Title: £711 Cheap Flights from Brussels to São Tomé Island (BRU to TMS) - Expedia.co.uk ![A pretty sunset in São Tomé.](https://images.trvl-media.com/place/553248635976006815/07aca925-8318-4676-9191-b2ca4e7702d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Toshiaki Yoshitake ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £711 Cheap Flights from Brussels (BRU) to São Tomé Island (TMS) [View £711 flight on Sat, 25 Oct 2025](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:BRU,to:TMS,departure:25/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:710.10&airProductToken=AQptCjQI1KABEgM2NDUYoaQBIIuSASjPqPsCMP6p-wI4QUAAWAFqB0RJU0NJTlRyCEFMMERTSTA1CjUI1KABEgQxNTI3GIuSASCTkwEov6_7AjC9s_sCOEFAAFgBagdESVNDSU5UcghBTDBEU0kwNRIKCAEQARgBKgJUUBgBIgQIARABKAIoAygEMA0) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from Brussels Airport (BRU) to São Tomé Island (TMS-São Tomé Intl.) - ![TAP Portugal](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_TP.svg) TAP Portugal [](https://www.expedia.co.uk/Flights-Search?leg1=from:bru,to:tms,departure:10/10/2025TANYT&leg2=from:tms,to:bru,departure:17/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"TP"}}]) - ![Ethiopian Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_ET.svg) Ethiopian Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:bru,to:tms,departure:10/10/2025TANYT&leg2=from:tms,to:bru,departure:17/10/2025TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"ET"}}]) ![notification illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from Brussels (BRU) to São Tomé Island (TMS) Prices were available within the past 7 days and start at £711 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return Flight from Brussels to São Tomé Island route information | Origin airport | Brussels - National | | --- | --- | | Destination airport | São Tomé Intl. | | Distance | 5588 km | ## Compare flights from Brussels to São Tomé Island easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from Brussels to São Tomé Island. Operating between them flights per day, 15 airlines cover the route. And fly direct, getting you to São Tomé Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Brussels - National to São Tomé Intl..   To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights.  Grab a great deal on your flight from Brussels - National (BRU) to São Tomé Intl. (TMS) The easiest way to view the best deals on flights from Brussels to São Tomé Island today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Brussels - National to São Tomé Intl. start at just and range up to .   To find an even better deal, try   - being flexible on your dates – midweek flights can be cheaper - looking for other airports near Brussels and São Tomé Island - booking your flight during , the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper  Why you should book your Brussels to São Tomé Island flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Brussels - National to São Tomé Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.   Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.   ## Explore a world of travel with Expedia - Accommodation ### Accommodation - [Água Grande Hotels](https://www.expedia.co.uk/Destinations-In-Agua-Grande.d553248635976006815.Hotel-Destinations) - [Hotels near Estadio Nacional 12 de Julho](https://www.expedia.co.uk/Estadio-Nacional-12-De-Julho-Hotels.0-l6118168-0.Travel-Guide-Filter-Hotels) - [São Tomé Hotels](https://www.expedia.co.uk/Sao-Tome-Hotels.d553248635975177343.Travel-Guide-Hotels) \*Available to Expedia members.