2F2025&endDate=29%2F09%2F2025®ionId=1187&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F09%2F2025&endDate=29%2F09%2F2025®ionId=1187&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=28%2F09%2F2025&endDate=29%2F09%2F2025®ionId=1187&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Key West Located at the southernmost tip of Florida, this sun-drenched, fun-loving island encourages visitors to leave their worries behind and embrace relaxation. [See all hotels in Key West](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12&adults=2®ionId=1187) ![](https://mediaim.expedia.com/destination/1/c4f5fbe406cfa98c536b7a56abbbef4c.jpg?impolicy=fcrop&w=900&h=495&p=1&q=high) ## Top Key West Hotel Reviews ## Find out more about Key West ## Frequently asked questions ### What are the best 5-star hotels in Key West? > Treat yourself to a luxurious stay at [Casa Marina Key West, Curio Collection by Hilton](https://www.expedia.co.uk/Key-West-Hotels-Casa-Marina-Key-West.h12346.Hotel-Information). This is one of the top 5-star hotels in Key West based on Expedia customer reviews. From its plush guest rooms to its premium amenities and services, you can expect an exceptional guest experience. ### How much does it cost to stay in a 5-star hotel in Key West? > How much you pay for a 5-star hotel in Key West depends on factors like when you plan to go and the length of your escape. An insider tip for scoring an awesome deal? Use our pricing filters to compare the available hotels for your preferred dates. > > > > - Search for the lowest price per night from £172 ### What makes a hotel 5 stars in Key West? > From high-end restaurants and all-day gyms to pools and deluxe bedding, the 5-star experience in Key West is all about comfort and luxury. But it requires more than just top-notch perks to receive a 5-star rating. 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