Title: Cheap Flights from Historic Route 66 - Expedia.co.uk ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights from Historic Route 66 - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only [Historic Route 66 Travel Guide](https://expedia.co.uk/Historic-Route-66.dx702654640613646336)[Hotels in Historic Route 66](https://expedia.co.uk/Historic-Route-66-Hotels.d702654640613646336.Travel-Guide-Hotels)[Historic Route 66 Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Historic-Route-66.d702654640613646336.Car-Hire-Guide)[Historic Route 66 Holidays](https://expedia.co.uk/Historic-Route-66.d702654640613646336.Holidays-City-Breaks) ## Popular airlines - ![Delta](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta - ![American Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines - ![United](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United - ![Frontier Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_F9.svg) Frontier Airlines - ![Spirit Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_NK.svg) Spirit Airlines - ![Alaska Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AS.svg) Alaska Airlines - ![Air Canada](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AC.svg) Air Canada ![notification illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheapest flights from Historic Route 66 These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, 29 Oct - Wed, 5 Nov ORD Chicago FLL Fort Lauderdale £112 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:FLL,departure:29/10/2025TANYT&leg2=from:FLL,to:ORD,departure:05/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:112.00&airProductToken=AQozCjEIwYIBEgQxNDI0GK4cIOVaKLfT-wIw89T7AjhCQABYAWoFQkFTSUNyCFFWQVVaTkJYCjMKMQjBggESBDE0MjQY5Vogrhwoj6T8AjDbpfwCOEJAAFgBagVCQVNJQ3IIT1ZBVVpOQlgSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Mon, 8 Dec - Thu, 11 Dec ORD Chicago LAX Los Angeles £119 Return found 12 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:LAX,departure:08/12/2025TANYT&leg2=from:LAX,to:ORD,departure:11/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:118.50&airProductToken=AQo0CjIIwYIBEgQyNzE2GK4cIIu4ASiwlP8CMMKW_wI4QkAAWAFqBUJBU0lDcghPV0FVWk5CWAo0CjIIwYIBEgQyMzk0GIu4ASCuHCjuuP8CMO-6_wI4QkAAWAFqBUJBU0lDcghPV0FVWk5CWBIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![Alaska Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AS.gif) Wed, 18 Feb - Wed, 25 Feb ORD Chicago LAS Las Vegas £133 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:LAS,departure:18/02/2026TANYT&leg2=from:LAS,to:ORD,departure:25/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:132.90&airProductToken=AQphCi4IwaYBEgQxNDQ3GK4cIJJoKMvChQMw1MSFAzhYQABYAWoCU1ZyCEdIMk9BSkJOCi8IwaYBEgQzMDQ1GJJoIIuQASjSxYUDMKLGhQM4WEABWAFqAlNWcghHSDJPQUpCTgphCi8IwaYBEgQzMDI4GIuQASCSaCikkoYDMOiShgM4WEAAWAFqAlNWcghHSDVPQ0pCTgouCMGmARIEMTQ5MxiSaCCuHCick4YDMJaVhgM4WEABWAFqAlNWcghHSDVPQ0pCThIKCAEQARgBKgJBUxgBIgQIARABKAIoAygEMAE) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Mon, 3 Nov - Sat, 8 Nov ORD Chicago PHX Phoenix £146 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:PHX,departure:03/11/2025TANYT&leg2=from:PHX,to:ORD,departure:08/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:145.60&airProductToken=AQozCjEIwYIBEgM5OTMYrhwg77kBKJSK_AIw-ov8AjhCQABYAWoFQkFTSUNyCFFXQVVaTkJYCjQKMgjBggESBDExNjQY77kBIK4cKKHI_AIw-Mn8AjhCQABYAWoFQkFTSUNyCE9XQVVKTkJYEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Sat, 10 Jan - Sat, 24 Jan ORD Chicago RSW Fort Myers £157 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:RSW,departure:10/01/2026TANYT&leg2=from:RSW,to:ORD,departure:24/01/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:156.90&airProductToken=AQpfCi0IwmwSAzMxMhiuHCDBkwEo7YmCAzD9ioIDOExAAFgBagJETnIIUEMyQVVFTDEKLgjCbBIDMTY1GMGTASDRtAEot4yCAzCTjoIDOExAAVgBagJETnIIUEMyQVVFTDEKXwouCMJsEgMzNjYY0bQBIMGTASjMpYMDMIWngwM4TEAAWAFqAkROcghQQzJBVUVMMQotCMJsEgM4MTEYwZMBIK4cKJOpgwMw0KqDAzhMQAFYAWoCRE5yCFBDMkFVRUwxEgoIARABGAEqAkI2GAEiBAgBEAEoAigEKAYwAQ) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Thu, 1 Jan - Sat, 17 Jan ORD Chicago MIA Miami £161 Return found 3 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:MIA,departure:01/01/2026TANYT&leg2=from:MIA,to:ORD,departure:17/01/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:160.80&airProductToken=AQpECiAIxJgBEgQxMjY0GK4cIOBcKJKigQMwlaOBAzhFQABYAQogCMSYARIEMTUxMBjgXCCMAijLo4EDMMSkgQM4RUABWAEKRAogCMSYARIEMTMyOBiMAiDgXCij3IIDMKrdggM4RUAAWAEKIAjEmAESBDExOTkY4Fwgrhwo4d2CAzDi3oIDOEVAAVgBEgoIARABGAEqAkRMGAEiBAgBEAEoBDAB) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Wed, 3 Dec - Tue, 16 Dec ORD Chicago MCO Orlando £161 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:MCO,departure:03/12/2025TANYT&leg2=from:MCO,to:ORD,departure:16/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:160.80&airProductToken=AQpECiAIxJgBEgQxNDc3GK4cIOBcKPzg_gIw9uH-AjhFQABYAQogCMSYARIEMTczMxjgXCDMcCir4v4CMIfj_gI4RUABWAEKQwofCMSYARIDNjY0GMxwIOBcKKfx_wIwhfL_AjhFQABYAQogCMSYARIEMjczOBjgXCCuHCi38v8CMLXz_wI4RUABWAESCggBEAEYASoCREwYASIECAEQASgEMAE) ![Hawaiian Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/HA.gif) Wed, 29 Oct - Tue, 4 Nov ORD Chicago SFO San Francisco £176 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:SFO,departure:29/10/2025TANYT&leg2=from:SFO,to:ORD,departure:04/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:175.20&airProductToken=AQpECiAIyIIBEgQ2Mjk5GK4cIJIBKOzS-wIwiNX7AjhVQABYAQogCMiCARIENjg4OBiSASCycSi41fsCMMLW-wI4VUABWAEKRAogCMiCARIENzAyMBiycSCSaCj7mPwCMN-Z_AI4VUAAWAEKIAjIggESBDc0OTMYkmggrhworZz8AjCnnvwCOFVAAVgBEgoIARABGAEqAkhBGAEiBAgBEAEoBDAB) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Sat, 25 Oct - Tue, 28 Oct STL St. Louis LAS Las Vegas £177 Return found 2 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:STL,to:LAS,departure:25/10/2025TANYT&leg2=from:LAS,to:STL,departure:28/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:177.00&airProductToken=AQpFCiAIxJgBEgQ0MDY0GPJcIMx8KOqn-wIwyqj7AjhFQABYAQohCMSYARIEMTU0MhjMfCCLkAEo96j7AjDDqvsCOEVAAVgBCkQKIAjEmAESAzU0NBiLkAEg8hIo7cz7AjDEzfsCOEVAAFgBCiAIxJgBEgQyNjY2GPISIPJcKPvN-wIwpM_7AjhFQAFYARIKCAEQARgBKgJETBgBIgQIARABKAQwAQ) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Wed, 12 Nov - Wed, 19 Nov ORD Chicago TPA Tampa £194 Return found 3 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:TPA,departure:12/11/2025TANYT&leg2=from:TPA,to:ORD,departure:19/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:193.10&airProductToken=AQpdCi0IwmwSBDIxMDYYrhwgqVEonfD8AjCj8fwCOExAAFgBagJETnIIUEMyQVVFTDEKLAjCbBIDMTI1GKlRIPMDKMXz_AIw_fT8AjhMQAFYAWoCRE5yCFBDMkFVRUwxCl0KLAjCbBIDMTI2GPMDIKlRKPTB_QIwlsP9AjhMQABYAWoCRE5yCFNJNFFSRUwxCi0IwmwSBDIxMDUYqVEgrhwo3MT9AjCIxv0COExAAVgBagJETnIIUEk0UVJTTDESCggBEAEYASoCQjYYASIECAEQASgCKAQoBjAB) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Wed, 15 Oct - Wed, 22 Oct MDW Chicago LAS Las Vegas £196 