Title: £741 Cheap Flights from Frankfurt to São Tomé Island (FRA to TMS) - Expedia.co.uk ![Newton's sunbird, male, beautiful bird singing on a palm tree, in Sao Tome and Principe, Anabathmis newtonii ](https://images.trvl-media.com/place/3486/5eee3996-3014-4835-bbeb-ffea36d9d490.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/3486/5eee3996-3014-4835-bbeb-ffea36d9d490.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £741 Cheap Flights from Frankfurt (FRA) to São Tomé Island (TMS) [View £741 flight on Thu, 12 Mar 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:740.70&airProductToken=AQpsCjMI1KABEgM1NzMYpQQgi5IBKI24hwMw0LmHAzhBQABYAWoHRElTQ0lOVHIIQUwwRFNJMDUKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4QUAAWAFqB0RJU0NJTlRyCEFMMERTSTA1EgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Frankfurt Airport (FRA) to São Tomé Island (TMS-São Tomé Intl.) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_TP.svg) TAP Portugal [](https://www.expedia.co.uk/Flights-Search?leg1=from:FRA,to:TMS,departure:18/02/2026TANYT&leg2=from:TMS,to:FRA,departure:25/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"TP"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_ET.svg) Ethiopian Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:FRA,to:TMS,departure:18/02/2026TANYT&leg2=from:TMS,to:FRA,departure:25/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"ET"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DT.svg) TAAG Angola Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:FRA,to:TMS,departure:18/02/2026TANYT&leg2=from:TMS,to:FRA,departure:25/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DT"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from Frankfurt (FRA) to São Tomé Island (TMS) Prices were available within the past 7 days and start at £741 for one-way flights and £974 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £974 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:973.70&airProductToken=AQpsCjMI1KABEgM1NzEYpQQgi5IBKIm2hwMwzLeHAzhFQABYAWoHRElTQ0lOVHIIRUwwRFNJODEKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4RUAAWAFqB0RJU0NJTlRyCEVMMERTSTgxCmwKNQjUoAESBDE1MjgYk5MBIIuSASiQ_YcDMLGBiAM4TEAAWAFqB0RJU0NJTlRyCExMMERTSTcxCjMI1KABEgM1NzIYi5IBIKUEKP2EiAMwu4aIAzhMQABYAWoHRElTQ0lOVHIITEwwRFNJNzESCggBEAEYASoCVFAYASIECAEQASgCKAMoBDAN) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,050 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1049.20&airProductToken=AQpsCjMI1KABEgM1NzMYpQQgi5IBKI24hwMw0LmHAzhMQABYAWoHRElTQ0lOVHIITEwwRFNJNzEKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4TEAAWAFqB0RJU0NJTlRyCExMMERTSTcxCmwKNQjUoAESBDE1MjgYk5MBIIuSASiQ_YcDMLGBiAM4TEAAWAFqB0RJU0NJTlRyCExMMERTSTcxCjMI1KABEgM1NzIYi5IBIKUEKP2EiAMwu4aIAzhMQABYAWoHRElTQ0lOVHIITEwwRFNJNzESCggBEAEYASoCVFAYASIECAEQASgCKAMoBDAN) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,145 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1144.40&airProductToken=AQpsCjMI1KABEgM1NzEYpQQgi5IBKIm2hwMwzLeHAzhFQABYAWoHRElTQ0lOVHIIRUwwRFNJODEKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4RUAAWAFqB0RJU0NJTlRyCEVMMERTSTgxCnkKNQjUoAESBDE1MjgYk5MBIIuSASiQ_YcDMLGBiAM4V0AAWAFqB0RJU0NJTlRyCFdMMEJTSTAxCkAI1KABEgQ2NzAzGIuSASClBCixhogDMOqHiAM4V0AAWAFqB0RJU0NJTlRyCFdMMEJTSTAxegoIzJABEgQ2NzAzEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,157 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1156.10&airProductToken=AQpsCjMI1KABEgM1NzEYpQQgi5IBKIm2hwMwzLeHAzhFQABYAWoHRElTQ0lOVHIIRUwwRFNJODEKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4RUAAWAFqB0RJU0NJTlRyCEVMMERTSTgxCroBCjUI1KABEgQxNTI4GJOTASCLkgEokP2HAzCxgYgDOFdAAFgBagdESVNDSU5UcghXTDBCU0kwMQpACNSgARIEMTkyMBiLkgEg7nMon4KIAzDggogDOFdAAFgBagdESVNDSU5UcghXTDBCU0kwMXoKCM6SARIEMTkyMAo_CNSgARIENjY4MRjucyClBCjuhIgDMJOGiAM4V0AAWAFqB0RJU0NJTlRyCFdMMEJTSTAxegoIzJABEgQ2NjgxEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,219 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1218.90&airProductToken=AQpsCjMI1KABEgM1NzMYpQQgi5IBKI24hwMw0LmHAzhMQABYAWoHRElTQ0lOVHIITEwwRFNJNzEKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4TEAAWAFqB0RJU0NJTlRyCExMMERTSTcxCnkKNQjUoAESBDE1MjgYk5MBIIuSASiQ_YcDMLGBiAM4V0AAWAFqB0RJU0NJTlRyCFdMMEJTSTAxCkAI1KABEgQ2NzAzGIuSASClBCixhogDMOqHiAM4V0AAWAFqB0RJU0NJTlRyCFdMMEJTSTAxegoIzJABEgQ2NzAzEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,231 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1230.60&airProductToken=AQpsCjMI1KABEgM1NzMYpQQgi5IBKI24hwMw0LmHAzhMQABYAWoHRElTQ0lOVHIITEwwRFNJNzEKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4TEAAWAFqB0RJU0NJTlRyCExMMERTSTcxCroBCjUI1KABEgQxNTI4GJOTASCLkgEokP2HAzCxgYgDOFdAAFgBagdESVNDSU5UcghXTDBCU0kwMQpACNSgARIEMTkyNBiLkgEg7nMo3YOIAzCZhIgDOFdAAFgBagdESVNDSU5UcghXTDBCU0kwMXoKCM6SARIEMTkyNAo_CNSgARIENjY4MRjucyClBCjuhIgDMJOGiAM4V0AAWAFqB0RJU0NJTlRyCFdMMEJTSTAxegoIzJABEgQ2NjgxEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![Ethiopian Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/ET.gif) Wed, 