Title: The 10 Best 5 Star Hotels in Key West - 2026 Updated Prices | Expedia.co.uk [Key West Travel Guide](https://expedia.co.uk/Key-West.dx1187)[Hotels in Key West](https://expedia.co.uk/Key-West-Hotels.d1187.Travel-Guide-Hotels)[Holiday Rentals in Key West](https://expedia.co.uk/Key-West-Holiday-Rentals.d1187.Travel-Guide-HolidayRentals)[Flights to Key West](https://expedia.co.uk/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)[Things to do in Key West](https://expedia.co.uk/Things-To-Do-In-Key-West.d1187.Travel-Guide-Activities)[Key West Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Key-West.d1187.Car-Hire-Guide)[Key West Holidays](https://expedia.co.uk/Key-West.d1187.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/1187/a7c3fad3-5f12-4d91-8996-ed0e1b61b0a3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Key West, Florida - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Key West 5 Star Hotels Tonight [31 Dec - 1 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2025-12-31&endDate=2026-01-01&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [1 Jan - 2 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2026-01-01&endDate=2026-01-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2026-01-02&endDate=2026-01-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [9 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=1187&startDate=2026-01-09&endDate=2026-01-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Key-West-Hotels.s50-0-d1187.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Key-West-Hotels.s50-0-d1187.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Key West. ![Blue Flamingo Resort Key West](https://images.trvl-media.com/lodging/13000000/12600000/12599300/12599231/c4b850d1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Blue Flamingo Resort Key West 3820 North Roosevelt Boulevard Key West FL £236 11 Jan - 12 Jan 2026 includes taxes & fees 8/10 Very Good! (1,803 reviews) [](https://expedia.co.uk/Key-West-Hotels-24-North-Hotel-Key-West-Newly-Renovated.h12599231.Hotel-Information) ![Southernmost Beach Resort and Guesthouses](https://images.trvl-media.com/lodging/1000000/870000/863400/863329/026f10af_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Southernmost Beach Resort and Guesthouses 1319 Duval Street Key West FL £289 13 Jan - 14 Jan 2026 includes taxes & fees 8.6/10 Excellent! (2,956 reviews) [](https://expedia.co.uk/Key-West-Hotels-Southernmost-Beach-Resort.h863329.Hotel-Information) ![Hyatt Centric Key West Resort and Spa](https://images.trvl-media.com/lodging/1000000/10000/1000/901/0b72a249_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Centric Key West Resort and Spa 601 Front St Key West FL £381 12 Jan - 13 Jan 2026 includes taxes & fees 8.8/10 Excellent! (1,001 reviews) [](https://expedia.co.uk/Key-West-Hotels-Hyatt-Centric-Key-West-Resort-And-Spa.h901.Hotel-Information) Still don't see what you're looking for? [See all properties in Key West.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F01%2F2026&endDate=02%2F01%2F2026®ionId=1187&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F01%2F2026&endDate=02%2F01%2F2026®ionId=1187&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F01%2F2026&endDate=02%2F01%2F2026®ionId=1187&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F01%2F2026&endDate=02%2F01%2F2026®ionId=1187&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F01%2F2026&endDate=02%2F01%2F2026®ionId=1187&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=01%2F01%2F2026&endDate=02%2F01%2F2026®ionId=1187&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Key West Stroll Duval Street's colourful shops and bars before catching the sunset celebration at Mallory Square with local performers. Explore Hemingway's historic home where six-toed cats roam freely, then snorkel the vibrant coral reefs just offshore. [See all hotels in Key West](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-14&endDate=2026-01-15&adults=2®ionId=1187) ![](https://images.trvl-media.com/place/1187/a7c3fad3-5f12-4d91-8996-ed0e1b61b0a3.jpg?impolicy=fcrop&w=900&h=495&p=1&q=high) ## Top Key West Hotel Reviews ## Find out more about Key West ## Frequently asked questions ### What are the best 5-star hotels in Key West? ### How much does it cost to stay in a 5-star hotel in Key West? > - Search for the lowest price per night from £236 ### What makes a hotel 5 stars in Key West? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [1 Star Hotels in Dredgers Key ](https://www.expedia.co.uk/1Star-Dredgers-Key-Hotels.s10-0-d180165.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Chokoloskee Island ](https://www.expedia.co.uk/2Star-Chokoloskee-Island-Hotels.s20-0-d553248635976468286.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Key Haven ](https://www.expedia.co.uk/2Star-Key-Haven-Hotels.s20-0-d553248635976197997.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Boca Chica Key ](https://www.expedia.co.uk/3Star-Boca-Chica-Key-Hotels.s30-0-d553248635083916609.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Dredgers Key ](https://www.expedia.co.uk/3Star-Dredgers-Key-Hotels.s30-0-d180165.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Duck Key ](https://www.expedia.co.uk/3Star-Duck-Key-Hotels.s30-0-d184267.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Marathon ](https://www.expedia.co.uk/3Star-Marathon-Hotels.s30-0-d2437.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Bahia Honda Key ](https://www.expedia.co.uk/4Star-Bahia-Honda-Key-Hotels.s40-0-d553248635083902001.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Chokoloskee Island ](https://www.expedia.co.uk/4Star-Chokoloskee-Island-Hotels.s40-0-d553248635976468286.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Duck Key ](https://www.expedia.co.uk/4Star-Duck-Key-Hotels.s40-0-d184267.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Fleming Key ](https://www.expedia.co.uk/4Star-Fleming-Key-Hotels.s40-0-d180162.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Islamorada ](https://www.expedia.co.uk/4Star-Islamorada-Hotels.s40-0-d10768.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Marathon ](https://www.expedia.co.uk/4Star-Marathon-Hotels.s40-0-d2437.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Marco Island ](https://www.expedia.co.uk/4Star-Marco-Island-Hotels.s40-0-d8812.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Rockland Key ](https://www.expedia.co.uk/4Star-Rockland-Key-Hotels.s40-0-d553248635976197596.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Duck Key ](https://www.expedia.co.uk/5Star-Duck-Key-Hotels.s50-0-d184267.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Everglades City ](https://www.expedia.co.uk/5Star-Everglades-City-Hotels.s50-0-d6023564.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Islamorada ](https://www.expedia.co.uk/5Star-Islamorada-Hotels.s50-0-d10768.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Key Largo ](https://www.expedia.co.uk/5Star-Key-Largo-Hotels.s50-0-d8369.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Marathon ](https://www.expedia.co.uk/5Star-Marathon-Hotels.s50-0-d2437.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Marco Island ](https://www.expedia.co.uk/5Star-Marco-Island-Hotels.s50-0-d8812.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Tingler Island ](https://www.expedia.co.uk/5Star-Tingler-Island-Hotels.s50-0-d553248635976196806.Travel-Guide-Filter-Hotels) - [Bahama Village Hotels ](https://www.expedia.co.uk/Bahama-Village-Key-West-Hotels.0-n553248621533115696-0.Travel-Guide-Filter-Hotels) - [Hotels near Clarence S. 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