Title: Hotels in Santa Isabel - Best Santa Isabel Hotels from £27 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Holiday-Rentals.d553248635975869828.Travel-Guide-HolidayRentals)[Santa Isabel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Isabel.d553248635975869828.Car-Hire-Guide)[Santa Isabel Holidays](https://expedia.co.uk/Santa-Isabel.d553248635975869828.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Santa Isabel from £27 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santa Isabel Family friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Mexicali%2C+Baja+California%2C+Mexico®ionId=553248635975869828&latLong=32.632687%2C-115.577461&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&travelerType=family_friendly) Pool [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Mexicali%2C+Baja+California%2C+Mexico®ionId=553248635975869828&latLong=32.632687%2C-115.577461&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&amenities=POOL) Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Santa+Isabel%2C+Mexicali%2C+Baja+California%2C+Mexico®ionId=553248635975869828&latLong=32.632687%2C-115.577461&adults=2&startDate=2025-12-08&d1=2025-12-08&endDate=2025-12-10&d2=2025-12-10&amenities=PETS) ## Check prices for these dates Tonight [24 Nov - 25 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975869828&startDate=2025-11-24&endDate=2025-11-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [25 Nov - 26 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975869828&startDate=2025-11-25&endDate=2025-11-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975869828&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975869828&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top 10 Santa Isabel hotels and places to stay ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/185f4103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room | 1 bedroom, premium bedding, pillow-top beds, minibar](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/a39bc3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 outdoor pools, open 10:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/883c858a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/2d1b8a75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Araiza Mexicali Mexicali 8.6/10 Excellent (1690) "Great hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Miguel £77 includes taxes & fees 9 Dec - 10 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Araiza-Mexicali.h22592.Hotel-Information) ![Daily cooked-to-order breakfast (MXN 290 per person)](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/928ca1d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/8e09f6a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite Ejecutiva King | Living area | 32-inch flat-screen TV with satellite channels, TV](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/a09279f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/b6948469.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Real Inn Mexicali Civic Center 8.2/10 Very good (1529) "The staff was amazing, Rooms were super clean 5 star's..." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gilbert £72 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Real-Inn-Mexicali.h600405.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/4d789164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/70e7eb7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/5d2422db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 2 Single Beds | Premium bedding, in-room safe, desk, free WiFi](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/3e808561.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### One Mexicali Mexicali 7.8/10 Good (1004) "Breakfast was delicious and it had several choices to pick." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Abraham £55 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-One-Mexicali.h17577142.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/9be1b557.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/6e6f2982.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/3c27d24e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 8:00 PM, pool loungers](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/0cad0e57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express Plus by Marriott Mexicali Mexicali 8.6/10 Excellent (974) "3rd time staying there I really like it" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carla £64 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-City-Express-Plus-Mexicali.h44945342.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/9bc6d08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/677d7bf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/90810982.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking | Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/25000000/24090000/24081400/24081334/5df61ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Mexicali Mexicali 8.2/10 Very good (1010) "Todo excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Silvia £62 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Sleep-Inn-Mexicali.h24081334.