Title: £325 Cheap Flights from Lisbon to São Tomé Island (LIS to TMS) - Expedia.co.uk ![Adobe](https://images.trvl-media.com/place/3486/703f69b0-0f4e-4999-b953-08659a8d079c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/3486/703f69b0-0f4e-4999-b953-08659a8d079c.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £325 Cheap Flights from Lisbon (LIS) to São Tomé Island (TMS) [View £325 flight on Fri, 6 Feb 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:LIS,to:TMS,departure:06/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:324.20&airProductToken=AQo3CjUI1KABEgQxNTI3GIuSASCTkwEon7aEAzCduoQDOEVAAFgBagdESVNDSU5UcghFTDBEU0kwNBIKCAEQARgBKgJUUBgBIgQIARABKAIoAygEMA0) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Humberto Delgado Airport (LIS) to São Tomé Island (TMS-São Tomé Intl.) - ![TAP Portugal](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_TP.svg) TAP Portugal [](https://www.expedia.co.uk/Flights-Search?leg1=from:lis,to:tms,departure:21/11/2025TANYT&leg2=from:tms,to:lis,departure:28/11/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"TP"}}]) - ![EuroAtlantic Airways](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_YU.svg) EuroAtlantic Airways [](https://www.expedia.co.uk/Flights-Search?leg1=from:lis,to:tms,departure:21/11/2025TANYT&leg2=from:tms,to:lis,departure:28/11/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"YU"}}]) - ![TAAG Angola Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DT.svg) TAAG Angola Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:lis,to:tms,departure:21/11/2025TANYT&leg2=from:tms,to:lis,departure:28/11/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DT"}}]) - ![notification illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from Lisbon (LIS) to São Tomé Island (TMS) Prices were available within the past 7 days and start at £325 for one-way flights and £490 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![EuroAtlantic Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/YU.gif) Sat, 14 Mar - Sat, 28 Mar LIS Lisbon TMS São Tomé Island £490 Return found 23 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:14/03/2026TANYT&leg2=from:TMS,to:LIS,departure:28/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:489.80&airProductToken=AQojCiEI2aoBEgM1MDcYi5IBIJOTASjlxocDMNzJhwM4UEAAWAEKIwohCNmqARIDNTA4GJOTASCLkgEo9ueIAzDt6ogDOE1AAFgBEgoIARABGAEqAllVGAEiBAgBEAEoBDAB) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Sun, 31 May - Wed, 10 Jun LIS Lisbon TMS São Tomé Island £508 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:31/05/2026TANYT&leg2=from:TMS,to:LIS,departure:10/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:507.40&airProductToken=AQo4CjYI1KABEgQxNTI3GIuSASCTkwEot7iOAzDEvI4DOFRAAFgBaghESVNDT1VOVHIIVEwwRFNJODAKOAo2CNSgARIEMTUyOBiTkwEgi5IBKPytjwMwhLKPAzhUQABYAWoIRElTQ09VTlRyCFRMMERTSTgwEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwAQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 22 May - Sun, 31 May LIS Lisbon TMS São Tomé Island £509 Return found 12 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:22/05/2026TANYT&leg2=from:TMS,to:LIS,departure:31/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:509.00&airProductToken=AQo3CjUI1KABEgQxNTI3GIuSASCTkwEol9ONAzCk140DOFRAAFgBagdESVNDSU5UcghUTDBEU0k4MAo3CjUI1KABEgQxNTI4GJOTASCLkgEovL2OAzDEwY4DOFRAAFgBagdESVNDSU5UcghUTDBEU0k4MBIKCAEQARgBKgJUUBgBIgQIARABKAIoAygEMA0) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Sun, 31 May - Sat, 6 Jun LIS Lisbon TMS São Tomé Island £518 Return found 2 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:31/05/2026TANYT&leg2=from:TMS,to:LIS,departure:06/06/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:517.55&airProductToken=AQo4CjYI1KABEgQxNTI3GIuSASCTkwEot7iOAzDEvI4DOFRAAFgBaghESVNDT1VOVHIIVEwwRFNJODAKOAo2CNSgARIEMTUzMhiTkwEgi5IBKO-BjwMwhIWPAzhUQABYAWoIRElTQ09VTlRyCFRMMERTSTgwEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwAQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 22 May - Sat, 30 May LIS Lisbon TMS São Tomé Island £520 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:22/05/2026TANYT&leg2=from:TMS,to:LIS,departure:30/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:519.08&airProductToken=AQo4CjYI1KABEgQxNTI3GIuSASCTkwEol9ONAzCk140DOFRAAFgBaghESVNDT1VOVHIIVEwwRFNJODAKOAo2CNSgARIEMTUzMhiTkwEgi5IBKI-zjgMwpLaOAzhUQABYAWoIRElTQ09VTlRyCFRMMERTSTgwEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwAQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 6 Mar - Sat, 14 Mar LIS Lisbon TMS São Tomé Island £523 Return found 2 