Title: £483 Cheap Flights from Santiago Island to São Tomé Island (RAI to TMS) - Expedia.co.uk ![A pretty sunset in São Tomé.](https://images.trvl-media.com/place/553248635976006815/07aca925-8318-4676-9191-b2ca4e7702d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Toshiaki Yoshitake ![](https://images.trvl-media.com/place/553248635976006815/07aca925-8318-4676-9191-b2ca4e7702d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £483 Cheap Flights from Santiago Island (RAI) to São Tomé Island (TMS) [View £483 flight on Sat, 25 Oct 2025](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:RAI,to:TMS,departure:25/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:482.90&airProductToken=AQptCjQI1KABEgQxNTQyGJFAIIuSASiFpvsCMPqn-wI4RUAAWAFqB0RJU0NJTlRyCEVMMERTSTgwCjUI1KABEgQxNTI3GIuSASCTkwEov6_7AjC9s_sCOEVAAFgBagdESVNDSU5UcghFTDBEU0k4MBIKCAEQARgBKgJUUBgBIgQIARABKAIoAygEMA0) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Santiago Island (RAI-Praia Intl.) to São Tomé Island (TMS-São Tomé Intl.) - ![TAP Portugal](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_TP.svg) TAP Portugal [](https://www.expedia.co.uk/Flights-Search?leg1=from:rai,to:tms,departure:30/09/2025TANYT&leg2=from:tms,to:rai,departure:07/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"TP"}}]) - ## Plan, book, fly with confidence - ### Be in the know Get alerts if flight prices drop or rise\* - ### Book smarter Save up to 25% on select hotels after you book a flight\* - ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from Santiago Island (RAI) to São Tomé Island (TMS) Prices were available within the past 7 days and start at £483 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ## Travel information | Origin airport | Praia Intl. | | --- | --- | | Destination airport | São Tomé Intl. | | Distance | 3670 km | ## Book with confidence ### Compare flights from Santiago Island to São Tomé Island easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from Santiago Island to São Tomé Island. Operating between them flights per day, 19 airlines cover the route. And fly direct, getting you to São Tomé Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Praia Intl. to São Tomé Intl..   To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights.  Grab a great deal on your flight from Praia Intl. (RAI) to São Tomé Intl. (TMS) The easiest way to view the best deals on flights from Santiago Island to São Tomé Island today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Praia Intl. to São Tomé Intl. start at just and range up to .   To find an even better deal, try   - being flexible on your dates – midweek flights can be cheaper - looking for other airports near Santiago Island and São Tomé Island - booking your flight during , the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper  Why you should book your Santiago Island to São Tomé Island flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Praia Intl. to São Tomé Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.   Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.   ## Explore a world of travel with Expedia - Trending Routes - Trending Flights - Top Flights Destinations - Related Airlines - Cheap Flights from Other Airports - Expedia's Latest Trends ### Top Routes from Santiago Island - [Santiago Island to Sao Vicente Island (RAI - VXE)](https://expedia.co.uk/lp/flights/rai/vxe/santiago-island-to-sao-vicente-island) - [Santiago Island to Boston (RAI - BOS)](https://expedia.co.uk/lp/flights/rai/bos/santiago-island-to-boston) - [Santiago Island to Boa Vista Island (RAI - BVC)](https://expedia.co.uk/lp/flights/rai/bvc/santiago-island-to-boa-vista-island) - [Santiago Island to Maio Island (RAI - MMO)](https://expedia.co.uk/lp/flights/rai/mmo/santiago-island-to-maio-island) - [Santiago Island to Sal Island (RAI - SID)](https://expedia.co.uk/lp/flights/rai/sid/santiago-island-to-sal-island) ### Top Routes to São Tomé Island - [Accra to São Tomé Island (ACC - TMS)](https://expedia.co.uk/lp/flights/acc/tms/accra-to-sao-tome-island) - [Geneva to São Tomé Island (GVA - TMS)](https://expedia.co.uk/lp/flights/gva/tms/geneva-to-sao-tome-island) - [Prague to São Tomé Island (PRG - TMS)](https://expedia.co.uk/lp/flights/prg/tms/prague-to-sao-tome-island) - [Cape Town to São Tomé Island (CPT - TMS)](https://expedia.co.uk/lp/flights/cpt/tms/cape-town-to-sao-tome-island) - [Lisbon to São Tomé Island (LIS - TMS)](https://expedia.co.uk/lp/flights/lis/tms/lisbon-to-sao-tome-island) - [London to São Tomé Island (LHR - TMS)](https://expedia.co.uk/lp/flights/lhr/tms/london-to-sao-tome-island) - [Amsterdam to São Tomé Island (AMS - TMS)](https://expedia.co.uk/lp/flights/ams/tms/amsterdam-to-sao-tome-island) - [Manchester to São Tomé Island (MAN - TMS)](https://expedia.co.uk/lp/flights/man/tms/manchester-to-sao-tome-island) - [Lome to São Tomé Island (LFW - TMS)](https://expedia.co.uk/lp/flights/lfw/tms/lome-to-sao-tome-island) - [London to São Tomé Island (LGW - TMS)](https://expedia.co.uk/lp/flights/lgw/tms/london-to-sao-tome-island) - [Johannesburg to São Tomé Island (JNB - TMS)](https://expedia.co.uk/lp/flights/jnb/tms/johannesburg-to-sao-tome-island) ### Top Routes to São Tomé Island - [Ethiopian Airlines Cape Town to São Tomé Island](https://expedia.co.uk/lp/flight-routes/ethiopian-airlines-from-cape-town-intl-to-sao-tome-intl/et/cpt/tms) ### Top Flight Destinations - [Flights to Príncipe Island](https://expedia.co.uk/Cheap-Flights-To-Principe-Island.d2752.Travel-Guide-Flights) ### Related Airlines - [TAP Portugal](https://expedia.co.uk/TAP-Portugal-Flights.cTP.Travel-Guide-Airlines) - [Royal Air Maroc](https://expedia.co.uk/Royal-Air-Maroc-Flights.cAT.Travel-Guide-Airlines) - [Turkish Airlines](https://expedia.co.uk/Turkish-Airlines-Flights.cTK.Travel-Guide-Airlines) - [SATA International-Azores Airlines S.A.](https://expedia.co.uk/SATA-International-Azores-Airlines-SA-Flights.cS4.Travel-Guide-Airlines) - [easyJet](https://expedia.co.uk/EasyJet-Flights.cU2.Travel-Guide-Airlines) - [ASKY](https://expedia.co.uk/ASKY-Flights.cKP.Travel-Guide-Airlines) - [Air Senegal](https://expedia.co.uk/Air-Senegal-Flights.cHC.Travel-Guide-Airlines) - [Ethiopian Airlines](https://expedia.co.uk/Ethiopian-Airlines-Flights.cET.Travel-Guide-Airlines) - [Swiss International Air Lines](https://expedia.co.uk/Swiss-International-Air-Lines-Flights.cLX.Travel-Guide-Airlines) - [Transavia France](https://expedia.co.uk/Transavia-France-Flights.cTO.Travel-Guide-Airlines) ### Nearby Airports - [Aristides Pereira Intl. 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