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MDW,to:LAS,departure:15/10/2025TANYT&leg2=from:LAS,to:MDW,departure:22/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:195.60&airProductToken=AQpxCjcIxJgBEgQ1Mjk4GOywASDjtAEo4Lf6AjCnuPoCOEVAAFgBaglNQUlOQkFTSUNyCFZBVU5LOEJHCjYIxJgBEgM3NjYY47QBIIuQASjpuPoCMO-6-gI4RUABWAFqCU1BSU5CQVNJQ3IIVkFVTks4QkcKcAo2CMSYARIEMjgzNBiLkAEgzHwox4H7AjCCg_sCOEVAAFgBaglNQUlOQkFTSUNyCFZBVk5LOEJHCjYIxJgBEgQzNTQzGMx8IOywASjfg_sCMMOE-wI4RUABWAFqCU1BSU5CQVNJQ3IIVkFWTks4QkcSCggBEAEYASoCREwYASIECAEQASgCKAMoBDAB) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Wed, 29 Oct - Wed, 5 Nov MDW Chicago FLL Fort Lauderdale £199 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MDW,to:FLL,departure:29/10/2025TANYT&leg2=from:FLL,to:MDW,departure:05/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:198.50&airProductToken=AQpxCjcIxJgBEgQzNjMxGOywASDjtAEoy9P7AjCR1PsCOEVAAFgBaglNQUlOQkFTSUNyCFhBVk9BMEJHCjYIxJgBEgQxMzc4GOO0ASDlWiiY1fsCMMjW-wI4RUABWAFqCU1BSU5CQVNJQ3IIWEFWT0EwQkcKbwo1CMSYARIEMTA4MxjlWiDgXCi2oPwCMKih_AI4RUAAWAFqCU1BSU5CQVNJQ3IIVkFWTkEwQkcKNgjEmAESBDEwNjMY4Fwg7LABKICi_AIw8aL8AjhFQAFYAWoJTUFJTkJBU0lDcghWQVZOQTBCRxIKCAEQARgBKgJETBgBIgQIARABKAIoAygEMAE) ![Alaska Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AS.gif) Thu, 12 Feb - Thu, 19 Feb ABQ Albuquerque SFO San Francisco £224 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ABQ,to:SFO,departure:12/02/2026TANYT&leg2=from:SFO,to:ABQ,departure:19/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:223.20&airProductToken=AQpjCjAIwaYBEgQ2Mzc1GKCAASCLuAEo_oCFAzCQgoUDOEdAAFgBagJQTXIIT0gyT0FLTU4KLwjBpgESBDM0NjEYi7gBILJxKIqDhQMw44OFAzhPQAFYAWoCUE1yCE9IMk9BS01OCmMKLwjBpgESBDMyNDkYsnEgi7gBKOvPhQMw0dCFAzhPQABYAWoCUE1yCE9IMk9BS01OCjAIwaYBEgQ2Nzc0GIu4ASCggAEomNGFAzCJ0oUDOEdAAVgBagJQTXIIT0gyT0FLTU4SCggBEAEYASoCQVMYASIECAEQASgCKAMoBDAB) ![avianca](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/av.gif) Wed, 18 Feb - Wed, 25 Feb ORD Chicago MEX Mexico City £227 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:MEX,departure:18/02/2026TANYT&leg2=from:MEX,to:ORD,departure:25/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:226.97&airProductToken=AQpkCjAIwawBEgMyNjMYrhwgwTMohMaFAzD2yIUDOFNAAFgBagVCQVNJQ3IIU0VPQjBCUjkKMAjBrAESAjcyGMEzIIy5ASigyoUDMMLMhQM4U0ABWAFqBUJBU0lDcghTRU9CMEJSORIKCAIQARgBKgJBVhgBIgQIARABKAIoAygEMAE) ![Alaska Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AS.gif) Wed, 18 Feb - Wed, 25 Feb STL St. Louis LAX Los Angeles £233 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:STL,to:LAX,departure:18/02/2026TANYT&leg2=from:LAX,to:STL,departure:25/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:232.90&airProductToken=AQpgCi0IwaYBEgM0NzMY8lwgkgEo7L6FAzD2wIUDOFhAAFgBagJTVnIIT0g0T0FKQk4KLwjBpgESBDEzMzMYkgEgi7gBKMLChQMw5MOFAzhYQAFYAWoCU1ZyCE9INE9BSkJOCmAKLwjBpgESBDEzMDUYi7gBIJIBKMiQhgMw-JGGAzhYQABYAWoCU1ZyCE9INU9YSkJOCi0IwaYBEgM2MTUYkgEg8lwo2JOGAzDElYYDOFhAAVgBagJTVnIIT0g1T1hKQk4SCggBEAEYASoCQVMYASIECAEQASgCKAMoBDAB) ![Alaska Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AS.gif) Wed, 18 Feb - Wed, 25 Feb STL St. Louis SFO San Francisco £237 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:STL,to:SFO,departure:18/02/2026TANYT&leg2=from:SFO,to:STL,departure:25/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:236.10&airProductToken=AQpeCi0IwaYBEgM0NzMY8lwgkgEo7L6FAzD2wIUDOFhAAFgBagJTVnIIT0gyWVhVQk4KLQjBpgESAzY1NRiSASCycSjowYUDMPLChQM4WEABWAFqAlNWcghPSDJZWFVCTgpfCi4IwaYBEgQxMzQwGLJxIJIBKJCShgMwl5OGAzhYQABYAWoCU1ZyCE9IMllYVUJOCi0IwaYBEgM2MTUYkgEg8lwo2JOGAzDElYYDOFhAAVgBagJTVnIIT0gyWVhVQk4SCggBEAEYASoCQVMYASIECAEQASgCKAMoBDAB) ![Volaris](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/Y4.gif) Mon, 