The Best Hotels Closest to Substance in Las Vegas - 2026 Updated Prices

Q: What's the area like around Substance?

Substance is located in Las Vegas. This welcoming area is known for its array of dining options and bar scene. If you're looking for a convenient place to stay, take a look at the 156 hotels and other accommodation options you'll find within a mile.

Q: What's the best hotel to stay near Substance?

Adjacent to Substance, Golden Nugget Las Vegas Hotel & Casino is one of the top choices for your stay based on our traveller data, and this resort offers 2 outdoor pools and a full-service spa. Other good options within a short distance include Plaza Hotel & Casino and Downtown Grand Las Vegas .

Q: How many hotels will I be able to find close to Substance?

Expedia has 156 hotels and other accommodation options within a mile from Substance.

Q: If I need to cancel the hotel reservation for my stay near Substance, will I receive a refund?

Yes! You'll find that most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within 24 hours of booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to view the top deals on offer near Substance.

Q: What can I see and do near Substance?

You might want to spend some time browsing the exhibits at Mob Museum, The Neon Museum or Zak Bagans Haunted Museum. Old Las Vegas Mormon Fort State Historic Park, Harrison House and First AME Church are monuments to see when you're exploring the area around Substance. You can watch performances at Colosseum at Caesars Palace, Sphere and Dolby Live if you're interested in local theatre.

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Our top choices for Substance hotels

A rooftop lounge with a fire pit, large windows, and a city view.

1. Circa Resort & Casino – Adults Only

Downtown Las Vegas, 0.3 mi from Substance

John

includes taxes & fees

8 Nov - 9 Nov

A storefront with a glass door, a black awning, and a floral archway.

2. The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over

Arts District, 0.9 mi from Substance

Enrico

includes taxes & fees

22 Nov - 23 Nov

A grand hotel lobby with a long wooden corridor, ornate chandeliers, and a central decorative fireplace.

3. Main Street Station Hotel, Casino and Brewery

Downtown Las Vegas, 0.4 mi from Substance

Michelle

includes taxes & fees

16 Nov - 17 Nov

A bar area with a leather couch, red chairs, and a bar counter.

4. Downtown Grand Las Vegas

Downtown Las Vegas, 0.1 mi from Substance

Chase

includes taxes & fees

16 Nov - 17 Nov

A hotel room with a large bed, a desk, a chair, a lamp, and a window with curtains.

5. Four Queens Hotel and Casino

Downtown Las Vegas, 0.2 mi from Substance

jose

includes taxes & fees

11 Nov - 12 Nov

6. the D Las Vegas

Downtown Las Vegas, 0.1 mi from Substance

Dave

includes taxes & fees

9 Nov - 10 Nov

An outdoor seating area with a wooden bench, a table with food, potted plants, and a view of the building's interior through a glass door.

7. AC Hotel by Marriott Las Vegas Symphony Park

0.7 mi from Substance

Janaina

includes taxes & fees

8 Nov - 9 Nov

A hotel with a modern facade, large signage for Marriott and Element brands, and a prominent entrance with a palm tree in the foreground.

8. Element by Marriott Las Vegas Symphony Park

0.7 mi from Substance

Suzanne

includes taxes & fees

23 Nov - 24 Nov

A brightly lit hotel with a prominent sign for 'Plaza' and 'Pinkbox' on the left, a carousel in the center, and a 'Casino' sign on the right.

9. Plaza Hotel & Casino

Downtown Las Vegas, 0.4 mi from Substance

saul

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a stone floor, wooden beams, and a large chandelier.

10. El Cortez Hotel and Casino - 21 and Over

Downtown Las Vegas, 0.1 mi from Substance

Evelia

includes taxes & fees

2 Dec - 3 Dec

A rooftop pool with lounge chairs and a view of the city skyline.

11. Hotel Apache

Downtown Las Vegas, 0.2 mi from Substance

jose

includes taxes & fees

1 Dec - 2 Dec

A bedroom with a bed, a small table, and a chair. There is a bathroom with a sink, mirror, and shower.

12. Desert Moon Motel

Downtown Las Vegas, 0.9 mi from Substance

Grant

includes taxes & fees

2 Dec - 3 Dec

A hotel with a prominent sign reading "California Hotel & Casino."

13. California Hotel and Casino

Downtown Las Vegas, 0.3 mi from Substance

Zoe

includes taxes & fees

16 Nov - 17 Nov

A hotel with a large indoor pool, palm trees, and a modern building in the background.

14. Golden Nugget Las Vegas Hotel & Casino

Downtown Las Vegas, 0.2 mi from Substance

Andrea

includes taxes & fees

9 Nov - 10 Nov

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and tall buildings.