11 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,261 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:11/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1260.10&airProductToken=AQqOAQooCMWoARIDNzA3GKUEIOAYKNOuhwMw7bGHAzhUQABYAXIHVExYRVNERQopCMWoARIDOTU1GOAYIKuoASiNs4cDMPq1hwM4VEABWAFyB1RMWEVTREUKNwjFqAESBDEwMjAYq6gBIJOTASiIuIcDMMS4hwM4VEABWAFyB1RMWEVTREV6CgjLoAESBDEwMjAKjAEKNQjFqAESBDEwMjEYk5MBIKuoASiE94cDMMD3hwM4VkAAWAFyBVZFRU9XegoIy6ABEgQxMDIxCikIxagBEgM5MjUYq6gBIOAYKKb5hwMwk_yHAzhWQAFYAXIHVkxYRVNERQooCMWoARIDNzA2GOAYIKUEKOD9hwMwnYGIAzhWQAFYAXIHVkxYRVNERRIKCAEQARgBKgJFVBgBIgQIARABKAIoBCgGMAE) ![Ethiopian Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/ET.gif) Wed, 11 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,459 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:11/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1459.00&airProductToken=AQqMAQooCMWoARIDNzA3GKUEIOAYKNOuhwMw7bGHAzhIQABYAXIHSExYT1dERQopCMWoARIDOTU1GOAYIKuoASiNs4cDMPq1hwM4SEABWAFyB0hMWE9XREUKNQjFqAESBDEwMjAYq6gBIJOTASiIuIcDMMS4hwM4VkABWAFyBVZFRU9XegoIy6ABEgQxMDIwEgoIARABGAEqAkVUGAEiBAgBEAEoAigEKAYwAQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,505 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1504.70&airProductToken=AQpsCjMI1KABEgM1NzMYpQQgi5IBKI24hwMw0LmHAzhBQABYAWoHRElTQ0lOVHIIQUwwRFNJMDUKNQjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4QUAAWAFqB0RJU0NJTlRyCEFMMERTSTA1EgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwDQ) ![Lufthansa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/LH.gif) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,607 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1606.40&airProductToken=AQqdAQoxCMyQARIDMTI0GKUEIIwVKJu6hwMw0rqHAzhXQABYAWoGQkFTSU5UcghBTDBCU0kwNQoyCNSgARIDNTU3GIwVIIuSASjxvYcDML6_hwM4QUAAWAFqBkJBU0lOVHIIQUwwQlNJMDUKNAjUoAESBDE1MjcYi5IBIJOTASj_v4cDMP3DhwM4QUAAWAFqBkJBU0lOVHIIQUwwQlNJMDUSCggBEAEYASoCVFAYASIECAEQASgCKAMoBDAN) ![Etihad Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/EY.GIF) Thu, 12 Mar - Wed, 18 Mar FRA Frankfurt TMS São Tomé Island £1,823 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:FRA,to:TMS,departure:12/03/2026TANYT&leg2=from:TMS,to:FRA,departure:18/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:1822.20&airProductToken=AQqcAQoxCMWyARIDMTIyGKUEIIA9KLK0hwMwqbeHAzhFQABYAWoGWUJBU0lDcghFTE4yMEgyOQoxCMWyARICOTkYgD0gi5IBKMi6hwMw376HAzhFQAFYAWoGWUJBU0lDcghFTE4yMEgyOQo0CNSgARIEMTUyNxiLkgEgk5MBKP-_hwMw_cOHAzhVQAFYAWoGWUJBU0lDcghFTE4yMEgyORIKCAEQARgBKgJFWRgBIgQIARABKAIoAygEMAE) __Flight from Frankfurt to São Tomé Island route information__ | Origin airport | Frankfurt Intl. | | ------------------- | --------------- | | Destination airport | São Tomé Intl. | | Return price | £974 | | Distance | 5494 km | ## Compare flights from Frankfurt to São Tomé Island easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from Frankfurt to São Tomé Island. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to São Tomé Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Frankfurt Intl. to São Tomé Intl.. To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. Grab a great deal on your flight from Frankfurt Intl. (FRA) to São Tomé Intl. (TMS) The easiest way to view the best deals on flights from Frankfurt to São Tomé Island today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Frankfurt Intl. to São Tomé Intl. start at just £974 and range up to £1,823\. To find an even better deal, try - being flexible on your dates – midweek flights can be cheaper - looking for other airports near Frankfurt and São Tomé Island - booking your flight during March, the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper Why you should book your Frankfurt to São Tomé Island flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Frankfurt Intl. to São Tomé Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you. Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight. ## Explore a world of travel with Expedia - Accommodation - [Água Grande Hotels ](https://www.expedia.co.uk/Destinations-In-Agua-Grande.d553248635976006815.Hotel-Destinations) - [Hotels near Estadio Nacional 12 de Julho ](https://www.expedia.co.uk/Estadio-Nacional-12-De-Julho-Hotels.0-l6118168-0.Travel-Guide-Filter-Hotels) - [São Tomé Hotels ](https://www.expedia.co.uk/Sao-Tome-Hotels.d553248635975177343.Travel-Guide-Hotels) \*Available to Expedia members.