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/fc9185d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/d5c9e706.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/1b6e837a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/13000000/12510000/12506500/12506422/fa7de1ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Mexicali by IHG Mexicali 9.4/10 Exceptional (1004) "The Location was the best, very conveniently close to the catedral and all the good restaurants around it" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MARCELINO £85 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Holiday-Inn-Express-Suites-Mexicali.h12506422.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/edfeecd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room | Iron/ironing board, free WiFi, wheelchair access](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/49970db3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room | Bathroom | Free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/54625619.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily cooked-to-order breakfast ](https://images.trvl-media.com/lodging/11000000/10080000/10071600/10071570/0e23dca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Azteca de Oro Mexicali Mexicali 7.6/10 Good (433) "can be noisy at night on the week ends. Convenient good restaurant on site" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) gilbert £30 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Mexicali-Hotels-Azteca-De-Oro-Mexicali.h10071570.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/e443b787.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/ee9d5f67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/100934ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Arcade](https://images.trvl-media.com/lodging/19000000/18310000/18301100/18301092/383d12a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Siesta Real Mexicali 8.2/10 Very good (878) "Great place to stay would love to stay here again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) José £62 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Siesta-Real.h18301092.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/5a8679ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed | View from room](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/67882e84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 8:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/4c46b9cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed | Desk, blackout curtains, bed sheets](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/fd4f05d0_edited_7172.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Suites Mexicali Cataviña Mexicali 8.0/10 Very good (2160) "Very nice people clean rooms all new appliances excellent service and great location will recommend to anyone looking for good rest! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JOSE [](https://www.expedia.co.uk/Mexicali-Hotels-Extended-Suites-Mexicali-Catavina.h17969178.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/a02730fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/3acf53a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/28a69af3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/586cc6c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Mexicali Mexicali 9.4/10 Exceptional (1013) "Great stay would go again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hugo £87 includes taxes & fees 12 Dec - 13 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Fairfield-Inn-Suites-By-Marriott-Mexicali.h33638137.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/8ef53b31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/5a6c7074.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bungalow, 1 King Bed | View from room](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/abb801cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/d0790816.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Lucerna Mexicali Mexicali 9.2/10 Wonderful (1423) "Great stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fabiola £86 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Lucerna-Mexicali.h437408.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/3b6504b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/e439c29a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/218fae64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/a79edbbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express by Marriott Mexicali Mexicali 8.2/10 Very good (1004) "Room spotless, staff Great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Oscar £54 includes taxes & fees 19 Dec - 20 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-City-Express-Mexicali.h1661225.