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:06/03/2026TANYT&leg2=from:TMS,to:LIS,departure:14/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:522.62&airProductToken=AQo4CjYI1KABEgQxNTI3GIuSASCTkwEon_GGAzCd9YYDOFRAAFgBaghESVNDT1VOVHIIVEwwRFNJODAKOAo2CNSgARIEMTUzMhiTkwEgi5IBKKHRhwMwsdSHAzhUQABYAWoIRElTQ09VTlRyCFRMMERTSTgwEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwAQ) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Fri, 13 Mar - Sat, 21 Mar LIS Lisbon TMS São Tomé Island £525 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:13/03/2026TANYT&leg2=from:TMS,to:LIS,departure:21/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:524.17&airProductToken=AQo4CjYI1KABEgQxNTI3GIuSASCTkwEo_7-HAzD9w4cDOFRAAFgBaghESVNDT1VOVHIIVEwwRFNJODAKOAo2CNSgARIEMTUzMhiTkwEgi5IBKIGgiAMwkaOIAzhUQABYAWoIRElTQ09VTlRyCFRMMERTSTgwEgoIARABGAEqAlRQGAEiBAgBEAEoAigDKAQwAQ) ![EuroAtlantic Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/YU.gif) Sat, 28 Mar - Sat, 11 Apr LIS Lisbon TMS São Tomé Island £526 Return found 23 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:28/03/2026TANYT&leg2=from:TMS,to:LIS,departure:11/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:525.50&airProductToken=AQojCiEI2aoBEgM1MDcYi5IBIJOTASil5IgDMJzniAM4TUAAWAEKIwohCNmqARIDNTA4GJOTASCLkgEojoWKAzCKiIoDOFhAAFgBEgoIARABGAEqAllVGAEiBAgBEAEoBDAB) ![TAP Portugal](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/TP.gif) Sat, 4 Apr - Sat, 9 May LIS Lisbon TMS São Tomé Island £535 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:04/04/2026TANYT&leg2=from:TMS,to:LIS,departure:09/05/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:534.90&airProductToken=AQo3CjUI1KABEgQxNTMxGIuSASCTkwEogLiJAzCVu4kDOEVAAFgBagdESVNDSU5UcghFTDBEU0k4MAo3CjUI1KABEgQxNTMyGJOTASCLkgEo78aMAzCEyowDOFRAAFgBagdESVNDSU5UcghUTDBEU0k4MBIKCAEQARgBKgJUUBgBIgQIARABKAIoAygEMA0) ![TAAG Angola Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DT.gif) Tue, 2 Dec - Mon, 22 Dec LIS Lisbon TMS São Tomé Island £722 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LIS,to:TMS,departure:02/12/2025TANYT&leg2=from:TMS,to:LIS,departure:22/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:721.70&airProductToken=AQpECiAIxKgBEgM2NTMYi5IBIK1IKOvV_gIwstn-AjhYQABYAQogCMSoARIDNTEwGK1IIJOTASj62v4CMJrc_gI4WEABWAEKRAogCMSoARIDNTExGJOTASCtSCi2soADML2zgAM4TEAAWAEKIAjEqAESAzY1MBitSCCLkgEo-raAAzDBuoADOExAAVgBEgoIARABGAEqAkRUGAEiBAgBEAEoBDAB) ## Alternative airports near São Tomé Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.co.uk/Flights-Search?leg1=from:LIS,to:TMS,departure:21/11/2025TANYT&leg2=from:TMS,to:LIS,departure:05/12/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) TMS Sao Tome Intl. Cheapest [Flights from £698](https://www.expedia.co.uk/Flights-Search?leg1=from:LIS,to:TMS,departure:21/11/2025TANYT&leg2=from:TMS,to:LIS,departure:05/12/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) Flight from Lisbon to São Tomé Island route information | Origin airport | Humberto Delgado | | --- | --- | | Destination airport | São Tomé Intl. | | Airlines serving | EuroAtlantic Airways, TAAG Angola Airlines, TAP Portugal | | Return price | £490 | | Distance | 4537 km | | Average flight time | 7 hours 8 mins | ## Compare flights from Lisbon to São Tomé Island easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from Lisbon to São Tomé Island. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to São Tomé Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Humberto Delgado to São Tomé Intl..   To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights.  Grab a great deal on your flight from Humberto Delgado (LIS) to São Tomé Intl. (TMS) The easiest way to view the best deals on flights from Lisbon to São Tomé Island today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Humberto Delgado to São Tomé Intl. start at just £490 and range up to £722.   To find an even better deal, try   - being flexible on your dates – midweek flights can be cheaper - looking for other airports near Lisbon and São Tomé Island - booking your flight during March, the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper  Why you should book your Lisbon to São Tomé Island flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Humberto Delgado to São Tomé Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.   Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.   ## Explore a world of travel with Expedia - Accommodation ### Accommodation - [Água Grande Hotels](https://www.expedia.co.uk/Destinations-In-Agua-Grande.d553248635976006815.Hotel-Destinations) - [Hotels near Estadio Nacional 12 de Julho](https://www.expedia.co.uk/Estadio-Nacional-12-De-Julho-Hotels.0-l6118168-0.Travel-Guide-Filter-Hotels) - [São Tomé Hotels](https://www.expedia.co.uk/Sao-Tome-Hotels.d553248635975177343.Travel-Guide-Hotels) \*Available to Expedia members.