Panama Adults Only Holidays
Book a Adults Only Hotel + Flight or Car together to unlock savings
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Better together
Save up to £335 when you book a flight and hotel together*
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With over 300,000 hotels worldwide, it's easy to create a perfect package
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Packages with flights are ATOL protected
Top Adults Only Panama Hotels
Tantalo Hotel
Calle 8 Este con Avenida B, Casco Viejo, San Felipe, Ciudad de Panama, Panama City, Panama
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free Wi-Fi, a rooftop terrace and breakfast (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (267 reviews)
"The hotel is in the heart of Casco Viejo. You have a great rooftop restaurant and bar. The service is friendly and professional."
Reviewed on 7 Jul 2025
The Haven and Spa - Health and Wellness Accommodation - Adults Only
Avenida A Oeste, Bajo, Boquete, Chiriqui
Stay at this 3.5-star spa hotel in Boquete. Enjoy free Wi-Fi, free parking and a full-service spa. Popular attractions Boquete Library and Municipal Park are ...
"Definitely a mountaintop heaven."
Reviewed on 25 Feb 2022
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.