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/fbfdde79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/w4000h2662x0y0-04bf55ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/3b84677b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/1ad6da57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express Junior by Marriott Mexicali Mexicali 7.8/10 Good (1007) "Excellent location and great price. Will definitely stay here again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis £46 includes taxes & fees 5 Dec - 6 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-City-Express-Junior-Mexicali.h4610858.Hotel-Information) ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/48bb48a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/0b1abeec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/3134e983.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/d9075b51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fiesta Inn Mexicali Civic Center 8.2/10 Very good (1004) "Great Hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) luis £65 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Fiesta-Inn-Mexicali.h1152269.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/2e8db822.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Double Room | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/f23e4d26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/da930419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/58d45afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Calafia Hotel Eguía 8.2/10 Very good (1008) "This hotel has been one of our favorites! Great place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sylvia £64 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Calafia-Hotel.h22599.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/4796b47e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Desk, blackout curtains, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/21f7b42d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/f2c1f75c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/916300/916204/d898e4f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Colonial Mexicali Civic Center 8.0/10 Very good (1013) "It’s a good place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yesenia £83 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Colonial-Mexicali.h916204.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/35c16f11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/e9d53767.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/2ef4393d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/71000000/70920000/70919700/70919640/c64aab50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Mexicali Mexicali 9.4/10 Exceptional (798) "Great location, clean hotel rooms, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth £90 includes taxes & fees 29 Nov - 30 Nov [](https://www.expedia.co.uk/Mexicali-Hotels-Courtyard-By-Marriott-Mexicali.h70919640.Hotel-Information) ![Deluxe Suite, Jetted Tub | 1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/c266de1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite | 1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/d6e80519.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/11d3da4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Jetted Tub | 1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102640000/102634000/102634000/0d0da065.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel Cies Mexicali 9.0/10 Wonderful (53) "Excellent place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandra £44 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Mexicali-Hotels-Motel-Cies.h102634000.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/19000000/18760000/18760000/18759903/b9040e72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/19000000/18760000/18760000/18759903/92a837f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/19000000/18760000/18760000/18759903/a66b0fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Triple Room | Free WiFi, bed sheets](https://images.trvl-media.com/lodging/19000000/18760000/18760000/18759903/0624ab03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Hacienda del Indio Mexicali 7.0/10 Good (131) "The room was clean and the parking was safe" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dulce £30 includes taxes & fees 25 Nov - 26 Nov [](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Hacienda-Del-Indio.h18759903.Hotel-Information) ![Breakfast, lunch, dinner served; Mexican cuisine ](https://images.trvl-media.com/lodging/13000000/12630000/12628100/12628065/2bb3460a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Limited parking](https://images.trvl-media.com/lodging/13000000/12630000/12628100/12628065/e9b2fef4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/13000000/12630000/12628100/12628065/7954ee87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | Free WiFi](https://images.trvl-media.com/lodging/13000000/12630000/12628100/12628065/67a0ba31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Regis Mexicali 7.2/10 Good (115) "Perfect " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) LLuviaa [](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Regis.h12628065.