15. Oasis at Gold Spike

Downtown Las Vegas, < 0.1 mi from Substance

Zachary

includes taxes & fees

8 Nov - 9 Nov

A hotel room with two beds, a desk, a chair, a large mirror, and a decorative wall with geometric patterns.

16. Downtowner Boutique Hotel

Downtown Las Vegas, 0.2 mi from Substance

Dylan

includes taxes & fees

3 Dec - 4 Dec

A nighttime view of a pool area with a city skyline in the background, including a prominent tower.

17. Bposhtels Las Vegas

1.1 mi from Substance

Nichole

includes taxes & fees

3 Nov - 4 Nov

A hotel with a prominent tower and the name "STRAT" illuminated on the facade.

18. The STRAT Hotel, Casino & Tower

Las Vegas Strip, 1.8 mi from Substance

Steve

includes taxes & fees

19 Nov - 20 Nov

The exterior of the Golden Gate Hotel with a prominent sign, a modern architectural design, and a parking lot with visible cars.

19. Golden Gate Hotel and Casino

Downtown Las Vegas, 0.3 mi from Substance

Christian

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a large bed, a bedside table, a chair, a desk, and a mirror.

20. Crown Motel

Sunrise Manor, 1.9 mi from Substance

Jeff

includes taxes & fees

3 Nov - 4 Nov

View all properties

Compare popular hotels close to Substance

Property	Property class	Guest rating
Circa Resort & Casino – Adults Only	4.5 star property	9.4 Exceptional 5,762 reviews	View
The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over	4.0 star property	9.2 Wonderful 159 reviews	View
Main Street Station Hotel, Casino and Brewery	2.5 star property	9.0 Wonderful 3,925 reviews	View
Downtown Grand Las Vegas	3.5 star property	8.6 Excellent 9,959 reviews	View
Four Queens Hotel and Casino	3.5 star property	8.6 Excellent 7,463 reviews	View

Top Substance Hotel Reviews

El Cortez Hotel and Casino - 21 and Over

10/10 Excellent

"N/A"

Other attractions near Substance

Neonopolis

You can spend time exploring the galleries in Neonopolis in Las Vegas. Discover the entertainment choices and casinos in this family-friendly area.

See properties

Frequently asked questions

What's the area like around Substance?

Substance is located in Las Vegas. This welcoming area is known for its array of dining options and bar scene. If you're looking for a convenient place to stay, take a look at the 156 hotels and other accommodation options you'll find within a mile.

What's the best hotel to stay near Substance?

Adjacent to Substance, Golden Nugget Las Vegas Hotel & Casino is one of the top choices for your stay based on our traveller data, and this resort offers 2 outdoor pools and a full-service spa. Other good options within a short distance include Plaza Hotel & Casino and Downtown Grand Las Vegas.

How many hotels will I be able to find close to Substance?

Expedia has 156 hotels and other accommodation options within a mile from Substance.

If I need to cancel the hotel reservation for my stay near Substance, will I receive a refund?

Yes! You'll find that most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within 24 hours of booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to view the top deals on offer near Substance.

What can I see and do near Substance?

You might want to spend some time browsing the exhibits at Mob Museum, The Neon Museum or Zak Bagans Haunted Museum. Old Las Vegas Mormon Fort State Historic Park, Harrison House and First AME Church are monuments to see when you're exploring the area around Substance. You can watch performances at Colosseum at Caesars Palace, Sphere and Dolby Live if you're interested in local theatre.

Search Hotels Near Substance, Las Vegas

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Our top choices for Substance hotels

1. Circa Resort & Casino – Adults Only

2. The ENGLISH Hotel, Las Vegas, a Tribute Portfolio Hotel, 21 and over

3. Main Street Station Hotel, Casino and Brewery

4. Downtown Grand Las Vegas

5. Four Queens Hotel and Casino

6. the D Las Vegas

7. AC Hotel by Marriott Las Vegas Symphony Park

8. Element by Marriott Las Vegas Symphony Park

9. Plaza Hotel & Casino

10. El Cortez Hotel and Casino - 21 and Over

11. Hotel Apache

12. Desert Moon Motel

13. California Hotel and Casino

14. Golden Nugget Las Vegas Hotel & Casino

15. Oasis at Gold Spike

16. Downtowner Boutique Hotel

17. Bposhtels Las Vegas

18. The STRAT Hotel, Casino & Tower

19. Golden Gate Hotel and Casino

20. Crown Motel

Compare popular hotels close to Substance

Top Substance Hotel Reviews

El Cortez Hotel and Casino - 21 and Over

Other attractions near Substance

Neonopolis

Frequently asked questions