Title: TOP Business Hotels in Southeast Illinois, IL for 2026 | Expedia.co.uk [Southeast Illinois Travel Guide](https://expedia.co.uk/Southeast-Illinois.dx6058934)[Hotels in Southeast Illinois](https://expedia.co.uk/Southeast-Illinois-Hotels.d6058934.Travel-Guide-Hotels)[Holiday Rentals in Southeast Illinois](https://expedia.co.uk/Southeast-Illinois-Holiday-Rentals.d6058934.Travel-Guide-HolidayRentals)[Flights to Southeast Illinois](https://expedia.co.uk/Cheap-Flights-To-Southeast-Illinois.d6058934.Travel-Guide-Flights)[Southeast Illinois Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Illinois.d6058934.Car-Hire-Guide)[Southeast Illinois Holidays](https://expedia.co.uk/Southeast-Illinois.d6058934.Holidays-City-Breaks) ![Southern Illinois which includes rocky coastline and a lake or waterhole](https://images.trvl-media.com/place/87494/1b8c6b56-b76a-4a6c-a179-ef7dda71d358.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau # Search Business Hotels in Southeast Illinois - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Illinois Business Hotels Tonight [24 Dec - 25 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [25 Dec - 26 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2025-12-25&endDate=2025-12-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Southeast Illinois business-friendly hotels ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ee5a3a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/d519a6dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/953ff133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/16f1378e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Effingham by IHG [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) Effingham 9.4/10 Exceptional (1000) "Clean room, excellent staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy £86 includes taxes & fees 10 Jan - 11 Jan 2026 [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/be582add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/82da38ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/9f18b0c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/5f2b59be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Delta Inn [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) Effingham 9.2/10 Wonderful (1000) "Great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michele £70 includes taxes & fees 6 Jan - 7 Jan 2026 [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/f2163f3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cb0960c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/4b6a91f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/0c22f262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Effingham, IL [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) Effingham 8.8/10 Excellent (1002) "Clean rooms and kind staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda £73 includes taxes & fees 14 Jan - 15 Jan 2026 [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/6cba26b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:00 AM to 11:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/453e2ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/8e4b3d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/140c98cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) Effingham 9.2/10 Wonderful (1007) "Clean, pleasant, fast check in, and warm pool! I have stayed here 2 times before and have already booked a room for my return trip here. Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara £77 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/13aae8b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/2e6379a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/de33eeeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/3340f2af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-Ramada-By-Wyndham-Effingham.h9151.Hotel-Information) Effingham 7.6/10 Good (1002) "Nice place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Saifullah £48 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Effingham-Hotels-Ramada-By-Wyndham-Effingham.h9151.Hotel-Information) ![Studio Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/5e25407f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/0be3bf86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/bba4b648.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/a3a4b14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Casey [](https://www.expedia.co.uk/Effingham-Hotels-Days-Inn-Suites-By-Wyndham-Casey.h5685735.Hotel-Information) Casey 7.4/10 Good (830) "Nice place, quiet, clean, and I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kym £57 includes taxes & fees 2 Jan - 3 Jan 2026 [](https://www.expedia.co.uk/Effingham-Hotels-Days-Inn-Suites-By-Wyndham-Casey.h5685735.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/ec495250.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/e9350d80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/w1024h676x0y0-c83e1009.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/ee0af2fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cobblestone Inn & Suites - Altamont [](https://www.expedia.co.uk/Effingham-Hotels-Cobblestone-Inn-Suites-Altamont.h14820315.Hotel-Information) Altamont 9.6/10 Exceptional (804) "Just beautiful. I love staying here. Very cozy and clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa [](https://www.expedia.co.uk/Effingham-Hotels-Cobblestone-Inn-Suites-Altamont.h14820315.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/2fb633cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/416a4136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/b86d8b28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/9bfd4c57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Effingham by IHG [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) Effingham 9.0/10 Wonderful (656) "Nice place with bar and restaurant on site." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steve £84 includes taxes & fees 25 Dec - 26 Dec [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/727bbbb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | Pillow-top beds, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/02443d9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/w3840h2550x0y4-a875172e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/36000000/35030000/35020800/35020703/w3837h2551x3y3-84f618ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Parkside Inn & Suites [](https://www.expedia.co.uk/Olney-Hotels-Best-Western-Plus-Parkside-Inn-Suites.h35020703.Hotel-Information) Olney 9.8/10 Exceptional (319) "A great hotel-- best in Olney! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nathan £90 includes taxes & fees 31 Dec - 1 Jan 2026 [](https://www.expedia.co.uk/Olney-Hotels-Best-Western-Plus-Parkside-Inn-Suites.h35020703.Hotel-Information) ![Gastropub](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/7a3778a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/ba0a6ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/22942804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/53516431.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) Effingham 8.0/10 Very good (1000) "Clean rooms, toiletries available, great breakfast and friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela £63 includes taxes & fees 30 Dec - 31 Dec [](https://www.expedia.co.uk/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-07&endDate=2026-01-08®ionId=6058934&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Illinois Hotel Reviews ![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Room was outstanding the staff was perfect " [](https://expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Unique Suites Hotel](https://images.trvl-media.com/lodging/1000000/50000/41000/40974/beaca786_y.jpg) ### Unique Suites Hotel 10/10 Excellent "Room was very nice, a few light bulbs needed to be changed, but the room was clean and easy parking. " [](https://expedia.co.uk/Effingham-Hotels-Unique-Suites-Hotel.h40974.Hotel-Information) ![Drury Inn & Suites Terre Haute](https://images.trvl-media.com/lodging/1000000/20000/15000/14944/69cc0b6a_y.jpg) ### Drury Inn & Suites Terre Haute 10/10 Excellent "Friendly and helpful staff. Fresh, hot and very tasty breakfast. Our room was nice and it was cleaned well. The bed was as comfortable as home. The next time we travel to Terre Haute, Indiana to vist relatives we will definitely stay at Drury Inn & Suites. I would highly recommend this hotel. This was our first time staying at Drury Inn we usually stay at Holiday Inn, Hampton Inn or Hilton Gardens, but next time we travel I'll look for a Drury Inn. Thank you for a great stay." [](https://expedia.co.uk/Terre-Haute-Hotels-Drury-Inn-Suites-Terre-Haute.h14944.Hotel-Information) ![Holiday Inn Express & Suites Effingham by IHG](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ee5a3a7f_y.jpg) ### Holiday Inn Express & Suites Effingham by IHG 10/10 Excellent "Great location and service " [](https://expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Drury Inn & Suites Paducah](https://images.trvl-media.com/lodging/1000000/50000/42500/42450/w3837h2560x3y0-d7f24a86_y.jpg) ### Drury Inn & Suites Paducah 10/10 Excellent "Yes, absolutely spotless clean. We have now become members and intend to stay on a regular basis wherever we can." [](https://expedia.co.uk/Paducah-Hotels-Drury-Inn-Suites-Paducah.h42450.Hotel-Information) ![Drury Inn & Suites Marion](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37_y.jpg) ### Drury Inn & Suites Marion 10/10 Excellent "Clean room, good food" [](https://expedia.co.uk/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) ![Comfort Suites Mattoon East](https://images.trvl-media.com/lodging/1000000/480000/474300/474235/6759fc3e_y.jpg) ### Comfort Suites Mattoon East 10/10 Excellent "Good" [](https://expedia.co.uk/Effingham-Hotels-Comfort-Suites-Mattoon.h474235.Hotel-Information) ![Holiday Inn Express Metropolis by IHG](https://images.trvl-media.com/lodging/1000000/220000/211900/211819/0b536094_y.jpg) ### Holiday Inn Express Metropolis by IHG 10/10 Excellent "Room was clean, staff was pleasant " [](https://expedia.co.uk/Metropolis-Hotels-Holiday-Inn-Express-Metropolis.h211819.Hotel-Information) ![Baymont by Wyndham Effingham](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/7a3778a0_y.jpg) ### Baymont by Wyndham Effingham 10/10 Excellent "Convenient location for us, property was clean, room was clean and nice. Staff member at check in was not the best but the rest of the staff was friendly. " [](https://expedia.co.uk/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Southeast Illinois cost? ### How many business hotels are there in Southeast Illinois? ### Why book your business hotel in Southeast Illinois with Expedia? ### How can I find cheap business hotels in Southeast Illinois? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Allendale Hotels ](https://www.expedia.co.uk/Allendale-Hotels.d553248634983235708.Travel-Guide-Hotels) - [Bridgeport Hotels ](https://www.expedia.co.uk/Bridgeport-Hotels.d178167.Travel-Guide-Hotels) - [Casey Hotels ](https://www.expedia.co.uk/Casey-Hotels.d7291.Travel-Guide-Hotels) - [Cisne Hotels ](https://www.expedia.co.uk/Cisne-Hotels.d3000346182.Travel-Guide-Hotels) - [Claremont Hotels ](https://www.expedia.co.uk/Claremont-Hotels.d553248634983482212.Travel-Guide-Hotels) - [Hotels with Indoor Pools in Decatur ](https://www.expedia.co.uk/Decatur-Hotels-Hotels-With-Indoor-Pools.0-0-d992-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels) - 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