16 Mar - Sun, 22 Mar ORD Chicago NLU Mexico City £250 Return found 3 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ORD,to:NLU,departure:16/03/2026TANYT&leg2=from:NLU,to:ORD,departure:22/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:249.62&airProductToken=AQpfCi0I2WgSBDE3MDMYrhwg5lgozeWHAzDZ54cDOEpAAFgBagRaZXJvcgZKTENTUzIKLgjZaBIEMTI5MhjmWCDtogEoi-mHAzDb6YcDOEpAAVgBagRaZXJvcgZKTENTUzISCggBEAEYASoCWTQYASIECAEQASgCKAMoBDAN) ![Alaska Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AS.gif) Wed, 18 Feb - Wed, 25 Feb ABQ Albuquerque LAS Las Vegas £251 Return found 3 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ABQ,to:LAS,departure:18/02/2026TANYT&leg2=from:LAS,to:ABQ,departure:25/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:250.70&airProductToken=AQpgCi4IwaYBEgMzMzAYoIABIJIBKOzDhQMwrMWFAzhYQABYAWoCU1ZyCE9IMk9YVUJOCi4IwaYBEgM2MzYYkgEgi5ABKMXGhQMw18eFAzhYQAFYAWoCU1ZyCE9IMk9DVUJOCpMBCi4IwaYBEgM3MDEYi5ABIJIBKIiOhgMwpo-GAzhYQABYAWoCU1ZyCE9IMk9DVUJOCi8IwaYBEgQyMzE4GJIBIO-4ASj4j4YDMK-QhgM4WEABWAFqAlNWcghPSDJZQVVCTgowCMGmARIEMjI2OBjvuAEgoIABKIaShgMwppOGAzhYQAFYAWoCU1ZyCE9IMllBVUJOEgoIARABGAEqAkFTGAEiBAgBEAEoAigDKAQwAQ) ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Mon, 29 Dec - Tue, 30 Dec MDW Chicago MIA Miami £254 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:MDW,to:MIA,departure:29/12/2025TANYT&leg2=from:MIA,to:MDW,departure:30/12/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:253.70&airProductToken=AQpFCiEIxJgBEgQxNzM5GOywASDgXCjuhYEDMPCGgQM4RUAAWAEKIAjEmAESBDE1ODkY4FwgjAIolYiBAzCFiYEDOEVAAVgBCkUKIAjEmAESBDEyMTEYjAIg4FwoiYyBAzCIjYEDOEVAAFgBCiEIxJgBEgQyNDE3GOBcIOywASjgjYEDMNaOgQM4RUABWAESCggBEAEYASoCREwYASIECAEQASgEMAE) ![Alaska Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AS.gif) Wed, 18 Feb - Wed, 25 Feb ABQ Albuquerque PHX Phoenix £255 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:ABQ,to:PHX,departure:18/02/2026TANYT&leg2=from:PHX,to:ABQ,departure:25/02/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:254.40&airProductToken=AQphCi4IwaYBEgMzMzAYoIABIJIBKOzDhQMwrMWFAzhYQABYAWoCU1ZyCE9IMk9YVUJOCi8IwaYBEgQxNDMzGJIBIO-5ASjwxYUDMKDHhQM4WEABWAFqAlNWcghPSDJPQVZCTgpgCi4IwaYBEgM2NDUY77kBIJIBKMSOhgMw94-GAzhYQABYAWoCU1ZyCE9IMk9BVkJOCi4IwaYBEgMzMjcYkgEgoIABKNyQhgMwkJKGAzhYQAFYAWoCU1ZyCE9IMk9YVUJOEgoIARABGAEqAkFTGAEiBAgBEAEoAigDKAQwAQ) ## Flights from Historic Route 66: Essential Travel Information | Cheapest flight from Historic Route 66 | £112 (roundtrip) | | --- | --- | | Best airlines to fly from Historic Route 66 | American Airlines, Alaska Airlines, JetBlue Airways, Delta, Hawaiian Airlines, avianca, Volaris | | Cheapest month to fly from Historic Route 66 | October | | Historic Route 66 IATA code | CHI | | Historic Route 66 Country/State | United States of America | | Airline ticket deals from Historic Route 66 | £112 - £255 | ## How to Find Cheap Flights from Historic Route 66 #### How much is a flight from Historic Route 66?        This week, flights from Historic Route 66 are available between £112–£255.  #### How to find cheap flights from Historic Route 66? Expedia makes it easy to compare cheap flights from Historic Route 66 to many destinations. Check out excellent deals on both domestic and international flights from Historic Route 66. Once you select an offer, use our filters and sort by “Price (Lowest)” to see the cheapest and most suitable options.  #### How can I get the best deal on flights from Historic Route 66? Expedia gives you access to all the hottest deals on plane tickets so you can get the most amount of value for the lowest price possible. An excellent strategy for finding the best deal on flights is to be flexible with your dates. For each offer, you can compare prices for similar time frames using our “Show flexible dates” feature. Depending on your destination, direct flights from Historic Route 66 may be more expensive. Airlines with strict bag policies or fees can also impact your costs.  #### What is the best airline to fly from Historic Route 66? At Expedia, we give you all the available options from our reputable partners. Select the airline that best suits your preferences and membership loyalties. You can fly from Historic Route 66 with: American Airlines, Alaska Airlines, JetBlue Airways, Delta, Hawaiian Airlines, avianca, Volaris.  #### What is the best month to fly from Historic Route 66? Prices on plane tickets vary considerably throughout the year due to seasonal demand. Historically, the cheapest time to buy flights from Historic Route 66 airport(s) is October.  #### When is the best time to book flights from Historic Route 66? ARC & Expedia Group historical data suggests that booking flights three weeks before departure and on a weekend, usually on a Sunday, can save you up to 20% on your fare. \* #### Are there any last-minute flights from Historic Route 66? Expedia is the place to find last-minute flights from Historic Route 66, making it easy for you to compare prices on flights in the near future for different combinations of travel dates and from multiple airlines. We source the best deals for you and display the best offers available over the next two weeks.  #### Why book with Expedia? Booking flights from Historic Route 66 with Expedia is the obvious choice to get low prices, save money and see more value for every pound spent. We show you the best deals happening right now and provide a vast inventory of airlines and flight routes to choose from. You can customise your journey to your timeline, route preferences, budget, rewards programmes and more. Not only will you get a stellar deal, but you’ll also get rewards points back and the opportunity for additional discounts when bundling with a hotel or car hire. #### Can I change/cancel my flight?  Some flights can be changed or cancelled, but fees and refunds will depend on the unique terms of your flight agreement. Airlines have different rules and restrictions for exchanging or refunding flights. For more information, go to your itinerary or visit our customer service portal. We recommend choosing flights with no change fees for maximum flexibility. Filter by “Flexible change policies” to see flights with no change fees. \**Data specialists from both ARC and Expedia Group analyzed ARC’s global flight data to distill actionable information to help people save money on travel. While it’s impossible to guarantee when to find the lowest prices, after examining the variables, we were able to observe trends. Best day of the week to book and travel recommendation is based on average round-trip ticket prices for January through early October, for both 2019 and 2020, sourced from ARC’s global airline sales database.*. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other ### Accommodation - [Hotels near Lake Michigan](https://www.expedia.co.uk/Lake-Michigan-Hotels.0-l6338716-0.Travel-Guide-Filter-Hotels) - [Cottages in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Cottages.d6233674-aaCottages.Travel-Guide-Accommodation) - [Casino Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Casino-Hotel.0-0-d6233674-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Gay-Friendly-Hotel.0-0-d6233674-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Historic-Hotel.0-0-d6233674-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Hotel-With-A-Bar.0-0-d6233674-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with Balcony in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Hotels-With-Balcony.0-0-d6233674-tHotelswithBalcony.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Hotels-With-Smoking-Rooms.0-0-d6233674-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Luxury-Hotel.0-0-d6233674-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Omni Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Omni.0-0-d6233674--bOmni.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Pet-Friendly-Hotel.0-0-d6233674-tPetFriendlyHotel.Travel-Guide-Filter-Hotels) - [Riverside Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Riverside-Hotel.0-0-d6233674-triversidehotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Romantic-Hotel.0-0-d6233674-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Ski Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Ski-Hotels.0-0-d6233674-tSkiHotels.Travel-Guide-Filter-Hotels) - [Spa Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Spa-Hotels.0-0-d6233674-tSpaHotels.Travel-Guide-Filter-Hotels) - [Winery Hotels in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Hotels-Winery-Hotels.0-0-d6233674-tWineryHotels.Travel-Guide-Filter-Hotels) - [Ohio River Valley Hotels](https://www.expedia.co.uk/Ohio-River-Valley-Hotels.d6233674.Travel-Guide-Hotels) - [Lodges in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Lodges.d6233674-aaLodges.Travel-Guide-Accommodation) - [Villas in Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley-Villas.d6233674-aaVillas.Travel-Guide-Accommodation) - [Boutique Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Boutique-Hotel.0-0-d603001-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Budget-Hotels.0-0-d603001-tBudgetHotels.Travel-Guide-Filter-Hotels) - [Casino Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Casino-Hotel.0-0-d603001-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Gay-Friendly-Hotel.0-0-d603001-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Golf-Hotels.0-0-d603001-tGolfHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Historic-Hotel.0-0-d603001-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels Suites in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Hotel-Suites.0-0-d603001-thotelsuites.Travel-Guide-Filter-Hotels) - [Hotels with Airport Transfers in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Hotel-With-Airport-Transfers.0-0-d603001-thotelwithairporttransfers.Travel-Guide-Filter-Hotels) - [Hotels with Restaurant in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Hotel-With-Restaurant.0-0-d603001-thotelwithrestaurant.Travel-Guide-Filter-Hotels) - [Hotels with Balcony in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Hotels-With-Balcony.0-0-d603001-tHotelswithBalcony.Travel-Guide-Filter-Hotels) - [Hotels