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-08&endDate=2025-12-09®ionId=553248635975869828&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_BF_PROMO_553248635975869828) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d553248635975869828.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Hotels.d553248635975869828.Travel-Guide-Hotels) ## Top Santa Isabel Hotel Reviews ![City Express by Marriott Mexicali](https://images.trvl-media.com/lodging/2000000/1670000/1661300/1661225/3b6504b5_y.jpg) ### City Express by Marriott Mexicali 10/10 Excellent "Clean room, friendly staff, safe parking." [](https://expedia.co.uk/Mexicali-Hotels-City-Express-Mexicali.h1661225.Hotel-Information) ![Calafia Hotel](https://images.trvl-media.com/lodging/1000000/30000/22600/22599/2e8db822_y.jpg) ### Calafia Hotel 10/10 Excellent "Clean, kind staff, and had amenities " [](https://expedia.co.uk/Mexicali-Hotels-Calafia-Hotel.h22599.Hotel-Information) ![City Express Junior by Marriott Mexicali](https://images.trvl-media.com/lodging/5000000/4620000/4610900/4610858/fbfdde79_y.jpg) ### City Express Junior by Marriott Mexicali 10/10 Excellent "Great stay. Small room, but it had everything we needed for a weekend stay. Would definitely stay here again. Friendly staff. " [](https://expedia.co.uk/Mexicali-Hotels-City-Express-Junior-Mexicali.h4610858.Hotel-Information) ![Hotel Lucerna Mexicali](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/8ef53b31_y.jpg) ### Hotel Lucerna Mexicali 10/10 Excellent "We are very pleased to have chosen this hotel. everything was what we expected that it will bed it will be." [](https://expedia.co.uk/Mexicali-Hotels-Hotel-Lucerna-Mexicali.h437408.Hotel-Information) ![Real Inn Mexicali](https://images.trvl-media.com/lodging/1000000/610000/600500/600405/928ca1d8_y.jpg) ### Real Inn Mexicali 10/10 Excellent "Great service" [](https://expedia.co.uk/Mexicali-Hotels-Real-Inn-Mexicali.h600405.Hotel-Information) ![Fiesta Inn Mexicali](https://images.trvl-media.com/lodging/2000000/1160000/1152300/1152269/48bb48a1_y.jpg) ### Fiesta Inn Mexicali 10/10 Excellent "Room was clean cleaning staff were attentive of our needs since we didn’t want to be disturbed any of the days we were there when they saw us going out while they cleaned other rooms they would give us the good morning and ask if we needed anything and of course coffee envelopes and water very nice and curtiese" [](https://expedia.co.uk/Mexicali-Hotels-Fiesta-Inn-Mexicali.h1152269.Hotel-Information) ![City Express Plus by Marriott Mexicali](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/9be1b557_y.jpg) ### City Express Plus by Marriott Mexicali 10/10 Excellent "3rd time staying there I really like it" [](https://expedia.co.uk/Mexicali-Hotels-City-Express-Plus-Mexicali.h44945342.Hotel-Information) ![One Mexicali](https://images.trvl-media.com/lodging/18000000/17580000/17577200/17577142/4d789164_y.jpg) ### One Mexicali 10/10 Excellent "The only thing was the body soap was empty" [](https://expedia.co.uk/Mexicali-Hotels-One-Mexicali.h17577142.Hotel-Information) ![Extended Suites Mexicali Cataviña](https://images.trvl-media.com/lodging/18000000/17970000/17969200/17969178/5a8679ec_y.jpg) ### Extended Suites Mexicali Cataviña 10/10 Excellent "Todo fue perfecto" [](https://expedia.co.uk/Mexicali-Hotels-Extended-Suites-Mexicali-Catavina.h17969178.Hotel-Information) ## More cheap stays in Santa Isabel ![Fairfield Inn & Suites by Marriott Mexicali](https://images.trvl-media.com/lodging/34000000/33640000/33638200/33638137/a02730fc_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn & Suites by Marriott Mexicali Calzada Manuel Gomez Morin 856 Mexicali BC £87 12 Dec - 13 Dec includes taxes & fees 9.4/10 Exceptional! (1,009 reviews) [](https://expedia.co.uk/Mexicali-Hotels-Fairfield-Inn-Suites-By-Marriott-Mexicali.h33638137.Hotel-Information) ![Motel Las Fuentes](https://images.trvl-media.com/lodging/19000000/18760000/18760000/18759923/794b14f4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel Las Fuentes Blvd Lopez Mateos 1655 Mexicali BC £31 25 Nov - 26 Nov includes taxes & fees 7.8/10 Good! (146 reviews) [](https://expedia.co.uk/Mexicali-Hotels-Motel-Las-Fuentes.h18759923.Hotel-Information) ![Hotel Misión Plaza Mexicali](https://images.trvl-media.com/lodging/102000000/101490000/101486400/101486351/17b18c98_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Misión Plaza Mexicali 366 Av. Francisco I. Madero Mexicali BC £34 25 Nov - 26 Nov includes taxes & fees 7.2/10 Good! (50 reviews) [](https://expedia.co.uk/Tijuana-Hotels-Hotel-Mision-Plaza-Mexicali.h101486351.Hotel-Information) ![Motel Olimpo](https://images.trvl-media.com/lodging/119000000/118100000/118098400/118098332/e16a19c6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel Olimpo KM 11.5 San Luis Río Colorado Mexicali BC £31 25 Nov - 26 Nov includes taxes & fees [](https://expedia.co.uk/Mexicali-Hotels-Motel-Olimpo.h118098332.Hotel-Information) ![Motel Diana ](https://images.trvl-media.com/lodging/118000000/117770000/117766600/117766546/9ba5b8f3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel Diana 200 Av. Tabasco Loma Linda Mexicali BC £27 25 