Title: TOP Business Hotels in Southeast Illinois, IL for 2026 | Expedia.co.uk [Southeast Illinois Travel Guide](https://expedia.co.uk/Southeast-Illinois.dx6058934)[Hotels in Southeast Illinois](https://expedia.co.uk/Southeast-Illinois-Hotels.d6058934.Travel-Guide-Hotels)[Holiday Rentals in Southeast Illinois](https://expedia.co.uk/Southeast-Illinois-Holiday-Rentals.d6058934.Travel-Guide-HolidayRentals)[Flights to Southeast Illinois](https://expedia.co.uk/Cheap-Flights-To-Southeast-Illinois.d6058934.Travel-Guide-Flights)[Southeast Illinois Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Illinois.d6058934.Car-Hire-Guide)[Southeast Illinois Holidays](https://expedia.co.uk/Southeast-Illinois.d6058934.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/6161415/c6d2a0ae-73d3-4729-9d8e-80038cc61bdc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau ![](https://images.trvl-media.com/place/6161415/c6d2a0ae-73d3-4729-9d8e-80038cc61bdc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Illinois Business Hotels Tonight [29 Mar - 30 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2026-03-29&endDate=2026-03-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [30 Mar - 31 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2026-03-30&endDate=2026-03-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058934&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Southeast Illinois business-friendly hotels ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cb0960c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/69929aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/4c50f376.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cbdc6ef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Effingham, IL [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) Effingham 8.8/10 Excellent (1,001 reviews) "Clean room, comfy beds, easy and friendly check in. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee £72 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/ec495250.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/f91689c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/0a146f1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/15000000/14830000/14820400/14820315/7407fe6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cobblestone Inn & Suites - Altamont [](https://www.expedia.co.uk/Effingham-Hotels-Cobblestone-Inn-Suites-Altamont.h14820315.Hotel-Information) Altamont 9.6/10 Exceptional (828 reviews) "Room was clean and comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevn £73 includes taxes & fees 6 Apr - 7 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Cobblestone-Inn-Suites-Altamont.h14820315.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/16f1378e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ee5a3a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Premium bedding, down duvets, desk, blackout curtains](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/64c87a0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/953ff133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Effingham by IHG [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) Effingham 9.4/10 Exceptional (1,003 reviews) "Great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £105 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3840h2556x0y4-dd5ad558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-d7de35fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/40f05879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-57613b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Delta Inn [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) Effingham 9.2/10 Wonderful (1,008 reviews) "Great staff, clean room, and good breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gayle £83 includes taxes & fees 3 Apr - 4 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/8e4b3d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/47490a5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/6cba26b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/3a991e8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) Effingham 9.2/10 Wonderful (1,001 reviews) " Very pleased with our stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy £82 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/21d0c56a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/6604cc4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/a3a4b14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5690000/5685800/5685735/0be3bf86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Casey [](https://www.expedia.co.uk/Effingham-Hotels-Days-Inn-Suites-By-Wyndham-Casey.h5685735.Hotel-Information) Casey 7.4/10 Good (844 reviews) "Room was good for a sleep while on a road trip. Breakfast was simple, not good, but not bad. Very nice staff. Quick check in on arrival late at night and very friendly morning crew. Extra star for the nice people. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Richard £56 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Days-Inn-Suites-By-Wyndham-Casey.h5685735.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/14e61266.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/13aae8b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/2e6379a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/10000/9200/9151/3340f2af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-Ramada-By-Wyndham-Effingham.h9151.Hotel-Information) Effingham 7.6/10 Good (1,001 reviews) "It was a nice place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donna £50 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Ramada-By-Wyndham-Effingham.h9151.