with Indoor Pools in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Hotels-With-Indoor-Pools.0-0-d603001-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Luxury-Hotel.0-0-d603001-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Pet-Friendly-Hotel.0-0-d603001-tPetFriendlyHotel.Travel-Guide-Filter-Hotels) - [Riverside Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Riverside-Hotel.0-0-d603001-triversidehotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Romantic-Hotel.0-0-d603001-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Spa-Hotels.0-0-d603001-tSpaHotels.Travel-Guide-Filter-Hotels) - [Hotels with Waterpark in Quad Cities](https://www.expedia.co.uk/Quad-Cities-Hotels-Waterpark-Hotel.0-0-d603001-twaterparkhotel.Travel-Guide-Filter-Hotels) - [Quad Cities Hotels](https://www.expedia.co.uk/Quad-Cities-Hotels.d603001.Travel-Guide-Hotels) - [B&B in Southeast Iowa](https://www.expedia.co.uk/Southeast-Iowa-Bed-And-Breakfasts.d6234151-aaBedAndBreakfasts.Travel-Guide-Accommodation) - [Hotels with Hot Tubs in Southeast Iowa](https://www.expedia.co.uk/Southeast-Iowa-Hotels-Hotels-With-Hot-Tubs.0-0-d6234151-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Spa Hotels in Southeast Iowa](https://www.expedia.co.uk/Southeast-Iowa-Hotels-Spa-Hotels.0-0-d6234151-tSpaHotels.Travel-Guide-Filter-Hotels) - [Hotels with Waterpark in Southeast Iowa](https://www.expedia.co.uk/Southeast-Iowa-Hotels-Waterpark-Hotel.0-0-d6234151-twaterparkhotel.Travel-Guide-Filter-Hotels) - [Southeast Iowa Hotels](https://www.expedia.co.uk/Southeast-Iowa-Hotels.d6234151.Travel-Guide-Hotels) ### Flights - [Flights to Ohio River Valley](https://www.expedia.co.uk/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights) - [Flights to Quad Cities](https://www.expedia.co.uk/Cheap-Flights-To-Quad-Cities.d603001.Travel-Guide-Flights) - [Flights from Ohio River Valley](https://www.expedia.co.uk/lp/flights/6233674/flights-from-ohio-river-valley) ### Packages - [Lake Michigan](https://www.expedia.co.uk/Lake-Michigan-United-States-of-America.d6338716.Attraction) - [Ohio River Valley Holidays](https://www.expedia.co.uk/Ohio-River-Valley.d6233674.Holidays-City-Breaks) - [Visit Ohio River Valley](https://www.expedia.co.uk/Ohio-River-Valley.dx6233674) - [Quad Cities Holidays](https://www.expedia.co.uk/Quad-Cities.d603001.Holidays-City-Breaks) - [Visit Quad Cities](https://www.expedia.co.uk/Quad-Cities.dx603001) ### Cars - [Ace Rental Cars in Ohio River Valley](https://www.expedia.co.uk/Ace-Car-Rentals-In-Ohio-River-Valley.d6233674-c2.Car-Rental-Guide-Suppliers) - [Goldcar rental Rental Cars in Quad Cities](https://www.expedia.co.uk/Goldcar-Rental-Car-Rentals-In-Quad-Cities.d603001-c1022.Car-Rental-Guide-Suppliers) - [People Carrier Car Hire in Quad Cities](https://www.expedia.co.uk/Van-Car-Rentals-In-Quad-Cities.d603001-tVan.Car-Rental-Guide-Class) ### Holiday Homes - [Ohio River Valley Holiday Rentals](https://www.expedia.co.uk/Ohio-River-Valley-Holiday-Rentals.d6233674.Travel-Guide-HolidayRentals) - [Quad Cities Holiday Rentals](https://www.expedia.co.uk/Quad-Cities-Holiday-Rentals.d603001.Travel-Guide-HolidayRentals) - [Southeast Iowa Holiday Rentals](https://www.expedia.co.uk/Southeast-Iowa-Holiday-Rentals.d6234151.Travel-Guide-HolidayRentals) ### Other - [Things to do in Quad Cities](https://www.expedia.co.uk/Things-To-Do-In-Quad-Cities.d603001.Travel-Guide-Activities) \*Available to Expedia members.