Nov - 26 Nov includes taxes & fees 9.6/10 Exceptional! (6 reviews) [](https://expedia.co.uk/Mexicali-Hotels-Motel-Diana.h117766546.Hotel-Information) ![HOTEL DON QUIJOTE](https://images.trvl-media.com/lodging/112000000/111350000/111343500/111343437/6318d665_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### HOTEL DON QUIJOTE Calz Independencia Independencia Mexicali BC [Get rates](https://expedia.co.uk/Hotel-Search?startDate=08%2F12%2F2025&endDate=09%2F12%2F2025&selected=111343437&PinnedHotelID=111343437&HadPinnedHotel=true®ionId=553248635975869828) 6.8/10 (13 reviews) [](https://expedia.co.uk/Mexicali-Hotels-HOTEL-DON-QUIJOTE.h111343437.Hotel-Information) ## Frequently asked questions ### What's the best place for a stay in Santa Isabel? > [Hotel Lucerna Mexicali](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Lucerna-Mexicali.h437408.Hotel-Information), located 7.5 mi (12.1 km) from the heart of Santa Isabel, is a top choice for your stay, based on our traveller data. Other good choices for your stay in the area are [Hotel Araiza Mexicali](https://www.expedia.co.uk/Mexicali-Hotels-Hotel-Araiza-Mexicali.h22592.Hotel-Information) and [Real Inn Mexicali](https://www.expedia.co.uk/Mexicali-Hotels-Real-Inn-Mexicali.h600405.Hotel-Information). See all available [top hotels](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975869828), or [vacation rentals in Santa Isabel](https://www.expedia.co.uk/Santa-Isabel-Holiday-Rentals.d553248635975869828.Travel-Guide-HolidayRentals). ### What are some of the best holiday rentals that Santa Isabel has to offer? > [Casa Grande Los Laureles With Kids games, Plenty of open space.](https://www.expedia.co.uk/Mexicali-Hotels-Casa-Grande-4-Bedroom-House-With-Adjacent-Lot-As-The-Patio.h112613033.Hotel-Information): This holiday home rental outside of Santa Isabel offers a balcony, a pool table and a BBQ to help you feel perfectly comfortable in your new surroundings. It has 4 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. See all [vacation rentals in Santa Isabel](https://www.expedia.co.uk/Santa-Isabel-Holiday-Rentals.d553248635975869828.Travel-Guide-HolidayRentals). ### If I need to cancel my hotel reservation in Santa Isabel, will I receive a refund? > Yes! You'll find that most hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within 24 hours of your booking. Filter your search by [fully refundable](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975869828&paymentType=FREE_CANCELLATION) to find flexible hotel deals in Santa Isabel. ### What is staying in Santa Isabel like? > Visitors to Santa Isabel will definitely find plenty to explore and enjoy. There are 70 hotels and other accommodation options in the surrounding area. Find out more about [Santa Isabel](https://www.expedia.co.uk/Santa-Isabel.dx553248635975869828). ### What is there to see in Santa Isabel? > Places to visit in the wider area include [Mexicali Border Port I](https://www.expedia.co.uk/Mexicali-Border-Port-I-Mexicali.d553248635998150182.Attraction), [Plaza Comercial La Cachanilla](https://www.expedia.co.uk/Plaza-Comercial-La-Cachanilla-Zona-Industrial.d6291021.Attraction) and [Eagles Nest Stadium](https://www.expedia.co.uk/Aguilas-De-Mexicali-Stadium-Mexicali.d6269341.Attraction). You'll also find [Imperial Valley Mall](https://www.expedia.co.uk/Imperial-Valley-Mall-El-Centro.d553248621561088057.Attraction) and [Plaza San Pedro](https://www.expedia.co.uk/Plaza-San-Pedro-Mexicali.d736176621473898496.Attraction) in the area. Take a look at what more there is to see and do in Expedia's [Santa Isabel guide](https://www.expedia.co.uk/Santa-Isabel.dx553248635975869828). ### What's the seasonal weather like in Santa Isabel? > The hottest months are usually July and August, with an average temperature of 34°C, while the coldest months are December and January, with an average of 16°C. 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[Zona Industrial Hotels](https://www.expedia.co.uk/Zona-Industrial-Mexicali-Hotels.0-n553248635976399090-0.Travel-Guide-Filter-Hotels) - [Flights to Ensenada](https://www.expedia.co.uk/Cheap-Flights-To-Ensenada.d6144237.Travel-Guide-Flights) - [Flights to Los Algodones](https://www.expedia.co.uk/Cheap-Flights-To-Los-Algodones.d6158212.Travel-Guide-Flights) - [Flights to Luis Echeverria Alvarez](https://www.expedia.co.uk/Cheap-Flights-To-Luis-Echeverria-Alvarez.d6347195.Travel-Guide-Flights) - [Flights to Mexicali](https://www.expedia.co.uk/Cheap-Flights-To-Mexicali.d2478.Travel-Guide-Flights) - [Flights to Santa Veronica](https://www.expedia.co.uk/Cheap-Flights-To-Santa-Veronica.d6347107.Travel-Guide-Flights) - [Flights to Tecate](https://www.expedia.co.uk/Cheap-Flights-To-Tecate.d179908.Travel-Guide-Flights) - [Flights to Valle de Guadalupe](https://www.expedia.co.uk/Cheap-Flights-To-Valle-De-Guadalupe.d6269310.Travel-Guide-Flights) - [Flights from General Rodolfo Sanchez Taboada Intl.](https://www.expedia.co.uk/lp/airports/mxl/flights-from-general-rodolfo-sanchez-taboada-intl-airport) - [Flights from Mexicali](https://www.expedia.co.uk/lp/flights/2478/flights-from-mexicali) - [Flights