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1720000/1710800/1710768/eb3ef88a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/2000000/1720000/1710800/1710768/af31ff58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/2000000/1720000/1710800/1710768/2b4f4c37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1720000/1710800/1710768/a4fadff7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Marriott Effingham [](https://www.expedia.co.uk/Effingham-Hotels-Fairfield-Inn-Suites-Marriott-Effingham.h1710768.Hotel-Information) Effingham 9.0/10 Wonderful (494 reviews) "Front desk attendant was fantastic." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard £80 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Fairfield-Inn-Suites-Marriott-Effingham.h1710768.Hotel-Information) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/1593eb79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/8e838144.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/ee46f96e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/a5253ac0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) Effingham 8.0/10 Very good (1,002 reviews) "Room was very clean easy friendly check in " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MICHAEL £67 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/709a29b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/18787a9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/7cc37c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113164/416a4136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Effingham by IHG [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) Effingham 9.0/10 Wonderful (669 reviews) "Nice place with bar and restaurant on site." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steve £89 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Effingham.h1113164.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-12&endDate=2026-04-13®ionId=6058934&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Illinois Hotel Reviews ![Baymont by Wyndham Effingham](https://images.trvl-media.com/lodging/1000000/10000/1600/1591/1593eb79_y.jpg) ### Baymont by Wyndham Effingham 10/10 Excellent "The staff were very friendly! The room we stayed was clean, this is a very nice hotel especially for a single, overnight stay, with a great price! " [](https://expedia.co.uk/Effingham-Hotels-Baymont-By-Wyndham-Effingham.h1591.Hotel-Information) ![Best Western Delta Inn](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3840h2556x0y4-dd5ad558_y.jpg) ### Best Western Delta Inn 10/10 Excellent "The room was clean and staff was amazing! The lady who checked us in let us know a bus was coming in and when they would be eating breakfast so we could avoid them. Without us asking she also told us where to park our car so we could see it from our room. Super thoughtful! If you are a light sleeper, the highway noise is very loud and noticeable. Maybe call and request a room on the other side of the building. As far as I can tell the only part of the team that has some room for improvement is the maintenance staff. There was painting missing from the walls that looks like it was from changing the headboard and they just didn’t fix it correctly, and other wear and tear. The shower also really needed to be recaulked. But overall this was a nice stay for the money. " [](https://expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Country Inn & Suites by Radisson, Effingham, IL](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cb0960c2_y.jpg) ### Country Inn & Suites by Radisson, Effingham, IL 10/10 Excellent "Amazing bang for your buck! Very friendly staff, clean, big rooms " [](https://expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Super 8 by Wyndham Metropolis](https://images.trvl-media.com/lodging/1000000/200000/196100/196091/ecad4ffc_y.jpg) ### Super 8 by Wyndham Metropolis 6/10 Okay "Room was sub par ants all over and needed some tlc and paint" [](https://expedia.co.uk/Metropolis-Hotels-Super-8-By-Wyndham-Metropolis.h196091.Hotel-Information) ![Comfort Suites Mattoon East](https://images.trvl-media.com/lodging/1000000/480000/474300/474235/2220d6ff_y.jpg) ### Comfort Suites Mattoon East 10/10 Excellent "Good breakfast in clean setting" [](https://expedia.co.uk/Effingham-Hotels-Comfort-Suites-Mattoon.h474235.Hotel-Information) ![Holiday Inn Express & Suites Effingham by IHG](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/16f1378e_y.jpg) ### Holiday Inn Express & Suites Effingham by IHG 8/10 Good "Clean room and quiet place." [](https://expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Holiday Inn Express Metropolis by IHG](https://images.trvl-media.com/lodging/1000000/220000/211900/211819/667d8a92_y.jpg) ### Holiday Inn Express Metropolis by IHG 6/10 Okay "Pool was under construction and entire first floor smelled like toluene. " [](https://expedia.co.uk/Metropolis-Hotels-Holiday-Inn-Express-Metropolis.h211819.Hotel-Information) ![Quality Inn & Suites Metropolis I-24](https://images.trvl-media.com/lodging/1000000/20000/17100/17025/b08fbb78_y.jpg) ### Quality Inn & Suites Metropolis I-24 10/10 Excellent "Everything went good " [](https://expedia.co.uk/Metropolis-Hotels-Quality-Inn-Suites-Metropolis-I-24.h17025.Hotel-Information) ![Holiday Inn Express & Suites Mattoon by IHG](https://images.trvl-media.com/lodging/2000000/1860000/1850700/1850633/c6bf8414_y.jpg) ### Holiday Inn Express & Suites Mattoon by IHG 8/10 Good "Clean" [](https://expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-Suites-Mattoon.h1850633.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Southeast Illinois cost? ### How many business hotels are there in Southeast Illinois? ### Why book your business hotel in Southeast Illinois with Expedia? ### How can I find cheap business hotels in Southeast Illinois? ## Explore a world of travel with Expedia - 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