A river surrounded by dense tropical vegetation and palm trees.

£309 Cheap Flights from Lisbon (LIS) to São Tomé Island (TMS)

View £309 flight on Thu, 5 Nov 2026Opens in a new window

Popular airlines from Humberto Delgado Airport (LIS) to São Tomé Island (TMS-São Tomé Intl.)

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Cheap Flights from Lisbon (LIS) to São Tomé Island (TMS)

Prices were available within the past 7 days and start at £309 for one-way flights and £431 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

TAAG Angola Airlines
Tue, 3 Nov - Wed, 18 Nov
LIS
Lisbon
TMS
São Tomé Island
£431 Return, found 2 hours ago
£431
Return
found 2 hours ago
Select TAAG Angola Airlines flight, departing Tue, 3 Nov from Lisbon to São Tomé Island, returning Wed, 18 Nov, priced at £431 found 2 hours ago
TAAG Angola Airlines
Tue, 12 Jan - Wed, 27 Jan
LIS
Lisbon
TMS
São Tomé Island
£453 Return, found 6 hours ago
£453
Return
found 6 hours ago
Select TAAG Angola Airlines flight, departing Tue, 12 Jan from Lisbon to São Tomé Island, returning Wed, 27 Jan, priced at £453 found 6 hours ago
TAAG Angola Airlines
Sat, 17 Oct - Fri, 23 Oct
LIS
Lisbon
TMS
São Tomé Island
£475 Return, found 6 days ago
£475
Return
found 6 days ago
Select TAAG Angola Airlines flight, departing Sat, 17 Oct from Lisbon to São Tomé Island, returning Fri, 23 Oct, priced at £475 found 6 days ago
TAAG Angola Airlines
Sat, 10 Oct - Wed, 28 Oct
LIS
Lisbon
TMS
São Tomé Island
£484 Return, found 7 hours ago
£484
Return
found 7 hours ago
Select TAAG Angola Airlines flight, departing Sat, 10 Oct from Lisbon to São Tomé Island, returning Wed, 28 Oct, priced at £484 found 7 hours ago
TAAG Angola Airlines
Tue, 12 Jan - Sun, 31 Jan
LIS
Lisbon
TMS
São Tomé Island
£505 Return, found 2 days ago
£505
Return
found 2 days ago
Select TAAG Angola Airlines flight, departing Tue, 12 Jan from Lisbon to São Tomé Island, returning Sun, 31 Jan, priced at £505 found 2 days ago
TAAG Angola Airlines
Sat, 17 Oct - Fri, 30 Oct
LIS
Lisbon
TMS
São Tomé Island
£505 Return, found 7 hours ago
£505
Return
found 7 hours ago
Select TAAG Angola Airlines flight, departing Sat, 17 Oct from Lisbon to São Tomé Island, returning Fri, 30 Oct, priced at £505 found 7 hours ago
TAAG Angola Airlines
Tue, 13 Oct - Fri, 23 Oct
LIS
Lisbon
TMS
São Tomé Island
£506 Return, found 6 days ago
£506
Return
found 6 days ago
Select TAAG Angola Airlines flight, departing Tue, 13 Oct from Lisbon to São Tomé Island, returning Fri, 23 Oct, priced at £506 found 6 days ago
TAP Portugal
Wed, 3 Mar - Fri, 12 Mar
LIS
Lisbon
TMS
São Tomé Island
£512 Return, found 3 hours ago
£512
Return
found 3 hours ago
Select TAP Portugal flight, departing Wed, 3 Mar from Lisbon to São Tomé Island, returning Fri, 12 Mar, priced at £512 found 3 hours ago
TAAG Angola Airlines
Tue, 12 Jan - Wed, 27 Jan
LIS
Lisbon
TMS
São Tomé Island
£522 Return, found 6 hours ago
£522
Return
found 6 hours ago
Select TAAG Angola Airlines flight, departing Tue, 12 Jan from Lisbon to São Tomé Island, returning Wed, 27 Jan, priced at £522 found 6 hours ago
EuroAtlantic Airways
Sat, 20 Feb - Sat, 6 Mar
LIS
Lisbon
TMS
São Tomé Island
£573 Return, found 7 hours ago
£573
Return
found 7 hours ago
Select EuroAtlantic Airways flight, departing Sat, 20 Feb from Lisbon to São Tomé Island, returning Sat, 6 Mar, priced at £573 found 7 hours ago