from Los Algodones](https://www.expedia.co.uk/lp/flights/6158212/flights-from-los-algodones) - [Flights from Addis Ababa (ADD) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/add/mxl/addis-ababa-to-mexicali) - [Flights from Belfast (BFS) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/bfs/tij/belfast-to-tijuana) - [Flights from Birmingham (BHX) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/bhx/tij/birmingham-to-tijuana) - [Flights from Cancun (CUN) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/cun/tij/cancun-to-tijuana) - [Flights from Chihuahua (CUU) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/cuu/mxl/chihuahua-to-mexicali) - [Flights from Calexico (CXL) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/cxl/mxl/calexico-to-mexicali) - [Flights from Edinburgh (EDI) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/edi/tij/edinburgh-to-tijuana) - [Flights from Guadalajara (GDL) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/gdl/tij/guadalajara-to-tijuana) - [Flights from Grand Junction (GJT) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/gjt/mxl/grand-junction-to-mexicali) - [Flights from Las Vegas (LAS) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/las/tij/las-vegas-to-tijuana) - [Flights from Los Angeles (LAX) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/lax/tij/los-angeles-to-tijuana) - [Flights from London (LGW) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/lgw/tij/london-to-tijuana) - [Flights from London (LHR) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/lhr/mxl/london-to-mexicali) - [Flights from London (LHR) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/lhr/tij/london-to-tijuana) - [Flights from Manchester (MAN) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/man/mxl/manchester-to-mexicali) - [Flights from Manchester (MAN) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/man/tij/manchester-to-tijuana) - [Flights from Mexico City (MEX) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/mex/mxl/mexico-city-to-mexicali) - [Flights from Mexico City (MEX) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/mex/tij/mexico-city-to-tijuana) - [Flights from Milan (MXP) to Mexicali (MXL)](https://www.expedia.co.uk/lp/flights/mxp/mxl/milan-to-mexicali) - [Flights from Newcastle (NCL) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/ncl/tij/newcastle-to-tijuana) - [Flights from Puerto Vallarta (PVR) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/pvr/tij/puerto-vallarta-to-tijuana) - [Flights from San Francisco (SFO) to Tijuana (TIJ)](https://www.expedia.co.uk/lp/flights/sfo/tij/san-francisco-to-tijuana) - [Visit Zona Centro](https://www.expedia.co.uk/Ensenada-Zona-Centro.dx553248635976007931) - [Ensenada Holidays](https://www.expedia.co.uk/Ensenada.d6144237.Holidays-City-Breaks) - [Visit Ensenada](https://www.expedia.co.uk/Ensenada.dx6144237) - [Juventud 2000 Sport Center](https://www.expedia.co.uk/Juventud-2000-Sport-Center-Mexicali.d553248621551385142.Attraction) - [Visit La Rumorosa](https://www.expedia.co.uk/La-Rumorosa.dx553248635823471502) - [Mexicali Holidays](https://www.expedia.co.uk/Mexicali.d2478.Holidays-City-Breaks) - [Visit Mexicali](https://www.expedia.co.uk/Mexicali.dx2478) - [Monte Xanic Winery](https://www.expedia.co.uk/Monte-Xanic-Winery-Valle-de-Guadalupe.d553248621532630241.Attraction) - [Playas de Rosarito Holidays](https://www.expedia.co.uk/Playas-De-Rosarito.d553248635943688104.Holidays-City-Breaks) - [Visit Playas de Rosarito](https://www.expedia.co.uk/Playas-De-Rosarito.dx553248635943688104) - [Sol Children's Museum](https://www.expedia.co.uk/Sol-Childrens-Museum-Zona-Industrial.d6224748.Attraction) - [Tecate Holidays](https://www.expedia.co.uk/Tecate.d179908.Holidays-City-Breaks) - [Visit Tecate](https://www.expedia.co.uk/Tecate.dx179908) - [Visit Garita de Otay](https://www.expedia.co.uk/Tijuana-Garita-De-Otay.dx553248635976007811) - [Visit Rinconada de Otay](https://www.expedia.co.uk/Tijuana-Rinconada-De-Otay.dx553248635976007603) - [Valle de Guadalupe Holidays](https://www.expedia.co.uk/Valle-De-Guadalupe.d6269310.Holidays-City-Breaks) - [Visit Valle de Guadalupe](https://www.expedia.co.uk/Valle-De-Guadalupe.dx6269310) - [Winery Santo Tomas](https://www.expedia.co.uk/Winery-Santo-Tomas-Valle-de-Guadalupe.d553248634214860757.Attraction) - [Car hire Ensenada](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Ensenada.d6144237.Car-Hire-Guide) - [Car hire Mexicali](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Mexicali.d2478.Car-Hire-Guide) - [Valle de Guadalupe Holiday Rentals](https://www.expedia.co.uk/Valle-De-Guadalupe-Holiday-Rentals.d6269310.Travel-Guide-HolidayRentals) - [Things to do in Ensenada](https://www.expedia.co.uk/Things-To-Do-In-Ensenada.d6144237.Travel-Guide-Activities) - [Book Hotels in Santa Isabel on Expedia.mx](https://www.expedia.mx/Santa-Isabel-Hoteles.d553248635975869828.Guia-Viajes-Hoteles) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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