Photo by Michael Schuier
Search Historic Hotels in Southeast Iowa
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Iowa Historic Hotels
Our top choices for Southeast Iowa historic hotels
"THE SHOP" retro 60's
"THE SHOP" retro 60'sKeosauqua
10.0 out of 10, Exceptional, (56 reviews)
"Great place to stay!"
Amy S.
The price is £125
includes taxes & fees
20 May - 21 May
Stay in Historic Downtown Keokuk
Stay in Historic Downtown KeokukKeokuk
10.0 out of 10, Exceptional, (3 reviews)
"The place was very clean and very nice."
Anonymous traveller
The price is £129
includes taxes & fees
20 May - 21 May
Grand Victorian on the Mississippi
Grand Victorian on the MississippiFort Madison
9.8 out of 10, Exceptional, (24 reviews)
"The home was beautifully decorated! We enjoyed our stay."
Theresa G.
The price is £321
includes taxes & fees
31 May - 1 Jun
Experience Beautiful Pioneer Home In Nauvoo!
Experience Beautiful Pioneer Home In Nauvoo!Nauvoo
9.8 out of 10, Exceptional, (81 reviews)
"awesome stay"
Aaron
The price is £342
includes taxes & fees
24 May - 25 May
The Red Front Suite - Sleeps 15
The Red Front Suite - Sleeps 15Nauvoo
9.8 out of 10, Exceptional, (90 reviews)
"Great location, comfortable beds."
Diane P.
The price is £250
includes taxes & fees
22 May - 23 May
Johnston Mansion Bed and Breakfast price shown is Vrbo Mansion price
Johnston Mansion Bed and Breakfast price shown is Vrbo Mansion priceKeokuk
9.0 out of 10, Wonderful, (2 reviews)
"Beautiful place in lovely, walkable neighborhood near the Mississippi. The hosts couldn't have been more accommodating or kind."
Kathryn C.
The price is £1,445
includes taxes & fees
20 May - 21 May
Idyllic Biggsville Vacation Rental: 10 Mi to River
Idyllic Biggsville Vacation Rental: 10 Mi to RiverBiggsville
10.0 out of 10, Exceptional, (3 reviews)
"Rooms were clean and the bed was comfortable! Highly recommend this rental. "
Brennan
The price is £152
includes taxes & fees
20 May - 21 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Iowa Hotel Reviews
Rivers Inn Fort Madison
10/10 Excellent
Explore a world of travel with Expedia
- 1 Star Hotels in Central United States
- 2 Star Hotels in Central United States
- 2 Star Hotels in Historic Route 66
- 3 Star Hotels in Historic Route 66
- 5 Star Hotels in Central United States
- 5 Star Hotels in Historic Route 66
- Farmstay in Central United States
- Serviced Apartments in Central United States
- Apartments in Central United States
- Caravan Parks in Central United States
- Condo Rentals in Central United States
- Cottages in Central United States
- Resorts in Central United States
- All-Inclusive Hotels in Central United States
- Beach Resorts & in Central United States
- Boutique Hotels in Central United States
- Cheap Hotels in Central United States
- Citizenm Hotels in Central United States
- Drury Inn & Suites Hotels in Central United States
- Four Seasons Hotels in Central United States
- Gay-Friendly Hotels in Central United States
- Hard Rock Hotels in Central United States
- Hilton Hotels in Central United States
- Historic Hotels in Central United States
- Hotels with Gym in Central United States
- Hotels with Room Service in Central United States
- Hotels with Hot Tubs in Central United States
- Hotels with Pool in Central United States
- Hyatt Hotels in Central United States
- Lakeside Hotels in Central United States
- Marriott Hotels & Resorts in Central United States
- Motel 6 Hotels in Central United States
- Omni Hotels in Central United States
- Red Roof Inn Hotels in Central United States
- Remington Hotels in Central United States
- Ski Hotels in Central United States
- Sonesta Hotel in Central United States
- Westgate Resorts in Central United States
- Winery Hotels in Central United States
- Wyndham Hotels in Central United States
- Central United States Hotels
- Caravan Parks in Historic Route 66
- Drury Inn & Suites Hotels in Historic Route 66
- Hyatt Hotels in Historic Route 66
- Omni Hotels in Historic Route 66
- Historic Route 66 Hotels
- Hotels near Mississippi River
- Boutique Hotels in Quad Cities
- Cheap Hotels in Quad Cities
- Casino Hotels in Quad Cities
- Gay-Friendly Hotels in Quad Cities
- Golf Hotels in Quad Cities
- Historic Hotels in Quad Cities
- Hotels Suites in Quad Cities
- Hotels with Airport Transfers in Quad Cities
- Hotels with Restaurant in Quad Cities
- Hotels with Balcony in Quad Cities
- Hotels with Indoor Pools in Quad Cities
- Luxury Hotels in Quad Cities
- Pet-Friendly Hotels in Quad Cities
- Riverside Hotels in Quad Cities
- Romantic Hotels in Quad Cities
- Spa Hotels in Quad Cities
- Hotels with Waterpark in Quad Cities
- Quad Cities Hotels
- Aircar Car rental Rental Cars in Historic Route 66
- Alamo Rent A Car Rental Cars in Historic Route 66
- Auto Rent Rental Cars in Historic Route 66
- Car hire near Central United States
- Car hire near Historic Route 66
- Enterprise Rental Cars in Historic Route 66
- Essence Car Rental Rental Cars in Historic Route 66
- Firefly Portugal Rental Cars in Historic Route 66
- First Car Rental Rental Cars in Historic Route 66
- Full-Size Car Hire in Historic Route 66
- Goldcar rental Rental Cars in Quad Cities
- Hertz Rental Cars in Historic Route 66
- Island Car Rentals Rental Cars in Historic Route 66
- Jumbo Car Rental Cars in Central United States
- Luxury Car Hire in Historic Route 66
- National Car Rental Rental Cars in Central United States
- Pickup Car Hire in Historic Route 66
- Right Cars Rental Cars in Historic Route 66
- Suv Car Hire in Historic Route 66
- Sixt Rental Cars in Historic Route 66
- Thrifty Car Rental Rental Cars in Historic Route 66
- People Carrier Car Hire in Quad Cities