Alternative airports

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Sao Tome Intl. TMS. Cheapest option available. Flights from £1,103
TMS
Sao Tome Intl.
Cheapest
Flights from £1,103

Frequently asked questions

How much does a flight from Lisbon (LIS) to São Tomé Island (TMS) cost?
You can find one-way and return flights from Lisbon (LIS) to São Tomé Island (TMS) with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when LIS to TMS ticket fares go up or down.
What is the cheapest month to fly from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
The cheapest months to fly from LIS to TMS are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Lisbon (LIS) to São Tomé Island (TMS)?
Enter LIS to TMS and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
To find a cheap flight from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
The best airline to fly with from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.) will differ from traveler to traveler. If you like to fly early, TAP Portugal offers early morning flights. If price is the most important factor, TAP Portugal typically offers the lowest fares. Air France offers the most daily flights from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
There are approximately 3 connecting flights per day from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.). Some common connection points include NBJ, Roissy-Charles de Gaulle (CDG), and Kotoka Intl. (ACC).
What is the earliest flight from Lisbon (LIS) to São Tomé Island (TMS)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from Lisbon (LIS) to São Tomé Island (TMS). To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
You'll typically find the most flights from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.) on a Saturday, with around 3 flights available. This gives you a good selection for your travel plans. Major airlines on this route include TAP Portugal, TAAG Angola Airlines, and Air France. Flight schedules are fairly consistent throughout the week, with Saturday offering only slightly more options than other days.
What are the most popular departure times for flights from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
The most popular departure times for flights from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.) are between 9am and 12pm. Many major carriers, including TAP Portugal and TAAG Angola Airlines, offer flights during this window. This timing works well because it allows you to start your journey in the morning and arrive at your destination with plenty of daylight left.
How long does it take to fly from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
Direct flights from LIS to TMS usually take about 6 hours 50 minutes, traveling roughly 4,564 kilometers. If you opt for a connecting flight, expect to add around 1 hour 40 minutes to your journey. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
Yes, you can fly business class between Lisbon (LIS) and São Tomé Island (TMS). Airlines that offer business class service on this route include:

  • TAP Portugal
  • TAAG Angola Airlines

How do I earn miles on a Lisbon (LIS) to São Tomé Island (TMS) flight with Expedia?
It's easy to earn miles on a Lisbon (LIS) to Island (TMS) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
Is it cheaper to buy a plane ticket from Lisbon (LIS) to São Tomé Island (TMS) at the last minute?
Typically, booking a last minute flight from Lisbon (LIS) to Island (TMS) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Lisbon (LIS) to São Tomé Island (TMS) flight and hotel package?
Securing a Lisbon (LIS) to Island (TMS) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.)?
If you booked your Lisbon (LIS-Humberto Delgado) to São Tomé Island (TMS-São Tomé Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Humberto Delgado
Destination airport
São Tomé Intl.
Airlines serving
TAAG Angola Airlines, TAP Portugal
Roundtrip price
£430
Distance
4537 km
Average flight time
6 hours 21 mins

Book with confidence

Compare flights from Lisbon to São Tomé Island easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Lisbon to São Tomé Island. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to São Tomé Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Humberto Delgado to São Tomé Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Humberto Delgado (LIS) to São Tomé Intl. (TMS)

The easiest way to view the best deals on flights from Lisbon to São Tomé Island today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Humberto Delgado to São Tomé Intl. start at just £431 and range up to £573.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Lisbon and São Tomé Island
  • booking your flight during November, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Lisbon to São Tomé Island flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Humberto Delgado to São Tomé Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Lisbon to São Tomé Island easily and book with confidence

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